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The map label for this gene is htrA

Identifier: 45656921

GI number: 45656921

Start: 1275996

End: 1277093

Strand: Direct

Name: htrA

Synonym: LIC11037

Alternate gene names: 45656921

Gene position: 1275996-1277093 (Clockwise)

Preceding gene: 45656917

Following gene: 45656922

Centisome position: 29.83

GC content: 39.89

Gene sequence:

>1098_bases
ATGGAATGGATACGTTCTCTCCCCGTCTTTAACGGAATTCTTTTAGCCGTCTTAATTTTGATTCTAATCTTTCCGAAGGA
TTGTTCCTTGTCTTCTATTTTCTATGGTAAAAAACCAATCAGCCCTAGAGAACAGAAGAACGCGATCGAAATTCAAAATT
CTTTTAGAAATGTTTATCGTCTTGCAAAGGATTCAGTAGTTTCCATTCGAACAAAAAAAAGTGAATCGATTACAAGTCCT
TATCACTATTTTGATTTTAGAAACGAAAGACTCGCTTCTTTTGGGAGCGGATTTTTTGTTCACGAAAAAGGTTATATAGT
TACGAACTATCACGTGATCGAAGACGCGGAAAGTATAGAGGTGATTACTTCCAACGGAAGTATTCATCCCGCAAAATATA
TCGGAAGTCACGAAAGGGCCGATATTGCACTTTTAAAAATCAGAGAAGGTTCTGGATTGCGTGCGGTTGTATTTGGAGAT
TCGGATCGGATCGAAGTGGGTGACTGGGCGATAGCGATTGGTTCTCCTTTTGGTTTAGAACGTTCTTTTAGTGTAGGAGT
TGTTTCTGCCAAATATAGAGAAGATTTAGATGAGACGGGACAAGCTCATATTCAAACCGATAGTATGATCAATCCAGGCA
GTAGTGGTGGACCTCTTTTAAACATCTACGGAGAAGTCATAGGAATTAACCGATTGATTCGAAGTGAAACTGGTCGTAAC
TCCGGCATTAGTTTTGCGATTCCAAGTAACTATGCTTTGAAGATTATACGAATGATAGAATCCAATCAAGGCAGACATAT
TCGTTCCGCGATTTTAGGGGTGATGGCAACTGTCCCACTTCCGGATCATAGAATTGCTTTGGGAATTCCGGAGTCTTGGA
ATGGAGTTCTCGTTTATGATATGGATCCTCAGTCTTCTGCGGAATTAGGTGGAATAAGACGTTACGATTTTATTCTGGAA
GCGAATGGAACTCCGATCAAAAATATTAATGATTTACGCGAACAGGTTGGAATAGTGGGACTTGGGGGCAAGATCAAGCT
ACGTATCTACCGGGAAAAATCGATGCAGGAACTTTCGATAAAGTTGATTCAGAAATAG

Upstream 100 bases:

>100_bases
GAAACAAAGTAAGGTTAAGAGTAGAATGTTATAGAATCGAATTGCGGTTTTAGATTTACGTTTGTTTATAGAAGTAAAAA
AATTGAATTTAGGTTCTAAC

Downstream 100 bases:

>100_bases
AAATGGATAAGAATTTTTTAGAGGAAAAAGAGAAAACCGGATGAGAAGAAACATCGTTCACAGCGGAGCGGACGCCCTAA
TTTATGAAATCAGACAGATC

Product: periplasmic trypsin-like serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MEWIRSLPVFNGILLAVLILILIFPKDCSLSSIFYGKKPISPREQKNAIEIQNSFRNVYRLAKDSVVSIRTKKSESITSP
YHYFDFRNERLASFGSGFFVHEKGYIVTNYHVIEDAESIEVITSNGSIHPAKYIGSHERADIALLKIREGSGLRAVVFGD
SDRIEVGDWAIAIGSPFGLERSFSVGVVSAKYREDLDETGQAHIQTDSMINPGSSGGPLLNIYGEVIGINRLIRSETGRN
SGISFAIPSNYALKIIRMIESNQGRHIRSAILGVMATVPLPDHRIALGIPESWNGVLVYDMDPQSSAELGGIRRYDFILE
ANGTPIKNINDLREQVGIVGLGGKIKLRIYREKSMQELSIKLIQK

Sequences:

>Translated_365_residues
MEWIRSLPVFNGILLAVLILILIFPKDCSLSSIFYGKKPISPREQKNAIEIQNSFRNVYRLAKDSVVSIRTKKSESITSP
YHYFDFRNERLASFGSGFFVHEKGYIVTNYHVIEDAESIEVITSNGSIHPAKYIGSHERADIALLKIREGSGLRAVVFGD
SDRIEVGDWAIAIGSPFGLERSFSVGVVSAKYREDLDETGQAHIQTDSMINPGSSGGPLLNIYGEVIGINRLIRSETGRN
SGISFAIPSNYALKIIRMIESNQGRHIRSAILGVMATVPLPDHRIALGIPESWNGVLVYDMDPQSSAELGGIRRYDFILE
ANGTPIKNINDLREQVGIVGLGGKIKLRIYREKSMQELSIKLIQK
>Mature_365_residues
MEWIRSLPVFNGILLAVLILILIFPKDCSLSSIFYGKKPISPREQKNAIEIQNSFRNVYRLAKDSVVSIRTKKSESITSP
YHYFDFRNERLASFGSGFFVHEKGYIVTNYHVIEDAESIEVITSNGSIHPAKYIGSHERADIALLKIREGSGLRAVVFGD
SDRIEVGDWAIAIGSPFGLERSFSVGVVSAKYREDLDETGQAHIQTDSMINPGSSGGPLLNIYGEVIGINRLIRSETGRN
SGISFAIPSNYALKIIRMIESNQGRHIRSAILGVMATVPLPDHRIALGIPESWNGVLVYDMDPQSSAELGGIRRYDFILE
ANGTPIKNINDLREQVGIVGLGGKIKLRIYREKSMQELSIKLIQK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=300, Percent_Identity=35, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI22129776, Length=270, Percent_Identity=34.0740740740741, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI24308541, Length=256, Percent_Identity=33.59375, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI7019477, Length=257, Percent_Identity=33.0739299610895, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786356, Length=278, Percent_Identity=39.2086330935252, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1789629, Length=311, Percent_Identity=35.6913183279743, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789630, Length=367, Percent_Identity=30.5177111716621, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646839, Length=306, Percent_Identity=30.0653594771242, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40552; Mature: 40552

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50106 PDZ ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWIRSLPVFNGILLAVLILILIFPKDCSLSSIFYGKKPISPREQKNAIEIQNSFRNVYR
CCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHCCHHHHHHHHHHHHH
LAKDSVVSIRTKKSESITSPYHYFDFRNERLASFGSGFFVHEKGYIVTNYHVIEDAESIE
HHCCCEEEEEECCCCCCCCCCCEECCCCHHHHHCCCCEEEEECCEEEEEEEEECCCCCEE
VITSNGSIHPAKYIGSHERADIALLKIREGSGLRAVVFGDSDRIEVGDWAIAIGSPFGLE
EEECCCCCCHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCEEECCEEEEECCCCCCC
RSFSVGVVSAKYREDLDETGQAHIQTDSMINPGSSGGPLLNIYGEVIGINRLIRSETGRN
CCCEEEEEEHHHHHCHHHCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCC
SGISFAIPSNYALKIIRMIESNQGRHIRSAILGVMATVPLPDHRIALGIPESWNGVLVYD
CCEEEEECCHHHHHHEEEHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEE
MDPQSSAELGGIRRYDFILEANGTPIKNINDLREQVGIVGLGGKIKLRIYREKSMQELSI
CCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHCCEEEECCEEEEEEEECCCHHHHHH
KLIQK
HHHCC
>Mature Secondary Structure
MEWIRSLPVFNGILLAVLILILIFPKDCSLSSIFYGKKPISPREQKNAIEIQNSFRNVYR
CCHHHHCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHCCHHHHHHHHHHHHH
LAKDSVVSIRTKKSESITSPYHYFDFRNERLASFGSGFFVHEKGYIVTNYHVIEDAESIE
HHCCCEEEEEECCCCCCCCCCCEECCCCHHHHHCCCCEEEEECCEEEEEEEEECCCCCEE
VITSNGSIHPAKYIGSHERADIALLKIREGSGLRAVVFGDSDRIEVGDWAIAIGSPFGLE
EEECCCCCCHHHHCCCCCCCCEEEEEEECCCCEEEEEECCCCCEEECCEEEEECCCCCCC
RSFSVGVVSAKYREDLDETGQAHIQTDSMINPGSSGGPLLNIYGEVIGINRLIRSETGRN
CCCEEEEEEHHHHHCHHHCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCC
SGISFAIPSNYALKIIRMIESNQGRHIRSAILGVMATVPLPDHRIALGIPESWNGVLVYD
CCEEEEECCHHHHHHEEEHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEE
MDPQSSAELGGIRRYDFILEANGTPIKNINDLREQVGIVGLGGKIKLRIYREKSMQELSI
CCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHCCEEEECCEEEEEEEECCCHHHHHH
KLIQK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]