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The map label for this gene is npr [H]

Identifier: 46445694

GI number: 46445694

Start: 114884

End: 115738

Strand: Reverse

Name: npr [H]

Synonym: pc0060

Alternate gene names: 46445694

Gene position: 115738-114884 (Counterclockwise)

Preceding gene: 46445695

Following gene: 46445693

Centisome position: 4.79

GC content: 32.75

Gene sequence:

>855_bases
ATGGGTGCAAATTTGTCAGAAACTTATAATAATTTCTCACCTTATCAAGCAACCCTGGTTCTTTCATATTCTGAACAGGA
ATTTTTGCAAAAAAATGATCAAATTTTTGCTTGCAGAACCCCACAGGAAACAAAACTTTGTAGAAAAATTCAACAAACAG
TAGAAATAGTAAAAAAATTTTATTGGGATACTTTTAAACTAGTCGATATAGACGAAGAAAGAATAATTCCGCCATTATTT
ATTTATTATCCCAAAAAAAATGCCTATTATGCTTCAAAGCTGAAGCATTTCGCTTTTAATAACGAATTTGCTTCTCAGCC
AGATATTGTGTGTCATGAAATGACGCACGCTGTGATTAAACATAATAATCCACTTGACCATAAAGGAGAATCGGGAGCAT
TAGATGAAGCAATTGCAGATGTCGTTACTATAGAATTTAAACAAAAGGTAGGTTTAATTGATAATTTGTGGAAAATTAGT
CATCTTTGTGACCTAAGCACAGAACCTGAGCCATTTAAACCTGCAAGTACGTATACTCACGAAAATGATTACGGCCATGT
GCATCAAAATAGCTGGATTATCAGTCATACATTTTATCTAGCTTCAAAACAACTGAGCCATAATTCAATAGATTGTAATG
AACTCTTTAAAATTTGGTTTAAGTCGATGTTAGATCTTGAAGATAAATCATTTAGGGGGTTTAGAGATATGACAATCAAA
GTTGCTAGAAAAAAAATTTTTCATCGTCGTGAATTTGTTAAAGAGGCAATTATAGATGCTTGGGACCAAACCTCCCTTCT
TTTCCCAAAGGAAAGATCAAATTTCCCCAGTTTAAATTATCCTGGTAAGATTTGA

Upstream 100 bases:

>100_bases
CTACGATGAATATATAAATTTTTAAGTTTACTTGGTCGTTGCTAAAAGGAACCAATAAGTTTATTTTCTATTCAATAAAT
CAAAGAACCAAGGAATAAAA

Downstream 100 bases:

>100_bases
GAAAAATTGACCTTGAGCTGATTAAAAAAATGCCAAATCTAAGAAAATTACTAATCTAAGTTGGGAACTTGCCTTCAGTA
AACAATAAATGATGCCATTT

Product: putative extracellular metalloproteinase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 284; Mature: 283

Protein sequence:

>284_residues
MGANLSETYNNFSPYQATLVLSYSEQEFLQKNDQIFACRTPQETKLCRKIQQTVEIVKKFYWDTFKLVDIDEERIIPPLF
IYYPKKNAYYASKLKHFAFNNEFASQPDIVCHEMTHAVIKHNNPLDHKGESGALDEAIADVVTIEFKQKVGLIDNLWKIS
HLCDLSTEPEPFKPASTYTHENDYGHVHQNSWIISHTFYLASKQLSHNSIDCNELFKIWFKSMLDLEDKSFRGFRDMTIK
VARKKIFHRREFVKEAIIDAWDQTSLLFPKERSNFPSLNYPGKI

Sequences:

>Translated_284_residues
MGANLSETYNNFSPYQATLVLSYSEQEFLQKNDQIFACRTPQETKLCRKIQQTVEIVKKFYWDTFKLVDIDEERIIPPLF
IYYPKKNAYYASKLKHFAFNNEFASQPDIVCHEMTHAVIKHNNPLDHKGESGALDEAIADVVTIEFKQKVGLIDNLWKIS
HLCDLSTEPEPFKPASTYTHENDYGHVHQNSWIISHTFYLASKQLSHNSIDCNELFKIWFKSMLDLEDKSFRGFRDMTIK
VARKKIFHRREFVKEAIIDAWDQTSLLFPKERSNFPSLNYPGKI
>Mature_283_residues
GANLSETYNNFSPYQATLVLSYSEQEFLQKNDQIFACRTPQETKLCRKIQQTVEIVKKFYWDTFKLVDIDEERIIPPLFI
YYPKKNAYYASKLKHFAFNNEFASQPDIVCHEMTHAVIKHNNPLDHKGESGALDEAIADVVTIEFKQKVGLIDNLWKISH
LCDLSTEPEPFKPASTYTHENDYGHVHQNSWIISHTFYLASKQLSHNSIDCNELFKIWFKSMLDLEDKSFRGFRDMTIKV
ARKKIFHRREFVKEAIIDAWDQTSLLFPKERSNFPSLNYPGKI

Specific function: Involved in the generation of beta- and alpha-amylases from the large amylase precursor [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 33302; Mature: 33171

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGANLSETYNNFSPYQATLVLSYSEQEFLQKNDQIFACRTPQETKLCRKIQQTVEIVKKF
CCCCHHHHHCCCCCEEEEEEEEECHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
YWDTFKLVDIDEERIIPPLFIYYPKKNAYYASKLKHFAFNNEFASQPDIVCHEMTHAVIK
HCCCEEEEECCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
HNNPLDHKGESGALDEAIADVVTIEFKQKVGLIDNLWKISHLCDLSTEPEPFKPASTYTH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ENDYGHVHQNSWIISHTFYLASKQLSHNSIDCNELFKIWFKSMLDLEDKSFRGFRDMTIK
CCCCCCEECCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
VARKKIFHRREFVKEAIIDAWDQTSLLFPKERSNFPSLNYPGKI
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GANLSETYNNFSPYQATLVLSYSEQEFLQKNDQIFACRTPQETKLCRKIQQTVEIVKKF
CCCHHHHHCCCCCEEEEEEEEECHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHH
YWDTFKLVDIDEERIIPPLFIYYPKKNAYYASKLKHFAFNNEFASQPDIVCHEMTHAVIK
HCCCEEEEECCHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
HNNPLDHKGESGALDEAIADVVTIEFKQKVGLIDNLWKISHLCDLSTEPEPFKPASTYTH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ENDYGHVHQNSWIISHTFYLASKQLSHNSIDCNELFKIWFKSMLDLEDKSFRGFRDMTIK
CCCCCCEECCCEEEEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
VARKKIFHRREFVKEAIIDAWDQTSLLFPKERSNFPSLNYPGKI
HHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1834632 [H]