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The map label for this gene is ehaS [C]

Identifier: 45359029

GI number: 45359029

Start: 1427680

End: 1428321

Strand: Direct

Name: ehaS [C]

Synonym: MMP1466

Alternate gene names: 45359029

Gene position: 1427680-1428321 (Clockwise)

Preceding gene: 45359028

Following gene: 45359030

Centisome position: 85.95

GC content: 32.71

Gene sequence:

>642_bases
ATGAAAGTAAAAAGCTTGATGGATAAAAAATTTATTAAAATATATCCTGATTTTACTGTACAGACCGTTATTGACTTAAT
GTATAAAAATAAAAAATTTAGTACACCAATTGTTGATAATGACGGTAAAATGGTTGGATGGACAACGGCTATTGATTTAA
TGATAGTCTCTGATAAAAATATTCCAATAAAAGACATTATGAGCCCCATTGAAGACGTAATCGTTGTAAATAAAAACGAA
CCTGCAAGGGAAGCAGTTACTAAAATTGTAGAATACAAAGTCATAAGTATTCCTGTTTTAAACGATGAGGGCAGGGTTGT
TGGAATTGTTAGAAACTGCGATATTACAAAAACTCTTTCCAAATTATACGATATTCCTGTACACAGCATCTTTAAATCAT
TAATGGGCGAATTGAAAGGAATTTCATGGGAAGAATTAATGAATGCTGCCGCAATCGTTACAAAACAAACTACCGGGGAA
AAAATTACCGGTGAAGAATACGAAAAAAGAATAAAAGGTTCTACATTCGGACAGGCAATATGGGCGTGCGGAGGACTTGA
AAAATTCTTCACAGACCTCATAAAAATCGGTGAAGTTGCACTTGCAAGAAAAGTAAGCTGTAAAAATGTCATAAAAAAAT
AA

Upstream 100 bases:

>100_bases
GGATGATAAGATGTGCATATTCTGCGGAAAATGTGAGAAAAATTGTCCTGTAACTGCGATAGCGATTAAACAAAAAAATA
TGTAGTCGGGGAGGGGTAGT

Downstream 100 bases:

>100_bases
TCAATAATCGGGTGTCTGAATGTCTAACCTTATAAATATTCCTAAATACAGTAGGAAAATTGATTTCTGGACTTTCCTTG
AAAAAGCATTTGAAAAAAAT

Product: putative CBS domain-containing signal transduction protein

Products: H+; Nicotinamide adenine dinucleotide - reduced; Xanthosine 5'-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKVKSLMDKKFIKIYPDFTVQTVIDLMYKNKKFSTPIVDNDGKMVGWTTAIDLMIVSDKNIPIKDIMSPIEDVIVVNKNE
PAREAVTKIVEYKVISIPVLNDEGRVVGIVRNCDITKTLSKLYDIPVHSIFKSLMGELKGISWEELMNAAAIVTKQTTGE
KITGEEYEKRIKGSTFGQAIWACGGLEKFFTDLIKIGEVALARKVSCKNVIKK

Sequences:

>Translated_213_residues
MKVKSLMDKKFIKIYPDFTVQTVIDLMYKNKKFSTPIVDNDGKMVGWTTAIDLMIVSDKNIPIKDIMSPIEDVIVVNKNE
PAREAVTKIVEYKVISIPVLNDEGRVVGIVRNCDITKTLSKLYDIPVHSIFKSLMGELKGISWEELMNAAAIVTKQTTGE
KITGEEYEKRIKGSTFGQAIWACGGLEKFFTDLIKIGEVALARKVSCKNVIKK
>Mature_213_residues
MKVKSLMDKKFIKIYPDFTVQTVIDLMYKNKKFSTPIVDNDGKMVGWTTAIDLMIVSDKNIPIKDIMSPIEDVIVVNKNE
PAREAVTKIVEYKVISIPVLNDEGRVVGIVRNCDITKTLSKLYDIPVHSIFKSLMGELKGISWEELMNAAAIVTKQTTGE
KITGEEYEKRIKGSTFGQAIWACGGLEKFFTDLIKIGEVALARKVSCKNVIKK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000644
- InterPro:   IPR016486 [H]

Pfam domain/function: PF00571 CBS [H]

EC number: 1.1.1.205 [C]

Molecular weight: Translated: 23892; Mature: 23892

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKSLMDKKFIKIYPDFTVQTVIDLMYKNKKFSTPIVDNDGKMVGWTTAIDLMIVSDKN
CCCHHHHHCHHEEECCCCHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEEEEEEEECCCC
IPIKDIMSPIEDVIVVNKNEPAREAVTKIVEYKVISIPVLNDEGRVVGIVRNCDITKTLS
CCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCHHHHHH
KLYDIPVHSIFKSLMGELKGISWEELMNAAAIVTKQTTGEKITGEEYEKRIKGSTFGQAI
HHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCHHHHHHHCCCHHHHHH
WACGGLEKFFTDLIKIGEVALARKVSCKNVIKK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVKSLMDKKFIKIYPDFTVQTVIDLMYKNKKFSTPIVDNDGKMVGWTTAIDLMIVSDKN
CCCHHHHHCHHEEECCCCHHHHHHHHHHCCCCCCCCEECCCCCEEEEEEEEEEEEECCCC
IPIKDIMSPIEDVIVVNKNEPAREAVTKIVEYKVISIPVLNDEGRVVGIVRNCDITKTLS
CCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHEEEEEEEECCCCCEEEEEECCCHHHHHH
KLYDIPVHSIFKSLMGELKGISWEELMNAAAIVTKQTTGEKITGEEYEKRIKGSTFGQAI
HHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHEEECCCCCCCCCHHHHHHHCCCHHHHHH
WACGGLEKFFTDLIKIGEVALARKVSCKNVIKK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; IMP; Nicotinamide adenine dinucleotide [C]

Specific reaction: H2O + IMP + Nicotinamide adenine dinucleotide --> H+ + Nicotinamide adenine dinucleotide - reduced + Xanthosine 5'-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]