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The map label for this gene is sph [H]

Identifier: 45656924

GI number: 45656924

Start: 1279584

End: 1280303

Strand: Direct

Name: sph [H]

Synonym: LIC11040

Alternate gene names: 45656924

Gene position: 1279584-1280303 (Clockwise)

Preceding gene: 45656923

Following gene: 45656930

Centisome position: 29.92

GC content: 34.31

Gene sequence:

>720_bases
ATGAAAATGATACAAAATATTTTGCGAAAAGAAAAAGTTAAAACATGGAATCAATTGAAAGGCTCTAAATTTTTCAGATG
TTGTTGTCTGTTTATTATTTTATTTTTTTTCGATTGTTTACCTGATTCACAGTCTTCTGAAAATAATTTATTTTTATCTT
TGCTTTCTCTTCCAAAAAATCAAGGTATAATATTAAGAAACGATAAATCTATTGCAAAGTCTAAAACGACACGAAAATAC
GGCTGGGTTACTTTTACATCTCAAGTAACCGGAAAAAAAATCCAAGCAGATCCTGAACGACCTGACGGATGGTTAAGAGT
GAATGCTTCGAGTAACACGGATTTTACGACGTTCACTTTATATCAGGATGGAAAAGATCCAGATTGTATCAAAGGCGGCC
CTATCCGGGTTGAGCCTACTGCGTATCGAAATTATTATTGGAATTGGTGGCTTGGAGGAGGTGCGGGTAATTACGCCTAT
TATCCTAAATATAAAGATGGTTCTAACAAACTTCAAATTTACGTTTTAAAAGTCAGCGGCTGTTTGGAATCAGGAGATAG
AGTCTTATTTTCGGATTATGATACTATAACTCAGGATGATTATTTTGTCATAGATTGGGATGGAGGCAGCTGGAATGAGT
ATCTTTTTCTTTGGTATAAATTTCCTAAGGTTCAGAGAGGATATTTTTATGTTCAATTGAATGAAGGCCCTGAGGAATAA

Upstream 100 bases:

>100_bases
TATTAAATTTTTGTTTAGATAGGGTATTTTGTCCTAACTTGACTCTAATCTCTTTTTCAAATTATATACTAAGATATATA
AAAATTTTGAATAGAGATAT

Downstream 100 bases:

>100_bases
AAAGAATAATAATTTTAGAATATTATGAAATAAAGAAGAGTTGAATATTTTCATCTCTTCTTTATTTTCTATTTTAATAT
ATTGGCGAAAGAGGGAATGT

Product: hemolysin

Products: NA

Alternate protein names: Sphingomyelin phosphodiesterase; SMase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MKMIQNILRKEKVKTWNQLKGSKFFRCCCLFIILFFFDCLPDSQSSENNLFLSLLSLPKNQGIILRNDKSIAKSKTTRKY
GWVTFTSQVTGKKIQADPERPDGWLRVNASSNTDFTTFTLYQDGKDPDCIKGGPIRVEPTAYRNYYWNWWLGGGAGNYAY
YPKYKDGSNKLQIYVLKVSGCLESGDRVLFSDYDTITQDDYFVIDWDGGSWNEYLFLWYKFPKVQRGYFYVQLNEGPEE

Sequences:

>Translated_239_residues
MKMIQNILRKEKVKTWNQLKGSKFFRCCCLFIILFFFDCLPDSQSSENNLFLSLLSLPKNQGIILRNDKSIAKSKTTRKY
GWVTFTSQVTGKKIQADPERPDGWLRVNASSNTDFTTFTLYQDGKDPDCIKGGPIRVEPTAYRNYYWNWWLGGGAGNYAY
YPKYKDGSNKLQIYVLKVSGCLESGDRVLFSDYDTITQDDYFVIDWDGGSWNEYLFLWYKFPKVQRGYFYVQLNEGPEE
>Mature_239_residues
MKMIQNILRKEKVKTWNQLKGSKFFRCCCLFIILFFFDCLPDSQSSENNLFLSLLSLPKNQGIILRNDKSIAKSKTTRKY
GWVTFTSQVTGKKIQADPERPDGWLRVNASSNTDFTTFTLYQDGKDPDCIKGGPIRVEPTAYRNYYWNWWLGGGAGNYAY
YPKYKDGSNKLQIYVLKVSGCLESGDRVLFSDYDTITQDDYFVIDWDGGSWNEYLFLWYKFPKVQRGYFYVQLNEGPEE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.12 [H]

Molecular weight: Translated: 27900; Mature: 27900

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMIQNILRKEKVKTWNQLKGSKFFRCCCLFIILFFFDCLPDSQSSENNLFLSLLSLPKN
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCC
QGIILRNDKSIAKSKTTRKYGWVTFTSQVTGKKIQADPERPDGWLRVNASSNTDFTTFTL
CCEEEECCCHHHHCCCCCEEEEEEEECCCCCCEEECCCCCCCCEEEEECCCCCCEEEEEE
YQDGKDPDCIKGGPIRVEPTAYRNYYWNWWLGGGAGNYAYYPKYKDGSNKLQIYVLKVSG
EECCCCCCCCCCCCEEECCCHHCCCEEEEEEECCCCCCEECCCCCCCCCEEEEEEEEEEC
CLESGDRVLFSDYDTITQDDYFVIDWDGGSWNEYLFLWYKFPKVQRGYFYVQLNEGPEE
CCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKMIQNILRKEKVKTWNQLKGSKFFRCCCLFIILFFFDCLPDSQSSENNLFLSLLSLPKN
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCC
QGIILRNDKSIAKSKTTRKYGWVTFTSQVTGKKIQADPERPDGWLRVNASSNTDFTTFTL
CCEEEECCCHHHHCCCCCEEEEEEEECCCCCCEEECCCCCCCCEEEEECCCCCCEEEEEE
YQDGKDPDCIKGGPIRVEPTAYRNYYWNWWLGGGAGNYAYYPKYKDGSNKLQIYVLKVSG
EECCCCCCCCCCCCEEECCCHHCCCEEEEEEECCCCCCEECCCCCCCCCEEEEEEEEEEC
CLESGDRVLFSDYDTITQDDYFVIDWDGGSWNEYLFLWYKFPKVQRGYFYVQLNEGPEE
CCCCCCEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2163985 [H]