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The map label for this gene is phr

Identifier: 45657217

GI number: 45657217

Start: 1651973

End: 1653523

Strand: Direct

Name: phr

Synonym: LIC11339

Alternate gene names: 45657217

Gene position: 1651973-1653523 (Clockwise)

Preceding gene: 45657211

Following gene: 45657218

Centisome position: 38.62

GC content: 33.72

Gene sequence:

>1551_bases
ATGTTTCAAAAAGAAAATCTAGTTCGTGTGCGAGAAATTAAACAAAATCCAATTTTAGAAGAAAAACCTTATATTCTTTA
TTGGATGTCTATGGCCAGAAGACTTGTTTGGAATCATTCTTTAGATTATTCAATTCATCTTTCCCAAAAATATAAAAAAG
AACTGCTGATCTATGAACCTCTCAAAATGAATTATCCTTGGAGTTCTCTTAGGTTGCACAAGTTTATTTTAGAAGGAATG
TCATATAACATAAAAGAGGCGAAGAGATTAGGCCTTACATATCGGGCATTTGTAGAAACTCCTGGAAATCGGATCGAAGA
AGCGTTTGAAAAAATTAGTTCCGAGGCTGCGTTGGTGATCACCGATGATTATCCCGCATATATCATTCCAGAGTTATTGG
AACAAGTTTCTAAAAAAATTAAATGTAAATTTCTTGCAGTAGATTCTAATTCGATCATTCCACTTACTTTTTATGGTGAG
TTTGTTTCGGCGGCAAGAATTCTTCGACCTAGAGTCCACAAATTATTTCCAGAAGTTTGGAAGTTTCGATCTTTCCATAA
ACCAAATAAACCGTTTCGAGAAAAAGGAGATTCCTGGCTCGAAAAAAATCCAAATTCTCCTTTAAAAAAAAATATTTGGT
TTGAAGGTGACGTAGACCAAATTTCAGAAATATGCAAGAAATGTAATTTTAATTTTCAGAATATTCCCCCCGTCCCCGGA
AAAAAAGGAGGTAGAGAAGAGGGGATAAAACTTCTACAGAAATTTTTAAAACGTGGATTGTCCGGTTATGCAGAACTTAG
AAGTAATCCTAAACCACCGGAAGAATCTTATTCTTCTTTTTTATCTCCTTATATTCATTTTGGGCATATTTCTCAAGAGG
AAATTGTAAGCGAAGTTTTAAATTGGAACTTGGATGGATCTTGGACTCCTGGGGTTATCATTCCCGAAAATAAAAATAGA
AAAGAAGGTTACTTTCATCCGGATCCGAACGTAAATTCTTTTTTAGATGAACTCATAACGTGGAGAGACGTGGGTTTTTT
GATGTTTTGGAAAAAACCTTCTTTTAGAAAGGATCTTTCTATTCTTCCGGATTGGATTCAAAAAAATTTAGATTTTCATA
AAAACGATGTTCGTCCTTATATTTATACAAAAGAACAATTGGAAAATTCAAAGACGCATGACGTTATTTGGAACGCCGCG
CAAAAGGAATTGGTTTTATCCGGTTGTATGCAAAATTATTTAAGAATGCTCTGGGGAAAAAAGGTTATAGAATGGTCTCC
GGATTATCAAACTGCTTTTGAAATTTTAGAAGAATTTAATAATAAATATGCATACGATGGAAGAGACCCAAATTCGTATA
ACGGAATTTTATGGTGTTTTGGTTTGTTTGATCGTCCTTGGTTTCCGGAGAGAAACGTTTTTGGAAATATCCGAACTATG
TCCTCCGATTCGACAAAGAAAAAATTCAAACTTCAAACGTATTTGGACTATGTTCAATCTTTGGAAGAAAGAAATGATAA
ACTTGATTCTCAATTACTTTTTCCTACATAA

Upstream 100 bases:

>100_bases
AAAAGAAGCGAAGTTGTAGGAATTACTGCACTTTATTAAATATTTGGCGTTTAAATTTGTTTTGGAATGCTCTCTATAAA
ATCTGTTTAAAAAGGAAAAC

Downstream 100 bases:

>100_bases
AATATTTTAAATTAGGTTACTCGGACGTATTAAAAAGAATGTATGATTTAGAAGTATTTAATTTTAAGCTTGGTTTGAAA
TGAAAAAAATTTTCATTATT

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MFQKENLVRVREIKQNPILEEKPYILYWMSMARRLVWNHSLDYSIHLSQKYKKELLIYEPLKMNYPWSSLRLHKFILEGM
SYNIKEAKRLGLTYRAFVETPGNRIEEAFEKISSEAALVITDDYPAYIIPELLEQVSKKIKCKFLAVDSNSIIPLTFYGE
FVSAARILRPRVHKLFPEVWKFRSFHKPNKPFREKGDSWLEKNPNSPLKKNIWFEGDVDQISEICKKCNFNFQNIPPVPG
KKGGREEGIKLLQKFLKRGLSGYAELRSNPKPPEESYSSFLSPYIHFGHISQEEIVSEVLNWNLDGSWTPGVIIPENKNR
KEGYFHPDPNVNSFLDELITWRDVGFLMFWKKPSFRKDLSILPDWIQKNLDFHKNDVRPYIYTKEQLENSKTHDVIWNAA
QKELVLSGCMQNYLRMLWGKKVIEWSPDYQTAFEILEEFNNKYAYDGRDPNSYNGILWCFGLFDRPWFPERNVFGNIRTM
SSDSTKKKFKLQTYLDYVQSLEERNDKLDSQLLFPT

Sequences:

>Translated_516_residues
MFQKENLVRVREIKQNPILEEKPYILYWMSMARRLVWNHSLDYSIHLSQKYKKELLIYEPLKMNYPWSSLRLHKFILEGM
SYNIKEAKRLGLTYRAFVETPGNRIEEAFEKISSEAALVITDDYPAYIIPELLEQVSKKIKCKFLAVDSNSIIPLTFYGE
FVSAARILRPRVHKLFPEVWKFRSFHKPNKPFREKGDSWLEKNPNSPLKKNIWFEGDVDQISEICKKCNFNFQNIPPVPG
KKGGREEGIKLLQKFLKRGLSGYAELRSNPKPPEESYSSFLSPYIHFGHISQEEIVSEVLNWNLDGSWTPGVIIPENKNR
KEGYFHPDPNVNSFLDELITWRDVGFLMFWKKPSFRKDLSILPDWIQKNLDFHKNDVRPYIYTKEQLENSKTHDVIWNAA
QKELVLSGCMQNYLRMLWGKKVIEWSPDYQTAFEILEEFNNKYAYDGRDPNSYNGILWCFGLFDRPWFPERNVFGNIRTM
SSDSTKKKFKLQTYLDYVQSLEERNDKLDSQLLFPT
>Mature_516_residues
MFQKENLVRVREIKQNPILEEKPYILYWMSMARRLVWNHSLDYSIHLSQKYKKELLIYEPLKMNYPWSSLRLHKFILEGM
SYNIKEAKRLGLTYRAFVETPGNRIEEAFEKISSEAALVITDDYPAYIIPELLEQVSKKIKCKFLAVDSNSIIPLTFYGE
FVSAARILRPRVHKLFPEVWKFRSFHKPNKPFREKGDSWLEKNPNSPLKKNIWFEGDVDQISEICKKCNFNFQNIPPVPG
KKGGREEGIKLLQKFLKRGLSGYAELRSNPKPPEESYSSFLSPYIHFGHISQEEIVSEVLNWNLDGSWTPGVIIPENKNR
KEGYFHPDPNVNSFLDELITWRDVGFLMFWKKPSFRKDLSILPDWIQKNLDFHKNDVRPYIYTKEQLENSKTHDVIWNAA
QKELVLSGCMQNYLRMLWGKKVIEWSPDYQTAFEILEEFNNKYAYDGRDPNSYNGILWCFGLFDRPWFPERNVFGNIRTM
SSDSTKKKFKLQTYLDYVQSLEERNDKLDSQLLFPT

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=493, Percent_Identity=25.3549695740365, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24586398, Length=493, Percent_Identity=25.3549695740365, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24586404, Length=137, Percent_Identity=39.4160583941606, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 61105; Mature: 61105

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKENLVRVREIKQNPILEEKPYILYWMSMARRLVWNHSLDYSIHLSQKYKKELLIYEP
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHEEEECC
LKMNYPWSSLRLHKFILEGMSYNIKEAKRLGLTYRAFVETPGNRIEEAFEKISSEAALVI
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEE
TDDYPAYIIPELLEQVSKKIKCKFLAVDSNSIIPLTFYGEFVSAARILRPRVHKLFPEVW
ECCCCHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
KFRSFHKPNKPFREKGDSWLEKNPNSPLKKNIWFEGDVDQISEICKKCNFNFQNIPPVPG
HHHHCCCCCCCHHHCCCHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
KKGGREEGIKLLQKFLKRGLSGYAELRSNPKPPEESYSSFLSPYIHFGHISQEEIVSEVL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
NWNLDGSWTPGVIIPENKNRKEGYFHPDPNVNSFLDELITWRDVGFLMFWKKPSFRKDLS
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
ILPDWIQKNLDFHKNDVRPYIYTKEQLENSKTHDVIWNAAQKELVLSGCMQNYLRMLWGK
HCHHHHHHCCCCCCCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KVIEWSPDYQTAFEILEEFNNKYAYDGRDPNSYNGILWCFGLFDRPWFPERNVFGNIRTM
CCEECCCCHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEC
SSDSTKKKFKLQTYLDYVQSLEERNDKLDSQLLFPT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFQKENLVRVREIKQNPILEEKPYILYWMSMARRLVWNHSLDYSIHLSQKYKKELLIYEP
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHEEEECC
LKMNYPWSSLRLHKFILEGMSYNIKEAKRLGLTYRAFVETPGNRIEEAFEKISSEAALVI
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCEEEE
TDDYPAYIIPELLEQVSKKIKCKFLAVDSNSIIPLTFYGEFVSAARILRPRVHKLFPEVW
ECCCCHHHHHHHHHHHHHHHEEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
KFRSFHKPNKPFREKGDSWLEKNPNSPLKKNIWFEGDVDQISEICKKCNFNFQNIPPVPG
HHHHCCCCCCCHHHCCCHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
KKGGREEGIKLLQKFLKRGLSGYAELRSNPKPPEESYSSFLSPYIHFGHISQEEIVSEVL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
NWNLDGSWTPGVIIPENKNRKEGYFHPDPNVNSFLDELITWRDVGFLMFWKKPSFRKDLS
CCCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCHHHHH
ILPDWIQKNLDFHKNDVRPYIYTKEQLENSKTHDVIWNAAQKELVLSGCMQNYLRMLWGK
HCHHHHHHCCCCCCCCCCCEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KVIEWSPDYQTAFEILEEFNNKYAYDGRDPNSYNGILWCFGLFDRPWFPERNVFGNIRTM
CCEECCCCHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEC
SSDSTKKKFKLQTYLDYVQSLEERNDKLDSQLLFPT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]