| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is ilvB [H]
Identifier: 45657286
GI number: 45657286
Start: 1733773
End: 1735551
Strand: Direct
Name: ilvB [H]
Synonym: LIC11409
Alternate gene names: 45657286
Gene position: 1733773-1735551 (Clockwise)
Preceding gene: 45657282
Following gene: 45657287
Centisome position: 40.54
GC content: 39.97
Gene sequence:
>1779_bases TTGAAAATACGGTTCCTCTTGACAGTAGCCTTTCTGCTATCTTTATGGACGTTAAGGGGGAGAATCATCATGTCCGCAGA ATCAAGAAGAGTAACCGGTGCCAGATTGATGGTGGAACTTCTGGAAGAATACGGAGTGGACGTCGTTTTTGGATACCCCG GCGGAGCCATTCTTCCCTTTTATGATGAAATTTATAAGAGTAAAAAAATTAAACATATCTTGGTAAGACACGAACAAGGT GCGGTTCATATGGCCGAAGGATATGCAAGAGCGACTGGAAAATTGGGAGTTTGTATTGCAACGTCTGGACCGGGAGCAAC TAATCTAGTTACCGGAATTACTGACGCAAAAATGGATTCGGTTCCGATTTTAGCCATTACGGGACAGGTCGCTACGAATG CGATAGGGACAGACGCTTTTCAAGAAGCGGATATTTTCGGAATTACCATACCGATCACAAAATACAATGCTCTGATAAAA TCGGCAGACGATATAGCAAGACATTTTGAAGAGGCCACCTTAATTGCGTTAGGCGGTCGTCCTGGACCGGTTTTATTGGA TTTTCCTAAGGACGTACAAACGGAGCTGACTAATGTCAGAAAGTCTTCCCGATTAAAAATTGCTCCTCATCATTATAAAA AACCAGCGGTTAGTGGAAATTTAGAAGAATTTGCGGAAGCGATCAATCGATCTCAAAAACCTCTTTTATATGTAGGTGGG GGTGCAATTAACGCAGGCGCTTCCAAAGAAATTTTAGAATTAGCTACGAAAGGAGGAATTCCGGTTACAACAACTCTGAT GGGGCTTGGGGCTTTTCCAGGAACTCATCCTTTGAGTATTGGAATGTTGGGAATGCACGGAACCGCCACTGCAAATAAAG CAGTATTAGAATGTGATTATATACTTAATTTAGGAGCTAGATTTGACGACCGGGTTGCAAAAATAGGAGAATTTGCGGAA GGAGCGGTTCGAGCACATATTGATATAGACACGGCGGAGTTTAATAAGCGAATTCAGGTGGATTATCTTTTACACGGAGA TTTAAAAGACGCGTTAAGTGCCATTTTACCGTTTGTAAAAAAACAAGAACGTAAGGAATGGTTGACTCATCTTCAAAATT TGAAAAAAGAACATCCTTTAGATTTTGACAATTCTGGAAATGAAATTAAACCGCAGGACTTTTTAGAACGTCTTTATAAA AAAACACAAGGCAAAGCGATTGTTTCCACGGATGTAGGACAACATCAGATGTGGGCTGCTCAATATTATCTTATGGATGA ACCAAATAATTGGCTTACTTCCGGAGGATTAGGAACAATGGGTTACGGACTTCCCGCAGCGATTGGAGCGAAATTTGGAA GACCAGATAAAACTACCATCTGTATTTCGGGTGACGGATCGATTCAGATGAATATTCAAGAATTAGCAACTATTGTAGCG AACAAATTGGGAGTAAAAATTTTAGTATTCAATAATAACTTTTTAGGAATGGTTCGTCAGTGGCAGGAATTATTTTATGA GGAAAGGTTTTCAGAGTCCGAGTGGAATTTTAATCCTGATTTTGTGAAACTCGCGGAAGCGTATTCTATTCCAGCGATGA AAATTTCAAATAAGTCGGAAATAGATAAAGCGATTGAATTTTTTACAAAAGACGATGGAGCTGCATTTTTAGAAGTAATG ATACCGGCGGAAGAAAAAGTATTTCCGATGATACCGGCGGGAAAGTCTCAAAAGGAAATGATCGAATTTAAGGATTTGGC CGGATTAAAAAAAGTATGA
Upstream 100 bases:
>100_bases CAAACGACGTTTTGTATGAATTTGATTTTAAAAGATTCATTCATTTTTAAAGTTTTTAAAACGATCTAAAACCACATTTT TCTGAAAAAGGGCTGAGGAT
Downstream 100 bases:
>100_bases AACATATTCTAAAAATTCTGGTAAACAATCATCCTGGAGTTATGAGTCATGTATCCGGACTATTTACTCGCAGAAGTTAT AATATAGATTCGATTGCGGT
Product: acetolactate synthase large subunit
Products: NA
Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS; Vegetative protein 105; VEG105 [H]
Number of amino acids: Translated: 592; Mature: 592
Protein sequence:
>592_residues MKIRFLLTVAFLLSLWTLRGRIIMSAESRRVTGARLMVELLEEYGVDVVFGYPGGAILPFYDEIYKSKKIKHILVRHEQG AVHMAEGYARATGKLGVCIATSGPGATNLVTGITDAKMDSVPILAITGQVATNAIGTDAFQEADIFGITIPITKYNALIK SADDIARHFEEATLIALGGRPGPVLLDFPKDVQTELTNVRKSSRLKIAPHHYKKPAVSGNLEEFAEAINRSQKPLLYVGG GAINAGASKEILELATKGGIPVTTTLMGLGAFPGTHPLSIGMLGMHGTATANKAVLECDYILNLGARFDDRVAKIGEFAE GAVRAHIDIDTAEFNKRIQVDYLLHGDLKDALSAILPFVKKQERKEWLTHLQNLKKEHPLDFDNSGNEIKPQDFLERLYK KTQGKAIVSTDVGQHQMWAAQYYLMDEPNNWLTSGGLGTMGYGLPAAIGAKFGRPDKTTICISGDGSIQMNIQELATIVA NKLGVKILVFNNNFLGMVRQWQELFYEERFSESEWNFNPDFVKLAEAYSIPAMKISNKSEIDKAIEFFTKDDGAAFLEVM IPAEEKVFPMIPAGKSQKEMIEFKDLAGLKKV
Sequences:
>Translated_592_residues MKIRFLLTVAFLLSLWTLRGRIIMSAESRRVTGARLMVELLEEYGVDVVFGYPGGAILPFYDEIYKSKKIKHILVRHEQG AVHMAEGYARATGKLGVCIATSGPGATNLVTGITDAKMDSVPILAITGQVATNAIGTDAFQEADIFGITIPITKYNALIK SADDIARHFEEATLIALGGRPGPVLLDFPKDVQTELTNVRKSSRLKIAPHHYKKPAVSGNLEEFAEAINRSQKPLLYVGG GAINAGASKEILELATKGGIPVTTTLMGLGAFPGTHPLSIGMLGMHGTATANKAVLECDYILNLGARFDDRVAKIGEFAE GAVRAHIDIDTAEFNKRIQVDYLLHGDLKDALSAILPFVKKQERKEWLTHLQNLKKEHPLDFDNSGNEIKPQDFLERLYK KTQGKAIVSTDVGQHQMWAAQYYLMDEPNNWLTSGGLGTMGYGLPAAIGAKFGRPDKTTICISGDGSIQMNIQELATIVA NKLGVKILVFNNNFLGMVRQWQELFYEERFSESEWNFNPDFVKLAEAYSIPAMKISNKSEIDKAIEFFTKDDGAAFLEVM IPAEEKVFPMIPAGKSQKEMIEFKDLAGLKKV >Mature_592_residues MKIRFLLTVAFLLSLWTLRGRIIMSAESRRVTGARLMVELLEEYGVDVVFGYPGGAILPFYDEIYKSKKIKHILVRHEQG AVHMAEGYARATGKLGVCIATSGPGATNLVTGITDAKMDSVPILAITGQVATNAIGTDAFQEADIFGITIPITKYNALIK SADDIARHFEEATLIALGGRPGPVLLDFPKDVQTELTNVRKSSRLKIAPHHYKKPAVSGNLEEFAEAINRSQKPLLYVGG GAINAGASKEILELATKGGIPVTTTLMGLGAFPGTHPLSIGMLGMHGTATANKAVLECDYILNLGARFDDRVAKIGEFAE GAVRAHIDIDTAEFNKRIQVDYLLHGDLKDALSAILPFVKKQERKEWLTHLQNLKKEHPLDFDNSGNEIKPQDFLERLYK KTQGKAIVSTDVGQHQMWAAQYYLMDEPNNWLTSGGLGTMGYGLPAAIGAKFGRPDKTTICISGDGSIQMNIQELATIVA NKLGVKILVFNNNFLGMVRQWQELFYEERFSESEWNFNPDFVKLAEAYSIPAMKISNKSEIDKAIEFFTKDDGAAFLEVM IPAEEKVFPMIPAGKSQKEMIEFKDLAGLKKV
Specific function: Valine and isoleucine biosynthesis; first step. [C]
COG id: COG0028
COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family [H]
Homologues:
Organism=Homo sapiens, GI93004078, Length=491, Percent_Identity=26.4765784114053, Blast_Score=150, Evalue=4e-36, Organism=Homo sapiens, GI21361361, Length=502, Percent_Identity=26.0956175298805, Blast_Score=137, Evalue=2e-32, Organism=Escherichia coli, GI1790104, Length=558, Percent_Identity=44.2652329749104, Blast_Score=503, Evalue=1e-143, Organism=Escherichia coli, GI87081685, Length=565, Percent_Identity=42.8318584070797, Blast_Score=484, Evalue=1e-138, Organism=Escherichia coli, GI1786717, Length=578, Percent_Identity=32.5259515570934, Blast_Score=291, Evalue=9e-80, Organism=Escherichia coli, GI1787096, Length=552, Percent_Identity=28.2608695652174, Blast_Score=203, Evalue=2e-53, Organism=Escherichia coli, GI1788716, Length=497, Percent_Identity=25.5533199195171, Blast_Score=112, Evalue=5e-26, Organism=Caenorhabditis elegans, GI17542570, Length=510, Percent_Identity=27.0588235294118, Blast_Score=125, Evalue=5e-29, Organism=Caenorhabditis elegans, GI17531299, Length=583, Percent_Identity=23.6706689536878, Blast_Score=117, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17531301, Length=583, Percent_Identity=23.6706689536878, Blast_Score=117, Evalue=3e-26, Organism=Saccharomyces cerevisiae, GI6323755, Length=593, Percent_Identity=44.3507588532884, Blast_Score=472, Evalue=1e-134, Organism=Saccharomyces cerevisiae, GI6320816, Length=493, Percent_Identity=23.7322515212982, Blast_Score=100, Evalue=5e-22, Organism=Drosophila melanogaster, GI19922626, Length=482, Percent_Identity=25.7261410788382, Blast_Score=145, Evalue=6e-35,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012846 - InterPro: IPR012000 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.6 [H]
Molecular weight: Translated: 65070; Mature: 65070
Theoretical pI: Translated: 7.01; Mature: 7.01
Prosite motif: PS00187 TPP_ENZYMES
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKIRFLLTVAFLLSLWTLRGRIIMSAESRRVTGARLMVELLEEYGVDVVFGYPGGAILPF CEEHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCC YDEIYKSKKIKHILVRHEQGAVHMAEGYARATGKLGVCIATSGPGATNLVTGITDAKMDS HHHHHHHCCHHEEEEECCCCCEEECCCHHHCCCCEEEEEEECCCCCCHHEECCCCCCCCC VPILAITGQVATNAIGTDAFQEADIFGITIPITKYNALIKSADDIARHFEEATLIALGGR CEEEEEECCHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHCHHHHHHHHCCEEEEEECCC PGPVLLDFPKDVQTELTNVRKSSRLKIAPHHYKKPAVSGNLEEFAEAINRSQKPLLYVGG CCCEEEECCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECC GAINAGASKEILELATKGGIPVTTTLMGLGAFPGTHPLSIGMLGMHGTATANKAVLECDY CEECCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHH ILNLGARFDDRVAKIGEFAEGAVRAHIDIDTAEFNKRIQVDYLLHGDLKDALSAILPFVK HHHCCCCCHHHHHHHHHHHCCEEEEEEEEEHHHCCCEEEEEEEECCCHHHHHHHHHHHHH KQERKEWLTHLQNLKKEHPLDFDNSGNEIKPQDFLERLYKKTQGKAIVSTDVGQHQMWAA HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHEEEE QYYLMDEPNNWLTSGGLGTMGYGLPAAIGAKFGRPDKTTICISGDGSIQMNIQELATIVA EEEEEECCCCEEECCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCEEEEHHHHHHHHH NKLGVKILVFNNNFLGMVRQWQELFYEERFSESEWNFNPDFVKLAEAYSIPAMKISNKSE HHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEECCHHH IDKAIEFFTKDDGAAFLEVMIPAEEKVFPMIPAGKSQKEMIEFKDLAGLKKV HHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCC >Mature Secondary Structure MKIRFLLTVAFLLSLWTLRGRIIMSAESRRVTGARLMVELLEEYGVDVVFGYPGGAILPF CEEHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCC YDEIYKSKKIKHILVRHEQGAVHMAEGYARATGKLGVCIATSGPGATNLVTGITDAKMDS HHHHHHHCCHHEEEEECCCCCEEECCCHHHCCCCEEEEEEECCCCCCHHEECCCCCCCCC VPILAITGQVATNAIGTDAFQEADIFGITIPITKYNALIKSADDIARHFEEATLIALGGR CEEEEEECCHHHCCCCCCCCCCCCEEEEEEEHHHHHHHHHCHHHHHHHHCCEEEEEECCC PGPVLLDFPKDVQTELTNVRKSSRLKIAPHHYKKPAVSGNLEEFAEAINRSQKPLLYVGG CCCEEEECCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECC GAINAGASKEILELATKGGIPVTTTLMGLGAFPGTHPLSIGMLGMHGTATANKAVLECDY CEECCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEHH ILNLGARFDDRVAKIGEFAEGAVRAHIDIDTAEFNKRIQVDYLLHGDLKDALSAILPFVK HHHCCCCCHHHHHHHHHHHCCEEEEEEEEEHHHCCCEEEEEEEECCCHHHHHHHHHHHHH KQERKEWLTHLQNLKKEHPLDFDNSGNEIKPQDFLERLYKKTQGKAIVSTDVGQHQMWAA HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHEEEE QYYLMDEPNNWLTSGGLGTMGYGLPAAIGAKFGRPDKTTICISGDGSIQMNIQELATIVA EEEEEECCCCEEECCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCEEEEHHHHHHHHH NKLGVKILVFNNNFLGMVRQWQELFYEERFSESEWNFNPDFVKLAEAYSIPAMKISNKSE HHCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEECCHHH IDKAIEFFTKDDGAAFLEVMIPAEEKVFPMIPAGKSQKEMIEFKDLAGLKKV HHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8969504; 9384377; 1577690; 9298659 [H]