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The map label for this gene is ldhA [C]

Identifier: 41409778

GI number: 41409778

Start: 4088334

End: 4089503

Strand: Reverse

Name: ldhA [C]

Synonym: MAP3680c

Alternate gene names: 41409778

Gene position: 4089503-4088334 (Counterclockwise)

Preceding gene: 41409783

Following gene: 41409771

Centisome position: 84.67

GC content: 67.01

Gene sequence:

>1170_bases
ATGGAGGAGGAGCCAGTGGCTAAGTGTGTGATGGTGCTCTACCCCGATCCCGTTGACGGGTATCCGCCGAAGTACGCCCG
CGACAGCATCCCGGTGATCAACAGCTACCCCGACGGCTCGTCGCTGCCGACGCCGTCGAAGATCGACTTCACGCCCGGTG
AGCTGCTCGGCTGCGTCTCCGGTGCCCTGGGGTTGCGCAAGTTCTTCGAAGACGGCGGGCACGAGCTGGTCGTGACGTCG
GACAAGGACGGCCCCGATTCGGAGTTCGAGCGGGAACTGCCCGACGCCGATATCGTGATCTCCCAACCGTTTTGGCCCGC
CTACATCACCAAGGAGCGGTTCGCCAAGGCGCGCAACCTCAAGCTGGCGCTGACCGCCGGCATCGGGTCGGACCACGTGG
ACCTCGCCGAGGCGCAGGCGCGCGGGGTCACCGTCGCCGAGGAAACCTGGAGCAACAGCATCAGCGTCGCCGAGCACACG
GTGATGCAGATCCTGGCGTTGGTGCGCAACTTCGTCCCGTCGCACCAGTGGATCCGCGACGGCGGCTGGAATATCGCGGA
CTGTGTGCAGCGGTCCTACGACGTGGAGGGCATGGACGTCGGGGTGATCGCCGCCGGCCGGATCGGGCGCGCGGTGCTCG
AGCGGATGAAACCCTTTGGGGTGAACCTGCACTACTTCGATGTGCACCGGCTCTCGCCGGAGTACGAGAAGCAACTCGGC
GTGACGTATCACCCCGACGTCGAGTCGCTGGCCCGCTCGGTGGACGTGGTGTCGATCCACTCGCCGCTGATCGCCCAAAC
CCATCACATGTTCAACGAGAAGCTGCTGAAGTCGATGCGGCGCGGCTCCTACATCGTCAACACCGCCCGCGCCGAGGAGA
CCGACCACAAGGCGATCGTGGCGGCGCTGGAGAGCGGCCAGCTCGCCGGCTACGCCGGCGACGTGTGGTTCCCGCAGCCG
CCGCCACCGGATCACCCGTGGCGCACCATGCCCAATCACGCGATGACGCCGCATATCTCGGGCTCCAGCCTGTCGGCGCA
GGCCCGCTACTGCGCCGGGACCCGCGAGATCCTCGAGGACTGGTTCGCCGGCCGCCCCATCCGCTCGGAATACCTGATCG
TCGAGGGCGGCAAGTTCGCCGGGACGGGGGCCAAGTCCTACGCGCAGTAG

Upstream 100 bases:

>100_bases
GTTGCCACCCGGCCGCATCGCGCGAACGCTGATATGCGGTACGGCGCCGCGCGTGGCTGCGCCGGTCGTTGAGTCGTCCG
GTCCCTGCCAGACGCAACCC

Downstream 100 bases:

>100_bases
GCGTCACGAGCGAAGTCAAGAACGACGTGGGCCGATGGCCTGTTGCAGTTCGTCGATGCACGCATCGATGACGACGGCCA
CGCTGGCCGGGCTGCCCGCG

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MEEEPVAKCVMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGELLGCVSGALGLRKFFEDGGHELVVTS
DKDGPDSEFERELPDADIVISQPFWPAYITKERFAKARNLKLALTAGIGSDHVDLAEAQARGVTVAEETWSNSISVAEHT
VMQILALVRNFVPSHQWIRDGGWNIADCVQRSYDVEGMDVGVIAAGRIGRAVLERMKPFGVNLHYFDVHRLSPEYEKQLG
VTYHPDVESLARSVDVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTARAEETDHKAIVAALESGQLAGYAGDVWFPQP
PPPDHPWRTMPNHAMTPHISGSSLSAQARYCAGTREILEDWFAGRPIRSEYLIVEGGKFAGTGAKSYAQ

Sequences:

>Translated_389_residues
MEEEPVAKCVMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGELLGCVSGALGLRKFFEDGGHELVVTS
DKDGPDSEFERELPDADIVISQPFWPAYITKERFAKARNLKLALTAGIGSDHVDLAEAQARGVTVAEETWSNSISVAEHT
VMQILALVRNFVPSHQWIRDGGWNIADCVQRSYDVEGMDVGVIAAGRIGRAVLERMKPFGVNLHYFDVHRLSPEYEKQLG
VTYHPDVESLARSVDVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTARAEETDHKAIVAALESGQLAGYAGDVWFPQP
PPPDHPWRTMPNHAMTPHISGSSLSAQARYCAGTREILEDWFAGRPIRSEYLIVEGGKFAGTGAKSYAQ
>Mature_389_residues
MEEEPVAKCVMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGELLGCVSGALGLRKFFEDGGHELVVTS
DKDGPDSEFERELPDADIVISQPFWPAYITKERFAKARNLKLALTAGIGSDHVDLAEAQARGVTVAEETWSNSISVAEHT
VMQILALVRNFVPSHQWIRDGGWNIADCVQRSYDVEGMDVGVIAAGRIGRAVLERMKPFGVNLHYFDVHRLSPEYEKQLG
VTYHPDVESLARSVDVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTARAEETDHKAIVAALESGQLAGYAGDVWFPQP
PPPDHPWRTMPNHAMTPHISGSSLSAQARYCAGTREILEDWFAGRPIRSEYLIVEGGKFAGTGAKSYAQ

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=284, Percent_Identity=32.0422535211268, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI4557497, Length=236, Percent_Identity=31.7796610169492, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI61743967, Length=236, Percent_Identity=31.7796610169492, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI145580578, Length=238, Percent_Identity=31.0924369747899, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI4557499, Length=238, Percent_Identity=31.0924369747899, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI145580575, Length=238, Percent_Identity=31.0924369747899, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI6912396, Length=305, Percent_Identity=27.5409836065574, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1787645, Length=188, Percent_Identity=31.9148936170213, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789279, Length=225, Percent_Identity=31.5555555555556, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082289, Length=252, Percent_Identity=25.3968253968254, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788660, Length=277, Percent_Identity=24.5487364620939, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081824, Length=252, Percent_Identity=25, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=292, Percent_Identity=29.7945205479452, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=237, Percent_Identity=28.2700421940928, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=356, Percent_Identity=44.6629213483146, Blast_Score=295, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6324980, Length=220, Percent_Identity=38.6363636363636, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324979, Length=124, Percent_Identity=56.4516129032258, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324055, Length=228, Percent_Identity=34.6491228070175, Blast_Score=113, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=296, Percent_Identity=26.6891891891892, Blast_Score=109, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=254, Percent_Identity=27.9527559055118, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI19921140, Length=297, Percent_Identity=30.6397306397306, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646446, Length=236, Percent_Identity=30.5084745762712, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646448, Length=236, Percent_Identity=30.5084745762712, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646452, Length=236, Percent_Identity=30.5084745762712, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646450, Length=236, Percent_Identity=30.5084745762712, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62472511, Length=236, Percent_Identity=30.5084745762712, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28571528, Length=233, Percent_Identity=27.0386266094421, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=26.2548262548263, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585514, Length=252, Percent_Identity=25.3968253968254, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574282, Length=252, Percent_Identity=25.3968253968254, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574284, Length=252, Percent_Identity=25.3968253968254, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552429, Length=252, Percent_Identity=25.3968253968254, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551003, Length=252, Percent_Identity=25.3968253968254, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585516, Length=259, Percent_Identity=23.9382239382239, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 42870; Mature: 42870

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEEPVAKCVMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGELLGCVS
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHH
GALGLRKFFEDGGHELVVTSDKDGPDSEFERELPDADIVISQPFWPAYITKERFAKARNL
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCC
KLALTAGIGSDHVDLAEAQARGVTVAEETWSNSISVAEHTVMQILALVRNFVPSHQWIRD
EEEEEECCCCCCCHHHHHHHCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHC
GGWNIADCVQRSYDVEGMDVGVIAAGRIGRAVLERMKPFGVNLHYFDVHRLSPEYEKQLG
CCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHCC
VTYHPDVESLARSVDVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTARAEETDHKAIV
CEECCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHEE
AALESGQLAGYAGDVWFPQPPPPDHPWRTMPNHAMTPHISGSSLSAQARYCAGTREILED
EEHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
WFAGRPIRSEYLIVEGGKFAGTGAKSYAQ
HHCCCCCCCCEEEEECCCCCCCCCHHCCC
>Mature Secondary Structure
MEEEPVAKCVMVLYPDPVDGYPPKYARDSIPVINSYPDGSSLPTPSKIDFTPGELLGCVS
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHH
GALGLRKFFEDGGHELVVTSDKDGPDSEFERELPDADIVISQPFWPAYITKERFAKARNL
HHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHCCC
KLALTAGIGSDHVDLAEAQARGVTVAEETWSNSISVAEHTVMQILALVRNFVPSHQWIRD
EEEEEECCCCCCCHHHHHHHCCCEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHC
GGWNIADCVQRSYDVEGMDVGVIAAGRIGRAVLERMKPFGVNLHYFDVHRLSPEYEKQLG
CCCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHCC
VTYHPDVESLARSVDVVSIHSPLIAQTHHMFNEKLLKSMRRGSYIVNTARAEETDHKAIV
CEECCCHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHEE
AALESGQLAGYAGDVWFPQPPPPDHPWRTMPNHAMTPHISGSSLSAQARYCAGTREILED
EEHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
WFAGRPIRSEYLIVEGGKFAGTGAKSYAQ
HHCCCCCCCCEEEEECCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]