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The map label for this gene is dtpD [H]

Identifier: 45657408

GI number: 45657408

Start: 1896788

End: 1898092

Strand: Direct

Name: dtpD [H]

Synonym: LIC11535

Alternate gene names: 45657408

Gene position: 1896788-1898092 (Clockwise)

Preceding gene: 45657407

Following gene: 45657409

Centisome position: 44.35

GC content: 34.48

Gene sequence:

>1305_bases
ATGGACGTCCAGAACAAAGACGTAAATTCTCATCCCAAGGGTCTTACGATTTTATTTTTTACAGAAACTTGGGAAAGGTT
CAGCTTTTATGGAATGCGTGCCTTACTCGTGTTATTTCTTACTAAGGTTTTTCATTTTTCTGATGTGGACGCAAATCGAA
TCTATGGAATTTATACAGGTCTCGTTTATTTAACTCCTCTCCTAGGAGGTTATCTTGCAGATCGTTATTTAGGTTTTAAA
AAATGCATTTTTCTAGGAGCCACGTTGATGATGTTTGGGCATTTGAGTCTTGCCTTTGAAACAAAACCATTTTTCTTTTT
AGGTTTGGGATTGCTCATTTTAGGAGTTGGTTTTTTTAAACCAAATATCGCTACAGTTTTAGGAAGAATCTATGATGAAG
ATAATAAAACTCGAATGAAAGATTCTGGTTTTACGATTTTTTATATGGGAATTAATTTAGGAGGTTTTTTAGGACCTCTA
TTTTGTGGTTATTTTAGTAAATCTTGGGGCTGGGGATACGGATTTGGAGTGGCCGCCTTTGGAGTGTTATTCGGAATTTT
AATTCTTCTTTTGGGTCAAAAACAATTTCCGGAAAAAGTTTTTGAACCAGGTAAAAAATATCATACCGTCGAAGGACAAA
AACATTCTACTTTAAAAAAAGAAGAAAAACAAAAACTCGCAGTAATTTTTATTTTTACCTTATTTGTAATCATTTTTTGG
GCTGCTTTTGAACAAATCGGTTCTTCTATAAATCTTTTTATAGATCGTCACGTTAACCGAAATTTGTTCGGATACGATAT
TCCTACTCCTTTTTTTCAATCTTTAAATCCGCTTTTGATTTTGATTTTTGCTCCTATAATTGCTTCTTTTTGGACTACAC
TTGCAAAAAATAATTGGAAGCCAGATACTTCTACAAGATTTGCAACCGGTTTTTTCATTTTAGCTTTGGGTTTTTCAGTT
TTAACATTAGTCACTCTTGACTTTAGACCTGGTCATAAAATTTCGGCGGTTTGGCTTTTGTTAATGGTTCTTTGTATTAC
TGTAGGAGAGTTATTTACATCTCCTGGAGGTTTGGCTCTAGTTACTAAGTTGTCTCCTAAACAACTAGGTGGTTTTATGA
TGGGGGTTTGGCTTCTTTCTAGTTTTTTTGGTAACATTCTCGCCGGAGAATTGGCTGGGTTTATGAAAACAGATAGTTTT
CCTACTTTTTTTGGGATGTTTGCAATACTTGCATTTGTAGGTGGAATGATTCTCTATATTACAAGAAAAAAACTTCAAAA
CTGGATGCACGGAGCGGACCAGTGA

Upstream 100 bases:

>100_bases
AAATACTTTCTTCTCCTATGATTTTTATAAATCGTCTTTCGGATTATTTTTTTGTGGCCGCTCGTTTTGCAAATTTAGAA
GAGAATATTCAGGAACCATT

Downstream 100 bases:

>100_bases
AATATTCAATTTTTTATAGATTCTAAAATTTATATATTAGGGAATTTTTATGTTTAGAATTATTCAAATCTTTTTTGTTT
TGGTTTGGATGCCCATTTCC

Product: di-tripeptide proton symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MDVQNKDVNSHPKGLTILFFTETWERFSFYGMRALLVLFLTKVFHFSDVDANRIYGIYTGLVYLTPLLGGYLADRYLGFK
KCIFLGATLMMFGHLSLAFETKPFFFLGLGLLILGVGFFKPNIATVLGRIYDEDNKTRMKDSGFTIFYMGINLGGFLGPL
FCGYFSKSWGWGYGFGVAAFGVLFGILILLLGQKQFPEKVFEPGKKYHTVEGQKHSTLKKEEKQKLAVIFIFTLFVIIFW
AAFEQIGSSINLFIDRHVNRNLFGYDIPTPFFQSLNPLLILIFAPIIASFWTTLAKNNWKPDTSTRFATGFFILALGFSV
LTLVTLDFRPGHKISAVWLLLMVLCITVGELFTSPGGLALVTKLSPKQLGGFMMGVWLLSSFFGNILAGELAGFMKTDSF
PTFFGMFAILAFVGGMILYITRKKLQNWMHGADQ

Sequences:

>Translated_434_residues
MDVQNKDVNSHPKGLTILFFTETWERFSFYGMRALLVLFLTKVFHFSDVDANRIYGIYTGLVYLTPLLGGYLADRYLGFK
KCIFLGATLMMFGHLSLAFETKPFFFLGLGLLILGVGFFKPNIATVLGRIYDEDNKTRMKDSGFTIFYMGINLGGFLGPL
FCGYFSKSWGWGYGFGVAAFGVLFGILILLLGQKQFPEKVFEPGKKYHTVEGQKHSTLKKEEKQKLAVIFIFTLFVIIFW
AAFEQIGSSINLFIDRHVNRNLFGYDIPTPFFQSLNPLLILIFAPIIASFWTTLAKNNWKPDTSTRFATGFFILALGFSV
LTLVTLDFRPGHKISAVWLLLMVLCITVGELFTSPGGLALVTKLSPKQLGGFMMGVWLLSSFFGNILAGELAGFMKTDSF
PTFFGMFAILAFVGGMILYITRKKLQNWMHGADQ
>Mature_434_residues
MDVQNKDVNSHPKGLTILFFTETWERFSFYGMRALLVLFLTKVFHFSDVDANRIYGIYTGLVYLTPLLGGYLADRYLGFK
KCIFLGATLMMFGHLSLAFETKPFFFLGLGLLILGVGFFKPNIATVLGRIYDEDNKTRMKDSGFTIFYMGINLGGFLGPL
FCGYFSKSWGWGYGFGVAAFGVLFGILILLLGQKQFPEKVFEPGKKYHTVEGQKHSTLKKEEKQKLAVIFIFTLFVIIFW
AAFEQIGSSINLFIDRHVNRNLFGYDIPTPFFQSLNPLLILIFAPIIASFWTTLAKNNWKPDTSTRFATGFFILALGFSV
LTLVTLDFRPGHKISAVWLLLMVLCITVGELFTSPGGLALVTKLSPKQLGGFMMGVWLLSSFFGNILAGELAGFMKTDSF
PTFFGMFAILAFVGGMILYITRKKLQNWMHGADQ

Specific function: Probable proton-dependent permease that transports dipeptides [H]

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily [H]

Homologues:

Organism=Homo sapiens, GI226371746, Length=322, Percent_Identity=25.776397515528, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226371748, Length=312, Percent_Identity=26.2820512820513, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786927, Length=450, Percent_Identity=32.8888888888889, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1790572, Length=451, Percent_Identity=30.1552106430155, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1787922, Length=430, Percent_Identity=28.6046511627907, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789911, Length=429, Percent_Identity=27.039627039627, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71987453, Length=381, Percent_Identity=25.4593175853018, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17569141, Length=379, Percent_Identity=25.3298153034301, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541704, Length=376, Percent_Identity=26.063829787234, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571098, Length=318, Percent_Identity=28.3018867924528, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28571102, Length=318, Percent_Identity=28.3018867924528, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28571100, Length=318, Percent_Identity=28.3018867924528, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24639583, Length=316, Percent_Identity=27.8481012658228, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24639585, Length=316, Percent_Identity=27.8481012658228, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24639581, Length=316, Percent_Identity=27.8481012658228, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456 [H]

Pfam domain/function: PF00854 PTR2 [H]

EC number: NA

Molecular weight: Translated: 48819; Mature: 48819

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50850 MFS ; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVQNKDVNSHPKGLTILFFTETWERFSFYGMRALLVLFLTKVFHFSDVDANRIYGIYTG
CCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LVYLTPLLGGYLADRYLGFKKCIFLGATLMMFGHLSLAFETKPFFFLGLGLLILGVGFFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCC
PNIATVLGRIYDEDNKTRMKDSGFTIFYMGINLGGFLGPLFCGYFSKSWGWGYGFGVAAF
CCHHHHHHHHHCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
GVLFGILILLLGQKQFPEKVFEPGKKYHTVEGQKHSTLKKEEKQKLAVIFIFTLFVIIFW
HHHHHHHHHHHCCCCCCHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFEQIGSSINLFIDRHVNRNLFGYDIPTPFFQSLNPLLILIFAPIIASFWTTLAKNNWK
HHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
PDTSTRFATGFFILALGFSVLTLVTLDFRPGHKISAVWLLLMVLCITVGELFTSPGGLAL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VTKLSPKQLGGFMMGVWLLSSFFGNILAGELAGFMKTDSFPTFFGMFAILAFVGGMILYI
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TRKKLQNWMHGADQ
HHHHHHHHHCCCCC
>Mature Secondary Structure
MDVQNKDVNSHPKGLTILFFTETWERFSFYGMRALLVLFLTKVFHFSDVDANRIYGIYTG
CCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LVYLTPLLGGYLADRYLGFKKCIFLGATLMMFGHLSLAFETKPFFFLGLGLLILGVGFFK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCC
PNIATVLGRIYDEDNKTRMKDSGFTIFYMGINLGGFLGPLFCGYFSKSWGWGYGFGVAAF
CCHHHHHHHHHCCCCCCEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHH
GVLFGILILLLGQKQFPEKVFEPGKKYHTVEGQKHSTLKKEEKQKLAVIFIFTLFVIIFW
HHHHHHHHHHHCCCCCCHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFEQIGSSINLFIDRHVNRNLFGYDIPTPFFQSLNPLLILIFAPIIASFWTTLAKNNWK
HHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
PDTSTRFATGFFILALGFSVLTLVTLDFRPGHKISAVWLLLMVLCITVGELFTSPGGLAL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VTKLSPKQLGGFMMGVWLLSSFFGNILAGELAGFMKTDSFPTFFGMFAILAFVGGMILYI
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
TRKKLQNWMHGADQ
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]