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The map label for this gene is ybdR [H]

Identifier: 45657459

GI number: 45657459

Start: 1944091

End: 1945149

Strand: Direct

Name: ybdR [H]

Synonym: LIC11586

Alternate gene names: 45657459

Gene position: 1944091-1945149 (Clockwise)

Preceding gene: 45657458

Following gene: 45657466

Centisome position: 45.45

GC content: 44.29

Gene sequence:

>1059_bases
ATGAATCGAGTTCTCACATATCTTTCACCCGGAGAGTTGGATTGGCGTGAAATGCCCAGGCCTATACTATCACATCCGGA
AGATGCAATTGTTCGTCCCGTAGCGTCATCAACTTGTGATTTAGATATAATGATCATCCAAGGAAGAACTCCTTTTAAAG
GTCCTTTTGATATTGGTCACGAATGTATTGGTGAAATTATAGAGACTGGCGAAGGAGTTCGTCGTTTTTACCCTGGGCAG
TTGGTCGTTGTGAGTTGGCATATTTCTTGCGGTCAGTGCCACAGGTGTCGTAAGGGACTGATGAATACCTGTGCTTCTTA
TCCTCAAGGGGCAATGTTTGGTATGTCCATAGGCGGCAAATGGGGTGGCTTCTTTTCTGATTTTATTCGTGTGCCAAACG
CGGATATATCCCTATTTGTTTTGCCACCGGGAATTAATCCTTCATATGTTGCAAGTTTAAGTGACAACATTCCTTTCGGT
TACGAATTAACGGTACCACATCTCACTCGTAATTGCGGAGTAGACGTATTGATTATGGGTGGTACGGGTTCCATCGGACT
ATTTGCGGCTGCTTATGCAAAGGCTGGTGGGGCTGGGTCCGTCGACTATGTTGACACAAACAAAATGCGGTTAGGTATCG
CTGAAAAAATAGGAGTAAATCCGATCGAAAGTCCTCCAAAACAACGGATTGGCAGGCGCCCTGGAAAATACCCAATCACT
GTGGATACAAGCGGTTCATCCGAAGGTCTTTTATGTGCAATTCGTTCTACGGAACCCGAAGGTTATTGTTCTAGTATAGG
TGGTCACTTTGGAGACATTGCGTTTCCGATGTTAGAGATGTATGCCAAAGGGATACACTTTTATACGGGACGTGGTTTAG
GAAGAATCAACTTTGAAGCGGCTACGGATTTTATTATAAGTGGGAAAGTCAAACCGGAACTGATCGTTACAGAAGAAAGA
CCGTTTGATGAAGCGGCTGAAGTTTTACGGGATCCTTCTATGAAACCGGTATTAGTTCGACAGACCATGCTTTCTAAGGC
TTACCAACCCAAGGTATAA

Upstream 100 bases:

>100_bases
CGGATGGCGGCTGGGGAATGTCCGGAAAAGTTGTTACGATAGATGCGATGAAGAAATCGTTGGAAAAAACGGAATAAGAT
AAAATTTCAAGAGGAACGCA

Downstream 100 bases:

>100_bases
AATCATATAAATTTGATTTTTGGTCTCCAAAACCCGTATATCAAAACTCAACATAAAAAATAAAAAAGGTCTGAATGAAT
ATTCCTTCAGACCTTTCCAA

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNRVLTYLSPGELDWREMPRPILSHPEDAIVRPVASSTCDLDIMIIQGRTPFKGPFDIGHECIGEIIETGEGVRRFYPGQ
LVVVSWHISCGQCHRCRKGLMNTCASYPQGAMFGMSIGGKWGGFFSDFIRVPNADISLFVLPPGINPSYVASLSDNIPFG
YELTVPHLTRNCGVDVLIMGGTGSIGLFAAAYAKAGGAGSVDYVDTNKMRLGIAEKIGVNPIESPPKQRIGRRPGKYPIT
VDTSGSSEGLLCAIRSTEPEGYCSSIGGHFGDIAFPMLEMYAKGIHFYTGRGLGRINFEAATDFIISGKVKPELIVTEER
PFDEAAEVLRDPSMKPVLVRQTMLSKAYQPKV

Sequences:

>Translated_352_residues
MNRVLTYLSPGELDWREMPRPILSHPEDAIVRPVASSTCDLDIMIIQGRTPFKGPFDIGHECIGEIIETGEGVRRFYPGQ
LVVVSWHISCGQCHRCRKGLMNTCASYPQGAMFGMSIGGKWGGFFSDFIRVPNADISLFVLPPGINPSYVASLSDNIPFG
YELTVPHLTRNCGVDVLIMGGTGSIGLFAAAYAKAGGAGSVDYVDTNKMRLGIAEKIGVNPIESPPKQRIGRRPGKYPIT
VDTSGSSEGLLCAIRSTEPEGYCSSIGGHFGDIAFPMLEMYAKGIHFYTGRGLGRINFEAATDFIISGKVKPELIVTEER
PFDEAAEVLRDPSMKPVLVRQTMLSKAYQPKV
>Mature_352_residues
MNRVLTYLSPGELDWREMPRPILSHPEDAIVRPVASSTCDLDIMIIQGRTPFKGPFDIGHECIGEIIETGEGVRRFYPGQ
LVVVSWHISCGQCHRCRKGLMNTCASYPQGAMFGMSIGGKWGGFFSDFIRVPNADISLFVLPPGINPSYVASLSDNIPFG
YELTVPHLTRNCGVDVLIMGGTGSIGLFAAAYAKAGGAGSVDYVDTNKMRLGIAEKIGVNPIESPPKQRIGRRPGKYPIT
VDTSGSSEGLLCAIRSTEPEGYCSSIGGHFGDIAFPMLEMYAKGIHFYTGRGLGRINFEAATDFIISGKVKPELIVTEER
PFDEAAEVLRDPSMKPVLVRQTMLSKAYQPKV

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786825, Length=402, Percent_Identity=28.8557213930348, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1790045, Length=233, Percent_Identity=28.755364806867, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788407, Length=327, Percent_Identity=25.0764525993884, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=25.9701492537313, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082125, Length=351, Percent_Identity=26.2108262108262, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=321, Percent_Identity=24.6105919003115, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787863, Length=320, Percent_Identity=24.6875, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 38301; Mature: 38301

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVLTYLSPGELDWREMPRPILSHPEDAIVRPVASSTCDLDIMIIQGRTPFKGPFDIGH
CCCEEEEECCCCCCHHHCCCHHHCCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHH
ECIGEIIETGEGVRRFYPGQLVVVSWHISCGQCHRCRKGLMNTCASYPQGAMFGMSIGGK
HHHHHHHHCCCCHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCC
WGGFFSDFIRVPNADISLFVLPPGINPSYVASLSDNIPFGYELTVPHLTRNCGVDVLIMG
CCHHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCCCCCEEEECCHHHHCCCEEEEEEC
GTGSIGLFAAAYAKAGGAGSVDYVDTNKMRLGIAEKIGVNPIESPPKQRIGRRPGKYPIT
CCCCHHHHHHHHHHCCCCCCEEEEECCCEEECCHHHCCCCCCCCCHHHHHCCCCCCCEEE
VDTSGSSEGLLCAIRSTEPEGYCSSIGGHFGDIAFPMLEMYAKGIHFYTGRGLGRINFEA
EECCCCCCCEEEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCEEEHHH
ATDFIISGKVKPELIVTEERPFDEAAEVLRDPSMKPVLVRQTMLSKAYQPKV
HCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNRVLTYLSPGELDWREMPRPILSHPEDAIVRPVASSTCDLDIMIIQGRTPFKGPFDIGH
CCCEEEEECCCCCCHHHCCCHHHCCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHH
ECIGEIIETGEGVRRFYPGQLVVVSWHISCGQCHRCRKGLMNTCASYPQGAMFGMSIGGK
HHHHHHHHCCCCHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCC
WGGFFSDFIRVPNADISLFVLPPGINPSYVASLSDNIPFGYELTVPHLTRNCGVDVLIMG
CCHHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCCCCCEEEECCHHHHCCCEEEEEEC
GTGSIGLFAAAYAKAGGAGSVDYVDTNKMRLGIAEKIGVNPIESPPKQRIGRRPGKYPIT
CCCCHHHHHHHHHHCCCCCCEEEEECCCEEECCHHHCCCCCCCCCHHHHHCCCCCCCEEE
VDTSGSSEGLLCAIRSTEPEGYCSSIGGHFGDIAFPMLEMYAKGIHFYTGRGLGRINFEA
EECCCCCCCEEEEEECCCCCCHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCEEEHHH
ATDFIISGKVKPELIVTEERPFDEAAEVLRDPSMKPVLVRQTMLSKAYQPKV
HCCEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]