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The map label for this gene is hemN [H]

Identifier: 45657289

GI number: 45657289

Start: 1738228

End: 1739394

Strand: Reverse

Name: hemN [H]

Synonym: LIC11412

Alternate gene names: 45657289

Gene position: 1739394-1738228 (Counterclockwise)

Preceding gene: 45657290

Following gene: 45657288

Centisome position: 40.67

GC content: 33.85

Gene sequence:

>1167_bases
ATGATACACTATTCCGGAAATCCGATTTCTAAGGTCGGACGCCCCGGAATTTACATACACTATCCTTATTGCATTCAAAA
ATGTGAATATTGTGATTTTTATTCTGTAGGAAACGGTAAAAATCAGATCCCGGACGAAACCGGACTTTTTCAAAGATACA
AAGAAGAAATCGCGACAAGAATTTCGGATAATCCTTTCATTTCTGACTTAGAATTTGATACCATTTTTTTTGGAGGGGGC
ACACCTTCCAGAGCAGAAGTTTCTAAAATTTCAGATTTAATCTTTTTTTTGCGAAATAACATTAAATTTTCAAAATATTC
AGAAATAACTATGGAATGTAATCCGGAAGATATTACTCCAGATTTTTTAAAGTCTATCGAACAAGCTGGAATCAACCGTA
TATCTGTGGGAATTCAAAGTTTTCACCCGGAAAAACTTCAATTTTTAGGAAGATACTACGATCCGGATCGTTATGAAAAC
GTTTTAGAAACTGTGAAAAACTCGGGGATTTCCAATTTTTCTGCAGACTTAATCTATGGAATTCCGGGTCAAACAGTTCA
GGAAATCTTACAAGACATTCAAAAGGTTTTGTCCGCGGGAGGAAAACATATCAGCCTCTACGCACTCACGGTGGAAAAAG
GAACAGAATATTCCAGAAAGGTAATAGATAAAATCTCTCCAAGTCCAGAAGAAGAAATTCAAGAAAAAATTTTAAAACTT
TTACCTGACTTACTTTCACCCTATGAATTATTTCAGTACGAAGTCAGTAATTTTTCTAAACCTGGTTTTTTTTCCAAACA
CAACCTCAAATACTGGACGATGGAATATTATCTGGGAATCGGACCGGGAGCACATGGGTTTCTTCCTTCGGGAAGATATT
CCAATCCTAGAAACGTGGATACTTATAAAAGAAAGAACTTTTCTAAAGAATATACAAAGCCAAATTTCTATGAAGAGTTA
ATTTTATCTTTATTTCGTTTATTCCAACCGATTTTGATGGAAAGTTTTTATGAGCTAATTCCAGATCAAAGTCAAACTTT
AGATCTGCAGTTAAAAAAATTTCAAGAATCAGGGCTCTGTGAGTTTTCAAATGGAATCTTTCAATGGAAACCAGAAGCAG
TTTTATTTTTAGATTCTAAAATTTTAGAATTAACTTCTTTTGATTAA

Upstream 100 bases:

>100_bases
AAAAAGCTCTTTTGTATTCTGTATTAGAAAGAAAATCTACAATTCCGGTTGTAGATCTGATTTTAAAAGGTGAAAACGAA
AAAACCGCGTCCCAACAGCC

Downstream 100 bases:

>100_bases
ATCTATTTTATAATTTCTTGTGAGTATTTTTCATTTAACGTGAGTTCGGCGTTAGGAATCCATAGTTCATTTTTCTAAAA
AAGTTTGATCTCAATTCCTA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIHYSGNPISKVGRPGIYIHYPYCIQKCEYCDFYSVGNGKNQIPDETGLFQRYKEEIATRISDNPFISDLEFDTIFFGGG
TPSRAEVSKISDLIFFLRNNIKFSKYSEITMECNPEDITPDFLKSIEQAGINRISVGIQSFHPEKLQFLGRYYDPDRYEN
VLETVKNSGISNFSADLIYGIPGQTVQEILQDIQKVLSAGGKHISLYALTVEKGTEYSRKVIDKISPSPEEEIQEKILKL
LPDLLSPYELFQYEVSNFSKPGFFSKHNLKYWTMEYYLGIGPGAHGFLPSGRYSNPRNVDTYKRKNFSKEYTKPNFYEEL
ILSLFRLFQPILMESFYELIPDQSQTLDLQLKKFQESGLCEFSNGIFQWKPEAVLFLDSKILELTSFD

Sequences:

>Translated_388_residues
MIHYSGNPISKVGRPGIYIHYPYCIQKCEYCDFYSVGNGKNQIPDETGLFQRYKEEIATRISDNPFISDLEFDTIFFGGG
TPSRAEVSKISDLIFFLRNNIKFSKYSEITMECNPEDITPDFLKSIEQAGINRISVGIQSFHPEKLQFLGRYYDPDRYEN
VLETVKNSGISNFSADLIYGIPGQTVQEILQDIQKVLSAGGKHISLYALTVEKGTEYSRKVIDKISPSPEEEIQEKILKL
LPDLLSPYELFQYEVSNFSKPGFFSKHNLKYWTMEYYLGIGPGAHGFLPSGRYSNPRNVDTYKRKNFSKEYTKPNFYEEL
ILSLFRLFQPILMESFYELIPDQSQTLDLQLKKFQESGLCEFSNGIFQWKPEAVLFLDSKILELTSFD
>Mature_388_residues
MIHYSGNPISKVGRPGIYIHYPYCIQKCEYCDFYSVGNGKNQIPDETGLFQRYKEEIATRISDNPFISDLEFDTIFFGGG
TPSRAEVSKISDLIFFLRNNIKFSKYSEITMECNPEDITPDFLKSIEQAGINRISVGIQSFHPEKLQFLGRYYDPDRYEN
VLETVKNSGISNFSADLIYGIPGQTVQEILQDIQKVLSAGGKHISLYALTVEKGTEYSRKVIDKISPSPEEEIQEKILKL
LPDLLSPYELFQYEVSNFSKPGFFSKHNLKYWTMEYYLGIGPGAHGFLPSGRYSNPRNVDTYKRKNFSKEYTKPNFYEEL
ILSLFRLFQPILMESFYELIPDQSQTLDLQLKKFQESGLCEFSNGIFQWKPEAVLFLDSKILELTSFD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=304, Percent_Identity=31.9078947368421, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1789325, Length=380, Percent_Identity=32.1052631578947, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082341, Length=222, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 44762; Mature: 44762

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHYSGNPISKVGRPGIYIHYPYCIQKCEYCDFYSVGNGKNQIPDETGLFQRYKEEIATR
CCCCCCCCHHHHCCCCEEEECHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHH
ISDNPFISDLEFDTIFFGGGTPSRAEVSKISDLIFFLRNNIKFSKYSEITMECNPEDITP
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCH
DFLKSIEQAGINRISVGIQSFHPEKLQFLGRYYDPDRYENVLETVKNSGISNFSADLIYG
HHHHHHHHCCCCEEEHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEC
IPGQTVQEILQDIQKVLSAGGKHISLYALTVEKGTEYSRKVIDKISPSPEEEIQEKILKL
CCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHH
LPDLLSPYELFQYEVSNFSKPGFFSKHNLKYWTMEYYLGIGPGAHGFLPSGRYSNPRNVD
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCC
TYKRKNFSKEYTKPNFYEELILSLFRLFQPILMESFYELIPDQSQTLDLQLKKFQESGLC
HHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCE
EFSNGIFQWKPEAVLFLDSKILELTSFD
ECCCCEEEECCCEEEEECCHHHHHCCCC
>Mature Secondary Structure
MIHYSGNPISKVGRPGIYIHYPYCIQKCEYCDFYSVGNGKNQIPDETGLFQRYKEEIATR
CCCCCCCCHHHHCCCCEEEECHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHH
ISDNPFISDLEFDTIFFGGGTPSRAEVSKISDLIFFLRNNIKFSKYSEITMECNPEDITP
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCH
DFLKSIEQAGINRISVGIQSFHPEKLQFLGRYYDPDRYENVLETVKNSGISNFSADLIYG
HHHHHHHHCCCCEEEHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEC
IPGQTVQEILQDIQKVLSAGGKHISLYALTVEKGTEYSRKVIDKISPSPEEEIQEKILKL
CCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHH
LPDLLSPYELFQYEVSNFSKPGFFSKHNLKYWTMEYYLGIGPGAHGFLPSGRYSNPRNVD
HHHHHCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCC
TYKRKNFSKEYTKPNFYEELILSLFRLFQPILMESFYELIPDQSQTLDLQLKKFQESGLC
HHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCE
EFSNGIFQWKPEAVLFLDSKILELTSFD
ECCCCEEEECCCEEEEECCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]