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The map label for this gene is adh

Identifier: 45656700

GI number: 45656700

Start: 980016

End: 981062

Strand: Direct

Name: adh

Synonym: LIC10809

Alternate gene names: 45656700

Gene position: 980016-981062 (Clockwise)

Preceding gene: 45656697

Following gene: 45656707

Centisome position: 22.91

GC content: 39.45

Gene sequence:

>1047_bases
TTGGGGATAATGGGAATGAAAGCTGCGGTTTTAGAATCCGGTAAAAAAATTTTAGAGATCAGAGATGTTTCCGTTCCACA
ACTTAGGGCTGAACAAGTAAAGGTAAGAATTAAGGCTTGTGGTATTTGTGGTTCAGACGTACATCTCGTGGTTCATGGAA
CTCTCAAATGTAAACATTTTCCCAGAGTTCCAGGACATGAGTCATCGGGAATTATCGAAGAAGTAGGCGAGAACGTTAGA
CGATTCCGTAAAGGAGATCGAGTGGTCATCGCGGCCGGAACTTCATGTGGAGTTTGTTCTTATTGTAAAGAAGGAAAAGA
AAATCTATGTAAAGATTTAGGTGTGTTTGGTTTTGATCGAGATGGAAGTTTTGCAGAATTTAATATAGTAGAAGAACGTT
ATTTGTATTCTCTTCCAGATGAGATTCCATTTGATCAAGGAGCGATTCTTGCAGATGCTGTATCTACTCCTTATCACGCT
ATTCGTTACAGAGGGAATATTCAGGAAAGTGATACAGTAGCTATTTTTGGTTGTGGGGGGCTTGGAATCCATGCGGTGGC
GATTGCAAGGGCGATGACAAAAGGTAAGGTGATTGCATTGGATGTGGATTCGGGAGCTTTAGAAAACGCTACCAAATATG
GAGCTGATGAAGTGGTTAACTTGAAAGAAGTTCGAAATTCGGGCAAGGTTCTAAAGGAAGTATCGAAAGGTGTAGATCTA
CTTGCCGACTTTTCGGGTTATATGTCTAACGTAGAAGATTCAATACGAGCGATGAACCCGGGAGGTAGAATTGTACTTGT
AGGTATTGGAAGACAGCCCTTGAAATTTCAGATTCCTTTTATATTAATTGAAAAAATGATTTCTGTTTCTGGTTCTTATG
GATCCGATCGTAGAGCGATTCCTGAATTGATTGAACTTTATCTAAAAGGAAAAATCAATCTTTCTCATTCGATTACTTCT
CATCATCCATTAGAAGAATTGAATGAATGCCTTGAGGCCTTGGATCAGAGAAAAGGAAATCCGATTCGGTTTATTGTTGA
ACCTTAA

Upstream 100 bases:

>100_bases
CGTTTTTATAAAATCTTTTGAAGAGATACTAATTTTTAAAACAAATCGTCTTGACCACACTATAGATGGTCTTAATCTAA
CTCGGTTTTGATATAAAAAA

Downstream 100 bases:

>100_bases
ATAACGTGAATTCAACATAAAGAATCTATGATTCATGATTCTGAAAAAAGTTGGAATCTGAACTTTACAGATTGATTCTT
TAAATGTGGGAACCCTCACA

Product: zinc binding dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MGIMGMKAAVLESGKKILEIRDVSVPQLRAEQVKVRIKACGICGSDVHLVVHGTLKCKHFPRVPGHESSGIIEEVGENVR
RFRKGDRVVIAAGTSCGVCSYCKEGKENLCKDLGVFGFDRDGSFAEFNIVEERYLYSLPDEIPFDQGAILADAVSTPYHA
IRYRGNIQESDTVAIFGCGGLGIHAVAIARAMTKGKVIALDVDSGALENATKYGADEVVNLKEVRNSGKVLKEVSKGVDL
LADFSGYMSNVEDSIRAMNPGGRIVLVGIGRQPLKFQIPFILIEKMISVSGSYGSDRRAIPELIELYLKGKINLSHSITS
HHPLEELNECLEALDQRKGNPIRFIVEP

Sequences:

>Translated_348_residues
MGIMGMKAAVLESGKKILEIRDVSVPQLRAEQVKVRIKACGICGSDVHLVVHGTLKCKHFPRVPGHESSGIIEEVGENVR
RFRKGDRVVIAAGTSCGVCSYCKEGKENLCKDLGVFGFDRDGSFAEFNIVEERYLYSLPDEIPFDQGAILADAVSTPYHA
IRYRGNIQESDTVAIFGCGGLGIHAVAIARAMTKGKVIALDVDSGALENATKYGADEVVNLKEVRNSGKVLKEVSKGVDL
LADFSGYMSNVEDSIRAMNPGGRIVLVGIGRQPLKFQIPFILIEKMISVSGSYGSDRRAIPELIELYLKGKINLSHSITS
HHPLEELNECLEALDQRKGNPIRFIVEP
>Mature_347_residues
GIMGMKAAVLESGKKILEIRDVSVPQLRAEQVKVRIKACGICGSDVHLVVHGTLKCKHFPRVPGHESSGIIEEVGENVRR
FRKGDRVVIAAGTSCGVCSYCKEGKENLCKDLGVFGFDRDGSFAEFNIVEERYLYSLPDEIPFDQGAILADAVSTPYHAI
RYRGNIQESDTVAIFGCGGLGIHAVAIARAMTKGKVIALDVDSGALENATKYGADEVVNLKEVRNSGKVLKEVSKGVDLL
ADFSGYMSNVEDSIRAMNPGGRIVLVGIGRQPLKFQIPFILIEKMISVSGSYGSDRRAIPELIELYLKGKINLSHSITSH
HPLEELNECLEALDQRKGNPIRFIVEP

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=28.2258064516129, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI262073058, Length=372, Percent_Identity=26.6129032258064, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=26.4150943396226, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=26.2734584450402, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4501939, Length=365, Percent_Identity=26.027397260274, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI156627571, Length=339, Percent_Identity=27.4336283185841, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI71565152, Length=380, Percent_Identity=24.4736842105263, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=24.7311827956989, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI194239674, Length=258, Percent_Identity=27.1317829457364, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI13236495, Length=258, Percent_Identity=27.1317829457364, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI194239676, Length=222, Percent_Identity=27.4774774774775, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1787863, Length=334, Percent_Identity=29.0419161676647, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082125, Length=335, Percent_Identity=28.6567164179104, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790045, Length=334, Percent_Identity=28.1437125748503, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI87081918, Length=337, Percent_Identity=29.3768545994065, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788407, Length=298, Percent_Identity=27.1812080536913, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=26.7567567567568, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788073, Length=336, Percent_Identity=24.702380952381, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1788075, Length=330, Percent_Identity=27.8787878787879, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI226510992, Length=324, Percent_Identity=25.3086419753086, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790718, Length=347, Percent_Identity=27.0893371757925, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786518, Length=319, Percent_Identity=30.0940438871473, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786825, Length=389, Percent_Identity=23.9074550128535, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082401, Length=324, Percent_Identity=24.0740740740741, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=349, Percent_Identity=32.9512893982808, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17562878, Length=339, Percent_Identity=31.858407079646, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=27.4666666666667, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=27.0557029177719, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17565904, Length=315, Percent_Identity=26.984126984127, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71988145, Length=346, Percent_Identity=25.7225433526012, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=314, Percent_Identity=26.7515923566879, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=313, Percent_Identity=26.8370607028754, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=26.6846361185984, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323099, Length=354, Percent_Identity=30.5084745762712, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319258, Length=364, Percent_Identity=26.3736263736264, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=310, Percent_Identity=29.6774193548387, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324486, Length=319, Percent_Identity=29.7805642633229, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=355, Percent_Identity=28.7323943661972, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319955, Length=355, Percent_Identity=28.7323943661972, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=28.4848484848485, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=330, Percent_Identity=26.3636363636364, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=353, Percent_Identity=25.7790368271955, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319949, Length=287, Percent_Identity=29.616724738676, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=286, Percent_Identity=27.6223776223776, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17737895, Length=374, Percent_Identity=27.807486631016, Blast_Score=154, Evalue=9e-38,
Organism=Drosophila melanogaster, GI17737897, Length=350, Percent_Identity=28.8571428571429, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17137530, Length=332, Percent_Identity=26.8072289156627, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI45551930, Length=314, Percent_Identity=24.203821656051, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550770, Length=314, Percent_Identity=24.203821656051, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221457811, Length=314, Percent_Identity=24.203821656051, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37941; Mature: 37810

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIMGMKAAVLESGKKILEIRDVSVPQLRAEQVKVRIKACGICGSDVHLVVHGTLKCKHF
CCCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHEEEEEEECCCCCCEEEEEEEEEEECCC
PRVPGHESSGIIEEVGENVRRFRKGDRVVIAAGTSCGVCSYCKEGKENLCKDLGVFGFDR
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
DGSFAEFNIVEERYLYSLPDEIPFDQGAILADAVSTPYHAIRYRGNIQESDTVAIFGCGG
CCCEEEEEEHHHHHHHCCCCCCCCCCCCEEHHHHCCCCHHEEECCCCCCCCEEEEEECCC
LGIHAVAIARAMTKGKVIALDVDSGALENATKYGADEVVNLKEVRNSGKVLKEVSKGVDL
HHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LADFSGYMSNVEDSIRAMNPGGRIVLVGIGRQPLKFQIPFILIEKMISVSGSYGSDRRAI
HHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEECHHHHHHHHHHCCCCCCCCCHHH
PELIELYLKGKINLSHSITSHHPLEELNECLEALDQRKGNPIRFIVEP
HHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
GIMGMKAAVLESGKKILEIRDVSVPQLRAEQVKVRIKACGICGSDVHLVVHGTLKCKHF
CCCCHHHHHHHCCCCEEEEECCCCCHHHHHHHEEEEEEECCCCCCEEEEEEEEEEECCC
PRVPGHESSGIIEEVGENVRRFRKGDRVVIAAGTSCGVCSYCKEGKENLCKDLGVFGFDR
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
DGSFAEFNIVEERYLYSLPDEIPFDQGAILADAVSTPYHAIRYRGNIQESDTVAIFGCGG
CCCEEEEEEHHHHHHHCCCCCCCCCCCCEEHHHHCCCCHHEEECCCCCCCCEEEEEECCC
LGIHAVAIARAMTKGKVIALDVDSGALENATKYGADEVVNLKEVRNSGKVLKEVSKGVDL
HHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LADFSGYMSNVEDSIRAMNPGGRIVLVGIGRQPLKFQIPFILIEKMISVSGSYGSDRRAI
HHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEECHHHHHHHHHHCCCCCCCCCHHH
PELIELYLKGKINLSHSITSHHPLEELNECLEALDQRKGNPIRFIVEP
HHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]