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The map label for this gene is cyaA [H]

Identifier: 45656979

GI number: 45656979

Start: 1351221

End: 1352327

Strand: Direct

Name: cyaA [H]

Synonym: LIC11095

Alternate gene names: 45656979

Gene position: 1351221-1352327 (Clockwise)

Preceding gene: 45656978

Following gene: 45656984

Centisome position: 31.59

GC content: 38.03

Gene sequence:

>1107_bases
GTGAACCCAGGAACTGCGATCTATGAATCGACCATCAATCGGGGGCTTAATCGTTTCTTAAAAAGAAAGGGTGTTTTTTC
CGTTGCAAGATTCGGAAACGTACTCATTGAAATTTCTTCCGTAGGTTTATTACTTTGGTTTAATATAGGAGCCTTTGCGT
CTCCTTTAATTCCTCTTTATTCTCCCGCGGTTTTGACTTTTTTTATATTTATCATTCTTTCGGTCCTCCGACTTGAATTT
TGGTTGAGCGCATTTACTGGGTTTGTAGCCGGAGCAGAACTTTTAGTATTAGCGATTCTTTATATTCCTCAAAATCCGAT
TCCGATGCCGATCAACTTTTTTAATTCCGTGGCTCCTTTTATTTCTAAATCTCTATTGTTTTTCTTTAGCGGGATTGCAG
CGGGTCTTGTAGGTATCCAATTGAAACGTTCTTTGATTTCTGCGATGTCTGCGGTTCAAGAAAAGAATAAAGTAGTAGGA
ATGTTTGGACAGTACGTTTCTCCGGACGTAGTAGATAGACTTTTAGAACAGAAGAACGAAAGTTTTTCAGAGTTTAAAAG
GGTATGTGTAATGTTTTTAGATATTCGCAATTTTACTCGTTTTTCTGAAAAGAGACCTCCGGGCGAAGTGATCGATTATC
TAAATTATATATTTAGTCATTTGATTGATATTGTAAACGTGCACAACGGTATGATCAATAAGTTTCTTGGAGATGGGTTT
ATGGCTGTGTTTGGGGCTCCCATTTCAGACGGAGGTAACGACGTTAAAAATGCGGTTGAGGCTTCTTTAGAACTTCTTAA
GAAAATAGAATTCTTAAATCAGGAAGGTAAAATTCCAGAGACTCAAATTGGTATCGGACTTCATACTGGAGAAGCAATGA
CGGGTAACGTAGGTTCTGAAGCTAGAAAAGAATATACAATTATCGGAGACGTAGTTAATCTAGCGTCTAGAGTAGAGTCT
TTGAATAAAGAGTTTGGAACAAAACTTTTAGTGACTCAAGCCGTTTACGACGATATTAAAGATACGGTTCCAGGTAGACA
TCTTTCTTCTATCCATGTAAAAGGAAGAGAAGAGCCCGTAGACGTCTACGAACTGGGTAAGATCTAA

Upstream 100 bases:

>100_bases
TTGCCTCTACGTCCGTTATTATGACGCTCATATTTGTTGTTTTTCACCAATGGATCGTAAAAAAACGGGAGGCCACTTTC
CTTTTTACGCCGTTTTAGGA

Downstream 100 bases:

>100_bases
AGCCAAAATTCAAATTCTTTTTGGAACTTTACCGGGTTCCATTCTAAGATCTGATATTCAGCGACACCGTTGCTATAAAA
AGGATCTTGGCGACAAAAGG

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MNPGTAIYESTINRGLNRFLKRKGVFSVARFGNVLIEISSVGLLLWFNIGAFASPLIPLYSPAVLTFFIFIILSVLRLEF
WLSAFTGFVAGAELLVLAILYIPQNPIPMPINFFNSVAPFISKSLLFFFSGIAAGLVGIQLKRSLISAMSAVQEKNKVVG
MFGQYVSPDVVDRLLEQKNESFSEFKRVCVMFLDIRNFTRFSEKRPPGEVIDYLNYIFSHLIDIVNVHNGMINKFLGDGF
MAVFGAPISDGGNDVKNAVEASLELLKKIEFLNQEGKIPETQIGIGLHTGEAMTGNVGSEARKEYTIIGDVVNLASRVES
LNKEFGTKLLVTQAVYDDIKDTVPGRHLSSIHVKGREEPVDVYELGKI

Sequences:

>Translated_368_residues
MNPGTAIYESTINRGLNRFLKRKGVFSVARFGNVLIEISSVGLLLWFNIGAFASPLIPLYSPAVLTFFIFIILSVLRLEF
WLSAFTGFVAGAELLVLAILYIPQNPIPMPINFFNSVAPFISKSLLFFFSGIAAGLVGIQLKRSLISAMSAVQEKNKVVG
MFGQYVSPDVVDRLLEQKNESFSEFKRVCVMFLDIRNFTRFSEKRPPGEVIDYLNYIFSHLIDIVNVHNGMINKFLGDGF
MAVFGAPISDGGNDVKNAVEASLELLKKIEFLNQEGKIPETQIGIGLHTGEAMTGNVGSEARKEYTIIGDVVNLASRVES
LNKEFGTKLLVTQAVYDDIKDTVPGRHLSSIHVKGREEPVDVYELGKI
>Mature_368_residues
MNPGTAIYESTINRGLNRFLKRKGVFSVARFGNVLIEISSVGLLLWFNIGAFASPLIPLYSPAVLTFFIFIILSVLRLEF
WLSAFTGFVAGAELLVLAILYIPQNPIPMPINFFNSVAPFISKSLLFFFSGIAAGLVGIQLKRSLISAMSAVQEKNKVVG
MFGQYVSPDVVDRLLEQKNESFSEFKRVCVMFLDIRNFTRFSEKRPPGEVIDYLNYIFSHLIDIVNVHNGMINKFLGDGF
MAVFGAPISDGGNDVKNAVEASLELLKKIEFLNQEGKIPETQIGIGLHTGEAMTGNVGSEARKEYTIIGDVVNLASRVES
LNKEFGTKLLVTQAVYDDIKDTVPGRHLSSIHVKGREEPVDVYELGKI

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI134152694, Length=169, Percent_Identity=31.3609467455621, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4504217, Length=168, Percent_Identity=30.952380952381, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI167830411, Length=170, Percent_Identity=27.6470588235294, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4580422, Length=170, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI222080083, Length=138, Percent_Identity=32.6086956521739, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4504215, Length=227, Percent_Identity=25.1101321585903, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=219, Percent_Identity=29.6803652968037, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71982300, Length=175, Percent_Identity=31.4285714285714, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534657, Length=223, Percent_Identity=27.3542600896861, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193207841, Length=177, Percent_Identity=31.638418079096, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17534653, Length=175, Percent_Identity=30.8571428571429, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17561804, Length=174, Percent_Identity=29.8850574712644, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71989822, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71989805, Length=186, Percent_Identity=30.1075268817204, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193205840, Length=186, Percent_Identity=29.0322580645161, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17534655, Length=175, Percent_Identity=30.2857142857143, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534651, Length=175, Percent_Identity=29.7142857142857, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534649, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71995300, Length=179, Percent_Identity=29.0502793296089, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71995895, Length=210, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71995305, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71995893, Length=210, Percent_Identity=26.1904761904762, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508769, Length=261, Percent_Identity=26.8199233716475, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71995899, Length=210, Percent_Identity=26.1904761904762, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17561800, Length=174, Percent_Identity=28.735632183908, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193210669, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568383, Length=158, Percent_Identity=30.379746835443, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561802, Length=174, Percent_Identity=28.1609195402299, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994363, Length=181, Percent_Identity=27.0718232044199, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193206054, Length=143, Percent_Identity=32.1678321678322, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561794, Length=177, Percent_Identity=27.683615819209, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574512, Length=222, Percent_Identity=27.9279279279279, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161076872, Length=222, Percent_Identity=27.9279279279279, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI85725044, Length=211, Percent_Identity=27.4881516587678, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI62484298, Length=171, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI62484477, Length=171, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI116008008, Length=171, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330468, Length=169, Percent_Identity=29.585798816568, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221330470, Length=169, Percent_Identity=29.585798816568, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24663843, Length=169, Percent_Identity=28.9940828402367, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24663839, Length=169, Percent_Identity=28.9940828402367, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI281366459, Length=170, Percent_Identity=28.8235294117647, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366457, Length=170, Percent_Identity=28.8235294117647, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366455, Length=170, Percent_Identity=28.8235294117647, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI56292422, Length=170, Percent_Identity=28.8235294117647, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI56292424, Length=170, Percent_Identity=28.8235294117647, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666940, Length=170, Percent_Identity=28.8235294117647, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24647268, Length=170, Percent_Identity=30.5882352941176, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161078020, Length=194, Percent_Identity=27.319587628866, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 40728; Mature: 40728

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHCCCC
>Mature Secondary Structure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CHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]