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The map label for this gene is pkn1 [H]

Identifier: 45656872

GI number: 45656872

Start: 1190243

End: 1191211

Strand: Direct

Name: pkn1 [H]

Synonym: LIC10984

Alternate gene names: 45656872

Gene position: 1190243-1191211 (Clockwise)

Preceding gene: 45656864

Following gene: 45656873

Centisome position: 27.83

GC content: 39.11

Gene sequence:

>969_bases
TTGATTTGTCCGTTTCGTTTTTCAGTCTATCCTCATTCTAAAAGATTCTGTTTAAGTTTTAAATCTTTTTGGTTAGGACC
TTATATGAAATCGAAAATTCGAAATTTTCTTTTTTTGGTAGTAATGATTTTAATTGCTCACTGGGGGTGGATGTGTAAGT
TGCTTGCGGATCCTTCGGCTTGTGGAGGAAAAGAAATTCCAGGAATGAAATGTATTCCTGCCGGAGAATTTATACGCGGA
AGTAATGTTTACGATGCAGATGAAAAACCGGAAGAGAAGGTTTATGTAAGTGACTTTTATATGGACATCTATGAAGTCAC
AAATGAAGATTTTGACAAATGCAAAAACGCAGGTAAATGCCAAGAATGTTTAAAAACCGGGAAGTGTAATTATATCGGAC
CACGTTATGGTAAACCTTACTTAGGTCCCAAACAACCTGTAACAGGGATTAGTTGGTATACTGCAAAAGAGTTTTGTGAA
TGGGCTGGTAAAAGACTCCCAACGGAAGCCGAATGGGAGAAAGCTGCCAGGGGACCAAACGGAAATTTATATCCCTGGGG
GAATGAACCAGCAACTTGTGAAAGAGCGATCATTGAAGTAGGGGACATTAAAGGATGTGTTCCTAAAAAGACGGAAAAAC
CTCATCTAATGCCGACTGCAAACGTGGGTACAAGAGCTCCTGGAGTTTATGGATTGTATGATATGGCCGGAAATTCTTGG
GAATGGACTGCGGATTGGTATTCTACTTCTTTTAAGGCTTGTGGTAATTTTTGTAGAGGAAAGGATCCTAAGGGACCTTG
TGACGGAAAGGAAGTTTGTCCCGGTTATAAGAAAAAAGTTTTAAAAAGTGGTTCTTGGTGGTGGCCAGCTCATTATGCGA
GGGGTTCTAAAAGAAGATCTCATATTCCAGAGAATTTTCCAGAATATCACCATTTTGGATTTCGTTGTGCAAAGGATGTA
AATAAATAA

Upstream 100 bases:

>100_bases
TATGGTGTTTGAAGGAAGATACGATTTCATTCTTTATAAAATATTGGAACTAGTTTGTTCTTATCGCTTTCAGAATCCAG
AGATTTTTTTAAATACTTGA

Downstream 100 bases:

>100_bases
TATGTTTAATTATTCTAAATTAGGAATTTATGTTGTTCTTATGTTTCTTTCTTTTATTTTTTTGTTCTGTTCCGGGCCAA
AAAAAATCGAGGAAAACCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MICPFRFSVYPHSKRFCLSFKSFWLGPYMKSKIRNFLFLVVMILIAHWGWMCKLLADPSACGGKEIPGMKCIPAGEFIRG
SNVYDADEKPEEKVYVSDFYMDIYEVTNEDFDKCKNAGKCQECLKTGKCNYIGPRYGKPYLGPKQPVTGISWYTAKEFCE
WAGKRLPTEAEWEKAARGPNGNLYPWGNEPATCERAIIEVGDIKGCVPKKTEKPHLMPTANVGTRAPGVYGLYDMAGNSW
EWTADWYSTSFKACGNFCRGKDPKGPCDGKEVCPGYKKKVLKSGSWWWPAHYARGSKRRSHIPENFPEYHHFGFRCAKDV
NK

Sequences:

>Translated_322_residues
MICPFRFSVYPHSKRFCLSFKSFWLGPYMKSKIRNFLFLVVMILIAHWGWMCKLLADPSACGGKEIPGMKCIPAGEFIRG
SNVYDADEKPEEKVYVSDFYMDIYEVTNEDFDKCKNAGKCQECLKTGKCNYIGPRYGKPYLGPKQPVTGISWYTAKEFCE
WAGKRLPTEAEWEKAARGPNGNLYPWGNEPATCERAIIEVGDIKGCVPKKTEKPHLMPTANVGTRAPGVYGLYDMAGNSW
EWTADWYSTSFKACGNFCRGKDPKGPCDGKEVCPGYKKKVLKSGSWWWPAHYARGSKRRSHIPENFPEYHHFGFRCAKDV
NK
>Mature_322_residues
MICPFRFSVYPHSKRFCLSFKSFWLGPYMKSKIRNFLFLVVMILIAHWGWMCKLLADPSACGGKEIPGMKCIPAGEFIRG
SNVYDADEKPEEKVYVSDFYMDIYEVTNEDFDKCKNAGKCQECLKTGKCNYIGPRYGKPYLGPKQPVTGISWYTAKEFCE
WAGKRLPTEAEWEKAARGPNGNLYPWGNEPATCERAIIEVGDIKGCVPKKTEKPHLMPTANVGTRAPGVYGLYDMAGNSW
EWTADWYSTSFKACGNFCRGKDPKGPCDGKEVCPGYKKKVLKSGSWWWPAHYARGSKRRSHIPENFPEYHHFGFRCAKDV
NK

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=269, Percent_Identity=35.3159851301115, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI38202250, Length=294, Percent_Identity=32.6530612244898, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI257470977, Length=221, Percent_Identity=34.3891402714932, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI194248087, Length=289, Percent_Identity=29.0657439446367, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI194248088, Length=304, Percent_Identity=27.6315789473684, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI226437577, Length=180, Percent_Identity=33.8888888888889, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI20130397, Length=226, Percent_Identity=30.9734513274336, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 36672; Mature: 36672

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICPFRFSVYPHSKRFCLSFKSFWLGPYMKSKIRNFLFLVVMILIAHWGWMCKLLADPSA
CCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CGGKEIPGMKCIPAGEFIRGSNVYDADEKPEEKVYVSDFYMDIYEVTNEDFDKCKNAGKC
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCHHHHHHCCCCHH
QECLKTGKCNYIGPRYGKPYLGPKQPVTGISWYTAKEFCEWAGKRLPTEAEWEKAARGPN
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
GNLYPWGNEPATCERAIIEVGDIKGCVPKKTEKPHLMPTANVGTRAPGVYGLYDMAGNSW
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCC
EWTADWYSTSFKACGNFCRGKDPKGPCDGKEVCPGYKKKVLKSGSWWWPAHYARGSKRRS
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHCCCCCCCHHHHCCCCHHH
HIPENFPEYHHFGFRCAKDVNK
CCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MICPFRFSVYPHSKRFCLSFKSFWLGPYMKSKIRNFLFLVVMILIAHWGWMCKLLADPSA
CCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CGGKEIPGMKCIPAGEFIRGSNVYDADEKPEEKVYVSDFYMDIYEVTNEDFDKCKNAGKC
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCHHHHHHCCCCHH
QECLKTGKCNYIGPRYGKPYLGPKQPVTGISWYTAKEFCEWAGKRLPTEAEWEKAARGPN
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
GNLYPWGNEPATCERAIIEVGDIKGCVPKKTEKPHLMPTANVGTRAPGVYGLYDMAGNSW
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCC
EWTADWYSTSFKACGNFCRGKDPKGPCDGKEVCPGYKKKVLKSGSWWWPAHYARGSKRRS
EEEHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHCCCCCCCHHHHCCCCHHH
HIPENFPEYHHFGFRCAKDVNK
CCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]