| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is hom
Identifier: 45656469
GI number: 45656469
Start: 695784
End: 697073
Strand: Reverse
Name: hom
Synonym: LIC10571
Alternate gene names: 45656469
Gene position: 697073-695784 (Counterclockwise)
Preceding gene: 45656473
Following gene: 45656468
Centisome position: 16.3
GC content: 38.53
Gene sequence:
>1290_bases ATGGAACGCATTCGTATTGGATTGATCGGTGCCGGAACTGTCGGCTCAGGAGTCATCGAAATTTTAAAAAAAGAAAGTAA CAAGTATCTTGAAAAATTCGGAATAGAGCTGATCCTTTCCTCCGTTTGTACTCGAACTCCAGAAAAAATCAAAAAAGAAC TTCAAAGTTTCCCTAACTGCAAATTAGAATCCGATTATCAAAAATTAGTCACAGATCCCGAAATTGACATGATCTTAGAA CTCGTAGGTGGAACGGATATAGCTTATTCAATCGTAAAAGATGCGTTAAAGTTCGGTAAAACTGTAATTACTGCAAACAA AGCCTTACTTTCACAAAAAGGAGACGAGTTGTTTTCTTTTGCTCAAGAAAAGGGTTTGGAAATCGGAATAGAAGCTTCAG TTGCAGGTGCCATTCCAGTAATTCGTTCCATCAAGTCCAGTTTGGGTTCCGATTCTTTTCTTTCTTTATACGGTATTCTC AATGGAACTACAAATTTTATTCTTTCCAAAATGGAATTGGAAAATCTGGATTATTCAGAGGCTCTTCGTATCGCTCAAGA TTTGGGTTTTGCGGAAAAAGATCCTACCTTCGACGTGGAAGGTATTGATACGGCTCACAAAATCAGCATATTAGGAAGTT TAGCTTTCTCCGAAAAAATTCCTTTACAGAGTGTACAAATCGAAGGTATAACAAAGATTAGCGGATTGGATATTCGATTT GCGAGCGAACTTGGTTATAGAATTAAACTTCTTGGTTTGGTACGGAAGTTATCTCATAAAATCGAGGCCCGAGTTCAACC CGTGATGATTCCCATTAAACATCCGTTCGCAAATATTATGAACGAGATGAATGCAGTCTATTATCAAACCGCTTATGCGG GAACGGGTATGTTTGTAGGTAAGGGAGCCGGATCTTTACCAACGGCTTCTTCAGTTGTCTCCGATATTCTTTATTATGGA GCGAGAAGAAACAAAGGTATTTTTCAGGAAAAAAATATTTTTCCGCAAGCTATGATTTCGGAAGCCAATGTTTCTTTGGT ACGCTACTACCTCAGATTTACTACCGTGGATTTACCTGGAGTTCTTTCTGAAATTTCTAAAGTACTAGGGGACCACGGAG TTTCGATCTCTTCGGTAAGGCAAAATGAGACAGAAAAAGAGCCGGTTGAAGTTGTAGTAATTACACATCCAGCAACGGAA GAAAGTATTAAAAATTCATTGAAGATCATAGACGGGTTGTCTCTAATCCGACATACTTCGGTTGCAATTCGTTTAGAGGA TAAACTCTGA
Upstream 100 bases:
>100_bases GTACCAGAAAAATGAATCGTTGTAAATTAAAATTTCAATCCTTCTAAGAACATCACTTTTGCATTTGAATCTTACTCGCA AGTTATGAAAATGGTAAACC
Downstream 100 bases:
>100_bases AAATCTCCCCCTCGAACGTGAATCTGAAAGATTCTTCGAAGTGTCAGTAATAGAATTTAAAAAAAAATGTTCTTATAAAC ATAGTTAAGGAATTTTCATG
Product: homoserine dehydrogenase
Products: NA
Alternate protein names: HDH [H]
Number of amino acids: Translated: 429; Mature: 429
Protein sequence:
>429_residues MERIRIGLIGAGTVGSGVIEILKKESNKYLEKFGIELILSSVCTRTPEKIKKELQSFPNCKLESDYQKLVTDPEIDMILE LVGGTDIAYSIVKDALKFGKTVITANKALLSQKGDELFSFAQEKGLEIGIEASVAGAIPVIRSIKSSLGSDSFLSLYGIL NGTTNFILSKMELENLDYSEALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSVQIEGITKISGLDIRF ASELGYRIKLLGLVRKLSHKIEARVQPVMIPIKHPFANIMNEMNAVYYQTAYAGTGMFVGKGAGSLPTASSVVSDILYYG ARRNKGIFQEKNIFPQAMISEANVSLVRYYLRFTTVDLPGVLSEISKVLGDHGVSISSVRQNETEKEPVEVVVITHPATE ESIKNSLKIIDGLSLIRHTSVAIRLEDKL
Sequences:
>Translated_429_residues MERIRIGLIGAGTVGSGVIEILKKESNKYLEKFGIELILSSVCTRTPEKIKKELQSFPNCKLESDYQKLVTDPEIDMILE LVGGTDIAYSIVKDALKFGKTVITANKALLSQKGDELFSFAQEKGLEIGIEASVAGAIPVIRSIKSSLGSDSFLSLYGIL NGTTNFILSKMELENLDYSEALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSVQIEGITKISGLDIRF ASELGYRIKLLGLVRKLSHKIEARVQPVMIPIKHPFANIMNEMNAVYYQTAYAGTGMFVGKGAGSLPTASSVVSDILYYG ARRNKGIFQEKNIFPQAMISEANVSLVRYYLRFTTVDLPGVLSEISKVLGDHGVSISSVRQNETEKEPVEVVVITHPATE ESIKNSLKIIDGLSLIRHTSVAIRLEDKL >Mature_429_residues MERIRIGLIGAGTVGSGVIEILKKESNKYLEKFGIELILSSVCTRTPEKIKKELQSFPNCKLESDYQKLVTDPEIDMILE LVGGTDIAYSIVKDALKFGKTVITANKALLSQKGDELFSFAQEKGLEIGIEASVAGAIPVIRSIKSSLGSDSFLSLYGIL NGTTNFILSKMELENLDYSEALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSVQIEGITKISGLDIRF ASELGYRIKLLGLVRKLSHKIEARVQPVMIPIKHPFANIMNEMNAVYYQTAYAGTGMFVGKGAGSLPTASSVVSDILYYG ARRNKGIFQEKNIFPQAMISEANVSLVRYYLRFTTVDLPGVLSEISKVLGDHGVSISSVRQNETEKEPVEVVVITHPATE ESIKNSLKIIDGLSLIRHTSVAIRLEDKL
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0460
COG function: function code E; Homoserine dehydrogenase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ACT domain [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=248, Percent_Identity=27.0161290322581, Blast_Score=72, Evalue=5e-14, Organism=Escherichia coli, GI1790376, Length=349, Percent_Identity=24.6418338108883, Blast_Score=67, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR005106 - InterPro: IPR016204 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =1.1.1.3 [H]
Molecular weight: Translated: 46995; Mature: 46995
Theoretical pI: Translated: 6.54; Mature: 6.54
Prosite motif: PS01042 HOMOSER_DHGENASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.3 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MERIRIGLIGAGTVGSGVIEILKKESNKYLEKFGIELILSSVCTRTPEKIKKELQSFPNC CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC KLESDYQKLVTDPEIDMILELVGGTDIAYSIVKDALKFGKTVITANKALLSQKGDELFSF CCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEHHHHHHHCCCHHHHHH AQEKGLEIGIEASVAGAIPVIRSIKSSLGSDSFLSLYGILNGTTNFILSKMELENLDYSE HHHCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHH ALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSVQIEGITKISGLDIRF HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCEEE ASELGYRIKLLGLVRKLSHKIEARVQPVMIPIKHPFANIMNEMNAVYYQTAYAGTGMFVG HHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHEEEECCCCCEEEE KGAGSLPTASSVVSDILYYGARRNKGIFQEKNIFPQAMISEANVSLVRYYLRFTTVDLPG CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH VLSEISKVLGDHGVSISSVRQNETEKEPVEVVVITHPATEESIKNSLKIIDGLSLIRHTS HHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCE VAIRLEDKL EEEEEECCC >Mature Secondary Structure MERIRIGLIGAGTVGSGVIEILKKESNKYLEKFGIELILSSVCTRTPEKIKKELQSFPNC CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC KLESDYQKLVTDPEIDMILELVGGTDIAYSIVKDALKFGKTVITANKALLSQKGDELFSF CCCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEHHHHHHHCCCHHHHHH AQEKGLEIGIEASVAGAIPVIRSIKSSLGSDSFLSLYGILNGTTNFILSKMELENLDYSE HHHCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHH ALRIAQDLGFAEKDPTFDVEGIDTAHKISILGSLAFSEKIPLQSVQIEGITKISGLDIRF HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCEEE ASELGYRIKLLGLVRKLSHKIEARVQPVMIPIKHPFANIMNEMNAVYYQTAYAGTGMFVG HHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHEEEECCCCCEEEE KGAGSLPTASSVVSDILYYGARRNKGIFQEKNIFPQAMISEANVSLVRYYLRFTTVDLPG CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH VLSEISKVLGDHGVSISSVRQNETEKEPVEVVVITHPATEESIKNSLKIIDGLSLIRHTS HHHHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCE VAIRLEDKL EEEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 3139660; 9384377; 3098560 [H]