Click here to switch to the map view.

The map label for this gene is pheS [H]

Identifier: 45359059

GI number: 45359059

Start: 1457002

End: 1458504

Strand: Direct

Name: pheS [H]

Synonym: MMP1496

Alternate gene names: 45359059

Gene position: 1457002-1458504 (Clockwise)

Preceding gene: 45359057

Following gene: 45359060

Centisome position: 87.71

GC content: 33.13

Gene sequence:

>1503_bases
ATGGAACTTCATAACGACGAAAAAAGATTATTAAAGGCATTTCAGGAATCCAATGAAAAAACGATGAATTTAGAAGAACT
TTCAAAATATATTGAAAAAGAAAAAGTAATGAGAGCAGCATTTTGGCTTTCAGGGCGAGATTTTCTTGAAATTATTGAAA
ATAAAACAAAACTTTGTGAATTAAATGAACTTGGTAACAAGTCCCTTGATTTCGGAATTCCCGAGAGAAAAGTTGCCAAT
TATATTAAAGAAAATAACTTAGAATCGATTCCAATAAAAGAGCTTTCAAAAATTTTAGAAAAGGACGAAACAGGAGCCGC
ACTTGGAAATTTAAAGAAAAAGGGATTGGTTGAAATAGATAAAGGAAATATTGTATTTAAAAATTTAAACTACGAAGATA
TTGAAGAAGAAATATTAAAAAAAGTTTCAATCAACCCTGATTTATCAACATATTCAAAAGACGAAGTTAAAATAGTTGAA
AACCTGAAAAAAAGAGGTTTTTTAAACTTAAAAGAAGTAGTTGATAGAAGTTTTGAAATTAAGGATGCAGGAACTGAATT
TATTAAAAATCCAATAGAAATAAAAGAAGAAATTACCCAGCTTACAAGGGAAATGATTGTAAGTGGAAAATGGAAAGACT
ACTTTATAAGGCCGTATGATGCAAAAATTCCTACCGAAGACATTTACCCTGCAAAAGCACACCCCATGTCAAAAATTATT
CAAGAAGTAAACGAAGTTTTGATATCGATGGGTTTTAAGGAAGTAAAAAGCCAGATCGTCCAGACTGAATTTTGGAATTT
TGATACCTTGTTTGAGCCTCAGGACCACCCTGCAAGGGATATGCAAGATACATTCTTTGTAAAATATCCAAACACTGGAA
AAGTTCCAAAAGAATTGCTTGAAAAAGTAAAAGGAATCCACGAATGCGGAACTATTGATGGCGAAAAAATTTCAAAAGGT
TGGTGCTACAAATTCGATGAAAACGTATCTAAAAGAACAGTTTTAAGAACACACACAACCGTTTCATCGATAAAATATTT
AGCATCACTTTCAGAAAGCGAAAGAGAAAACCCCCACAAAGTATTCTGTATTGACAGGGTATTTAGAAATGAAACAATCG
ATTACAAACACCTTCCAGAATTCTACCAGTGTGAAGGAATCGTTATGGCAGAAGACGTCAACTTTGACAACCTCGTTGGC
ATTTTAAAAGAATTTTTAAGAAAATTAGGATTTGAAAAAGTAAGAATTAGACCTGCATACTTCCCATTTACAGAACCATC
CCTTGAAGCTGAAGTTTACATGGAAGGAAAAGGCTGGCTTGAACTTTTAGGTGCCGGAGTATTCAGACCTGAAGTTTTAG
AACCTTTCGGAATTAAAAAACCGGTTCTTGCATGGGGAATTGGCTTAAGCAGGCTTGCAATGTTAAGATTTGGACTTACA
GATATCCGTGAACTTCACAAAAACGACATGGAATGGCTTAAAAAAACTGCCGTTAATGAATAA

Upstream 100 bases:

>100_bases
AATTCGAGCGCCCCTATTCATGAAACCACCAAAAACTAAATTATAGGATATATTAAATAATTGGTGTTTATATTGATATA
TGTTCATAAAGGTGAAAATG

Downstream 100 bases:

>100_bases
ATTCAACTTTTTGAAGGGATTTTCGTGAATATTGAAAATACCATTAAATCTGCGTATGAAGAATCACTAAACAATGCACG
CTTTGGTGACAAAATAGAAG

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MELHNDEKRLLKAFQESNEKTMNLEELSKYIEKEKVMRAAFWLSGRDFLEIIENKTKLCELNELGNKSLDFGIPERKVAN
YIKENNLESIPIKELSKILEKDETGAALGNLKKKGLVEIDKGNIVFKNLNYEDIEEEILKKVSINPDLSTYSKDEVKIVE
NLKKRGFLNLKEVVDRSFEIKDAGTEFIKNPIEIKEEITQLTREMIVSGKWKDYFIRPYDAKIPTEDIYPAKAHPMSKII
QEVNEVLISMGFKEVKSQIVQTEFWNFDTLFEPQDHPARDMQDTFFVKYPNTGKVPKELLEKVKGIHECGTIDGEKISKG
WCYKFDENVSKRTVLRTHTTVSSIKYLASLSESERENPHKVFCIDRVFRNETIDYKHLPEFYQCEGIVMAEDVNFDNLVG
ILKEFLRKLGFEKVRIRPAYFPFTEPSLEAEVYMEGKGWLELLGAGVFRPEVLEPFGIKKPVLAWGIGLSRLAMLRFGLT
DIRELHKNDMEWLKKTAVNE

Sequences:

>Translated_500_residues
MELHNDEKRLLKAFQESNEKTMNLEELSKYIEKEKVMRAAFWLSGRDFLEIIENKTKLCELNELGNKSLDFGIPERKVAN
YIKENNLESIPIKELSKILEKDETGAALGNLKKKGLVEIDKGNIVFKNLNYEDIEEEILKKVSINPDLSTYSKDEVKIVE
NLKKRGFLNLKEVVDRSFEIKDAGTEFIKNPIEIKEEITQLTREMIVSGKWKDYFIRPYDAKIPTEDIYPAKAHPMSKII
QEVNEVLISMGFKEVKSQIVQTEFWNFDTLFEPQDHPARDMQDTFFVKYPNTGKVPKELLEKVKGIHECGTIDGEKISKG
WCYKFDENVSKRTVLRTHTTVSSIKYLASLSESERENPHKVFCIDRVFRNETIDYKHLPEFYQCEGIVMAEDVNFDNLVG
ILKEFLRKLGFEKVRIRPAYFPFTEPSLEAEVYMEGKGWLELLGAGVFRPEVLEPFGIKKPVLAWGIGLSRLAMLRFGLT
DIRELHKNDMEWLKKTAVNE
>Mature_500_residues
MELHNDEKRLLKAFQESNEKTMNLEELSKYIEKEKVMRAAFWLSGRDFLEIIENKTKLCELNELGNKSLDFGIPERKVAN
YIKENNLESIPIKELSKILEKDETGAALGNLKKKGLVEIDKGNIVFKNLNYEDIEEEILKKVSINPDLSTYSKDEVKIVE
NLKKRGFLNLKEVVDRSFEIKDAGTEFIKNPIEIKEEITQLTREMIVSGKWKDYFIRPYDAKIPTEDIYPAKAHPMSKII
QEVNEVLISMGFKEVKSQIVQTEFWNFDTLFEPQDHPARDMQDTFFVKYPNTGKVPKELLEKVKGIHECGTIDGEKISKG
WCYKFDENVSKRTVLRTHTTVSSIKYLASLSESERENPHKVFCIDRVFRNETIDYKHLPEFYQCEGIVMAEDVNFDNLVG
ILKEFLRKLGFEKVRIRPAYFPFTEPSLEAEVYMEGKGWLELLGAGVFRPEVLEPFGIKKPVLAWGIGLSRLAMLRFGLT
DIRELHKNDMEWLKKTAVNE

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758340, Length=339, Percent_Identity=38.6430678466077, Blast_Score=248, Evalue=1e-65,
Organism=Escherichia coli, GI1788007, Length=364, Percent_Identity=29.3956043956044, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17508957, Length=493, Percent_Identity=34.2799188640974, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI32563657, Length=493, Percent_Identity=34.2799188640974, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI32566635, Length=285, Percent_Identity=25.9649122807018, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321087, Length=500, Percent_Identity=32, Blast_Score=246, Evalue=9e-66,
Organism=Saccharomyces cerevisiae, GI6325304, Length=80, Percent_Identity=48.75, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18858079, Length=336, Percent_Identity=38.3928571428571, Blast_Score=228, Evalue=1e-59,
Organism=Drosophila melanogaster, GI17137424, Length=253, Percent_Identity=28.4584980237154, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR022917
- InterPro:   IPR002319 [H]

Pfam domain/function: PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 58088; Mature: 58088

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHNDEKRLLKAFQESNEKTMNLEELSKYIEKEKVMRAAFWLSGRDFLEIIENKTKLCE
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHEEE
LNELGNKSLDFGIPERKVANYIKENNLESIPIKELSKILEKDETGAALGNLKKKGLVEID
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCEEEC
KGNIVFKNLNYEDIEEEILKKVSINPDLSTYSKDEVKIVENLKKRGFLNLKEVVDRSFEI
CCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCC
KDAGTEFIKNPIEIKEEITQLTREMIVSGKWKDYFIRPYDAKIPTEDIYPAKAHPMSKII
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHH
QEVNEVLISMGFKEVKSQIVQTEFWNFDTLFEPQDHPARDMQDTFFVKYPNTGKVPKELL
HHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHH
EKVKGIHECGTIDGEKISKGWCYKFDENVSKRTVLRTHTTVSSIKYLASLSESERENPHK
HHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VFCIDRVFRNETIDYKHLPEFYQCEGIVMAEDVNFDNLVGILKEFLRKLGFEKVRIRPAY
EEEHHHHHCCCCCCHHHCCHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECC
FPFTEPSLEAEVYMEGKGWLELLGAGVFRPEVLEPFGIKKPVLAWGIGLSRLAMLRFGLT
CCCCCCCCCEEEEECCCHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCHH
DIRELHKNDMEWLKKTAVNE
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELHNDEKRLLKAFQESNEKTMNLEELSKYIEKEKVMRAAFWLSGRDFLEIIENKTKLCE
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHEEE
LNELGNKSLDFGIPERKVANYIKENNLESIPIKELSKILEKDETGAALGNLKKKGLVEID
HHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCEEEC
KGNIVFKNLNYEDIEEEILKKVSINPDLSTYSKDEVKIVENLKKRGFLNLKEVVDRSFEI
CCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCCC
KDAGTEFIKNPIEIKEEITQLTREMIVSGKWKDYFIRPYDAKIPTEDIYPAKAHPMSKII
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHH
QEVNEVLISMGFKEVKSQIVQTEFWNFDTLFEPQDHPARDMQDTFFVKYPNTGKVPKELL
HHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHH
EKVKGIHECGTIDGEKISKGWCYKFDENVSKRTVLRTHTTVSSIKYLASLSESERENPHK
HHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VFCIDRVFRNETIDYKHLPEFYQCEGIVMAEDVNFDNLVGILKEFLRKLGFEKVRIRPAY
EEEHHHHHCCCCCCHHHCCHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECC
FPFTEPSLEAEVYMEGKGWLELLGAGVFRPEVLEPFGIKKPVLAWGIGLSRLAMLRFGLT
CCCCCCCCCEEEEECCCHHHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCHH
DIRELHKNDMEWLKKTAVNE
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA