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The map label for this gene is accC

Identifier: 45657159

GI number: 45657159

Start: 1576451

End: 1577914

Strand: Direct

Name: accC

Synonym: LIC11277

Alternate gene names: 45657159

Gene position: 1576451-1577914 (Clockwise)

Preceding gene: 45657158

Following gene: 45657160

Centisome position: 36.86

GC content: 39.69

Gene sequence:

>1464_bases
TTGATTTCTAAACTTCTGATTGCGAACCGTGGAGAAATTGCGGTTCGAGTGATCCGTACTTGTAAAAAGCTGGGAATCAA
AACCGTTGCGATTTATTCGGATGCGGATAGAGATTCTCCACACGTAAAACTTGCGGACGAATCAGTATATGTAGGAGAGC
CTAGTCCTGCTTCTTCTTATTTAAATATTTCTAATATTCTCGAAGCGATTAAAAAGACAAAGACGGATGCGGTTCATCCA
GGTTATGGATTTTTATCCGAAAAAAGTGAATTTGCAAAAGCATTAGAAAAAGAGAATGTGTTATTTTTAGGTCCTAGTCC
GGAATCGATGGAACTCATGGGGGATAAGATCAATTCCAGGATTAAAATGGAAGCGTCTGGAGTTCCGGTTGTTCCAGGTT
ACAACGGACAAAATCAGGATCCTAAAATACTTCAAAAGGAAGCCGAGAAAATCGGTTATCCTTTGATGATTAAGGCGACC
GCCGGAGGAGGTGGAAAGGGAATGAAACGGGTTTATAAATCCGAAGAATTTCTTTTCGCACTTGAATCGGCGCAAAGAGA
AGCGCAAAAAGCTTTTGGAGATGGGACCGTTTTTTTAGAAAAATACGTAGAAACTCCTAGGCATATTGAAGTGCAGGTTT
TTGGAGATAAACACGGAAACGTTATGCATCTTTTTGAACGAGAATGTTCGATTCAAAGAAGACACCAAAAGGTAATTGAA
GAATCTCCTGCTCCAAATTTGCCAATTTCTCTTCGGGATGAAATTTGTAGGGTAGCTGTTAAAGCCGCACAGTCTATTGG
TTATGTGGGAGCAGGAACCGTAGAATTTATTTTAGGAAAAGATAATAAGTTTTATTTTCTAGAAATGAACACAAGGCTTC
AAGTGGAACATCCGGTAACGGAATATATTACCGGTCAGGATCTTGTAGAATGGCAGATCCAAGTGGCGGAAGGCAAAAAA
CTTTCCGAACTCACAAAAGGAAAAACCGTCATTCAAAATGGACATGCAATTGAAGCTCGTATCTATGCGGAAGATCCTGA
AAATAACTTTTTACCTTCTACGGGTATATTAGAATATATTGAATTTCCGGATCGTGAGTTTTTACGTGTAGATACTGGGG
TGGAAACTGGTTCTGAGATTACAGTTTATTACGATCCTATGATCGCTAAGATGATCGCTTGGGGAAAAACCAGAGAAGAG
TGTACTGCTCGTCTTAAAGAATCTATAGATTCGACAGTGATCTTCGGACCTGTAACCAATACCTTTTATTTATCTGGAAT
TCTTTCTCATGAAGAATTTAAAAAAGGGAATACCCATACTCATTTTTTGGAAGAACAAACGATTTTATTTACTCCTGAAA
AGGACGTTCAAGCAGATGCGTTTTCCTTTGCGGCAGCTGCACTTTCTGAAAAGAAAAAATCCCAGGGAATTTGGGAGGCG
GTAGGTCCGGGAGGTTTCTGGTGA

Upstream 100 bases:

>100_bases
AAGAATTTAAAGATTTTATTTTCGAAACTATGGATCGGGAAAAGAAAGCTCTTGATTCTATGCTTTCATCCGAAGTGCAA
AAAGAATCGGTGCTTGTATC

Downstream 100 bases:

>100_bases
TCGAAGAAAATTTTCGATTTAGACATAGAGAAGAAGAAATTCCGGTTCGAGTGCGTTCCGGTTCTCCCGGAGACGTTTCC
GTATCGATTACGTTAGGCGG

Product: acetyl-CoA carboxylase subunit alpha

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2 [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSYLNISNILEAIKKTKTDAVHP
GYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKAT
AGGGGKGMKRVYKSEEFLFALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
ESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDNKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIQVAEGKK
LSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREE
CTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKDVQADAFSFAAAALSEKKKSQGIWEA
VGPGGFW

Sequences:

>Translated_487_residues
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSYLNISNILEAIKKTKTDAVHP
GYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKAT
AGGGGKGMKRVYKSEEFLFALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
ESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDNKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIQVAEGKK
LSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREE
CTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKDVQADAFSFAAAALSEKKKSQGIWEA
VGPGGFW
>Mature_487_residues
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSYLNISNILEAIKKTKTDAVHP
GYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSRIKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKAT
AGGGGKGMKRVYKSEEFLFALESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
ESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDNKFYFLEMNTRLQVEHPVTEYITGQDLVEWQIQVAEGKK
LSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYIEFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREE
CTARLKESIDSTVIFGPVTNTFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKDVQADAFSFAAAALSEKKKSQGIWEA
VGPGGFW

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=475, Percent_Identity=50.1052631578947, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI189095269, Length=477, Percent_Identity=49.475890985325, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI65506442, Length=477, Percent_Identity=49.475890985325, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI295821183, Length=477, Percent_Identity=49.475890985325, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI106049528, Length=452, Percent_Identity=43.8053097345133, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049295, Length=452, Percent_Identity=43.8053097345133, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI106049292, Length=452, Percent_Identity=43.8053097345133, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=31.9444444444444, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=30.952380952381, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=30.952380952381, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=30.952380952381, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=30.952380952381, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=30.952380952381, Blast_Score=251, Evalue=1e-66,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=46.7561521252796, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI71987519, Length=484, Percent_Identity=48.5537190082645, Blast_Score=451, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17567343, Length=477, Percent_Identity=46.9601677148847, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=44.1241685144124, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=32.1792260692464, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71997168, Length=543, Percent_Identity=30.2025782688766, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71997163, Length=543, Percent_Identity=30.2025782688766, Blast_Score=227, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6319685, Length=449, Percent_Identity=45.2115812917595, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6319695, Length=453, Percent_Identity=42.1633554083885, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=453, Percent_Identity=42.1633554083885, Blast_Score=326, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6324343, Length=511, Percent_Identity=31.1154598825832, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6323863, Length=466, Percent_Identity=32.4034334763949, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6322331, Length=310, Percent_Identity=22.9032258064516, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24651757, Length=469, Percent_Identity=52.0255863539446, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24651759, Length=430, Percent_Identity=50.6976744186047, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI281363050, Length=457, Percent_Identity=45.9518599562363, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=457, Percent_Identity=45.9518599562363, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=457, Percent_Identity=45.9518599562363, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=457, Percent_Identity=45.9518599562363, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=457, Percent_Identity=45.9518599562363, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652212, Length=457, Percent_Identity=45.9518599562363, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=457, Percent_Identity=45.9518599562363, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=457, Percent_Identity=45.9518599562363, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=457, Percent_Identity=45.9518599562363, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=457, Percent_Identity=45.9518599562363, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=31.4, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=31.4, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=31.4, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=31.4, Blast_Score=244, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 54257; Mature: 54257

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCEEEECCCCCCCHH
LNISNILEAIKKTKTDAVHPGYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSR
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCE
IKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKATAGGGGKGMKRVYKSEEFLFA
EEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCHHHHHH
LESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHH
ESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDNKFYFLEMNTRLQVEHPVT
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEECCCHH
EYITGQDLVEWQIQVAEGKKLSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYI
HHCCCCCEEEEEEEECCCCHHHHHHCCCCEEECCCEEEEEEEEECCCCCCCCCCCHHHHH
EFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREECTARLKESIDSTVIFGPVTN
CCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCC
TFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKDVQADAFSFAAAALSEKKKSQGIWEA
EEEEHHHHCHHHHCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
VGPGGFW
CCCCCCC
>Mature Secondary Structure
MISKLLIANRGEIAVRVIRTCKKLGIKTVAIYSDADRDSPHVKLADESVYVGEPSPASSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCEEEECCCCCCCHH
LNISNILEAIKKTKTDAVHPGYGFLSEKSEFAKALEKENVLFLGPSPESMELMGDKINSR
CCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCE
IKMEASGVPVVPGYNGQNQDPKILQKEAEKIGYPLMIKATAGGGGKGMKRVYKSEEFLFA
EEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCHHHHHH
LESAQREAQKAFGDGTVFLEKYVETPRHIEVQVFGDKHGNVMHLFERECSIQRRHQKVIE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHH
ESPAPNLPISLRDEICRVAVKAAQSIGYVGAGTVEFILGKDNKFYFLEMNTRLQVEHPVT
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCEEEECCCHH
EYITGQDLVEWQIQVAEGKKLSELTKGKTVIQNGHAIEARIYAEDPENNFLPSTGILEYI
HHCCCCCEEEEEEEECCCCHHHHHHCCCCEEECCCEEEEEEEEECCCCCCCCCCCHHHHH
EFPDREFLRVDTGVETGSEITVYYDPMIAKMIAWGKTREECTARLKESIDSTVIFGPVTN
CCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCC
TFYLSGILSHEEFKKGNTHTHFLEEQTILFTPEKDVQADAFSFAAAALSEKKKSQGIWEA
EEEEHHHHCHHHHCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
VGPGGFW
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]