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The map label for this gene is glmS

Identifier: 45656344

GI number: 45656344

Start: 508027

End: 509859

Strand: Reverse

Name: glmS

Synonym: LIC10445

Alternate gene names: 45656344

Gene position: 509859-508027 (Counterclockwise)

Preceding gene: 45656345

Following gene: 45656343

Centisome position: 11.92

GC content: 39.39

Gene sequence:

>1833_bases
ATGTGTGGAATCGTCGGTTATGCAGGTAAAAAAAACGCGGAATCGGTACTAGTCGTAGGATTAATCTGTCTCGAATACAG
AGGTTATGATTCTGCAGGAATTGCAGTTTTAGATCAAGGTGATATTTTAGTTCGAAAATCGAAAGGAAAAATAAAAGATC
TAGAAGCTTATTTGCGTGAATTCCCAGCGCCTGGAAACGTAGGAATCGGTCATACTCGTTGGGCGACTCACGGAGAACCC
AATCAAATCAACGCTCACCCACATACAGATACAAATTCCACCGTCGCAGTAGTGCATAACGGAATCATCGAAAACTATTT
AGAACTCAAAAGCCAATTAAAGAAAAAAGGTCACGTATTCCAAAGCCTAACCGACACGGAAGTACTTCCTCATCTTTTAG
AAGAAAGTAAAAAAAACGGAAAGTCTAATAAAGATTCATTTTTAGAACTGTTTGGAAAAATCCACGGTAAATGGGCTATT
TCATCCGTATTCGAAACCGAACCGGATCGAGTTTACTTCGCTCAAGATGGTGCTCCTTTATTGATCGGAAAAGGAAAAGG
AGAATATTTTTTAGCCTCCGATATTTCTCCTCTAACCAGAAACTGCGAAGAAGTATATTATGTAAACTCTGGAGAATGGG
GCTATTTTTCTCAAAACGAATTCAAATTGTTTGATTTTTCAGGAAAAGAACTCAATCCTACTTTCAAAAAACAAGAACTT
CGTTGGGAAGACCTGGATAAAGGTGGTTATCCTCACTACATGATTAAGGAGATTCACGAACAAGCGGGGATCTTTCGTAA
AATCATTCAGGAAAGAATATTAGAAAATAGTGAAATTGTTTTTCCAGAAATCAAACTGAGCAAAGACGTACTTTCCAGAG
TCAATCGAATCATCATCCAAGCCGCCGGAACTAGTTATTACGCCGGAATGATCGGCAAACACTATCTCGAAAATTTCGCA
AAAATCCAAACAGATACAGAAGCTTCTTCTGAATTTCGTTATAGAAACCCTGTCGTAGAAGGTGACACTCTGATTATGGG
TATTTCCCAATCCGGAGAAACCGCAGACACGTTAGCTTCCATTCACGAAGCAAAAGCAAAATTTATCAAAGTTGTTTCTC
TTGTTAACAACGTTAACTCTACGATCGCAAGAGAATCAGATTCTTATATTCGAACCGACGCCGGCCCAGAGATAGGAGTT
GCCAGCACCAAGGCGTTTACCGCTCAGGTTTTAAATCTACTTTTATTTTCCATTTATATGGCTAACCTCAAATGGTTGAT
CAGTGACGAAGAGCAAAAAATACTTATCGAAGAAATCAAATTACTTCCTGCAAAAATCGATCGGATACTCGCACAAGCAA
GTAAGATAGAAGAGATGTCTTCTCACTTTACCACGGCAAAAGATTTTATATTTTTAGGAAGAACCTACAACCATCCGGTT
GCAATGGAAGGCGCGTTAAAACTGAAAGAAATTTCTTACATACACGCATCCGGTTATGCTGGCGGAGAATTTAAACACGG
ACCAATCGCATTAATCACGAACGAAGTTCCCGTAGTTTGTATCGCACCCAAATCCGAAATTTATACCAAGATGGTTTCCA
ACATTCAAGAAATCAAAGCTAGAAAAGGGATCATCATTTCGATCGTGACGGAAGGGGATCAAGAAGCAAAATCTCTTTCG
GATTATTGTTTTGAAATCCCGGAATGTTCCGAAATTCTAAGTCCGATCTTAAACGTAATTCCTCTTCAATTACTCGCTTA
TTACTCAGCGATCGCTAGAGGTTGTCCTCCGGATCAACCTAGAAACCTTGCTAAGTCCGTAACCGTAGAGTAA

Upstream 100 bases:

>100_bases
ATACAGAACCAATCATTCGAATTATAGGCGAAGCGAGGACTAAAAAAGACCTCAATTCTCTGCTGGACCGCGCAGGAAGA
CTCATGGAGAATGCCTGAAT

Downstream 100 bases:

>100_bases
CTACCATGCCCAAGGTTCAGAGAATTCTCATCGATGAAAGAGAGGTTCCGGCTGGTTTACGATCCTTAACTCGCATTCGA
TCTTTTTCCGAAATTCGAAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MCGIVGYAGKKNAESVLVVGLICLEYRGYDSAGIAVLDQGDILVRKSKGKIKDLEAYLREFPAPGNVGIGHTRWATHGEP
NQINAHPHTDTNSTVAVVHNGIIENYLELKSQLKKKGHVFQSLTDTEVLPHLLEESKKNGKSNKDSFLELFGKIHGKWAI
SSVFETEPDRVYFAQDGAPLLIGKGKGEYFLASDISPLTRNCEEVYYVNSGEWGYFSQNEFKLFDFSGKELNPTFKKQEL
RWEDLDKGGYPHYMIKEIHEQAGIFRKIIQERILENSEIVFPEIKLSKDVLSRVNRIIIQAAGTSYYAGMIGKHYLENFA
KIQTDTEASSEFRYRNPVVEGDTLIMGISQSGETADTLASIHEAKAKFIKVVSLVNNVNSTIARESDSYIRTDAGPEIGV
ASTKAFTAQVLNLLLFSIYMANLKWLISDEEQKILIEEIKLLPAKIDRILAQASKIEEMSSHFTTAKDFIFLGRTYNHPV
AMEGALKLKEISYIHASGYAGGEFKHGPIALITNEVPVVCIAPKSEIYTKMVSNIQEIKARKGIIISIVTEGDQEAKSLS
DYCFEIPECSEILSPILNVIPLQLLAYYSAIARGCPPDQPRNLAKSVTVE

Sequences:

>Translated_610_residues
MCGIVGYAGKKNAESVLVVGLICLEYRGYDSAGIAVLDQGDILVRKSKGKIKDLEAYLREFPAPGNVGIGHTRWATHGEP
NQINAHPHTDTNSTVAVVHNGIIENYLELKSQLKKKGHVFQSLTDTEVLPHLLEESKKNGKSNKDSFLELFGKIHGKWAI
SSVFETEPDRVYFAQDGAPLLIGKGKGEYFLASDISPLTRNCEEVYYVNSGEWGYFSQNEFKLFDFSGKELNPTFKKQEL
RWEDLDKGGYPHYMIKEIHEQAGIFRKIIQERILENSEIVFPEIKLSKDVLSRVNRIIIQAAGTSYYAGMIGKHYLENFA
KIQTDTEASSEFRYRNPVVEGDTLIMGISQSGETADTLASIHEAKAKFIKVVSLVNNVNSTIARESDSYIRTDAGPEIGV
ASTKAFTAQVLNLLLFSIYMANLKWLISDEEQKILIEEIKLLPAKIDRILAQASKIEEMSSHFTTAKDFIFLGRTYNHPV
AMEGALKLKEISYIHASGYAGGEFKHGPIALITNEVPVVCIAPKSEIYTKMVSNIQEIKARKGIIISIVTEGDQEAKSLS
DYCFEIPECSEILSPILNVIPLQLLAYYSAIARGCPPDQPRNLAKSVTVE
>Mature_610_residues
MCGIVGYAGKKNAESVLVVGLICLEYRGYDSAGIAVLDQGDILVRKSKGKIKDLEAYLREFPAPGNVGIGHTRWATHGEP
NQINAHPHTDTNSTVAVVHNGIIENYLELKSQLKKKGHVFQSLTDTEVLPHLLEESKKNGKSNKDSFLELFGKIHGKWAI
SSVFETEPDRVYFAQDGAPLLIGKGKGEYFLASDISPLTRNCEEVYYVNSGEWGYFSQNEFKLFDFSGKELNPTFKKQEL
RWEDLDKGGYPHYMIKEIHEQAGIFRKIIQERILENSEIVFPEIKLSKDVLSRVNRIIIQAAGTSYYAGMIGKHYLENFA
KIQTDTEASSEFRYRNPVVEGDTLIMGISQSGETADTLASIHEAKAKFIKVVSLVNNVNSTIARESDSYIRTDAGPEIGV
ASTKAFTAQVLNLLLFSIYMANLKWLISDEEQKILIEEIKLLPAKIDRILAQASKIEEMSSHFTTAKDFIFLGRTYNHPV
AMEGALKLKEISYIHASGYAGGEFKHGPIALITNEVPVVCIAPKSEIYTKMVSNIQEIKARKGIIISIVTEGDQEAKSLS
DYCFEIPECSEILSPILNVIPLQLLAYYSAIARGCPPDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=685, Percent_Identity=32.8467153284672, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI4826742, Length=685, Percent_Identity=32.7007299270073, Blast_Score=350, Evalue=2e-96,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=41.8831168831169, Blast_Score=481, Evalue=1e-137,
Organism=Escherichia coli, GI1788651, Length=242, Percent_Identity=27.6859504132231, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082251, Length=318, Percent_Identity=21.0691823899371, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=722, Percent_Identity=32.8254847645429, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=33.8747099767981, Blast_Score=253, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=33.8747099767981, Blast_Score=253, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322745, Length=451, Percent_Identity=33.2594235033259, Blast_Score=270, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6323731, Length=433, Percent_Identity=29.5612009237875, Blast_Score=197, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=212, Percent_Identity=38.2075471698113, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357745, Length=684, Percent_Identity=33.3333333333333, Blast_Score=376, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_LEPIC (Q72V57)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000430.1
- ProteinModelPortal:   Q72V57
- SMR:   Q72V57
- GeneID:   2771712
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10445
- HOGENOM:   HBG645312
- OMA:   ITIVIAE
- ProtClustDB:   PRK00331
- BioCyc:   LINT267671:LIC_10445-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67943; Mature: 67943

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 605-605

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYAGKKNAESVLVVGLICLEYRGYDSAGIAVLDQGDILVRKSKGKIKDLEAYLRE
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHH
FPAPGNVGIGHTRWATHGEPNQINAHPHTDTNSTVAVVHNGIIENYLELKSQLKKKGHVF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCHHH
QSLTDTEVLPHLLEESKKNGKSNKDSFLELFGKIHGKWAISSVFETEPDRVYFAQDGAPL
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEECCCCEE
LIGKGKGEYFLASDISPLTRNCEEVYYVNSGEWGYFSQNEFKLFDFSGKELNPTFKKQEL
EEECCCCCEEEECCCCHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHC
RWEDLDKGGYPHYMIKEIHEQAGIFRKIIQERILENSEIVFPEIKLSKDVLSRVNRIIIQ
CHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHEEEE
AAGTSYYAGMIGKHYLENFAKIQTDTEASSEFRYRNPVVEGDTLIMGISQSGETADTLAS
ECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEEEECCCCCHHHHHHH
IHEAKAKFIKVVSLVNNVNSTIARESDSYIRTDAGPEIGVASTKAFTAQVLNLLLFSIYM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ANLKWLISDEEQKILIEEIKLLPAKIDRILAQASKIEEMSSHFTTAKDFIFLGRTYNHPV
HHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCE
AMEGALKLKEISYIHASGYAGGEFKHGPIALITNEVPVVCIAPKSEIYTKMVSNIQEIKA
EECCCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
RKGIIISIVTEGDQEAKSLSDYCFEIPECSEILSPILNVIPLQLLAYYSAIARGCPPDQP
CCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RNLAKSVTVE
HHHHHHCCCC
>Mature Secondary Structure
MCGIVGYAGKKNAESVLVVGLICLEYRGYDSAGIAVLDQGDILVRKSKGKIKDLEAYLRE
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCHHHHHHHHHH
FPAPGNVGIGHTRWATHGEPNQINAHPHTDTNSTVAVVHNGIIENYLELKSQLKKKGHVF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCHHH
QSLTDTEVLPHLLEESKKNGKSNKDSFLELFGKIHGKWAISSVFETEPDRVYFAQDGAPL
HHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEEEECCCCEE
LIGKGKGEYFLASDISPLTRNCEEVYYVNSGEWGYFSQNEFKLFDFSGKELNPTFKKQEL
EEECCCCCEEEECCCCHHHCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHC
RWEDLDKGGYPHYMIKEIHEQAGIFRKIIQERILENSEIVFPEIKLSKDVLSRVNRIIIQ
CHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHEEEE
AAGTSYYAGMIGKHYLENFAKIQTDTEASSEFRYRNPVVEGDTLIMGISQSGETADTLAS
ECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEEEECCCCCHHHHHHH
IHEAKAKFIKVVSLVNNVNSTIARESDSYIRTDAGPEIGVASTKAFTAQVLNLLLFSIYM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ANLKWLISDEEQKILIEEIKLLPAKIDRILAQASKIEEMSSHFTTAKDFIFLGRTYNHPV
HHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCE
AMEGALKLKEISYIHASGYAGGEFKHGPIALITNEVPVVCIAPKSEIYTKMVSNIQEIKA
EECCCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
RKGIIISIVTEGDQEAKSLSDYCFEIPECSEILSPILNVIPLQLLAYYSAIARGCPPDQP
CCCEEEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RNLAKSVTVE
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA