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The map label for this gene is gapA [H]

Identifier: 46446069

GI number: 46446069

Start: 562779

End: 563798

Strand: Direct

Name: gapA [H]

Synonym: pc0435

Alternate gene names: 46446069

Gene position: 562779-563798 (Clockwise)

Preceding gene: 46446068

Following gene: 46446071

Centisome position: 23.31

GC content: 38.24

Gene sequence:

>1020_bases
ATGGCGGTCAATATAGCTATCAATGGATTTGGAAGAATTGGGAGATTGGTTTGTCGTCTCGCCATTGAAAGAGAAGATAT
TCGCATTATTGCCATCAACGATCTAGTTCCTGCAGATAATTTAGCTTATTTATTAAAGTTTGATTCAACTCATGGCCGAT
TTAAGGGCGAGATAAAGGTAGAAGAGAATGCTATCCATGTGAATGGAAAGAAAATACTAATTTTTTCTGAGAAAGATCCC
CAAAATTTACCTTGGAATGATTTGAAAATTGATTACGTTGTTGAGTCTACCGGCTTGTTTACAACTTCTGAATTGGCAGG
TAAACATTTAATTGCCGGGGCGCAGCGTGTTGTTATTTCTGCTCCAGCTAAAGGAGATGTTCCGACATTTGTAATGGGAG
TGAACGAAAAAAACTATAATCCTGCAACTGATCGGATTGTTTCTAATGCTTCTTGTACAACTAATTGCTTAGCTCCAATT
ACAAAAGTTTTATTAGATAATTTTGGAATTGACGAAGGTTTAATGACCACTATACATGCTGTCACAGCTTCTCAACCAAC
CGTTGACGGGCCTTCAAAAAAAGATTGGCGAGGAGGAAGAGGGGCTAGCCAAAATATCATTCCGGCTTCTACAGGTGCTG
CAAAAGCAGTTGCTCTATGCTTGCCTCAAGTTAAAGGGAAATTGACTGGAATGGCTTTTCGTGTACCTAATGCGGATGTG
TCTGCGATTGATTTAACGGTTCGTCTGAGCAAGGAGACATCCTATGAGGATATTTGCCAAGCAATGAAAAATGCATCGGA
AGGAGCAATGAAAGGAATTTTAGCATTTTGTGATGAACAAGTTGTATCCAGTGATTTTATCAGTAGCCCCTATTCCGCTA
TCTTTGATAAAGATGCGGGAATCACCTTGAATTCGAAGTTTTATAAATTAATTGCTTGGTATGATAATGAGATGGGATAT
GCTTGCCGAGTTATTGATTTAGTGAGTTATATGAATTGTTGTAACAACAATTCTCTTTAA

Upstream 100 bases:

>100_bases
AGCCATTCATTGTCTAAGTTAATAATTATCTTCCTCTATTCTTTGCTTTACAATCTCTTTGCGATACATTATTTTCAAAT
AATAATAAAAAGGAGGTCTT

Downstream 100 bases:

>100_bases
AAAACAGATTAAGCTATGTTATGAATTTATCGTAAGGTAAACCCTGCTTGTTTTTATCACATAGCTGCTGTTTTTGTGCC
GGAACTATTTGCGTAGTAAA

Product: glyceraldehyde 3-P dehydrogenase A

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MAVNIAINGFGRIGRLVCRLAIEREDIRIIAINDLVPADNLAYLLKFDSTHGRFKGEIKVEENAIHVNGKKILIFSEKDP
QNLPWNDLKIDYVVESTGLFTTSELAGKHLIAGAQRVVISAPAKGDVPTFVMGVNEKNYNPATDRIVSNASCTTNCLAPI
TKVLLDNFGIDEGLMTTIHAVTASQPTVDGPSKKDWRGGRGASQNIIPASTGAAKAVALCLPQVKGKLTGMAFRVPNADV
SAIDLTVRLSKETSYEDICQAMKNASEGAMKGILAFCDEQVVSSDFISSPYSAIFDKDAGITLNSKFYKLIAWYDNEMGY
ACRVIDLVSYMNCCNNNSL

Sequences:

>Translated_339_residues
MAVNIAINGFGRIGRLVCRLAIEREDIRIIAINDLVPADNLAYLLKFDSTHGRFKGEIKVEENAIHVNGKKILIFSEKDP
QNLPWNDLKIDYVVESTGLFTTSELAGKHLIAGAQRVVISAPAKGDVPTFVMGVNEKNYNPATDRIVSNASCTTNCLAPI
TKVLLDNFGIDEGLMTTIHAVTASQPTVDGPSKKDWRGGRGASQNIIPASTGAAKAVALCLPQVKGKLTGMAFRVPNADV
SAIDLTVRLSKETSYEDICQAMKNASEGAMKGILAFCDEQVVSSDFISSPYSAIFDKDAGITLNSKFYKLIAWYDNEMGY
ACRVIDLVSYMNCCNNNSL
>Mature_338_residues
AVNIAINGFGRIGRLVCRLAIEREDIRIIAINDLVPADNLAYLLKFDSTHGRFKGEIKVEENAIHVNGKKILIFSEKDPQ
NLPWNDLKIDYVVESTGLFTTSELAGKHLIAGAQRVVISAPAKGDVPTFVMGVNEKNYNPATDRIVSNASCTTNCLAPIT
KVLLDNFGIDEGLMTTIHAVTASQPTVDGPSKKDWRGGRGASQNIIPASTGAAKAVALCLPQVKGKLTGMAFRVPNADVS
AIDLTVRLSKETSYEDICQAMKNASEGAMKGILAFCDEQVVSSDFISSPYSAIFDKDAGITLNSKFYKLIAWYDNEMGYA
CRVIDLVSYMNCCNNNSL

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=330, Percent_Identity=58.4848484848485, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI7657116, Length=330, Percent_Identity=55.4545454545455, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI1788079, Length=332, Percent_Identity=58.7349397590361, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1789295, Length=335, Percent_Identity=39.7014925373134, Blast_Score=251, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17534677, Length=334, Percent_Identity=58.0838323353293, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17534679, Length=334, Percent_Identity=57.7844311377245, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI32566163, Length=334, Percent_Identity=57.7844311377245, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17568413, Length=334, Percent_Identity=57.7844311377245, Blast_Score=398, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6322409, Length=330, Percent_Identity=58.7878787878788, Blast_Score=415, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322468, Length=330, Percent_Identity=57.8787878787879, Blast_Score=407, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321631, Length=330, Percent_Identity=57.2727272727273, Blast_Score=407, Evalue=1e-114,
Organism=Drosophila melanogaster, GI17933600, Length=330, Percent_Identity=58.7878787878788, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI18110149, Length=330, Percent_Identity=58.7878787878788, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI85725000, Length=330, Percent_Identity=58.7878787878788, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI22023983, Length=330, Percent_Identity=58.7878787878788, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI19922412, Length=328, Percent_Identity=56.4024390243902, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36752; Mature: 36620

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNIAINGFGRIGRLVCRLAIEREDIRIIAINDLVPADNLAYLLKFDSTHGRFKGEIKV
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCEEEEEEEE
EENAIHVNGKKILIFSEKDPQNLPWNDLKIDYVVESTGLFTTSELAGKHLIAGAQRVVIS
ECCEEEECCEEEEEEECCCCCCCCCCCEEEEEEEECCCCEEEHHHCCHHHHCCCCEEEEE
APAKGDVPTFVMGVNEKNYNPATDRIVSNASCTTNCLAPITKVLLDNFGIDEGLMTTIHA
CCCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
VTASQPTVDGPSKKDWRGGRGASQNIIPASTGAAKAVALCLPQVKGKLTGMAFRVPNADV
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCC
SAIDLTVRLSKETSYEDICQAMKNASEGAMKGILAFCDEQVVSSDFISSPYSAIFDKDAG
EEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
ITLNSKFYKLIAWYDNEMGYACRVIDLVSYMNCCNNNSL
EEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVNIAINGFGRIGRLVCRLAIEREDIRIIAINDLVPADNLAYLLKFDSTHGRFKGEIKV
EEEEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEEEECCCCCEEEEEEEE
EENAIHVNGKKILIFSEKDPQNLPWNDLKIDYVVESTGLFTTSELAGKHLIAGAQRVVIS
ECCEEEECCEEEEEEECCCCCCCCCCCEEEEEEEECCCCEEEHHHCCHHHHCCCCEEEEE
APAKGDVPTFVMGVNEKNYNPATDRIVSNASCTTNCLAPITKVLLDNFGIDEGLMTTIHA
CCCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
VTASQPTVDGPSKKDWRGGRGASQNIIPASTGAAKAVALCLPQVKGKLTGMAFRVPNADV
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCC
SAIDLTVRLSKETSYEDICQAMKNASEGAMKGILAFCDEQVVSSDFISSPYSAIFDKDAG
EEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
ITLNSKFYKLIAWYDNEMGYACRVIDLVSYMNCCNNNSL
EEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]