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The map label for this gene is uppS

Identifier: 45656745

GI number: 45656745

Start: 1029291

End: 1030016

Strand: Direct

Name: uppS

Synonym: LIC10854

Alternate gene names: 45656745

Gene position: 1029291-1030016 (Clockwise)

Preceding gene: 45656744

Following gene: 45656746

Centisome position: 24.06

GC content: 41.05

Gene sequence:

>726_bases
GTGGGCTTGTTCGAGTCCAATCTCCCGAAACATATTGCCGTTATTATGGATGGTAACGGTCGTTGGGCAACATCCCGAGG
TAAATCCAGATCGGAAGGCCATAGAGAAGGTGCCCAGGCCATAGATAGACTTATGGATGCGAGTCTGGAACTAGGTTTAA
AAAATATTTCCCTTTATGCTTTTTCTACCGAGAATTGGAAACGCCCTGTCACCGAAATCCGTTCTATCTTTAGCCTTTTA
ATTGAATTTATAGAAACTCGATTAGATACGATTCACAAAAGAGGAATTCGAATTCTTCATTCCGGAAGCCGAAAAAAACT
TACCCGAGGAGTTTTAGACAAGATAGACTTTGCGGTAGATAAGACTCAAAAAAACAAAAATCTTACTGTAAACTTCTGTT
TGAACTACGGTTCCAGAGATGAACTTCTCAGGGCGGCACAAGAGCTTTTTTTAGAAAGAAAACGTTCTAAAGTTGCTTTA
GAAAAGCCTTTGAAAGAAAAAGAGTTCGAAAAATTTTTATATACGTCCATCCTTCCTCCCGTAGATTTACTGATCAGAAC
CGCCGGGGAACAAAGACTTTCCAATTTTCTACTTTGGCAATCCGCGTATGCGGAGTTGTATTTTACGGATACTCTCTGGC
CCGAGTTCGATAAAAATTCTCTGGTGGATTCCCTAAAGTGGTACGAAACCAGAACCCGAAAATTCGGAGGACTTACGAAT
GGGTGA

Upstream 100 bases:

>100_bases
AAATCGGTTCAAGATCAGATTCAAAAAATCACAGATTCCTATATCGATAAAATTTCCGCTCTTACCGCAGAGAAGGAAAA
GGAAATCACTACGATCTAAC

Downstream 100 bases:

>100_bases
AACTTCTAAGAGACTCGCTTCCGCGGCTGTGCTCATACTATTTTATCTTTTTATGATATTCTATCCTGGTTTTTATTATC
TGCAAACCTATTTGATTCTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MGLFESNLPKHIAVIMDGNGRWATSRGKSRSEGHREGAQAIDRLMDASLELGLKNISLYAFSTENWKRPVTEIRSIFSLL
IEFIETRLDTIHKRGIRILHSGSRKKLTRGVLDKIDFAVDKTQKNKNLTVNFCLNYGSRDELLRAAQELFLERKRSKVAL
EKPLKEKEFEKFLYTSILPPVDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPEFDKNSLVDSLKWYETRTRKFGGLTN
G

Sequences:

>Translated_241_residues
MGLFESNLPKHIAVIMDGNGRWATSRGKSRSEGHREGAQAIDRLMDASLELGLKNISLYAFSTENWKRPVTEIRSIFSLL
IEFIETRLDTIHKRGIRILHSGSRKKLTRGVLDKIDFAVDKTQKNKNLTVNFCLNYGSRDELLRAAQELFLERKRSKVAL
EKPLKEKEFEKFLYTSILPPVDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPEFDKNSLVDSLKWYETRTRKFGGLTN
G
>Mature_240_residues
GLFESNLPKHIAVIMDGNGRWATSRGKSRSEGHREGAQAIDRLMDASLELGLKNISLYAFSTENWKRPVTEIRSIFSLLI
EFIETRLDTIHKRGIRILHSGSRKKLTRGVLDKIDFAVDKTQKNKNLTVNFCLNYGSRDELLRAAQELFLERKRSKVALE
KPLKEKEFEKFLYTSILPPVDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPEFDKNSLVDSLKWYETRTRKFGGLTNG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=218, Percent_Identity=37.1559633027523, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI45580738, Length=218, Percent_Identity=37.1559633027523, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=37.0689655172414, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=236, Percent_Identity=30.9322033898305, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=36.4485981308411, Blast_Score=141, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=222, Percent_Identity=33.7837837837838, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI18857969, Length=211, Percent_Identity=34.1232227488152, Blast_Score=130, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_LEPIC (Q72U10)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000831.1
- ProteinModelPortal:   Q72U10
- SMR:   Q72U10
- GeneID:   2771293
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10854
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14842
- BioCyc:   LINT267671:LIC_10854-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27862; Mature: 27731

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 17-17

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLFESNLPKHIAVIMDGNGRWATSRGKSRSEGHREGAQAIDRLMDASLELGLKNISLYA
CCCCCCCCCCEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FSTENWKRPVTEIRSIFSLLIEFIETRLDTIHKRGIRILHSGSRKKLTRGVLDKIDFAVD
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHHHHHHHHHHHHH
KTQKNKNLTVNFCLNYGSRDELLRAAQELFLERKRSKVALEKPLKEKEFEKFLYTSILPP
HCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
VDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPEFDKNSLVDSLKWYETRTRKFGGLTN
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
G
C
>Mature Secondary Structure 
GLFESNLPKHIAVIMDGNGRWATSRGKSRSEGHREGAQAIDRLMDASLELGLKNISLYA
CCCCCCCCCEEEEEECCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
FSTENWKRPVTEIRSIFSLLIEFIETRLDTIHKRGIRILHSGSRKKLTRGVLDKIDFAVD
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCHHHHHHHHHHHHHHHHH
KTQKNKNLTVNFCLNYGSRDELLRAAQELFLERKRSKVALEKPLKEKEFEKFLYTSILPP
HCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCH
VDLLIRTAGEQRLSNFLLWQSAYAELYFTDTLWPEFDKNSLVDSLKWYETRTRKFGGLTN
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA