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The map label for this gene is fmt

Identifier: 45657425

GI number: 45657425

Start: 1915944

End: 1916891

Strand: Direct

Name: fmt

Synonym: LIC11552

Alternate gene names: 45657425

Gene position: 1915944-1916891 (Clockwise)

Preceding gene: 45657424

Following gene: 45657426

Centisome position: 44.79

GC content: 38.29

Gene sequence:

>948_bases
ATGAAAATCGGATATTTTGGAACCCCCGAGCATTCTGCAAAACTTTTAGAAGCTCTCATTGATTCTCAACTTACAGAAGT
ATTATTTGTAGTTACCAATCCGGATCGTCCTAAGGGCAGGAGTAAAATTCCCGAGCCCGGTCCAGTCAAAAAGAAAGCTC
TTGAATATAACATTCCGGTATTTCAATACGAATCTATCAAAAAGGAAAAAGAAAAAGCTCTCTCCGATTTCGGTTTATTT
TCTGCAGATCTCTATGTAGTTTTTGCTTACGGATCCATTCTTCCCAAAGAAGTATATGCACATTCTACTTTGACTTCGAT
CAACTTACACGGATCTTTATTGCCGGATCTACGTGGAGCCTCTCCCGTTCAAACCGCGCTTTGGAAAGGTTATACTAAAA
CCGGAATCACAATTCAATACATTGGAGAGAAAATGGATGAAGGAGATATTCTTTTAACGAAAGAAGTTGAAATTGCTCCA
GAAGATAACACAGGAACTTTGATGGATAAAATCACAGATGCAGGAATAGAATCTATTCTTCAATTATTGAAAACATACGA
TGGAAAACCTTTTCCTTCAGTTCCACAAGCTCACGATAAAGCAACCTATTGTGGGAAAATCAAATCGGAAGATAGAATTT
TAGATTGGTCTTTAAAATCGGAGGAGTTACACAATCGAATCCGAGCCTTATATCCCGATATGATTGCAACTACTACCTTT
CGAGATAAAAGGATGAACATTCTAAAAACAAAACCTTCTTCTTTGTCACTAGAAATCAATCCTACGCCGGGCAAATTGAA
ACGATTGGACAAAAAACGCCTTCTTACACAGTGTGGTGATGGTAGATTTCTGGAGATTTTGGAACTGCAACCGGAAAATA
AAAACAGGATGACTGCATCCGATTTTCTCAACGGTTTCAGAATTCAAGAAGGGGAAACATTCGGGTGA

Upstream 100 bases:

>100_bases
AGCCTTGCTACGGTTATCTCGCTTATAGCTCGATAGGGACAGAACCTTGCAGCTTATTTTTTTGAGAAGATAAAATATAT
TTTTTAGGAAGCGCTGTAAT

Downstream 100 bases:

>100_bases
ATCAAGAGCAAATTAGAGAAAAGTATCTTCCAATCGGAGGTTATGTTTTATTCTTAGCGGTGGGTCTTCTATTATTTTTT
AGTGCAGCCTTCTTAGTAGT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MKIGYFGTPEHSAKLLEALIDSQLTEVLFVVTNPDRPKGRSKIPEPGPVKKKALEYNIPVFQYESIKKEKEKALSDFGLF
SADLYVVFAYGSILPKEVYAHSTLTSINLHGSLLPDLRGASPVQTALWKGYTKTGITIQYIGEKMDEGDILLTKEVEIAP
EDNTGTLMDKITDAGIESILQLLKTYDGKPFPSVPQAHDKATYCGKIKSEDRILDWSLKSEELHNRIRALYPDMIATTTF
RDKRMNILKTKPSSLSLEINPTPGKLKRLDKKRLLTQCGDGRFLEILELQPENKNRMTASDFLNGFRIQEGETFG

Sequences:

>Translated_315_residues
MKIGYFGTPEHSAKLLEALIDSQLTEVLFVVTNPDRPKGRSKIPEPGPVKKKALEYNIPVFQYESIKKEKEKALSDFGLF
SADLYVVFAYGSILPKEVYAHSTLTSINLHGSLLPDLRGASPVQTALWKGYTKTGITIQYIGEKMDEGDILLTKEVEIAP
EDNTGTLMDKITDAGIESILQLLKTYDGKPFPSVPQAHDKATYCGKIKSEDRILDWSLKSEELHNRIRALYPDMIATTTF
RDKRMNILKTKPSSLSLEINPTPGKLKRLDKKRLLTQCGDGRFLEILELQPENKNRMTASDFLNGFRIQEGETFG
>Mature_315_residues
MKIGYFGTPEHSAKLLEALIDSQLTEVLFVVTNPDRPKGRSKIPEPGPVKKKALEYNIPVFQYESIKKEKEKALSDFGLF
SADLYVVFAYGSILPKEVYAHSTLTSINLHGSLLPDLRGASPVQTALWKGYTKTGITIQYIGEKMDEGDILLTKEVEIAP
EDNTGTLMDKITDAGIESILQLLKTYDGKPFPSVPQAHDKATYCGKIKSEDRILDWSLKSEELHNRIRALYPDMIATTTF
RDKRMNILKTKPSSLSLEINPTPGKLKRLDKKRLLTQCGDGRFLEILELQPENKNRMTASDFLNGFRIQEGETFG

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=294, Percent_Identity=29.9319727891156, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI164663775, Length=322, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI238814322, Length=293, Percent_Identity=27.3037542662116, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789683, Length=308, Percent_Identity=38.3116883116883, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1788589, Length=314, Percent_Identity=25.796178343949, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI133930964, Length=216, Percent_Identity=24.537037037037, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45550868, Length=227, Percent_Identity=33.0396475770925, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=33.0396475770925, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585660, Length=319, Percent_Identity=24.7648902821317, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_LEPIC (Q72S34)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001511.1
- ProteinModelPortal:   Q72S34
- SMR:   Q72S34
- GeneID:   2772823
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11552
- NMPDR:   fig|267671.1.peg.1511
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- ProtClustDB:   CLSK574385
- BioCyc:   LINT267671:LIC_11552-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 35399; Mature: 35399

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGYFGTPEHSAKLLEALIDSQLTEVLFVVTNPDRPKGRSKIPEPGPVKKKALEYNIPV
CCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCHHHEEECCCE
FQYESIKKEKEKALSDFGLFSADLYVVFAYGSILPKEVYAHSTLTSINLHGSLLPDLRGA
EEHHHHHHHHHHHHHHCCCHHHHEEEEEEHHCCCHHHHHHHHHEEEEEECCCCCCCCCCC
SPVQTALWKGYTKTGITIQYIGEKMDEGDILLTKEVEIAPEDNTGTLMDKITDAGIESIL
CHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
QLLKTYDGKPFPSVPQAHDKATYCGKIKSEDRILDWSLKSEELHNRIRALYPDMIATTTF
HHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHCCC
RDKRMNILKTKPSSLSLEINPTPGKLKRLDKKRLLTQCGDGRFLEILELQPENKNRMTAS
CHHCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
DFLNGFRIQEGETFG
HHHCCEEECCCCCCC
>Mature Secondary Structure
MKIGYFGTPEHSAKLLEALIDSQLTEVLFVVTNPDRPKGRSKIPEPGPVKKKALEYNIPV
CCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCHHHEEECCCE
FQYESIKKEKEKALSDFGLFSADLYVVFAYGSILPKEVYAHSTLTSINLHGSLLPDLRGA
EEHHHHHHHHHHHHHHCCCHHHHEEEEEEHHCCCHHHHHHHHHEEEEEECCCCCCCCCCC
SPVQTALWKGYTKTGITIQYIGEKMDEGDILLTKEVEIAPEDNTGTLMDKITDAGIESIL
CHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
QLLKTYDGKPFPSVPQAHDKATYCGKIKSEDRILDWSLKSEELHNRIRALYPDMIATTTF
HHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHCCC
RDKRMNILKTKPSSLSLEINPTPGKLKRLDKKRLLTQCGDGRFLEILELQPENKNRMTAS
CHHCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHH
DFLNGFRIQEGETFG
HHHCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA