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The map label for this gene is phbA

Identifier: 45656296

GI number: 45656296

Start: 452995

End: 454176

Strand: Direct

Name: phbA

Synonym: LIC10396

Alternate gene names: 45656296

Gene position: 452995-454176 (Clockwise)

Preceding gene: 45656294

Following gene: 45656297

Centisome position: 10.59

GC content: 44.67

Gene sequence:

>1182_bases
ATGGAAGAAGCAGTTATACTGGATGGGATTAGAACTCCGTTCGGAAATTTTGGAGGAACCTTAAAAGACCTGAGTGCGGT
CGATCTGGGAGTTTTGGTTTCTAAGACGATTCTGGAAAGAACGGGAGTTTCTCCTGAAGCGATTGGAGAATCGATTTTTG
GAAATGTGATTCCGACAGGAAAAGAAGCGATTTATCTTGCGCGTCATATTGGTCTGAAAACGGGTCTTCCTTTAGGAGTT
CCGGCTCTGACTCTCAATCGTCTTTGTGGTTCTGGTATGGAAGCGATTATCCAAGCTGCAAAAAAGATTTATCTAGGGGA
TGCGGATGCGGTTCTTGCAGGTGGAGTGGAATCGATGAGTAATGCTCCTTACGTTGTGCGTAACGCGCGTTGGGGAGTTC
GTTACGGTTCCGCCGAATTTGAAGATACGTTAGAACAAGGTCTCACCGACCAATACGTAGGTTTGATCATGGGACAGACC
GCTGAAAATCTTGCCGATCAGTATAAAATTTCCAGACAAGAACAGGATGAATGGGCGGCGATTTCTCAAACTCGTGCCGA
AAAAGCCACTTTAGAAGGACGTCTTAAAGAAGAAATTTTTACCGTTACGATCCCAGGTAAAAAACCGGTTATATTAGAAA
AAGATGAATTTATTAAGGGAGCCTCTGGTGTTGATAAACTTGGAAGTTTAAAGGCTGTTTTTAGGGAAGGTGGAACCGTG
ACCGCTGGAAATGCTTCCGGCTTAAACGACGGAGCGGCGGTTACAATTGTAGCATCTTCTTCTTATGCTAAGAAGTTAGG
TAAAAAACCTTTGGCGATTATCCGAGGTTATGGTCACGCTGGTTGTGATCCTGCTAAAATGGGAATTGGTCCGGCACTTG
CAATTCCAGCTGCTTTGAAAAAAGCAGGTCTTAAACTTTCGGATATGAGTTTAGTGGAAGTAAATGAAGCTTTTGCGGCT
CAATATCTTGCGGTTCAAAAAGAATTAGGGCTCAATCCGGAAATTACCAATGTGAATGGCGGTGCGGTAGCGATTGGGCA
TCCTCTGGGAGCTTCTGGTGCCAGGGTTACGATCACACTCGCGTACGAACTCAAAAGAAGAAAGGCGAAATACGGAATTG
CTTCCCTTTGTATTGGAGGTGGTCAGGGAATTGCACTCGTTCTGGAAAATCCAGAAGTGTAA

Upstream 100 bases:

>100_bases
TTTATAAAAGTATTATGTTTGAGTGTACGTTTTTGGGTGATGTCAAGCCTTTTTCGTATGGGATTGGTATATTAAAATAT
TATAATTATTAGGAGTAATT

Downstream 100 bases:

>100_bases
TTGAAGTTTCGTCTAACGTTATTACAAGGCTCGAAGAGGAAGGGCCTTGTATGTAAAAGATAGGAATGGATGTGACTTGA
AAGTTATCGAAAGAATATTA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MEEAVILDGIRTPFGNFGGTLKDLSAVDLGVLVSKTILERTGVSPEAIGESIFGNVIPTGKEAIYLARHIGLKTGLPLGV
PALTLNRLCGSGMEAIIQAAKKIYLGDADAVLAGGVESMSNAPYVVRNARWGVRYGSAEFEDTLEQGLTDQYVGLIMGQT
AENLADQYKISRQEQDEWAAISQTRAEKATLEGRLKEEIFTVTIPGKKPVILEKDEFIKGASGVDKLGSLKAVFREGGTV
TAGNASGLNDGAAVTIVASSSYAKKLGKKPLAIIRGYGHAGCDPAKMGIGPALAIPAALKKAGLKLSDMSLVEVNEAFAA
QYLAVQKELGLNPEITNVNGGAVAIGHPLGASGARVTITLAYELKRRKAKYGIASLCIGGGQGIALVLENPEV

Sequences:

>Translated_393_residues
MEEAVILDGIRTPFGNFGGTLKDLSAVDLGVLVSKTILERTGVSPEAIGESIFGNVIPTGKEAIYLARHIGLKTGLPLGV
PALTLNRLCGSGMEAIIQAAKKIYLGDADAVLAGGVESMSNAPYVVRNARWGVRYGSAEFEDTLEQGLTDQYVGLIMGQT
AENLADQYKISRQEQDEWAAISQTRAEKATLEGRLKEEIFTVTIPGKKPVILEKDEFIKGASGVDKLGSLKAVFREGGTV
TAGNASGLNDGAAVTIVASSSYAKKLGKKPLAIIRGYGHAGCDPAKMGIGPALAIPAALKKAGLKLSDMSLVEVNEAFAA
QYLAVQKELGLNPEITNVNGGAVAIGHPLGASGARVTITLAYELKRRKAKYGIASLCIGGGQGIALVLENPEV
>Mature_393_residues
MEEAVILDGIRTPFGNFGGTLKDLSAVDLGVLVSKTILERTGVSPEAIGESIFGNVIPTGKEAIYLARHIGLKTGLPLGV
PALTLNRLCGSGMEAIIQAAKKIYLGDADAVLAGGVESMSNAPYVVRNARWGVRYGSAEFEDTLEQGLTDQYVGLIMGQT
AENLADQYKISRQEQDEWAAISQTRAEKATLEGRLKEEIFTVTIPGKKPVILEKDEFIKGASGVDKLGSLKAVFREGGTV
TAGNASGLNDGAAVTIVASSSYAKKLGKKPLAIIRGYGHAGCDPAKMGIGPALAIPAALKKAGLKLSDMSLVEVNEAFAA
QYLAVQKELGLNPEITNVNGGAVAIGHPLGASGARVTITLAYELKRRKAKYGIASLCIGGGQGIALVLENPEV

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=382, Percent_Identity=51.8324607329843, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=43.1122448979592, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=41.2213740458015, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=39.7984886649874, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI4504327, Length=431, Percent_Identity=32.9466357308585, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI194353979, Length=91, Percent_Identity=56.043956043956, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=44.6700507614213, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=46.1734693877551, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=44.1102756892231, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=42.3173803526448, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=36.1702127659575, Blast_Score=212, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI133906874, Length=381, Percent_Identity=53.5433070866142, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=40.4092071611253, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=40.3598971722365, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=35.0588235294118, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=32.6530612244898, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=42.6065162907268, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=37.3737373737374, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=47.3145780051151, Blast_Score=333, Evalue=9e-92,
Organism=Drosophila melanogaster, GI17648125, Length=382, Percent_Identity=48.1675392670157, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=42.4552429667519, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17137578, Length=429, Percent_Identity=34.2657342657343, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41047; Mature: 41047

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEAVILDGIRTPFGNFGGTLKDLSAVDLGVLVSKTILERTGVSPEAIGESIFGNVIPTG
CCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
KEAIYLARHIGLKTGLPLGVPALTLNRLCGSGMEAIIQAAKKIYLGDADAVLAGGVESMS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHEECCCCCHHHHCCHHHHC
NAPYVVRNARWGVRYGSAEFEDTLEQGLTDQYVGLIMGQTAENLADQYKISRQEQDEWAA
CCCEEEECCCCCEEECCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHH
ISQTRAEKATLEGRLKEEIFTVTIPGKKPVILEKDEFIKGASGVDKLGSLKAVFREGGTV
HHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHHCCCCCHHHHHHHHHHHHCCCEE
TAGNASGLNDGAAVTIVASSSYAKKLGKKPLAIIRGYGHAGCDPAKMGIGPALAIPAALK
EECCCCCCCCCCEEEEEECCHHHHHHCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHHHH
KAGLKLSDMSLVEVNEAFAAQYLAVQKELGLNPEITNVNGGAVAIGHPLGASGARVTITL
HHCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEEEEE
AYELKRRKAKYGIASLCIGGGQGIALVLENPEV
EEHHHHHHHHCCHHHEEECCCCEEEEEECCCCC
>Mature Secondary Structure
MEEAVILDGIRTPFGNFGGTLKDLSAVDLGVLVSKTILERTGVSPEAIGESIFGNVIPTG
CCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
KEAIYLARHIGLKTGLPLGVPALTLNRLCGSGMEAIIQAAKKIYLGDADAVLAGGVESMS
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHEECCCCCHHHHCCHHHHC
NAPYVVRNARWGVRYGSAEFEDTLEQGLTDQYVGLIMGQTAENLADQYKISRQEQDEWAA
CCCEEEECCCCCEEECCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHH
ISQTRAEKATLEGRLKEEIFTVTIPGKKPVILEKDEFIKGASGVDKLGSLKAVFREGGTV
HHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCHHHHCCCCCHHHHHHHHHHHHCCCEE
TAGNASGLNDGAAVTIVASSSYAKKLGKKPLAIIRGYGHAGCDPAKMGIGPALAIPAALK
EECCCCCCCCCCEEEEEECCHHHHHHCCCCEEEEECCCCCCCCHHHCCCCHHHHHHHHHH
KAGLKLSDMSLVEVNEAFAAQYLAVQKELGLNPEITNVNGGAVAIGHPLGASGARVTITL
HHCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCCEEEEEE
AYELKRRKAKYGIASLCIGGGQGIALVLENPEV
EEHHHHHHHHCCHHHEEECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]