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The map label for this gene is cyoE

Identifier: 45656109

GI number: 45656109

Start: 233941

End: 234810

Strand: Reverse

Name: cyoE

Synonym: LIC10204

Alternate gene names: 45656109

Gene position: 234810-233941 (Counterclockwise)

Preceding gene: 45656110

Following gene: 45656107

Centisome position: 5.49

GC content: 37.47

Gene sequence:

>870_bases
ATGGCTAGTTCCACTTTCTTTTCAGACTGGAATCAAATGCTGAAACCCAGAGTAACCTCTCTGGTTTTAGCGACAATCAT
TCCAGGTTTGTATCTTGCAAGCGAACAATCCCCTTCCGGATTTTTAATCGCGATTACTTTGTTTGGAACATTTTTAATGT
CTTCCGCTTCGTTTATATTCAATCAGGTGATCGAAAAGGATAGAGACGCAAAAATGAAACGTACTTCGAACCGTCCAATT
CCTTCGGGAAGAATTAGTGTTGTACAAGCAACATTAGTTGGAATTGCCATGATGGGATCTTCCTTTTACGTTCTAGCGGT
TTACGTAAATCTTTTGACCGCCTTGTGTGCCTTTGCTGCCTTAATTTCTTACGTCTTTCTTTATACAATTTTTTTAAAAC
CCAGAACAACTCAAAACATAGTAATCGGCGGAGTAGCTGGATGTGTGGGACCTTTGATCGGTTACGCTGCAATCGGGAAC
TCTCTACCAGTGCAGGCATGGAGTTTGTTTATGATGATTTTCTTATGGACCCCGGCGCATTTTTGGGCTTTAGCAATTTT
TCTGAAAGAAGAATATTCGGACGCTGATTTTCCTATGTTGCCAGTTGTCAAAGGAATCCATCAGACTACAAAGTCTATAT
TCTTTTATACAATTCTTTATTCTATTGCCTGTGTAAGTTTTTATTTTTTAGAATCTTCTATGGGATTTTTGTACCTCATT
GTTTCTTTGATCGTCTGCATTTGGATGGGAATTCTTTCTTATCAATTGATTCAAAACCCGGAACCTCAATCTGCTAGAAA
ATTTTTTTTCTTTTCCATACTTCATCTTTTCATAATCAACATTACGATCGTAGTTGATCATCTTATTTAA

Upstream 100 bases:

>100_bases
TGTACTTTTACTTACCTCTACTTATTTGTCCCTAATTTCCAGAGTTGTCGTATTAACTAACGAACGGAGGGCCGAAAAAT
AATTTCGGCAAGCTATAATA

Downstream 100 bases:

>100_bases
TGTAAGTTCGGCGTAAGAGATTCGTTTTATAAAAACCTGATTTTTCCATAAAGAATAAATGGGCAACCCCCCGCTCAAAT
CATAAAAGTTGAATTTTAGA

Product: cytochrome C oxidase assembly protein

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MASSTFFSDWNQMLKPRVTSLVLATIIPGLYLASEQSPSGFLIAITLFGTFLMSSASFIFNQVIEKDRDAKMKRTSNRPI
PSGRISVVQATLVGIAMMGSSFYVLAVYVNLLTALCAFAALISYVFLYTIFLKPRTTQNIVIGGVAGCVGPLIGYAAIGN
SLPVQAWSLFMMIFLWTPAHFWALAIFLKEEYSDADFPMLPVVKGIHQTTKSIFFYTILYSIACVSFYFLESSMGFLYLI
VSLIVCIWMGILSYQLIQNPEPQSARKFFFFSILHLFIINITIVVDHLI

Sequences:

>Translated_289_residues
MASSTFFSDWNQMLKPRVTSLVLATIIPGLYLASEQSPSGFLIAITLFGTFLMSSASFIFNQVIEKDRDAKMKRTSNRPI
PSGRISVVQATLVGIAMMGSSFYVLAVYVNLLTALCAFAALISYVFLYTIFLKPRTTQNIVIGGVAGCVGPLIGYAAIGN
SLPVQAWSLFMMIFLWTPAHFWALAIFLKEEYSDADFPMLPVVKGIHQTTKSIFFYTILYSIACVSFYFLESSMGFLYLI
VSLIVCIWMGILSYQLIQNPEPQSARKFFFFSILHLFIINITIVVDHLI
>Mature_288_residues
ASSTFFSDWNQMLKPRVTSLVLATIIPGLYLASEQSPSGFLIAITLFGTFLMSSASFIFNQVIEKDRDAKMKRTSNRPIP
SGRISVVQATLVGIAMMGSSFYVLAVYVNLLTALCAFAALISYVFLYTIFLKPRTTQNIVIGGVAGCVGPLIGYAAIGNS
LPVQAWSLFMMIFLWTPAHFWALAIFLKEEYSDADFPMLPVVKGIHQTTKSIFFYTILYSIACVSFYFLESSMGFLYLIV
SLIVCIWMGILSYQLIQNPEPQSARKFFFFSILHLFIINITIVVDHLI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=195, Percent_Identity=31.7948717948718, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1786631, Length=290, Percent_Identity=32.4137931034483, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790473, Length=166, Percent_Identity=28.3132530120482, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71998235, Length=276, Percent_Identity=30.0724637681159, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=192, Percent_Identity=30.2083333333333, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921064, Length=275, Percent_Identity=28.3636363636364, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_LEPIC (Q72VU2)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000195.1
- GeneID:   2769474
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10204
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- ProtClustDB:   CLSK573404
- BioCyc:   LINT267671:LIC_10204-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32291; Mature: 32160

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xda93f84)-; HASH(0xd92a624)-; HASH(0xcd884d8)-; HASH(0xd7d4e10)-; HASH(0xd5bd8ac)-; HASH(0xd566974)-; HASH(0xdf50ae0)-; HASH(0xdea9ae8)-; HASH(0xd6566f4)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSTFFSDWNQMLKPRVTSLVLATIIPGLYLASEQSPSGFLIAITLFGTFLMSSASFIF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCCCEEHHHHHHHHHHHHHHHHH
NQVIEKDRDAKMKRTSNRPIPSGRISVVQATLVGIAMMGSSFYVLAVYVNLLTALCAFAA
HHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LISYVFLYTIFLKPRTTQNIVIGGVAGCVGPLIGYAAIGNSLPVQAWSLFMMIFLWTPAH
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FWALAIFLKEEYSDADFPMLPVVKGIHQTTKSIFFYTILYSIACVSFYFLESSMGFLYLI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VSLIVCIWMGILSYQLIQNPEPQSARKFFFFSILHLFIINITIVVDHLI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
ASSTFFSDWNQMLKPRVTSLVLATIIPGLYLASEQSPSGFLIAITLFGTFLMSSASFIF
CCCHHHHHHHHHHHHHHHHHHHHHHHCHHHEECCCCCCCCEEHHHHHHHHHHHHHHHHH
NQVIEKDRDAKMKRTSNRPIPSGRISVVQATLVGIAMMGSSFYVLAVYVNLLTALCAFAA
HHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
LISYVFLYTIFLKPRTTQNIVIGGVAGCVGPLIGYAAIGNSLPVQAWSLFMMIFLWTPAH
HHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FWALAIFLKEEYSDADFPMLPVVKGIHQTTKSIFFYTILYSIACVSFYFLESSMGFLYLI
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
VSLIVCIWMGILSYQLIQNPEPQSARKFFFFSILHLFIINITIVVDHLI
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA