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The map label for this gene is tyrA [C]

Identifier: 45359077

GI number: 45359077

Start: 1473136

End: 1474458

Strand: Direct

Name: tyrA [C]

Synonym: MMP1514

Alternate gene names: 45359077

Gene position: 1473136-1474458 (Clockwise)

Preceding gene: 45359072

Following gene: 45359083

Centisome position: 88.68

GC content: 30.61

Gene sequence:

>1323_bases
ATGATAATTTCGATAATCGGCGGAACTGACGGGCTTGGAAAATGGTTTGCATCATTTCTTAAAAATAGGGGTTACGATGT
ACTCGTATCTGGAAGGGATGTAATAAAAGGAAAAGAAGTTGAAAAAGAACTTGGTGTAACTTACACAAATAACAATATCG
ATGCTGCAGAAAAAGGAGATATTGTAATAATTTCTGTCCCTATAAATGTTACAGAATCTGTGATTAAAGAAGTTGCTCCG
CATGTTAAAAAAGGTTCACTTTTAATGGACATAACATCGATAAAAGAAAGGCCTGCAAAACTGATGGCAGAATTTTCAAA
AACTGGAGTATTTGTACTTCCGACACACCCTATGTTTGGGCCAGAAACTCCTTCGTTAAACCGGCAGGTTGTAATACTTA
CACCTACTGAAAAAGAAAAAACAAATCCATTTTTTGAAAAAATTAAAGAATTTTTAGAAATTGAAGGTGCAAAAGTAATT
GTTGTATCCCCAAAAGAACACGATAAAATAATGGGTGTAGTTCAAGGGCTAACTCATTTTGTATATATTTCACTTGGATC
CACTCTAAAAGATCTTGGAATAGATATAAAAGAATCCAGAAACTTTGCGTCGCCAATTTACGAACTTATGATTAATATTA
TTGCACGGATAATCGGCCAAAACCCGTACCTATATGCAGATATCCAGATGCACAACCCGCAAATAAAAACCATTCACGAA
ACATTCATTAAAAACTGCGAAAATATAAGTGAAATTGTCCAGAATAAGGATAGGGATAGTTTTGTAGAAAACATGAAAAA
TTCTGCAAGGCATTTTGGAAATGAAACAAAAAGAGGACTTAACTGTTCTAACAAAGCAGTTTACGCAATTTCAAAAGAAA
CTGAAAAATTGATTAAATCCGTTGGAAAAGAAATTGGTTTAAAGCATATCTATTCTGAAAACGTGCACTACGGTATTTTA
AAAGAAGTTTATGCTGACAATATCGTTTTAAAACAAAATGAAAAGGAAGTACTTTTAAACATTTCAAATGTTTCTTTAAT
GGAAGATAAGGAACTTGAAGAATGGAAAATTAAAAATTTAGAAAAATATTTCGTAGATATTTCAGTATTATTTAAAAAAG
ACGTTGATTTAAACATAATTCTTGAATTATTAACCCATAAATTTGAAATCGAAGTAATTGATACATATTATGGAGATAAA
ATTGATGAAAATGACTTAAGTGCAACTTTTAGAATAAGCTCTTACGAAAAAGAAGATTTGAAAAAATTGGAAGAAACATT
CAATAAAATTATTGAAAATATCGGCGGAAAATTAAGATATTAA

Upstream 100 bases:

>100_bases
GGAATTTTATAAAAAAAATGTAAAAATTTTATTATGTAAGAATAACTTAATACAATAAAAGAAATAATATAAACCAATCA
AACTGAGAAATGGAAAAATT

Downstream 100 bases:

>100_bases
TTTTATATATTGCCCGAAAAACCGAATACTTTTTTAAATATATTTAAATCTATAAATATTGTTTTATAAAAATAAAAAAA
GAAGGGAATGAAAATTACAT

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MIISIIGGTDGLGKWFASFLKNRGYDVLVSGRDVIKGKEVEKELGVTYTNNNIDAAEKGDIVIISVPINVTESVIKEVAP
HVKKGSLLMDITSIKERPAKLMAEFSKTGVFVLPTHPMFGPETPSLNRQVVILTPTEKEKTNPFFEKIKEFLEIEGAKVI
VVSPKEHDKIMGVVQGLTHFVYISLGSTLKDLGIDIKESRNFASPIYELMINIIARIIGQNPYLYADIQMHNPQIKTIHE
TFIKNCENISEIVQNKDRDSFVENMKNSARHFGNETKRGLNCSNKAVYAISKETEKLIKSVGKEIGLKHIYSENVHYGIL
KEVYADNIVLKQNEKEVLLNISNVSLMEDKELEEWKIKNLEKYFVDISVLFKKDVDLNIILELLTHKFEIEVIDTYYGDK
IDENDLSATFRISSYEKEDLKKLEETFNKIIENIGGKLRY

Sequences:

>Translated_440_residues
MIISIIGGTDGLGKWFASFLKNRGYDVLVSGRDVIKGKEVEKELGVTYTNNNIDAAEKGDIVIISVPINVTESVIKEVAP
HVKKGSLLMDITSIKERPAKLMAEFSKTGVFVLPTHPMFGPETPSLNRQVVILTPTEKEKTNPFFEKIKEFLEIEGAKVI
VVSPKEHDKIMGVVQGLTHFVYISLGSTLKDLGIDIKESRNFASPIYELMINIIARIIGQNPYLYADIQMHNPQIKTIHE
TFIKNCENISEIVQNKDRDSFVENMKNSARHFGNETKRGLNCSNKAVYAISKETEKLIKSVGKEIGLKHIYSENVHYGIL
KEVYADNIVLKQNEKEVLLNISNVSLMEDKELEEWKIKNLEKYFVDISVLFKKDVDLNIILELLTHKFEIEVIDTYYGDK
IDENDLSATFRISSYEKEDLKKLEETFNKIIENIGGKLRY
>Mature_440_residues
MIISIIGGTDGLGKWFASFLKNRGYDVLVSGRDVIKGKEVEKELGVTYTNNNIDAAEKGDIVIISVPINVTESVIKEVAP
HVKKGSLLMDITSIKERPAKLMAEFSKTGVFVLPTHPMFGPETPSLNRQVVILTPTEKEKTNPFFEKIKEFLEIEGAKVI
VVSPKEHDKIMGVVQGLTHFVYISLGSTLKDLGIDIKESRNFASPIYELMINIIARIIGQNPYLYADIQMHNPQIKTIHE
TFIKNCENISEIVQNKDRDSFVENMKNSARHFGNETKRGLNCSNKAVYAISKETEKLIKSVGKEIGLKHIYSENVHYGIL
KEVYADNIVLKQNEKEVLLNISNVSLMEDKELEEWKIKNLEKYFVDISVLFKKDVDLNIILELLTHKFEIEVIDTYYGDK
IDENDLSATFRISSYEKEDLKKLEETFNKIIENIGGKLRY

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=277, Percent_Identity=29.2418772563177, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099 [H]

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH [H]

EC number: 1.3.1.12

Molecular weight: Translated: 50037; Mature: 50037

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISIIGGTDGLGKWFASFLKNRGYDVLVSGRDVIKGKEVEKELGVTYTNNNIDAAEKGD
CEEEEECCCCCHHHHHHHHHHCCCCEEEECCCHHHCCCHHHHHCCCEEECCCCCCCCCCC
IVIISVPINVTESVIKEVAPHVKKGSLLMDITSIKERPAKLMAEFSKTGVFVLPTHPMFG
EEEEEECCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
PETPSLNRQVVILTPTEKEKTNPFFEKIKEFLEIEGAKVIVVSPKEHDKIMGVVQGLTHF
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
VYISLGSTLKDLGIDIKESRNFASPIYELMINIIARIIGQNPYLYADIQMHNPQIKTIHE
EEHECCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHH
TFIKNCENISEIVQNKDRDSFVENMKNSARHFGNETKRGLNCSNKAVYAISKETEKLIKS
HHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEECHHHHHHHHH
VGKEIGLKHIYSENVHYGILKEVYADNIVLKQNEKEVLLNISNVSLMEDKELEEWKIKNL
HHHHHCHHHHHCCCCCHHHHHHHHHCCEEEECCCCEEEEEECCCEECCCCCHHHHHHHHH
EKYFVDISVLFKKDVDLNIILELLTHKFEIEVIDTYYGDKIDENDLSATFRISSYEKEDL
HHHHHEEEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHH
KKLEETFNKIIENIGGKLRY
HHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIISIIGGTDGLGKWFASFLKNRGYDVLVSGRDVIKGKEVEKELGVTYTNNNIDAAEKGD
CEEEEECCCCCHHHHHHHHHHCCCCEEEECCCHHHCCCHHHHHCCCEEECCCCCCCCCCC
IVIISVPINVTESVIKEVAPHVKKGSLLMDITSIKERPAKLMAEFSKTGVFVLPTHPMFG
EEEEEECCCHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
PETPSLNRQVVILTPTEKEKTNPFFEKIKEFLEIEGAKVIVVSPKEHDKIMGVVQGLTHF
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
VYISLGSTLKDLGIDIKESRNFASPIYELMINIIARIIGQNPYLYADIQMHNPQIKTIHE
EEHECCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHH
TFIKNCENISEIVQNKDRDSFVENMKNSARHFGNETKRGLNCSNKAVYAISKETEKLIKS
HHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEECHHHHHHHHH
VGKEIGLKHIYSENVHYGILKEVYADNIVLKQNEKEVLLNISNVSLMEDKELEEWKIKNL
HHHHHCHHHHHCCCCCHHHHHHHHHCCEEEECCCCEEEEEECCCEECCCCCHHHHHHHHH
EKYFVDISVLFKKDVDLNIILELLTHKFEIEVIDTYYGDKIDENDLSATFRISSYEKEDL
HHHHHEEEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHH
KKLEETFNKIIENIGGKLRY
HHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]