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The map label for this gene is trxA

Identifier: 45657831

GI number: 45657831

Start: 2384404

End: 2384718

Strand: Reverse

Name: trxA

Synonym: LIC11978

Alternate gene names: 45657831

Gene position: 2384718-2384404 (Counterclockwise)

Preceding gene: 45657832

Following gene: 45657830

Centisome position: 55.75

GC content: 38.41

Gene sequence:

>315_bases
ATGGCATTGGCAGAAGTCAACGATACAAATTTTAAAAGTGAGACATCCGGAGGATTGGTTCTCATTGATTGTTGGGCGGA
ATGGTGTGGCCCTTGTAGAATGGTGGCTCCGGTTTTGGAAGAACTTTCCGGTGAATTGGATGGGTTGGTAAAAATCAAAA
AACTGAATGTAGATGATAATCAGGATACAGCTCAAAGTTTAGGGATTTCTTCCATTCCGACATTGTTGCTTTACAAAGAC
GGACAACTTGTCGATAAAGTAATTGGGGCACTTCCAAAAGCTCAAATTAAAAATTTTATAGAAAGACATAAATAA

Upstream 100 bases:

>100_bases
AAGTCGAATCCATAGAGGCAGATAAGGATAAAAAGAAAAAGAAAAAATAGACCCTGTGAGTCTGATCTGTATTGTAGGAA
AAAAGGAGAAAGAATCAAAG

Downstream 100 bases:

>100_bases
TTTTTTTACTTCTTTATTTATTATGCTGAAAGAAACATACAAAGGTTATACGGAATTGCCTAGAGGAGGGTATCTCATTG
ATACTTCCGAGGGATACCTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MALAEVNDTNFKSETSGGLVLIDCWAEWCGPCRMVAPVLEELSGELDGLVKIKKLNVDDNQDTAQSLGISSIPTLLLYKD
GQLVDKVIGALPKAQIKNFIERHK

Sequences:

>Translated_104_residues
MALAEVNDTNFKSETSGGLVLIDCWAEWCGPCRMVAPVLEELSGELDGLVKIKKLNVDDNQDTAQSLGISSIPTLLLYKD
GQLVDKVIGALPKAQIKNFIERHK
>Mature_103_residues
ALAEVNDTNFKSETSGGLVLIDCWAEWCGPCRMVAPVLEELSGELDGLVKIKKLNVDDNQDTAQSLGISSIPTLLLYKDG
QLVDKVIGALPKAQIKNFIERHK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=34.6938775510204, Blast_Score=73, Evalue=6e-14,
Organism=Homo sapiens, GI21361657, Length=82, Percent_Identity=36.5853658536585, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082331, Length=101, Percent_Identity=43.5643564356436, Blast_Score=102, Evalue=6e-24,
Organism=Escherichia coli, GI1788936, Length=81, Percent_Identity=43.2098765432099, Blast_Score=86, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17507705, Length=102, Percent_Identity=39.2156862745098, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=82, Percent_Identity=40.2439024390244, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17510299, Length=91, Percent_Identity=37.3626373626374, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=76, Percent_Identity=44.7368421052632, Blast_Score=78, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=76, Percent_Identity=47.3684210526316, Blast_Score=78, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=75, Percent_Identity=42.6666666666667, Blast_Score=68, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17648013, Length=81, Percent_Identity=41.9753086419753, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24583090, Length=81, Percent_Identity=41.9753086419753, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=35.2941176470588, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24658597, Length=94, Percent_Identity=35.1063829787234, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=36.6197183098592, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=70, Percent_Identity=31.4285714285714, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11369; Mature: 11238

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALAEVNDTNFKSETSGGLVLIDCWAEWCGPCRMVAPVLEELSGELDGLVKIKKLNVDDN
CCCCCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHHHHHHHCCHHCCEEEEEEECCCCC
QDTAQSLGISSIPTLLLYKDGQLVDKVIGALPKAQIKNFIERHK
CHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALAEVNDTNFKSETSGGLVLIDCWAEWCGPCRMVAPVLEELSGELDGLVKIKKLNVDDN
CCCCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHHHHHHHCCHHCCEEEEEEECCCCC
QDTAQSLGISSIPTLLLYKDGQLVDKVIGALPKAQIKNFIERHK
CHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]