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The map label for this gene is ffh [H]

Identifier: 46446288

GI number: 46446288

Start: 800667

End: 802031

Strand: Direct

Name: ffh [H]

Synonym: pc0654

Alternate gene names: 46446288

Gene position: 800667-802031 (Clockwise)

Preceding gene: 46446287

Following gene: 46446289

Centisome position: 33.16

GC content: 37.07

Gene sequence:

>1365_bases
TTGTTCAATGTCGATAAAAGTTGCATAGAGGATTTCATGCTAGGATCGTTAACAACACAATTACAAAATGTTTTTTCAAA
GTTGAGCGGGAAAAAGCGTTTGACTGAAGAAAATATTTCTGATGCTGTTAACGAAGTTCGATTAGCGTTATTAGAAGCAG
ATGTTAACTATGGAGTCACTAAAACGCTGGTCAAGAGACTCAAAGAACAGTCTTTGGGAGAGCAAGTTATCAAATCTGTC
ACACCTGGGCAACAGTTTATTAAAATTGTGCATGATGAGCTAGTGGCTTTAATGGGTGGTGAAGAAGCGACGCTTCATTT
AGAAGGAAAACCTGCTGTCATTATGTTATGTGGTTTACAAGGAGCAGGTAAAACGACTCATTGTGCTAAATTAGCGAAAT
ATCTGAAAAAAAAGGGATTATGTAAAAATCCTCTCTTGGCAGCTTGTGACTTACAAAGGCCTGCAGCTGTTGAACAATTA
AAAACTTTAGGGCAACAAATTCATGTCCCTGTTTTTACAATTGTGGGCGAAAAAGATCCTGTCCGCATTGCAAAAGATGC
TTTAAAGCATGCACAAGAAGCACAGCATGATCTTCTGATTGTGGATACGGCTGGTCGGCTGCATGTCGACAATGAGTTGA
TGACACAATTAGAAAAAATAAAAGAAGTTTTAAATCCAGGTGAGATACTTTTCGTTGCTAATGCGACAACTGGGCAAGAT
GCCGTTAATGTTGCAACAGAGTTTAGTAAACGAATAGAAGTATCTGGAACAATTTTGACTATGTTAGATGGTAATGCCCG
AGGAGGAGCTGCGATATCCATTCGAGAAGTAACGGGAAAACCGTTAAAATTCGAAGGGATTGGCGAGAAAGTTGATGATC
TTCAATTATTCAATCCTAATTCGATGGCTGATCGTATTTTAGGAATGGGTGATACCATTAATTTAGTCAAAAAAGCTCAA
GAACATATTAACGAAGAAGAAGCTCAAAAGCTCGAACAAAAAATTCGTTCGGCAACTTTTACTTATGATGATTATTTGAA
ACAAATTCAAACAGTCAAAAAGATGGGCTCTATCAAAAGTTTATTGGGTATGCTACCTGGAATGAATCAATTTCCTGCAA
TGGATTTTGATGAGAAAGAATTTTTTAAAGTTGAAGCGATGATCTTGTCCATGACTCGTGAAGAGAGGACGGAAAAAAGT
GAATTAACAACCTCGAGACGTAAGCGCCTTGCTCAAGGAAGTGGAACTAAAATTGAAGATGTTAATAAACTAGTTAAATC
GTTTAAACAAGCGAAGCAATTTTTTAAAAATATGCCAAATATGAAACAATTAGAAAAGATGATGGGAGGATCCCTATGGC
GTTAA

Upstream 100 bases:

>100_bases
CGGTGTGGAAGGTTTGCAAAGGACTGTCTTTACCTTTAAAAGTTGCTCGTTAAGTAAAAAATGTTGCTTTAGAAGATTTT
TGTTTTGATTTTTAAGAGTC

Downstream 100 bases:

>100_bases
AAATTAGACTGCGACAGCATGGTCGCACAAATCGTTCATTCTTTCGTTTAGTTGTGACCGATGCTCGTTCACCAAGAGAT
GGAAAGTATGTCGAAGCCCT

Product: signal recognition particle chain ffh

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MFNVDKSCIEDFMLGSLTTQLQNVFSKLSGKKRLTEENISDAVNEVRLALLEADVNYGVTKTLVKRLKEQSLGEQVIKSV
TPGQQFIKIVHDELVALMGGEEATLHLEGKPAVIMLCGLQGAGKTTHCAKLAKYLKKKGLCKNPLLAACDLQRPAAVEQL
KTLGQQIHVPVFTIVGEKDPVRIAKDALKHAQEAQHDLLIVDTAGRLHVDNELMTQLEKIKEVLNPGEILFVANATTGQD
AVNVATEFSKRIEVSGTILTMLDGNARGGAAISIREVTGKPLKFEGIGEKVDDLQLFNPNSMADRILGMGDTINLVKKAQ
EHINEEEAQKLEQKIRSATFTYDDYLKQIQTVKKMGSIKSLLGMLPGMNQFPAMDFDEKEFFKVEAMILSMTREERTEKS
ELTTSRRKRLAQGSGTKIEDVNKLVKSFKQAKQFFKNMPNMKQLEKMMGGSLWR

Sequences:

>Translated_454_residues
MFNVDKSCIEDFMLGSLTTQLQNVFSKLSGKKRLTEENISDAVNEVRLALLEADVNYGVTKTLVKRLKEQSLGEQVIKSV
TPGQQFIKIVHDELVALMGGEEATLHLEGKPAVIMLCGLQGAGKTTHCAKLAKYLKKKGLCKNPLLAACDLQRPAAVEQL
KTLGQQIHVPVFTIVGEKDPVRIAKDALKHAQEAQHDLLIVDTAGRLHVDNELMTQLEKIKEVLNPGEILFVANATTGQD
AVNVATEFSKRIEVSGTILTMLDGNARGGAAISIREVTGKPLKFEGIGEKVDDLQLFNPNSMADRILGMGDTINLVKKAQ
EHINEEEAQKLEQKIRSATFTYDDYLKQIQTVKKMGSIKSLLGMLPGMNQFPAMDFDEKEFFKVEAMILSMTREERTEKS
ELTTSRRKRLAQGSGTKIEDVNKLVKSFKQAKQFFKNMPNMKQLEKMMGGSLWR
>Mature_454_residues
MFNVDKSCIEDFMLGSLTTQLQNVFSKLSGKKRLTEENISDAVNEVRLALLEADVNYGVTKTLVKRLKEQSLGEQVIKSV
TPGQQFIKIVHDELVALMGGEEATLHLEGKPAVIMLCGLQGAGKTTHCAKLAKYLKKKGLCKNPLLAACDLQRPAAVEQL
KTLGQQIHVPVFTIVGEKDPVRIAKDALKHAQEAQHDLLIVDTAGRLHVDNELMTQLEKIKEVLNPGEILFVANATTGQD
AVNVATEFSKRIEVSGTILTMLDGNARGGAAISIREVTGKPLKFEGIGEKVDDLQLFNPNSMADRILGMGDTINLVKKAQ
EHINEEEAQKLEQKIRSATFTYDDYLKQIQTVKKMGSIKSLLGMLPGMNQFPAMDFDEKEFFKVEAMILSMTREERTEKS
ELTTSRRKRLAQGSGTKIEDVNKLVKSFKQAKQFFKNMPNMKQLEKMMGGSLWR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=451, Percent_Identity=32.5942350332594, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI226371618, Length=374, Percent_Identity=33.9572192513369, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI23308697, Length=307, Percent_Identity=28.9902280130293, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI295424842, Length=317, Percent_Identity=28.391167192429, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI89061728, Length=145, Percent_Identity=33.7931034482759, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=46.2085308056872, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1789874, Length=266, Percent_Identity=33.4586466165414, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=442, Percent_Identity=30.7692307692308, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=306, Percent_Identity=28.7581699346405, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=387, Percent_Identity=35.4005167958656, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6320498, Length=271, Percent_Identity=28.7822878228782, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647949, Length=453, Percent_Identity=29.8013245033113, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24641198, Length=274, Percent_Identity=30.6569343065693, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50461; Mature: 50461

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNVDKSCIEDFMLGSLTTQLQNVFSKLSGKKRLTEENISDAVNEVRLALLEADVNYGVT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
KTLVKRLKEQSLGEQVIKSVTPGQQFIKIVHDELVALMGGEEATLHLEGKPAVIMLCGLQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCC
GAGKTTHCAKLAKYLKKKGLCKNPLLAACDLQRPAAVEQLKTLGQQIHVPVFTIVGEKDP
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
VRIAKDALKHAQEAQHDLLIVDTAGRLHVDNELMTQLEKIKEVLNPGEILFVANATTGQD
HHHHHHHHHHHHHHCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
AVNVATEFSKRIEVSGTILTMLDGNARGGAAISIREVTGKPLKFEGIGEKVDDLQLFNPN
HHHHHHHHHHHEEECCEEEEEECCCCCCCCEEEEEECCCCCEEECCCCCCCCCCEEECCC
SMADRILGMGDTINLVKKAQEHINEEEAQKLEQKIRSATFTYDDYLKQIQTVKKMGSIKS
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLGMLPGMNQFPAMDFDEKEFFKVEAMILSMTREERTEKSELTTSRRKRLAQGSGTKIED
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VNKLVKSFKQAKQFFKNMPNMKQLEKMMGGSLWR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MFNVDKSCIEDFMLGSLTTQLQNVFSKLSGKKRLTEENISDAVNEVRLALLEADVNYGVT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
KTLVKRLKEQSLGEQVIKSVTPGQQFIKIVHDELVALMGGEEATLHLEGKPAVIMLCGLQ
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCC
GAGKTTHCAKLAKYLKKKGLCKNPLLAACDLQRPAAVEQLKTLGQQIHVPVFTIVGEKDP
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
VRIAKDALKHAQEAQHDLLIVDTAGRLHVDNELMTQLEKIKEVLNPGEILFVANATTGQD
HHHHHHHHHHHHHHCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
AVNVATEFSKRIEVSGTILTMLDGNARGGAAISIREVTGKPLKFEGIGEKVDDLQLFNPN
HHHHHHHHHHHEEECCEEEEEECCCCCCCCEEEEEECCCCCEEECCCCCCCCCCEEECCC
SMADRILGMGDTINLVKKAQEHINEEEAQKLEQKIRSATFTYDDYLKQIQTVKKMGSIKS
HHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LLGMLPGMNQFPAMDFDEKEFFKVEAMILSMTREERTEKSELTTSRRKRLAQGSGTKIED
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VNKLVKSFKQAKQFFKNMPNMKQLEKMMGGSLWR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]