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The map label for this gene is cmaA2

Identifier: 41410093

GI number: 41410093

Start: 4452641

End: 4453540

Strand: Reverse

Name: cmaA2

Synonym: MAP3995c

Alternate gene names: 41410093

Gene position: 4453540-4452641 (Counterclockwise)

Preceding gene: 41410094

Following gene: 41410084

Centisome position: 92.21

GC content: 62.56

Gene sequence:

>900_bases
ATGACGTCACAGGGGGAAACACAGCTCAAACCGCCCGTCGAGGCGGTCCGATCCCACTACGACAAGTCGAACGAGTTCTT
CAAGCTCTGGCTTGACCCGTCGATGACCTACAGCTGCGGTTACTGGGAAGAGGGCGCCAAGACGCTGGAAGAGGCCCAGT
ACGCCAAGCGCAAGCTCGCGCTGGACAAGTTGAACCTCGAGCCGGGAATGACGCTGCTCGACATCGGCTGCGGCTGGGGT
TCCACCATGCGCCACGCCATGGAGGAGTACGACGTCGACGTCATCGGCCTGACGCTCAGCGAGAACCAGTACGCCCATTG
CGTGGCGGAATTCGACAAGATGGACAGCCCCCGCCGCAAAGAGGTGCGGATCCAGGGGTGGGAGGAATTCCCCGACGAGC
CGATCGACCGCATCGTGTCGCTGGGCGCGTTCGAGCACTTCGCCGACGGCGCCGGTGACGCCGGGTACGAGCGCTACGCC
ACCTTCTTCAAGAAGTACTACGACCTGCTGCCCGACGACGGCCGCATGCTGCTGCACTCGATCGTGGTGCCGACCCGCGA
AGAGGGCAACGCGATGGGCTTGAAGGTGAACATGACCCTGCTGCGGTTCATCAGCTTCATCCTCAAGGAGATCTACCCGG
GCGGGAAGCTGCCGCAGGTCAACCTGGTGGACAAGTACGCCACCGACGCGGGTTTCAAGATCGAGCGGCACCACTTCATC
GGAAAGAACTACGTCCCGACGCTGACCGCCTGGGGCGACGCGCTGGAGGCCCACAAGGAAGAGGCGATCGCCCTCAAGGG
TCAGGAGACCTACGACATCTACCTCAAGTACTTGCGGGGCTGCGCCGAGCTGTTCCGCGACGGCTACACCAACGTCTGCC
AGTTCACCATGGTCAAGTAA

Upstream 100 bases:

>100_bases
CGTCACGATGCTGGGGGAGGCCGCACACCAAGAGGCCGACGCGGCAGCGACCGCCGCGGCAGTTGCATCCATATCAGCAG
GAAAGTTAGGGGCGATATAG

Downstream 100 bases:

>100_bases
GCCGGCCAGCGTCGAGTTGTTGGGCCGAAAAACGGCTTAATCGCCCAACAACTCGACGTTCGGCGGGCAGGCCGAAGAAC
TCAGCCGAAGAAGATGTTGC

Product: CmaA2

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTSQGETQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCGYWEEGAKTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWG
STMRHAMEEYDVDVIGLTLSENQYAHCVAEFDKMDSPRRKEVRIQGWEEFPDEPIDRIVSLGAFEHFADGAGDAGYERYA
TFFKKYYDLLPDDGRMLLHSIVVPTREEGNAMGLKVNMTLLRFISFILKEIYPGGKLPQVNLVDKYATDAGFKIERHHFI
GKNYVPTLTAWGDALEAHKEEAIALKGQETYDIYLKYLRGCAELFRDGYTNVCQFTMVK

Sequences:

>Translated_299_residues
MTSQGETQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCGYWEEGAKTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWG
STMRHAMEEYDVDVIGLTLSENQYAHCVAEFDKMDSPRRKEVRIQGWEEFPDEPIDRIVSLGAFEHFADGAGDAGYERYA
TFFKKYYDLLPDDGRMLLHSIVVPTREEGNAMGLKVNMTLLRFISFILKEIYPGGKLPQVNLVDKYATDAGFKIERHHFI
GKNYVPTLTAWGDALEAHKEEAIALKGQETYDIYLKYLRGCAELFRDGYTNVCQFTMVK
>Mature_298_residues
TSQGETQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCGYWEEGAKTLEEAQYAKRKLALDKLNLEPGMTLLDIGCGWGS
TMRHAMEEYDVDVIGLTLSENQYAHCVAEFDKMDSPRRKEVRIQGWEEFPDEPIDRIVSLGAFEHFADGAGDAGYERYAT
FFKKYYDLLPDDGRMLLHSIVVPTREEGNAMGLKVNMTLLRFISFILKEIYPGGKLPQVNLVDKYATDAGFKIERHHFIG
KNYVPTLTAWGDALEAHKEEAIALKGQETYDIYLKYLRGCAELFRDGYTNVCQFTMVK

Specific function: Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfers of a methylene group from S-adenosyl-L

COG id: COG2230

COG function: function code M; Cyclopropane fatty acid synthase and related methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=270, Percent_Identity=35.1851851851852, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI133904226, Length=302, Percent_Identity=26.8211920529801, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 34226; Mature: 34095

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQGETQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCGYWEEGAKTLEEAQYAKRKLA
CCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
LDKLNLEPGMTLLDIGCGWGSTMRHAMEEYDVDVIGLTLSENQYAHCVAEFDKMDSPRRK
HHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCC
EVRIQGWEEFPDEPIDRIVSLGAFEHFADGAGDAGYERYATFFKKYYDLLPDDGRMLLHS
CEEECCHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
IVVPTREEGNAMGLKVNMTLLRFISFILKEIYPGGKLPQVNLVDKYATDAGFKIERHHFI
HHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEHEEEC
GKNYVPTLTAWGDALEAHKEEAIALKGQETYDIYLKYLRGCAELFRDGYTNVCQFTMVK
CCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEECC
>Mature Secondary Structure 
TSQGETQLKPPVEAVRSHYDKSNEFFKLWLDPSMTYSCGYWEEGAKTLEEAQYAKRKLA
CCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHH
LDKLNLEPGMTLLDIGCGWGSTMRHAMEEYDVDVIGLTLSENQYAHCVAEFDKMDSPRRK
HHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCC
EVRIQGWEEFPDEPIDRIVSLGAFEHFADGAGDAGYERYATFFKKYYDLLPDDGRMLLHS
CEEECCHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
IVVPTREEGNAMGLKVNMTLLRFISFILKEIYPGGKLPQVNLVDKYATDAGFKIERHHFI
HHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCEEEHEEEC
GKNYVPTLTAWGDALEAHKEEAIALKGQETYDIYLKYLRGCAELFRDGYTNVCQFTMVK
CCCCCCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]