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The map label for this gene is menA

Identifier: 41410127

GI number: 41410127

Start: 4490292

End: 4491164

Strand: Reverse

Name: menA

Synonym: MAP4029c

Alternate gene names: 41410127

Gene position: 4491164-4490292 (Counterclockwise)

Preceding gene: 41410131

Following gene: 41410126

Centisome position: 92.99

GC content: 75.03

Gene sequence:

>873_bases
GTGGCCAATCTCGGGCAGTGGATCTCCGGTGCGCGGCCGCGCACGTTGCCCAACGCGCTGGCGCCGGTGGTCGCCGGCAC
CGGCGCGGCGGCGTGGCTGCACGCCGCGGTGTGGTGGAAGGCGCTGCTGGCGTTGGTCGTGGCGGTCGCGATGACGGTCG
GCGTCAACTACGCCAACGACTACTCCGACGGCATCCGCGGCACCGACGACGACCGCGCCGGCCCGGTGCGGCTGGTCGGC
TCGCGGCTGGCGGCGCCGCGCGCGGTGCTGGGCGCCGCGATCGTGAGCCTGACCGTCGGGGCGATCGCCGGGCTGGTCCT
GGCACTGTCCAGCGCGCCGTGGCTGATCGCGGTGGGGGCGGCGTGCATCGCCGGGGCGTGGCTGTACACCGGCGGGTCGA
AACCCTACGGCTACACCGGTTTTGGCGAGGTCGCGGTGTTCGTGTTCTTCGGCCTGGTCGCCGTGCTGGGCACCGAGTAC
ACCCAGGCGCTGCGGGTGGACTGGGTGGGCCTGGTGCTGGCGGTGGCGGTCGGGGCGCTGTCGTCGTCGGTGCTGGTGGC
CAACAACCTGCGCGACATTCCCACCGACGCCCGGTCGGGCAAGATCACCCTGGCGGTGCGGCTGGGCGACGCCCGCACCC
GGGTGCTGTACCAGGCGCTGCTTTCCGCCGCCGCCGCGTTGACCCTGGTGCTCGTGGCGGCCACGCCGTGGTGCGCCGCG
GGATTGGTGGCCACGCCGCTGGCGCTGCGCGCGGCGACCCCGGTGCGGTCCGGGCGCGGCGGCGCCGAGCTGATCCCGGT
GCTGCGCGACACCGGCCTGGCGATGGTGGTGTGGGCGGTCGCGGTGGCGGCGGCGTTGACGTGGGGTACCTGA

Upstream 100 bases:

>100_bases
AGAAGCCGCTGCCGCCGATGACTCCGAGCATCCGACCATTGTGGTGCATGAGCGCGGGCTGATCGCAGGGCCCGGCCGCG
CATCCTGGCAGGATGTCGGT

Downstream 100 bases:

>100_bases
CAGTGCGACCAGACGCAAAGGCGCCCGCGCACCGCGCTTTTGGGGTACTTTTGCGTCTGCTCGGGGGATAGCGAAGGACC
GCAATGAAGCAGATTGCCGC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MANLGQWISGARPRTLPNALAPVVAGTGAAAWLHAAVWWKALLALVVAVAMTVGVNYANDYSDGIRGTDDDRAGPVRLVG
SRLAAPRAVLGAAIVSLTVGAIAGLVLALSSAPWLIAVGAACIAGAWLYTGGSKPYGYTGFGEVAVFVFFGLVAVLGTEY
TQALRVDWVGLVLAVAVGALSSSVLVANNLRDIPTDARSGKITLAVRLGDARTRVLYQALLSAAAALTLVLVAATPWCAA
GLVATPLALRAATPVRSGRGGAELIPVLRDTGLAMVVWAVAVAAALTWGT

Sequences:

>Translated_290_residues
MANLGQWISGARPRTLPNALAPVVAGTGAAAWLHAAVWWKALLALVVAVAMTVGVNYANDYSDGIRGTDDDRAGPVRLVG
SRLAAPRAVLGAAIVSLTVGAIAGLVLALSSAPWLIAVGAACIAGAWLYTGGSKPYGYTGFGEVAVFVFFGLVAVLGTEY
TQALRVDWVGLVLAVAVGALSSSVLVANNLRDIPTDARSGKITLAVRLGDARTRVLYQALLSAAAALTLVLVAATPWCAA
GLVATPLALRAATPVRSGRGGAELIPVLRDTGLAMVVWAVAVAAALTWGT
>Mature_289_residues
ANLGQWISGARPRTLPNALAPVVAGTGAAAWLHAAVWWKALLALVVAVAMTVGVNYANDYSDGIRGTDDDRAGPVRLVGS
RLAAPRAVLGAAIVSLTVGAIAGLVLALSSAPWLIAVGAACIAGAWLYTGGSKPYGYTGFGEVAVFVFFGLVAVLGTEYT
QALRVDWVGLVLAVAVGALSSSVLVANNLRDIPTDARSGKITLAVRLGDARTRVLYQALLSAAAALTLVLVAATPWCAAG
LVATPLALRAATPVRSGRGGAELIPVLRDTGLAMVVWAVAVAAALTWGT

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=256, Percent_Identity=26.171875, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1790365, Length=275, Percent_Identity=34.5454545454545, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17737429, Length=272, Percent_Identity=26.8382352941176, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 29446; Mature: 29314

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANLGQWISGARPRTLPNALAPVVAGTGAAAWLHAAVWWKALLALVVAVAMTVGVNYAND
CCCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YSDGIRGTDDDRAGPVRLVGSRLAAPRAVLGAAIVSLTVGAIAGLVLALSSAPWLIAVGA
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ACIAGAWLYTGGSKPYGYTGFGEVAVFVFFGLVAVLGTEYTQALRVDWVGLVLAVAVGAL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSSVLVANNLRDIPTDARSGKITLAVRLGDARTRVLYQALLSAAAALTLVLVAATPWCAA
HCCHHEECCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GLVATPLALRAATPVRSGRGGAELIPVLRDTGLAMVVWAVAVAAALTWGT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ANLGQWISGARPRTLPNALAPVVAGTGAAAWLHAAVWWKALLALVVAVAMTVGVNYAND
CCHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YSDGIRGTDDDRAGPVRLVGSRLAAPRAVLGAAIVSLTVGAIAGLVLALSSAPWLIAVGA
CCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
ACIAGAWLYTGGSKPYGYTGFGEVAVFVFFGLVAVLGTEYTQALRVDWVGLVLAVAVGAL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSSVLVANNLRDIPTDARSGKITLAVRLGDARTRVLYQALLSAAAALTLVLVAATPWCAA
HCCHHEECCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
GLVATPLALRAATPVRSGRGGAELIPVLRDTGLAMVVWAVAVAAALTWGT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]