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The map label for this gene is umaA2

Identifier: 41410062

GI number: 41410062

Start: 4424631

End: 4425497

Strand: Reverse

Name: umaA2

Synonym: MAP3964c

Alternate gene names: 41410062

Gene position: 4425497-4424631 (Counterclockwise)

Preceding gene: 41410063

Following gene: 41410057

Centisome position: 91.63

GC content: 63.9

Gene sequence:

>867_bases
ATGTCCGTGCAGCTCACGCCGCATTTTGGAAACGTAAAGGCCCACTACGACTTGTCCGACGACTTCTTCCGCCTGTTCCT
GGACCCCACTCAGACCTACAGCTGCGCGTACTTCGAGCGCGACGACATGACCCTGGAAGAGGCCCAGATCGCCAAGATCG
ACCTGGCGCTGGGCAAGTTGAAGCTCGAGCCGGGAATGACGTTGCTGGACATCGGGTGTGGCTGGGGCGCCACCATGCGG
CGGGCCATCGAGAAGTATGACGTCAACGTGGTGGGCCTGACGCTGTCGGAGAACCAGGCCGAGCACGTGCAGAAGACCTT
CGACGCGATGGACACCCCGCGCACCCGGCGGGTGCTGCTGGAGGGCTGGGAGAAGTTCCACGAGCCCGTGGACCGCATCG
TCTCGATCGGCGCGTTCGAGCACTTCGGCCGGCAACGCTACGGCCGCTTCTTCAGGATGGCCTACGACGTGCTGCCGCCC
GGCGGAATCATGTTGCTGCACACCATCGTTCGGCCCTCCTTCAAGGACGCCCGGGCCAAGGGCATGAAGCTGACCCACGA
GATCGTCGAGTTCTCCCGGTTCATCCTGGCCGAGATCTTCCCCGGCGGTTGGCTGCCCACACCGCAGACCGTCGGCGAAT
ACGGCGTGACGGCGGGCTTCGACCTGACCCGGGTGCAGTCGCTGCAGCTGCACTACGCCCGGACGCTGGACCTGTGGGCG
CAGGCACTCGAGGCCAATCGCGAGCAGGCCATCGCCATCCAGTCCCAAGAGGTCTACGACCGGTACATGAAGTATTTGAC
CGGCTGCGCCAAGCTGTTCCGGGAGGGCTACACCGACGTCAACCAGTTCACCATGGAGAAGAAGTAG

Upstream 100 bases:

>100_bases
CGCCCCAGCGACTACCATGCAGGACAGCGTTGGGGGACGAAGCGGGGTGGTTGCGTGGCTGCCCACCCCCGCCATCTCAT
ATAGAAAGGCTCGTGTCGAC

Downstream 100 bases:

>100_bases
CCGTCCTGCCCGACCCGCCTACTTGACCAGCGTGAATTGCCCCACATTGCTGATGCCCTTGCGGAAGAAGTTCTCGCACC
CGGTCAGGTAGTGCATGTAG

Product: UmaA2

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSVQLTPHFGNVKAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLKLEPGMTLLDIGCGWGATMR
RAIEKYDVNVVGLTLSENQAEHVQKTFDAMDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGRQRYGRFFRMAYDVLPP
GGIMLLHTIVRPSFKDARAKGMKLTHEIVEFSRFILAEIFPGGWLPTPQTVGEYGVTAGFDLTRVQSLQLHYARTLDLWA
QALEANREQAIAIQSQEVYDRYMKYLTGCAKLFREGYTDVNQFTMEKK

Sequences:

>Translated_288_residues
MSVQLTPHFGNVKAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLKLEPGMTLLDIGCGWGATMR
RAIEKYDVNVVGLTLSENQAEHVQKTFDAMDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGRQRYGRFFRMAYDVLPP
GGIMLLHTIVRPSFKDARAKGMKLTHEIVEFSRFILAEIFPGGWLPTPQTVGEYGVTAGFDLTRVQSLQLHYARTLDLWA
QALEANREQAIAIQSQEVYDRYMKYLTGCAKLFREGYTDVNQFTMEKK
>Mature_287_residues
SVQLTPHFGNVKAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKLKLEPGMTLLDIGCGWGATMRR
AIEKYDVNVVGLTLSENQAEHVQKTFDAMDTPRTRRVLLEGWEKFHEPVDRIVSIGAFEHFGRQRYGRFFRMAYDVLPPG
GIMLLHTIVRPSFKDARAKGMKLTHEIVEFSRFILAEIFPGGWLPTPQTVGEYGVTAGFDLTRVQSLQLHYARTLDLWAQ
ALEANREQAIAIQSQEVYDRYMKYLTGCAKLFREGYTDVNQFTMEKK

Specific function: Catalyzes the conversion of a double bond to a cyclopropane ring at the proximal position of an alpha mycolic acid via the transfers of a methylene group from S-adenosyl-L- methionine. Cyclopropanated mycolic acids are key factors participating in cell en

COG id: COG2230

COG function: function code M; Cyclopropane fatty acid synthase and related methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=262, Percent_Identity=35.8778625954198, Blast_Score=148, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI133904226, Length=286, Percent_Identity=32.8671328671329, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 33099; Mature: 32968

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQLTPHFGNVKAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKL
CCEEECCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEE
KLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAEHVQKTFDAMDTPRTRRVLL
EECCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHH
EGWEKFHEPVDRIVSIGAFEHFGRQRYGRFFRMAYDVLPPGGIMLLHTIVRPSFKDARAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
GMKLTHEIVEFSRFILAEIFPGGWLPTPQTVGEYGVTAGFDLTRVQSLQLHYARTLDLWA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QALEANREQAIAIQSQEVYDRYMKYLTGCAKLFREGYTDVNQFTMEKK
HHHHCCCHHEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC
>Mature Secondary Structure 
SVQLTPHFGNVKAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLEEAQIAKIDLALGKL
CEEECCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHEE
KLEPGMTLLDIGCGWGATMRRAIEKYDVNVVGLTLSENQAEHVQKTFDAMDTPRTRRVLL
EECCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHCCCHHHHHHH
EGWEKFHEPVDRIVSIGAFEHFGRQRYGRFFRMAYDVLPPGGIMLLHTIVRPSFKDARAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHH
GMKLTHEIVEFSRFILAEIFPGGWLPTPQTVGEYGVTAGFDLTRVQSLQLHYARTLDLWA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QALEANREQAIAIQSQEVYDRYMKYLTGCAKLFREGYTDVNQFTMEKK
HHHHCCCHHEEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]