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The map label for this gene is pncB1 [H]

Identifier: 41408528

GI number: 41408528

Start: 2724532

End: 2725935

Strand: Direct

Name: pncB1 [H]

Synonym: MAP2430

Alternate gene names: 41408528

Gene position: 2724532-2725935 (Clockwise)

Preceding gene: 41408517

Following gene: 41408529

Centisome position: 56.41

GC content: 71.23

Gene sequence:

>1404_bases
ATGGCCCCCACGATACCGAGGGATGGACGACGTTACCGAGCCCCGATTCGCAGCCGATACCGTTATGGAATGAACGACCC
GGTCGTCACTGGGCTCCTGACCGACAAATACGAGTTGACCATGTTGGCGGCCGCGTTGCGCGACGGCAGCGCCGGTCGGC
GGACCACCTTCGAACTGTTCGCGCGCCGGCTTCCCGAGGGACGCCGGTACGGCGTCGTGGGCGGAACCGGCCGGCTGCTC
GAGGCGCTGCCGCAGTTCACCTTCGGCGACGAGGCCTGCCAGTCGCTGCGGCAATTCCTCGATCCCGACACGCTGCGGTA
CCTGCGCGATTTTCGGTTCGGCGGCGACATCGACGGCTACGCCGAGGGCGAGCTGTATTTCCCCGGGTCGCCGGTGCTGT
CGGTGACCGGGACCTTCGCGGAATGCGTGGTGCTCGAAACGCTGGCGCTGTCGATCTTCAACCACGACACCGCGATCGCG
TCCGCCGCGGCGCGCATGGTCAGCGCGGCCAGGGGCCGGCCGCTGATCGAGATGGGGTCACGGCGCACGCATGAGCAGGC
GGCGGTGGCCGCGGCCCGCGCCGCCTACATCGCCGGCTTCGCCGCCTCCTCGAACTTGGAGGCCCAGCGCTGCTACGGAA
TTCCGGCCGAGGGCACCTCGGCGCACGCGTTCACCATGCTGCACGCCCGCACCGACGCCGCCGCGGAATCCACTGAACTG
GCGGCGTTTCGGGCACAGGTGCAGGCGCTCGGCGTCGACACCACGCTGCTGGTGGACACCTACGACGTGACGACCGGGGT
GGCCAACGCGGTGACGGCGGCCGGCGCCGGGCTGGGCGCGGTGCGCATCGACTCCGGCGAGCTGGGCGTGCTGGCCCGCC
AGGTCCGCGAGCAGCTGGACAGGCTGGGAGCCTCCCGCACCCGCATCGTGGTCTCCGGTGACCTCGACGAGTTCTCCATC
GCCGCGCTGGCCGCCGAGCCGGTGGACAGCTACGGCGTGGGCACCTCAGTGGTGACCGGTTCGGGCGCCCCGACGGCGAA
CATGGTCTACAAGCTCGTCGAGGTGGACGGCCTGCCGGTGCAGAAGCGCAGCAGCCACAAGGAATCCCGGGGCGGGCGCA
AGGAGGCGCTGCGGCTCTCCCGGGACACCGGCATCATCACCGAGGAGCTGGTCTACCCGGCCGGCCATCGGCCGGACGTC
GCCGAGCCGGCCCGGGCGGTGACGGTGCCGTTGGTGCGCGGCGGCGAGCTGGTGTCCAAACCGAACCTCGCCGCGGCGCG
CGAACTGGTAGCTTCCGGGCTGCGCAGTCTGCCGTGGGAGGGGCTGAACCTGTCCCACGGCGAACCGGCGATCCCGACCA
CCCAGATCCCGGCCGACCGGCGACGGCCGCCCGGCATCGACTGA

Upstream 100 bases:

>100_bases
CGTGACCCACGGGCTGGCCGTGACGTCCTCGGGAGCGGACTCGCGTTGTCCTGTAGTGCCCGGCCTGGACTTCGGCTCGG
TGGGCGCTGACATAACAACC

Downstream 100 bases:

>100_bases
CCGGGCTCGACCGAGCAGAACCGAGCGAAGAGGATCGTCACGTCCGAGCTTTCCGTGCCCGAGTTGCTGGCCACCGCCGT
GGCCGCGCTGGGCGGCAGCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAPTIPRDGRRYRAPIRSRYRYGMNDPVVTGLLTDKYELTMLAAALRDGSAGRRTTFELFARRLPEGRRYGVVGGTGRLL
EALPQFTFGDEACQSLRQFLDPDTLRYLRDFRFGGDIDGYAEGELYFPGSPVLSVTGTFAECVVLETLALSIFNHDTAIA
SAAARMVSAARGRPLIEMGSRRTHEQAAVAAARAAYIAGFAASSNLEAQRCYGIPAEGTSAHAFTMLHARTDAAAESTEL
AAFRAQVQALGVDTTLLVDTYDVTTGVANAVTAAGAGLGAVRIDSGELGVLARQVREQLDRLGASRTRIVVSGDLDEFSI
AALAAEPVDSYGVGTSVVTGSGAPTANMVYKLVEVDGLPVQKRSSHKESRGGRKEALRLSRDTGIITEELVYPAGHRPDV
AEPARAVTVPLVRGGELVSKPNLAAARELVASGLRSLPWEGLNLSHGEPAIPTTQIPADRRRPPGID

Sequences:

>Translated_467_residues
MAPTIPRDGRRYRAPIRSRYRYGMNDPVVTGLLTDKYELTMLAAALRDGSAGRRTTFELFARRLPEGRRYGVVGGTGRLL
EALPQFTFGDEACQSLRQFLDPDTLRYLRDFRFGGDIDGYAEGELYFPGSPVLSVTGTFAECVVLETLALSIFNHDTAIA
SAAARMVSAARGRPLIEMGSRRTHEQAAVAAARAAYIAGFAASSNLEAQRCYGIPAEGTSAHAFTMLHARTDAAAESTEL
AAFRAQVQALGVDTTLLVDTYDVTTGVANAVTAAGAGLGAVRIDSGELGVLARQVREQLDRLGASRTRIVVSGDLDEFSI
AALAAEPVDSYGVGTSVVTGSGAPTANMVYKLVEVDGLPVQKRSSHKESRGGRKEALRLSRDTGIITEELVYPAGHRPDV
AEPARAVTVPLVRGGELVSKPNLAAARELVASGLRSLPWEGLNLSHGEPAIPTTQIPADRRRPPGID
>Mature_466_residues
APTIPRDGRRYRAPIRSRYRYGMNDPVVTGLLTDKYELTMLAAALRDGSAGRRTTFELFARRLPEGRRYGVVGGTGRLLE
ALPQFTFGDEACQSLRQFLDPDTLRYLRDFRFGGDIDGYAEGELYFPGSPVLSVTGTFAECVVLETLALSIFNHDTAIAS
AAARMVSAARGRPLIEMGSRRTHEQAAVAAARAAYIAGFAASSNLEAQRCYGIPAEGTSAHAFTMLHARTDAAAESTELA
AFRAQVQALGVDTTLLVDTYDVTTGVANAVTAAGAGLGAVRIDSGELGVLARQVREQLDRLGASRTRIVVSGDLDEFSIA
ALAAEPVDSYGVGTSVVTGSGAPTANMVYKLVEVDGLPVQKRSSHKESRGGRKEALRLSRDTGIITEELVYPAGHRPDVA
EPARAVTVPLVRGGELVSKPNLAAARELVASGLRSLPWEGLNLSHGEPAIPTTQIPADRRRPPGID

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=489, Percent_Identity=31.9018404907975, Blast_Score=139, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71997952, Length=481, Percent_Identity=29.1060291060291, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71997947, Length=482, Percent_Identity=29.253112033195, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71997955, Length=207, Percent_Identity=32.8502415458937, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24581587, Length=494, Percent_Identity=28.1376518218623, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=30.5825242718447, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=30.5825242718447, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=30.5825242718447, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=30.5825242718447, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=30.5825242718447, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 49780; Mature: 49649

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPTIPRDGRRYRAPIRSRYRYGMNDPVVTGLLTDKYELTMLAAALRDGSAGRRTTFELF
CCCCCCCCCCHHHCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHH
ARRLPEGRRYGVVGGTGRLLEALPQFTFGDEACQSLRQFLDPDTLRYLRDFRFGGDIDGY
HHHCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCC
AEGELYFPGSPVLSVTGTFAECVVLETLALSIFNHDTAIASAAARMVSAARGRPLIEMGS
CCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCC
RRTHEQAAVAAARAAYIAGFAASSNLEAQRCYGIPAEGTSAHAFTMLHARTDAAAESTEL
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHH
AAFRAQVQALGVDTTLLVDTYDVTTGVANAVTAAGAGLGAVRIDSGELGVLARQVREQLD
HHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
RLGASRTRIVVSGDLDEFSIAALAAEPVDSYGVGTSVVTGSGAPTANMVYKLVEVDGLPV
HCCCCCEEEEEECCCCCHHHHHHHHCCCHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCC
QKRSSHKESRGGRKEALRLSRDTGIITEELVYPAGHRPDVAEPARAVTVPLVRGGELVSK
HHHHCCHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
PNLAAARELVASGLRSLPWEGLNLSHGEPAIPTTQIPADRRRPPGID
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
APTIPRDGRRYRAPIRSRYRYGMNDPVVTGLLTDKYELTMLAAALRDGSAGRRTTFELF
CCCCCCCCCHHHCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHH
ARRLPEGRRYGVVGGTGRLLEALPQFTFGDEACQSLRQFLDPDTLRYLRDFRFGGDIDGY
HHHCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCC
AEGELYFPGSPVLSVTGTFAECVVLETLALSIFNHDTAIASAAARMVSAARGRPLIEMGS
CCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHCC
RRTHEQAAVAAARAAYIAGFAASSNLEAQRCYGIPAEGTSAHAFTMLHARTDAAAESTEL
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHH
AAFRAQVQALGVDTTLLVDTYDVTTGVANAVTAAGAGLGAVRIDSGELGVLARQVREQLD
HHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
RLGASRTRIVVSGDLDEFSIAALAAEPVDSYGVGTSVVTGSGAPTANMVYKLVEVDGLPV
HCCCCCEEEEEECCCCCHHHHHHHHCCCHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCC
QKRSSHKESRGGRKEALRLSRDTGIITEELVYPAGHRPDVAEPARAVTVPLVRGGELVSK
HHHHCCHHHCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
PNLAAARELVASGLRSLPWEGLNLSHGEPAIPTTQIPADRRRPPGID
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]