Click here to switch to the map view.

The map label for this gene is neuB

Identifier: 46446898

GI number: 46446898

Start: 1509676

End: 1510731

Strand: Reverse

Name: neuB

Synonym: pc1264

Alternate gene names: NA

Gene position: 1510731-1509676 (Counterclockwise)

Preceding gene: 46446899

Following gene: 46446897

Centisome position: 62.57

GC content: 38.35

Gene sequence:

>1056_bases
ATGGATATTTCAATTGGATCTAAAAAAATTGGACCTGAGCATCCTCCGTTTATTATCGCTGAATTATCTGGCAATCATAA
CGGTTCACTTGAACGGGCCTTAAAACTTGTTGAAGAAGCTGCGCGAGCTGGGGCCCATGCTGTCAAATTACAAACTTACA
CACCGGATACTATTACCTTAAATGTTCGGCGTTCTGAATTTTTAATCGAAGAAAAATCGAGTTTGTGGACTGGACGGTAT
CTCTATGATCTTTACCAAGAAGCTCATATGCCTTGGGAATGGCATCAACCTATTTTTGAAAAATGCAAAGTTTTAGGATT
GGTTGCTTTTAGTACACCTTTTGATGAAAGTGCAGTAGATTTTTTGGAAGCGTTAGATGTCCCTTGTTATAAAATTGCTT
CTCCCGAAATCGTCGATTTACCCTTAATTCGAAAAATTGCTTCACTTGGTAAACCCGTGCTTTTATCAACAGGGGGTGCC
AATTTAGAAGAAATCACAGAAGCTGTGAATGCAGCCAGACAAGTTGGTTGCCAAGATTTAATTTTACTCAAATGTACAGC
TGCCTATCCTGCGAAATCGATAGATATGCATTTACGTACAATTTTTCACATGAGCGAAAATTTTCAAGTACTGATAGGAT
TGTCAGATCATACTCTAGGAATAGGTGCTTCTATCGCAAGTTTAGCTTTTGGATGTTGCCTTATAGAAAAACATTTAACC
CTTTCTCGAAAAGAAGGGGGAGTTGACAGTGTTTTTTCTTTGGAGCCGGAAGAGTTAAAACTTTTAGTTAACGAATCAAA
AAATGCTTGGGAAGCGTTAGGTCAGATTCACTATGGGCCTCTTGCCGTTGAACAAACTACGCATTCTCATCGCCCTTCTC
TTTATTTTGTGGAAGACCTTGAGCAAGGAGAAAAAATACAGCTGCACCATATTCGATCAGTTAGGCCCAATAAAGGGTTA
CCCCCAAAAGAAATTGATAAAATCATAGGATTGACTATTAATCAATCTATTGCAAAGGGAACACCTGTTACTTGGGATTT
ATTTAATATGGTTTAG

Upstream 100 bases:

>100_bases
GGATTGGATGCCCACCGCCTGAAAAACAGGAAGCTGCTAAACCTCGAAAAAGACGCCCTTACCCCAATAAAAAAAGTTCT
AAGCCTCATTAAGGTTCGAC

Downstream 100 bases:

>100_bases
CTGAAAGAACTTAATATAATTATTACATATATTTTAAAAATTCAATAAACTGATGATAAAAAAATTACCGTTGAGTTTTT
TAAAAGAATATCGCTTTATT

Product: putative sialic acid synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MDISIGSKKIGPEHPPFIIAELSGNHNGSLERALKLVEEAARAGAHAVKLQTYTPDTITLNVRRSEFLIEEKSSLWTGRY
LYDLYQEAHMPWEWHQPIFEKCKVLGLVAFSTPFDESAVDFLEALDVPCYKIASPEIVDLPLIRKIASLGKPVLLSTGGA
NLEEITEAVNAARQVGCQDLILLKCTAAYPAKSIDMHLRTIFHMSENFQVLIGLSDHTLGIGASIASLAFGCCLIEKHLT
LSRKEGGVDSVFSLEPEELKLLVNESKNAWEALGQIHYGPLAVEQTTHSHRPSLYFVEDLEQGEKIQLHHIRSVRPNKGL
PPKEIDKIIGLTINQSIAKGTPVTWDLFNMV

Sequences:

>Translated_351_residues
MDISIGSKKIGPEHPPFIIAELSGNHNGSLERALKLVEEAARAGAHAVKLQTYTPDTITLNVRRSEFLIEEKSSLWTGRY
LYDLYQEAHMPWEWHQPIFEKCKVLGLVAFSTPFDESAVDFLEALDVPCYKIASPEIVDLPLIRKIASLGKPVLLSTGGA
NLEEITEAVNAARQVGCQDLILLKCTAAYPAKSIDMHLRTIFHMSENFQVLIGLSDHTLGIGASIASLAFGCCLIEKHLT
LSRKEGGVDSVFSLEPEELKLLVNESKNAWEALGQIHYGPLAVEQTTHSHRPSLYFVEDLEQGEKIQLHHIRSVRPNKGL
PPKEIDKIIGLTINQSIAKGTPVTWDLFNMV
>Mature_351_residues
MDISIGSKKIGPEHPPFIIAELSGNHNGSLERALKLVEEAARAGAHAVKLQTYTPDTITLNVRRSEFLIEEKSSLWTGRY
LYDLYQEAHMPWEWHQPIFEKCKVLGLVAFSTPFDESAVDFLEALDVPCYKIASPEIVDLPLIRKIASLGKPVLLSTGGA
NLEEITEAVNAARQVGCQDLILLKCTAAYPAKSIDMHLRTIFHMSENFQVLIGLSDHTLGIGASIASLAFGCCLIEKHLT
LSRKEGGVDSVFSLEPEELKLLVNESKNAWEALGQIHYGPLAVEQTTHSHRPSLYFVEDLEQGEKIQLHHIRSVRPNKGL
PPKEIDKIIGLTINQSIAKGTPVTWDLFNMV

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=343, Percent_Identity=27.1137026239067, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21357081, Length=259, Percent_Identity=32.4324324324324, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 38920; Mature: 38920

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISIGSKKIGPEHPPFIIAELSGNHNGSLERALKLVEEAARAGAHAVKLQTYTPDTITL
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEE
NVRRSEFLIEEKSSLWTGRYLYDLYQEAHMPWEWHQPIFEKCKVLGLVAFSTPFDESAVD
EEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEECCCCCHHHHH
FLEALDVPCYKIASPEIVDLPLIRKIASLGKPVLLSTGGANLEEITEAVNAARQVGCQDL
HHHHCCCCCEECCCCCEECHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEE
ILLKCTAAYPAKSIDMHLRTIFHMSENFQVLIGLSDHTLGIGASIASLAFGCCLIEKHLT
EEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LSRKEGGVDSVFSLEPEELKLLVNESKNAWEALGQIHYGPLAVEQTTHSHRPSLYFVEDL
EECCCCCCCCEECCCHHHHHEEECCCCHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCC
EQGEKIQLHHIRSVRPNKGLPPKEIDKIIGLTINQSIAKGTPVTWDLFNMV
CCCCEEEEEECCCCCCCCCCCHHHHHHHHCCEECCHHHCCCCCEEHHHHCC
>Mature Secondary Structure
MDISIGSKKIGPEHPPFIIAELSGNHNGSLERALKLVEEAARAGAHAVKLQTYTPDTITL
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEE
NVRRSEFLIEEKSSLWTGRYLYDLYQEAHMPWEWHQPIFEKCKVLGLVAFSTPFDESAVD
EEEHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEECCCCCHHHHH
FLEALDVPCYKIASPEIVDLPLIRKIASLGKPVLLSTGGANLEEITEAVNAARQVGCQDL
HHHHCCCCCEECCCCCEECHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEE
ILLKCTAAYPAKSIDMHLRTIFHMSENFQVLIGLSDHTLGIGASIASLAFGCCLIEKHLT
EEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LSRKEGGVDSVFSLEPEELKLLVNESKNAWEALGQIHYGPLAVEQTTHSHRPSLYFVEDL
EECCCCCCCCEECCCHHHHHEEECCCCHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCC
EQGEKIQLHHIRSVRPNKGLPPKEIDKIIGLTINQSIAKGTPVTWDLFNMV
CCCCEEEEEECCCCCCCCCCCHHHHHHHHCCEECCHHHCCCCCEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]