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The map label for this gene is pgi

Identifier: 45358858

GI number: 45358858

Start: 1279866

End: 1281182

Strand: Direct

Name: pgi

Synonym: MMP1295

Alternate gene names: 45358858

Gene position: 1279866-1281182 (Clockwise)

Preceding gene: 45358857

Following gene: 45358859

Centisome position: 77.05

GC content: 32.04

Gene sequence:

>1317_bases
ATGAATGGGGAACTATCCTTCAAATATGATAATGTAATGGAAGAAAATTTGGGCAATTTAGGAATTAGTAATGGAAAATT
AGAATCATTTAACAATGAATCTTCAAAAATTATTGAAATTTTAAAAGAAAAAGAACTTAATGGGGAATTTGGATTTTTAG
ATGTTTTGAATGATAATTTAGATAAATATTACGAATTAAATGAGTACTCCAAAAACTTTGAAAATATCCTTATTATTGGA
ATAGGCGGATCAAATTTAGGTTTAAGGGCTGCTGAAACAGGAATACTTGGAAGTTTCACATCTCGGTACGAAATTCCAAG
AATATATTATATGGACAATTCTGACCCTGAAAAAACCCATGATATTTTATCAAACATTGATTTGGAAAAAACCCTCGTAT
TTGTCATAAGTAAATCGGGAAATACAGTTGAAACCCTCGCAAATTTCTTTATAGTTAGGAATTTAATGAAAAAGAAAAAT
ATTGATTTGGAAAAACACGTTGTTTCAATTACGAGCGGTGGCGAACTTGAAAAAATTACAAAAAAAGAAAATTACATTCA
TTTTGAAGTTCCGGAAAATGTCGGAGGAAGATTTTCTGTTCTTTCATCAGTTGGGATTGCTCCACTTTCATGCACTTCCG
TAGATATCAAAAAATTAATTGATGGTGCTAAAAGTATAGAAAAATCTTGCAAATGCGAAGATATTTTCAAAAATCCGGCT
TTAATGAATGCAGTAATTCATAAACTTATGTACAACCGCGGAAAAACTGTTTCAGTAATGATGCCATATATTGAAAGACT
TAGAAGTTTTGGAATGTGGTACGGACAGCTCTGGGCTGAAAGTCTTGGAAAAAATGGTTTTGGACAGACCCCCGTTATTG
CAGTTGGTGCAACAAGCCAGCATTCCCAACTTCAACTCTACATGGATGGCCCGAACGATAAAATCGCGACATTTTTAAAA
GTAAATAAATATAGAAATGACTTGAAAATCGAGTACGAATATGACCACCATCTTTCAGGCCATAATTTATCCGAAGTAAT
TACTTCAGAACTAGTTGGAACTGAAAACTCGATGAAACACAATAATATTCCAAATGTAAAGATTACACTTTCAAAATTAA
ATGAAATCACCATGGGAAAACTTTTCTTGATGTACGAAATGCAGACTGCAATTTCTGGAGAACTTTATGGAATTAATGCA
TTTGACCAGCCTGCAGTCGAATATGGAAAAAAAATAGCCCATGAGTGTTTAACAGGTTCAAAAGTTGATTCTGAAAACAA
ATATATAAACGGAAAATACATTATAACTTCCAAATAA

Upstream 100 bases:

>100_bases
CAAAATAACGACAGTTCTGAACGATACAGGGCACTTTTTGGCGGTGCAATGTACAAACACTACTTTTAAATAACCATAAC
TATTTTTCAGGAGGGTTACT

Downstream 100 bases:

>100_bases
TTTTATTTTTGAGAGGGGGCAGATATGGAAATTATTAATCACTTTAAAGACTTTTCAAACGTTTCTATTTTTTTAGCATA
TAATGTAAATGTCGATGCAT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MNGELSFKYDNVMEENLGNLGISNGKLESFNNESSKIIEILKEKELNGEFGFLDVLNDNLDKYYELNEYSKNFENILIIG
IGGSNLGLRAAETGILGSFTSRYEIPRIYYMDNSDPEKTHDILSNIDLEKTLVFVISKSGNTVETLANFFIVRNLMKKKN
IDLEKHVVSITSGGELEKITKKENYIHFEVPENVGGRFSVLSSVGIAPLSCTSVDIKKLIDGAKSIEKSCKCEDIFKNPA
LMNAVIHKLMYNRGKTVSVMMPYIERLRSFGMWYGQLWAESLGKNGFGQTPVIAVGATSQHSQLQLYMDGPNDKIATFLK
VNKYRNDLKIEYEYDHHLSGHNLSEVITSELVGTENSMKHNNIPNVKITLSKLNEITMGKLFLMYEMQTAISGELYGINA
FDQPAVEYGKKIAHECLTGSKVDSENKYINGKYIITSK

Sequences:

>Translated_438_residues
MNGELSFKYDNVMEENLGNLGISNGKLESFNNESSKIIEILKEKELNGEFGFLDVLNDNLDKYYELNEYSKNFENILIIG
IGGSNLGLRAAETGILGSFTSRYEIPRIYYMDNSDPEKTHDILSNIDLEKTLVFVISKSGNTVETLANFFIVRNLMKKKN
IDLEKHVVSITSGGELEKITKKENYIHFEVPENVGGRFSVLSSVGIAPLSCTSVDIKKLIDGAKSIEKSCKCEDIFKNPA
LMNAVIHKLMYNRGKTVSVMMPYIERLRSFGMWYGQLWAESLGKNGFGQTPVIAVGATSQHSQLQLYMDGPNDKIATFLK
VNKYRNDLKIEYEYDHHLSGHNLSEVITSELVGTENSMKHNNIPNVKITLSKLNEITMGKLFLMYEMQTAISGELYGINA
FDQPAVEYGKKIAHECLTGSKVDSENKYINGKYIITSK
>Mature_438_residues
MNGELSFKYDNVMEENLGNLGISNGKLESFNNESSKIIEILKEKELNGEFGFLDVLNDNLDKYYELNEYSKNFENILIIG
IGGSNLGLRAAETGILGSFTSRYEIPRIYYMDNSDPEKTHDILSNIDLEKTLVFVISKSGNTVETLANFFIVRNLMKKKN
IDLEKHVVSITSGGELEKITKKENYIHFEVPENVGGRFSVLSSVGIAPLSCTSVDIKKLIDGAKSIEKSCKCEDIFKNPA
LMNAVIHKLMYNRGKTVSVMMPYIERLRSFGMWYGQLWAESLGKNGFGQTPVIAVGATSQHSQLQLYMDGPNDKIATFLK
VNKYRNDLKIEYEYDHHLSGHNLSEVITSELVGTENSMKHNNIPNVKITLSKLNEITMGKLFLMYEMQTAISGELYGINA
FDQPAVEYGKKIAHECLTGSKVDSENKYINGKYIITSK

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=401, Percent_Identity=26.6832917705736, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1790457, Length=390, Percent_Identity=25.8974358974359, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71996708, Length=409, Percent_Identity=26.4058679706601, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71996703, Length=409, Percent_Identity=26.4058679706601, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319673, Length=375, Percent_Identity=26.1333333333333, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24651916, Length=390, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24651914, Length=390, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737445, Length=390, Percent_Identity=26.9230769230769, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_METMP (Q6LXQ4)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_988415.1
- ProteinModelPortal:   Q6LXQ4
- SMR:   Q6LXQ4
- GeneID:   2761531
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP1295
- NMPDR:   fig|267377.1.peg.1295
- HOGENOM:   HBG615843
- OMA:   MMQGAAD
- ProtClustDB:   PRK00973
- BioCyc:   MMAR267377:MMP1295-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 49257; Mature: 49257

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 280-280 ACT_SITE 301-301 ACT_SITE 410-410

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGELSFKYDNVMEENLGNLGISNGKLESFNNESSKIIEILKEKELNGEFGFLDVLNDNL
CCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHCCH
DKYYELNEYSKNFENILIIGIGGSNLGLRAAETGILGSFTSRYEIPRIYYMDNSDPEKTH
HHHEEHHHHCCCCCEEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCEEEEECCCCHHHHH
DILSNIDLEKTLVFVISKSGNTVETLANFFIVRNLMKKKNIDLEKHVVSITSGGELEKIT
HHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCHHHHH
KKENYIHFEVPENVGGRFSVLSSVGIAPLSCTSVDIKKLIDGAKSIEKSCKCEDIFKNPA
CCCCEEEEECCCCCCCHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHCCHH
LMNAVIHKLMYNRGKTVSVMMPYIERLRSFGMWYGQLWAESLGKNGFGQTPVIAVGATSQ
HHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEECCCC
HSQLQLYMDGPNDKIATFLKVNKYRNDLKIEYEYDHHLSGHNLSEVITSELVGTENSMKH
CCEEEEEEECCCCHHEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC
NNIPNVKITLSKLNEITMGKLFLMYEMQTAISGELYGINAFDQPAVEYGKKIAHECLTGS
CCCCCEEEEHHHCCCHHHHHEEEEEEHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCC
KVDSENKYINGKYIITSK
CCCCCCCEECCEEEEECC
>Mature Secondary Structure
MNGELSFKYDNVMEENLGNLGISNGKLESFNNESSKIIEILKEKELNGEFGFLDVLNDNL
CCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEHHHCCH
DKYYELNEYSKNFENILIIGIGGSNLGLRAAETGILGSFTSRYEIPRIYYMDNSDPEKTH
HHHEEHHHHCCCCCEEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCEEEEECCCCHHHHH
DILSNIDLEKTLVFVISKSGNTVETLANFFIVRNLMKKKNIDLEKHVVSITSGGELEKIT
HHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCCCCHHHHH
KKENYIHFEVPENVGGRFSVLSSVGIAPLSCTSVDIKKLIDGAKSIEKSCKCEDIFKNPA
CCCCEEEEECCCCCCCHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHCCHH
LMNAVIHKLMYNRGKTVSVMMPYIERLRSFGMWYGQLWAESLGKNGFGQTPVIAVGATSQ
HHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEECCCC
HSQLQLYMDGPNDKIATFLKVNKYRNDLKIEYEYDHHLSGHNLSEVITSELVGTENSMKH
CCEEEEEEECCCCHHEEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCC
NNIPNVKITLSKLNEITMGKLFLMYEMQTAISGELYGINAFDQPAVEYGKKIAHECLTGS
CCCCCEEEEHHHCCCHHHHHEEEEEEHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCC
KVDSENKYINGKYIITSK
CCCCCCCEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA