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The map label for this gene is rncS [H]

Identifier: 45359089

GI number: 45359089

Start: 1485329

End: 1486021

Strand: Direct

Name: rncS [H]

Synonym: MMP1526

Alternate gene names: 45359089

Gene position: 1485329-1486021 (Clockwise)

Preceding gene: 45359088

Following gene: 45359096

Centisome position: 89.42

GC content: 27.56

Gene sequence:

>693_bases
TTGATGAAAAATTTTGAAAAACTGCTTTCGAAACTTGATATACAATTTAATGATTTAAATATATTTAAACGAGCATTTAT
GCATTCTTCGTACGTAAATGAACAGAAAAATACTAATTTAGAAGATAATGAACGATTGGAATATTTAGGAGATGCTGTTT
TAGACTTAATAATTAGTGAATACTTGTTTAAAAAAGAAAATTTATCCGAAGGGGAAATGTCAAAATTGCGGGCAAAATAC
GTCTGTGAAAGTGCACTTTTTACATATGCTAAAAAACTTAAATTTAACAATTACGTGCTTTTAGGAAAAGGAGAAATAAA
TTCTAAAGGATATAACAAACCTGCAATTGTTTCAGACGTTTTTGAAGCATTTATCGCCGCAATATATTTAGATCAGGGGC
TAGATTCAGTTAAAAAGTTTGTATACGAATTTATAATCCCGATTATCGAAGAAAGTTCAAAAGAATTGTTTATCGATTAC
AAAACTAAATTGCAGGAATTTCCAGAATTAATCAATAAATCAATAAATTATGTAAATTTAGAAGAAACTGGGGAAGCCCA
TGATAAAAAATTTGTTATTGCCGTAAAATCTGGGCGAAAAATACTTGGAAAAGGAATTGGAAAAAGTAAAAAAGAAGCTG
AAATGAAAGCTGCTAAAAATGCACTTTTAAAACTTGAAAAAAATAAAAATTAA

Upstream 100 bases:

>100_bases
AGGAAAATTAATTTCACCACCACTTTTATTCAACGGAAAAATCCTTGTTTAACTAAAAACCAATAATTAACTATTTTTTT
AATTTATTTTTGCAGAGGGT

Downstream 100 bases:

>100_bases
ATTAATTTAGATTAAATTAAAAATTTAAAAAAAGTTTAAAATTTATTCGAAAACAAATTCTACTTCAGTTAATCTTCTTT
TAACTTCGTTTAAGATTCTG

Product: ribonuclease III family protein

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MMKNFEKLLSKLDIQFNDLNIFKRAFMHSSYVNEQKNTNLEDNERLEYLGDAVLDLIISEYLFKKENLSEGEMSKLRAKY
VCESALFTYAKKLKFNNYVLLGKGEINSKGYNKPAIVSDVFEAFIAAIYLDQGLDSVKKFVYEFIIPIIEESSKELFIDY
KTKLQEFPELINKSINYVNLEETGEAHDKKFVIAVKSGRKILGKGIGKSKKEAEMKAAKNALLKLEKNKN

Sequences:

>Translated_230_residues
MMKNFEKLLSKLDIQFNDLNIFKRAFMHSSYVNEQKNTNLEDNERLEYLGDAVLDLIISEYLFKKENLSEGEMSKLRAKY
VCESALFTYAKKLKFNNYVLLGKGEINSKGYNKPAIVSDVFEAFIAAIYLDQGLDSVKKFVYEFIIPIIEESSKELFIDY
KTKLQEFPELINKSINYVNLEETGEAHDKKFVIAVKSGRKILGKGIGKSKKEAEMKAAKNALLKLEKNKN
>Mature_230_residues
MMKNFEKLLSKLDIQFNDLNIFKRAFMHSSYVNEQKNTNLEDNERLEYLGDAVLDLIISEYLFKKENLSEGEMSKLRAKY
VCESALFTYAKKLKFNNYVLLGKGEINSKGYNKPAIVSDVFEAFIAAIYLDQGLDSVKKFVYEFIIPIIEESSKELFIDY
KTKLQEFPELINKSINYVNLEETGEAHDKKFVIAVKSGRKILGKGIGKSKKEAEMKAAKNALLKLEKNKN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=237, Percent_Identity=26.5822784810127, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI155030236, Length=237, Percent_Identity=26.5822784810127, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1788920, Length=224, Percent_Identity=32.5892857142857, Blast_Score=106, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193202651, Length=238, Percent_Identity=28.1512605042017, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506883, Length=238, Percent_Identity=28.1512605042017, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323895, Length=234, Percent_Identity=28.6324786324786, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137682, Length=237, Percent_Identity=29.535864978903, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26471; Mature: 26471

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKNFEKLLSKLDIQFNDLNIFKRAFMHSSYVNEQKNTNLEDNERLEYLGDAVLDLIISE
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YLFKKENLSEGEMSKLRAKYVCESALFTYAKKLKFNNYVLLGKGEINSKGYNKPAIVSDV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHH
FEAFIAAIYLDQGLDSVKKFVYEFIIPIIEESSKELFIDYKTKLQEFPELINKSINYVNL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCEEEC
EETGEAHDKKFVIAVKSGRKILGKGIGKSKKEAEMKAAKNALLKLEKNKN
CCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MMKNFEKLLSKLDIQFNDLNIFKRAFMHSSYVNEQKNTNLEDNERLEYLGDAVLDLIISE
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YLFKKENLSEGEMSKLRAKYVCESALFTYAKKLKFNNYVLLGKGEINSKGYNKPAIVSDV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHH
FEAFIAAIYLDQGLDSVKKFVYEFIIPIIEESSKELFIDYKTKLQEFPELINKSINYVNL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCEEEC
EETGEAHDKKFVIAVKSGRKILGKGIGKSKKEAEMKAAKNALLKLEKNKN
CCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA