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The map label for this gene is clpP2

Identifier: 45657810

GI number: 45657810

Start: 2359332

End: 2359925

Strand: Reverse

Name: clpP2

Synonym: LIC11951

Alternate gene names: 45657810

Gene position: 2359925-2359332 (Counterclockwise)

Preceding gene: 45657811

Following gene: 45657809

Centisome position: 55.17

GC content: 39.73

Gene sequence:

>594_bases
ATGCCAGAAACAGAAAAAATCGCAGAAGTATTCGAAGAACTCACAGGAAGTAAAATTTCCAAAAATTTCCTCGACCATAG
AAAGATTTTTCTCTGGGGTCCTGTTACAGACGAATCTTCTAAGGATTTAGTTGGTAAACTACTTTATCTGGAAATGAAAG
ATCCAGGTAAAAAAATCACTTTTTATATCAATAGTCCCGGTGGAGTTGTAACTTCGGGAATGACCGTTTTTGACACGATC
AAGATGATCAGTTCTCCAGTTCACACGGTTTGTATGGGAATGGCTGCTTCTATGGGTTCTGTTCTACTTGCAGCAGGAAC
TAAAGGAGAACGTTCTATTTGGCCGAACGGTAAAGTGATGATTCATCAACCTAGTATTGGTGGACAGATTGTAGCACCTG
CAACGGATTTGAAAATTCACGCGGAAGAAATTCTCAAAACAAAGACGAAATTGAATCAAATCCTTGCGGACGCTTGTGGA
CATCCCATTTCTAAGTTGGAAGAGGATACGGACCGAGATTATTACATGGACGCGGAAGAAGCGATCAAATACGGAATCGT
AGATAAACTCGCTACTAAAATCGATTTTAATTGA

Upstream 100 bases:

>100_bases
CGGATTTTCTATGCAATCTTCTCTAGTTTCATTTGTATTGGAGTTTTCATAAAAATGAGGAAGAAGAAACTGGACTTTAG
AAACGAATAAGGAAAGGTTC

Downstream 100 bases:

>100_bases
TTCGAATAAAACCTTGTCTAAACCAATCTCCTTAGAAGAATTCCTAAAAGAATTTTTAGTCTCTTCCGAACAAAAGGGAA
GAAATTCGGAAGTAGATCAA

Product: ATP-dependent Clp protease-like, proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MPETEKIAEVFEELTGSKISKNFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKKITFYINSPGGVVTSGMTVFDTI
KMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVMIHQPSIGGQIVAPATDLKIHAEEILKTKTKLNQILADACG
HPISKLEEDTDRDYYMDAEEAIKYGIVDKLATKIDFN

Sequences:

>Translated_197_residues
MPETEKIAEVFEELTGSKISKNFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKKITFYINSPGGVVTSGMTVFDTI
KMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVMIHQPSIGGQIVAPATDLKIHAEEILKTKTKLNQILADACG
HPISKLEEDTDRDYYMDAEEAIKYGIVDKLATKIDFN
>Mature_196_residues
PETEKIAEVFEELTGSKISKNFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKKITFYINSPGGVVTSGMTVFDTIK
MISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVMIHQPSIGGQIVAPATDLKIHAEEILKTKTKLNQILADACGH
PISKLEEDTDRDYYMDAEEAIKYGIVDKLATKIDFN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=172, Percent_Identity=44.1860465116279, Blast_Score=150, Evalue=8e-37,
Organism=Escherichia coli, GI1786641, Length=174, Percent_Identity=48.2758620689655, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17538017, Length=174, Percent_Identity=45.4022988505747, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI20129427, Length=172, Percent_Identity=44.1860465116279, Blast_Score=149, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_LEPIC (Q72R01)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001896.1
- ProteinModelPortal:   Q72R01
- SMR:   Q72R01
- GeneID:   2771980
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11951
- NMPDR:   fig|267671.1.peg.1896
- HOGENOM:   HBG558421
- OMA:   FSEPVTD
- ProtClustDB:   CLSK574113
- BioCyc:   LINT267671:LIC_11951-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21635; Mature: 21504

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 97-97 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETEKIAEVFEELTGSKISKNFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKKIT
CCCHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHEEEEEEECCCCCEEE
FYINSPGGVVTSGMTVFDTIKMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVM
EEEECCCCEEECCHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEE
IHQPSIGGQIVAPATDLKIHAEEILKTKTKLNQILADACGHPISKLEEDTDRDYYMDAEE
EECCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEECHHH
AIKYGIVDKLATKIDFN
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PETEKIAEVFEELTGSKISKNFLDHRKIFLWGPVTDESSKDLVGKLLYLEMKDPGKKIT
CCHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCCCCHHHHHEEEEEEECCCCCEEE
FYINSPGGVVTSGMTVFDTIKMISSPVHTVCMGMAASMGSVLLAAGTKGERSIWPNGKVM
EEEECCCCEEECCHHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEE
IHQPSIGGQIVAPATDLKIHAEEILKTKTKLNQILADACGHPISKLEEDTDRDYYMDAEE
EECCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEECHHH
AIKYGIVDKLATKIDFN
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA