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The map label for this gene is top6A [H]

Identifier: 45359000

GI number: 45359000

Start: 1407714

End: 1408973

Strand: Direct

Name: top6A [H]

Synonym: MMP1437

Alternate gene names: 45359000

Gene position: 1407714-1408973 (Clockwise)

Preceding gene: 45358991

Following gene: 45359001

Centisome position: 84.74

GC content: 35.32

Gene sequence:

>1260_bases
TTGGAAATATATAAGTTACAAGATTTATATCTTTTGATTAGGACCAATACCAAAAATATAGTTATAAATAAAAATACTTA
TATTCGGAATATAAAAGCCGATTATAGCTTTCATTTATTTGATTCATATTTATATTATTTTCTATTAAAATGCGGTGAAA
CTGTGATAACCTCAGAAGAGAGAAATTTAGCGGCCAAAAAATTACTAAAACTTGCTAATGGCATGTATGAAGATATCATA
CGAGGAAAAAGACCAAAACTCACCTTCCCAATAAGAAGCCTTGCCAATGCAAAATTTGATGTTGAAAAAGGAACTTTTGC
GATACTTGGAAAAGAAAAAGATAGGATGTTAACGGTAAATCAGGCAAAAATATTTGCTCAGACTATCAAAATGATGGAAT
TTTCAAAAGGACTGCTTGATACAAACGATTTCTCAACTCTGAGAGAAGCATATTATGTTTCCAAAAACTGGGGTGAAGCA
AGATTCGATGACCAGCAACCATCAAACGGAGTTATTGAAGATATTGAAGCTGCTTCAGAATTTTTAAGAGAAGATTTAGG
ATTTATTCCTGAAGAAGATGGTGCAGCAGTTATCGGACCGTTAAGAATTGTTGACAGGACTGCTGAAGGAGACGAAATTA
AAATTGACTGTACAAAACTTGGAAGTGGTGCATACAGCATCCCTAATGATGTTACGAAATTGGAATTTGAAACAAAAGCA
GATTTTATTTTGGCAATCGAAACTGCAGGTATGTTTGCAAGGTTAAATGCAGAAGGATTCTGGAAAAAACACAACTGTAT
TTTAATCTCTTTAAAAGGGGTTCCTGCAAGGGCAACTAGAAGGTTTATCAAAAGATTAAATGAAGAATATAAATTACCGA
TTTTAGTATTCACGGATGGTGACCCTTACGGGTATTTAAACATCTACAGGACGTTAAAGGTAGGAAGTGGTAAGGCAGTC
CACTTAGCAGACAAATTGGCAGTACCCGAAGCCAGACTTATTGGAGTAACGCCTCAGGATATTGTTGACTACGAACTTCC
AACGCACCCCCTAAAAGACCACGACATAAAAAGATTAAAAGATGGTTTGAAAAACGATGATTTCGTTAAATCATTCCCTC
AATGGCAAAATGCGCTTGTTCAAATGGCAGACAGTAAAGTAAGGGCAGAACAGCAGTCTTTAGCAAAATACGGTTTAAAG
TACGTTGTTGAAGAATACTTGCCTGCAAAAGTTGAAGACTCAAGTACATGGCTCCCTTAA

Upstream 100 bases:

>100_bases
ATCTGTTTGTGCTATGTTTTTTAAGAATTTCAAGATTATTACCTCCTCATGAAATAGTGCATGCCCTCAAAGCCCTGATT
GTGTGGGTTTTAAATAATCA

Downstream 100 bases:

>100_bases
TTAATCCAACTACAATTAATATATCTCAACATTCTGGGATCAAAACCAATATCCTAAAACTATTTTTCTTTTATTACGAT
AAAATCGGCCGATATTAAGT

Product: DNA topoisomerase VI subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MEIYKLQDLYLLIRTNTKNIVINKNTYIRNIKADYSFHLFDSYLYYFLLKCGETVITSEERNLAAKKLLKLANGMYEDII
RGKRPKLTFPIRSLANAKFDVEKGTFAILGKEKDRMLTVNQAKIFAQTIKMMEFSKGLLDTNDFSTLREAYYVSKNWGEA
RFDDQQPSNGVIEDIEAASEFLREDLGFIPEEDGAAVIGPLRIVDRTAEGDEIKIDCTKLGSGAYSIPNDVTKLEFETKA
DFILAIETAGMFARLNAEGFWKKHNCILISLKGVPARATRRFIKRLNEEYKLPILVFTDGDPYGYLNIYRTLKVGSGKAV
HLADKLAVPEARLIGVTPQDIVDYELPTHPLKDHDIKRLKDGLKNDDFVKSFPQWQNALVQMADSKVRAEQQSLAKYGLK
YVVEEYLPAKVEDSSTWLP

Sequences:

>Translated_419_residues
MEIYKLQDLYLLIRTNTKNIVINKNTYIRNIKADYSFHLFDSYLYYFLLKCGETVITSEERNLAAKKLLKLANGMYEDII
RGKRPKLTFPIRSLANAKFDVEKGTFAILGKEKDRMLTVNQAKIFAQTIKMMEFSKGLLDTNDFSTLREAYYVSKNWGEA
RFDDQQPSNGVIEDIEAASEFLREDLGFIPEEDGAAVIGPLRIVDRTAEGDEIKIDCTKLGSGAYSIPNDVTKLEFETKA
DFILAIETAGMFARLNAEGFWKKHNCILISLKGVPARATRRFIKRLNEEYKLPILVFTDGDPYGYLNIYRTLKVGSGKAV
HLADKLAVPEARLIGVTPQDIVDYELPTHPLKDHDIKRLKDGLKNDDFVKSFPQWQNALVQMADSKVRAEQQSLAKYGLK
YVVEEYLPAKVEDSSTWLP
>Mature_419_residues
MEIYKLQDLYLLIRTNTKNIVINKNTYIRNIKADYSFHLFDSYLYYFLLKCGETVITSEERNLAAKKLLKLANGMYEDII
RGKRPKLTFPIRSLANAKFDVEKGTFAILGKEKDRMLTVNQAKIFAQTIKMMEFSKGLLDTNDFSTLREAYYVSKNWGEA
RFDDQQPSNGVIEDIEAASEFLREDLGFIPEEDGAAVIGPLRIVDRTAEGDEIKIDCTKLGSGAYSIPNDVTKLEFETKA
DFILAIETAGMFARLNAEGFWKKHNCILISLKGVPARATRRFIKRLNEEYKLPILVFTDGDPYGYLNIYRTLKVGSGKAV
HLADKLAVPEARLIGVTPQDIVDYELPTHPLKDHDIKRLKDGLKNDDFVKSFPQWQNALVQMADSKVRAEQQSLAKYGLK
YVVEEYLPAKVEDSSTWLP

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity [H]

COG id: COG1697

COG function: function code L; DNA topoisomerase VI, subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6A family [H]

Homologues:

Organism=Homo sapiens, GI6912680, Length=377, Percent_Identity=28.3819628647215, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38201680, Length=297, Percent_Identity=29.96632996633, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45552753, Length=230, Percent_Identity=29.1304347826087, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002815
- InterPro:   IPR013049
- InterPro:   IPR004085
- InterPro:   IPR022904
- InterPro:   IPR011991 [H]

Pfam domain/function: PF04406 TP6A_N [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 47744; Mature: 47744

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIYKLQDLYLLIRTNTKNIVINKNTYIRNIKADYSFHLFDSYLYYFLLKCGETVITSEE
CCEEEEEEEEEEEEECCCEEEEECCCEEEEEECCCEEHHHHHHHHHHHHHCCCCEEECCH
RNLAAKKLLKLANGMYEDIIRGKRPKLTFPIRSLANAKFDVEKGTFAILGKEKDRMLTVN
HHHHHHHHHHHHCCHHHHHHCCCCCCEEECHHHHCCCEEEECCCEEEEEECCCCCEEEEH
QAKIFAQTIKMMEFSKGLLDTNDFSTLREAYYVSKNWGEARFDDQQPSNGVIEDIEAASE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHH
FLREDLGFIPEEDGAAVIGPLRIVDRTAEGDEIKIDCTKLGSGAYSIPNDVTKLEFETKA
HHHHHCCCCCCCCCCEEEECEEEEECCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCC
DFILAIETAGMFARLNAEGFWKKHNCILISLKGVPARATRRFIKRLNEEYKLPILVFTDG
CEEEEEECCCEEEEECCCCCEEECCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECC
DPYGYLNIYRTLKVGSGKAVHLADKLAVPEARLIGVTPQDIVDYELPTHPLKDHDIKRLK
CCCEEEEEEEEEEECCCCEEEEHHHHCCCCCEEECCCHHHHHCCCCCCCCCCCCHHHHHH
DGLKNDDFVKSFPQWQNALVQMADSKVRAEQQSLAKYGLKYVVEEYLPAKVEDSSTWLP
CCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEIYKLQDLYLLIRTNTKNIVINKNTYIRNIKADYSFHLFDSYLYYFLLKCGETVITSEE
CCEEEEEEEEEEEEECCCEEEEECCCEEEEEECCCEEHHHHHHHHHHHHHCCCCEEECCH
RNLAAKKLLKLANGMYEDIIRGKRPKLTFPIRSLANAKFDVEKGTFAILGKEKDRMLTVN
HHHHHHHHHHHHCCHHHHHHCCCCCCEEECHHHHCCCEEEECCCEEEEEECCCCCEEEEH
QAKIFAQTIKMMEFSKGLLDTNDFSTLREAYYVSKNWGEARFDDQQPSNGVIEDIEAASE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHHHHHHHH
FLREDLGFIPEEDGAAVIGPLRIVDRTAEGDEIKIDCTKLGSGAYSIPNDVTKLEFETKA
HHHHHCCCCCCCCCCEEEECEEEEECCCCCCEEEEEEEECCCCCCCCCCCCEEEEEECCC
DFILAIETAGMFARLNAEGFWKKHNCILISLKGVPARATRRFIKRLNEEYKLPILVFTDG
CEEEEEECCCEEEEECCCCCEEECCEEEEEECCCCHHHHHHHHHHCCCCCCCEEEEEECC
DPYGYLNIYRTLKVGSGKAVHLADKLAVPEARLIGVTPQDIVDYELPTHPLKDHDIKRLK
CCCEEEEEEEEEEECCCCEEEEHHHHCCCCCEEECCCHHHHHCCCCCCCCCCCCHHHHHH
DGLKNDDFVKSFPQWQNALVQMADSKVRAEQQSLAKYGLKYVVEEYLPAKVEDSSTWLP
CCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087; 10545127 [H]