| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is pbp1
Identifier: 45656432
GI number: 45656432
Start: 648129
End: 650537
Strand: Reverse
Name: pbp1
Synonym: LIC10534
Alternate gene names: 45656432
Gene position: 650537-648129 (Counterclockwise)
Preceding gene: 45656433
Following gene: 45656430
Centisome position: 15.21
GC content: 38.61
Gene sequence:
>2409_bases ATGTCATTCTCAATTTTCAAATCCATTGGAGCCGGCCTCATAAAGATTCTCCATTTTTCAAGAAATCACTGGAGAAAAAT TTTACGTTATGCGATCATTGTAACGATCTCGGTCATCTCTTTCTTAATCGGTGGTTCTTATGTAGTTTGGTTATCCAAAA AAGATAAAGTTGTCTCCAATCTAGATAAGTTTAAAAACGAGGTCACAAATTATTACGAAGTCAGTCAAATTCGTCCAATT CGAATTTTAGATAGAAACGGTAAATTAATCGGAGAATTTTCCAGAAGAAAGTTTAAACCGATTCGCACGGACAATCTCGC CGAACACGGAAATATTATCTGGGCGCTTCTTTCTTCCGAAGATAGAGAATTTTATAACCATCACGGAATCAATTACACCG CGCTTTTAAGAGCAATCTTTATCAATTTGACTACATTTCAAAAACAAGGTGGTTCCACGATCACTCAACAACTTGCAAAA CTTACCTTGGATTTGGGAGCACGAAACATATTTAACAAAATTACGGAATTCTACTGTACTTTTTATCTCGAAAACCAATT TGATAAGAACACGATTCTTTCCATGTATCTCAATCGAATCTTTTTAGGAGAAGGAAATACCGGAGTAGAAGAAGCGAGCC GTTATTACTTCAACAAGGCTGCTACGGAACTGACTCCCGAAGAAGCAGCTATGCTCGTAGGAATCATTCCAGCCCCTTCT AATTATAATCCAGTTAGAAGTTTAAAAACCGCTCTAAAAAGACAGAAGCTCGTTTTGATTCCGATGGCACAAAATCAACA TCTACATCCCAATCCTTCTAACATCGATAAAAACTTTCCTCGTAAGATAGATTCGAATCTGAAAAAATTCAAATCCTTCT ACAATGTGGAAATCACTAAAGACGGCGAAAAAGAATTCTATTCTTCTGATATAGCAAGATACGGCTTTGATAAGGACTTT ACTGTTAATCTCGCCCCCGATTTTAATTACGGAATTCGTCAGCATATTTTAGATACGTTCTCCGAAATAGACATTGAAAC GAGAGGAATGAACGTTTATACAACTCTGGACTATGATAAACAAGAAGCCGCTGAAAAATCTTTAAGAGAAGGTATCGAAT CCGTTCGCAAAAAACTGAATGAAACAAAAGCTTCCTACTCTAAAAAAGGAAATTCCGAAGAAACAAGAATCCAACAATCG ATCATAGACAATATGAACGGCTCCTTGATTTCAATCAATCCAGGAAACGGTTATATAGAGGCAATGGTAGGTAGTTACAA AATTTCTAATATATTTAGACTTAACAGAGCAGTGTCGGCGCTCAGACAACCAGGCTCTACAATCAAGGCCTTAGTCTACA CAATTGCTTTCGAGAATAGAATTATCACTCCCTCTTCTATGGTAATAGACGAAGCGATCAACATCAGAGGTTATTCCCCT AAAAATTGGTATAAAGGTTACAAAGGAGAAGTCACAGCAAGAATCGCTTTCGCACAATCGATCAACACAATCGCAGTCAA ATTGTTAAACGAATTCGGTGTGAATGAATTTTTGGAAAAAATTTCAATGATCTTAGACATAGACAAGTCAACTCTTGAAA AAAGGTTCCAACCAAATCTTTCTTTAGCATTAGGTTCAGGAGAATTGTCTCCGATGGAACTCGCTTTAATTTACGCTACA ATCGCAAACGGAGGCAAAAAAGTTTCCCCCATTCAAATTCTTAGAATTACGGATTTTGAAGGTAGCGAAATGTTCTCCAC TCCTCTAAAGGATCCAAACGAAGCGGTTCAGATTTTAGATTCTGTTGCCTGTGCAGAAACGATCAATCTTTTAGAGGCGG TGTTAAGCGAACAGGGAACAATGAAGCTAAAATTGAAAGATGAAGATTCTTTTCCGATGGGAGGTAAAACTGGAACGGTC CAATCTCCCAAAGAAGCCCGTAAAAAATGGGGATCACGCAAAGGAGTGAGAGACGTTTGGTTTGCGGGAATCAATCCTGA TTTAGTCACAACCGTTTGGATTGGAAACGACGTGGGGGCTCCGTTTGAAGGTTCTGGTTCCGCGATCAGTGGAAACATCT GGTTTCGTTACGTAAACTATATTGCAAAAAATATAGGATTTTCAAACACGCTAATCAAACCGTTTAACGGTGATTTTGTG CAAGTGGACGTCTGCGGAGAAACCGGTTTACAATTACATTCTTCCGTTCCTTGTATGTATCCGTTGTATGGTCAATATTA TTATATCGGAGAACAACCTCCTTCTCCTGCTGGTTCTATAACTGCAACTCCGGAAACTTCCGCCCAAGAACCTGGGACTA CTACAAACCCTCTTCCTCAAGCAGAAGATGGAGACGGAGATTCCGTAGAATTAGAACTTCCAGAAACTACAGATAATCCT CCAAATTAG
Upstream 100 bases:
>100_bases TTAATACCAAAGAAATGAATATCGTTGTAGAATTCTTTTTAAATGTTTTCTTATTTTTTAAAAAGATTCATTGTTTTTAA GATAATCTGTTAGAGGAATC
Downstream 100 bases:
>100_bases AATAACGTTTTGCTTTTTCGGATATTAGAAAAGCTTCATATGGTGACCAAAGAAAGATCCAAGGATTTTCTCTGAGAAGA ATCCTTAAAGCCTGAGTCGC
Product: penicillin-binding protein 1
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 802; Mature: 801
Protein sequence:
>802_residues MSFSIFKSIGAGLIKILHFSRNHWRKILRYAIIVTISVISFLIGGSYVVWLSKKDKVVSNLDKFKNEVTNYYEVSQIRPI RILDRNGKLIGEFSRRKFKPIRTDNLAEHGNIIWALLSSEDREFYNHHGINYTALLRAIFINLTTFQKQGGSTITQQLAK LTLDLGARNIFNKITEFYCTFYLENQFDKNTILSMYLNRIFLGEGNTGVEEASRYYFNKAATELTPEEAAMLVGIIPAPS NYNPVRSLKTALKRQKLVLIPMAQNQHLHPNPSNIDKNFPRKIDSNLKKFKSFYNVEITKDGEKEFYSSDIARYGFDKDF TVNLAPDFNYGIRQHILDTFSEIDIETRGMNVYTTLDYDKQEAAEKSLREGIESVRKKLNETKASYSKKGNSEETRIQQS IIDNMNGSLISINPGNGYIEAMVGSYKISNIFRLNRAVSALRQPGSTIKALVYTIAFENRIITPSSMVIDEAINIRGYSP KNWYKGYKGEVTARIAFAQSINTIAVKLLNEFGVNEFLEKISMILDIDKSTLEKRFQPNLSLALGSGELSPMELALIYAT IANGGKKVSPIQILRITDFEGSEMFSTPLKDPNEAVQILDSVACAETINLLEAVLSEQGTMKLKLKDEDSFPMGGKTGTV QSPKEARKKWGSRKGVRDVWFAGINPDLVTTVWIGNDVGAPFEGSGSAISGNIWFRYVNYIAKNIGFSNTLIKPFNGDFV QVDVCGETGLQLHSSVPCMYPLYGQYYYIGEQPPSPAGSITATPETSAQEPGTTTNPLPQAEDGDGDSVELELPETTDNP PN
Sequences:
>Translated_802_residues MSFSIFKSIGAGLIKILHFSRNHWRKILRYAIIVTISVISFLIGGSYVVWLSKKDKVVSNLDKFKNEVTNYYEVSQIRPI RILDRNGKLIGEFSRRKFKPIRTDNLAEHGNIIWALLSSEDREFYNHHGINYTALLRAIFINLTTFQKQGGSTITQQLAK LTLDLGARNIFNKITEFYCTFYLENQFDKNTILSMYLNRIFLGEGNTGVEEASRYYFNKAATELTPEEAAMLVGIIPAPS NYNPVRSLKTALKRQKLVLIPMAQNQHLHPNPSNIDKNFPRKIDSNLKKFKSFYNVEITKDGEKEFYSSDIARYGFDKDF TVNLAPDFNYGIRQHILDTFSEIDIETRGMNVYTTLDYDKQEAAEKSLREGIESVRKKLNETKASYSKKGNSEETRIQQS IIDNMNGSLISINPGNGYIEAMVGSYKISNIFRLNRAVSALRQPGSTIKALVYTIAFENRIITPSSMVIDEAINIRGYSP KNWYKGYKGEVTARIAFAQSINTIAVKLLNEFGVNEFLEKISMILDIDKSTLEKRFQPNLSLALGSGELSPMELALIYAT IANGGKKVSPIQILRITDFEGSEMFSTPLKDPNEAVQILDSVACAETINLLEAVLSEQGTMKLKLKDEDSFPMGGKTGTV QSPKEARKKWGSRKGVRDVWFAGINPDLVTTVWIGNDVGAPFEGSGSAISGNIWFRYVNYIAKNIGFSNTLIKPFNGDFV QVDVCGETGLQLHSSVPCMYPLYGQYYYIGEQPPSPAGSITATPETSAQEPGTTTNPLPQAEDGDGDSVELELPETTDNP PN >Mature_801_residues SFSIFKSIGAGLIKILHFSRNHWRKILRYAIIVTISVISFLIGGSYVVWLSKKDKVVSNLDKFKNEVTNYYEVSQIRPIR ILDRNGKLIGEFSRRKFKPIRTDNLAEHGNIIWALLSSEDREFYNHHGINYTALLRAIFINLTTFQKQGGSTITQQLAKL TLDLGARNIFNKITEFYCTFYLENQFDKNTILSMYLNRIFLGEGNTGVEEASRYYFNKAATELTPEEAAMLVGIIPAPSN YNPVRSLKTALKRQKLVLIPMAQNQHLHPNPSNIDKNFPRKIDSNLKKFKSFYNVEITKDGEKEFYSSDIARYGFDKDFT VNLAPDFNYGIRQHILDTFSEIDIETRGMNVYTTLDYDKQEAAEKSLREGIESVRKKLNETKASYSKKGNSEETRIQQSI IDNMNGSLISINPGNGYIEAMVGSYKISNIFRLNRAVSALRQPGSTIKALVYTIAFENRIITPSSMVIDEAINIRGYSPK NWYKGYKGEVTARIAFAQSINTIAVKLLNEFGVNEFLEKISMILDIDKSTLEKRFQPNLSLALGSGELSPMELALIYATI ANGGKKVSPIQILRITDFEGSEMFSTPLKDPNEAVQILDSVACAETINLLEAVLSEQGTMKLKLKDEDSFPMGGKTGTVQ SPKEARKKWGSRKGVRDVWFAGINPDLVTTVWIGNDVGAPFEGSGSAISGNIWFRYVNYIAKNIGFSNTLIKPFNGDFVQ VDVCGETGLQLHSSVPCMYPLYGQYYYIGEQPPSPAGSITATPETSAQEPGTTTNPLPQAEDGDGDSVELELPETTDNPP N
Specific function: Cell Wall Formation. Synthesis Of Cross-Linked Peptidoglycan From The Lipid Intermediates. The Enzyme Has A Penicillin-Insensitive Transglycosylase N-Terminal Domain (Formation Of Linear Glycan Strands) And A Penicillin-Sensitive Transpeptidase C-Terminal
COG id: COG0744
COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=767, Percent_Identity=25.03259452412, Blast_Score=196, Evalue=4e-51, Organism=Escherichia coli, GI1786343, Length=596, Percent_Identity=26.6778523489933, Blast_Score=170, Evalue=3e-43, Organism=Escherichia coli, GI1788867, Length=577, Percent_Identity=24.9566724436742, Blast_Score=135, Evalue=1e-32, Organism=Escherichia coli, GI1789601, Length=151, Percent_Identity=33.112582781457, Blast_Score=80, Evalue=7e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.- [C]
Molecular weight: Translated: 89874; Mature: 89743
Theoretical pI: Translated: 8.20; Mature: 8.20
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSFSIFKSIGAGLIKILHFSRNHWRKILRYAIIVTISVISFLIGGSYVVWLSKKDKVVSN CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHH LDKFKNEVTNYYEVSQIRPIRILDRNGKLIGEFSRRKFKPIRTDNLAEHGNIIWALLSSE HHHHHHHHHCCEECCCCCEEEEECCCCCEEEHHHHHHCCCCCCCCCHHCCCEEEEEECCC DREFYNHHGINYTALLRAIFINLTTFQKQGGSTITQQLAKLTLDLGARNIFNKITEFYCT CHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE FYLENQFDKNTILSMYLNRIFLGEGNTGVEEASRYYFNKAATELTPEEAAMLVGIIPAPS EEECCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCHHHCEEEEEEECCCC NYNPVRSLKTALKRQKLVLIPMAQNQHLHPNPSNIDKNFPRKIDSNLKKFKSFYNVEITK CCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEC DGEKEFYSSDIARYGFDKDFTVNLAPDFNYGIRQHILDTFSEIDIETRGMNVYTTLDYDK CCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECCEEEEEECCCCH QEAAEKSLREGIESVRKKLNETKASYSKKGNSEETRIQQSIIDNMNGSLISINPGNGYIE HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCEEE AMVGSYKISNIFRLNRAVSALRQPGSTIKALVYTIAFENRIITPSSMVIDEAINIRGYSP EEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCEEECCHHHHHHHHHCCCCCCC KNWYKGYKGEVTARIAFAQSINTIAVKLLNEFGVNEFLEKISMILDIDKSTLEKRFQPNL HHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHCCCCC SLALGSGELSPMELALIYATIANGGKKVSPIQILRITDFEGSEMFSTPLKDPNEAVQILD EEEECCCCCCHHHHEEEEEEHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH SVACAETINLLEAVLSEQGTMKLKLKDEDSFPMGGKTGTVQSPKEARKKWGSRKGVRDVW HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHE FAGINPDLVTTVWIGNDVGAPFEGSGSAISGNIWFRYVNYIAKNIGFSNTLIKPFNGDFV EECCCCCEEEEEEECCCCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCCEECCCCCCEE QVDVCGETGLQLHSSVPCMYPLYGQYYYIGEQPPSPAGSITATPETSAQEPGTTTNPLPQ EEEECCCCCCCHHCCCCEEEECCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCC AEDGDGDSVELELPETTDNPPN CCCCCCCEEEEECCCCCCCCCC >Mature Secondary Structure SFSIFKSIGAGLIKILHFSRNHWRKILRYAIIVTISVISFLIGGSYVVWLSKKDKVVSN CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHH LDKFKNEVTNYYEVSQIRPIRILDRNGKLIGEFSRRKFKPIRTDNLAEHGNIIWALLSSE HHHHHHHHHCCEECCCCCEEEEECCCCCEEEHHHHHHCCCCCCCCCHHCCCEEEEEECCC DREFYNHHGINYTALLRAIFINLTTFQKQGGSTITQQLAKLTLDLGARNIFNKITEFYCT CHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEE FYLENQFDKNTILSMYLNRIFLGEGNTGVEEASRYYFNKAATELTPEEAAMLVGIIPAPS EEECCCCCHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCHHHCEEEEEEECCCC NYNPVRSLKTALKRQKLVLIPMAQNQHLHPNPSNIDKNFPRKIDSNLKKFKSFYNVEITK CCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEC DGEKEFYSSDIARYGFDKDFTVNLAPDFNYGIRQHILDTFSEIDIETRGMNVYTTLDYDK CCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEECCEEEEEECCCCH QEAAEKSLREGIESVRKKLNETKASYSKKGNSEETRIQQSIIDNMNGSLISINPGNGYIE HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCEEE AMVGSYKISNIFRLNRAVSALRQPGSTIKALVYTIAFENRIITPSSMVIDEAINIRGYSP EEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEECCEEECCHHHHHHHHHCCCCCCC KNWYKGYKGEVTARIAFAQSINTIAVKLLNEFGVNEFLEKISMILDIDKSTLEKRFQPNL HHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHCCCCC SLALGSGELSPMELALIYATIANGGKKVSPIQILRITDFEGSEMFSTPLKDPNEAVQILD EEEECCCCCCHHHHEEEEEEHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH SVACAETINLLEAVLSEQGTMKLKLKDEDSFPMGGKTGTVQSPKEARKKWGSRKGVRDVW HHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHE FAGINPDLVTTVWIGNDVGAPFEGSGSAISGNIWFRYVNYIAKNIGFSNTLIKPFNGDFV EECCCCCEEEEEEECCCCCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCCEECCCCCCEE QVDVCGETGLQLHSSVPCMYPLYGQYYYIGEQPPSPAGSITATPETSAQEPGTTTNPLPQ EEEECCCCCCCHHCCCCEEEECCCCEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCC AEDGDGDSVELELPETTDNPPN CCCCCCCEEEEECCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9537320 [H]