Definition Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession NC_002944
Length 4,829,781

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The map label for this gene is ucpA [C]

Identifier: 41408508

GI number: 41408508

Start: 2706632

End: 2707453

Strand: Direct

Name: ucpA [C]

Synonym: MAP2410

Alternate gene names: 41408508

Gene position: 2706632-2707453 (Clockwise)

Preceding gene: 41408507

Following gene: 41408509

Centisome position: 56.04

GC content: 68.98

Gene sequence:

>822_bases
ATGGCCGGAAAGCTCGAGGGGCGAGTGGCTTTCATCACCGGGGCGGCCCGCGGCCAGGGCCGGGCGCATGCGGTCAGGAT
GGCCGCCGAGGGCGCCGACATCATCGCCGTCGACATCGCCGGCAAGCTGCCCTCGTGTGTCCCCTACGATCCGGCGAGCC
CGGACGACCTGAGCGAAACCGTGCGCCTGGTCGAGGCCGCGAACCGCCGGATCGTCGCCGCGGTGGTGGACACCCGCGAC
TTCGACAGGCTGCGAAAGGTGGTGGACGACGGCGTGGCCGCGTTGGGGCGCCTCGACATCATCGTCGCCAACGCCGGGGT
CGCGGCCCCGCAGGCCTGGGACGACATCACCCCGGAAGACTTCCGCGACGTCATGGACATCAACGTCACCGGCACCTGGA
ACACGGTGATGGCCGGCGCGCCCCGGATCATCGAGGGCGGCCGCGGCGGCTCCATCATCCTGATCAGTTCGGCGGCCGGA
ATGAAGATGCAGCCGTTCATGATTCACTACACGGCCAGCAAGCACGCGGTGACCGGGCTGGCGCGGGCGTTCGCCGCGGA
GTTGGGCAAGCATTCGATCCGGGTCAACAGCGTCCATCCCGGACCGGTGAACACGCCGATGGGCTCGGGCGACATGGTCA
CCGCGGTGGGCCAGGCCATGGAGACCAACCCGCAGCTGTCGCACGTGCTGACACCGTTTTTGCCCGACTGGGTCGCCGAG
CCGGAGGATATCGCCGACACGGTGTGCTGGTTGGCCAGCGACGAATCGCGCAAGGTCACCGCCGCCCAGATCCCGGTCGA
TCAGGGCTCGACCCAGTACTGA

Upstream 100 bases:

>100_bases
TGCTGCGGCTCTACGAGGGCACCAGCGAGATCCAGCGTCTGATCATCGGGTCGAACCTCGTCAAGGCGGCCCAGCGAGCC
ACTACTACGAAGGAGCGCTG

Downstream 100 bases:

>100_bases
GCGCCGGCCCCGGGAATAGATCGCGCGCGCCGCGCACTTGCAGGCCACATGAAACCCTTCAGCGAATCCGAACGCCAGGA
GTTCCTCGCCGGCACACACG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MAGKLEGRVAFITGAARGQGRAHAVRMAAEGADIIAVDIAGKLPSCVPYDPASPDDLSETVRLVEAANRRIVAAVVDTRD
FDRLRKVVDDGVAALGRLDIIVANAGVAAPQAWDDITPEDFRDVMDINVTGTWNTVMAGAPRIIEGGRGGSIILISSAAG
MKMQPFMIHYTASKHAVTGLARAFAAELGKHSIRVNSVHPGPVNTPMGSGDMVTAVGQAMETNPQLSHVLTPFLPDWVAE
PEDIADTVCWLASDESRKVTAAQIPVDQGSTQY

Sequences:

>Translated_273_residues
MAGKLEGRVAFITGAARGQGRAHAVRMAAEGADIIAVDIAGKLPSCVPYDPASPDDLSETVRLVEAANRRIVAAVVDTRD
FDRLRKVVDDGVAALGRLDIIVANAGVAAPQAWDDITPEDFRDVMDINVTGTWNTVMAGAPRIIEGGRGGSIILISSAAG
MKMQPFMIHYTASKHAVTGLARAFAAELGKHSIRVNSVHPGPVNTPMGSGDMVTAVGQAMETNPQLSHVLTPFLPDWVAE
PEDIADTVCWLASDESRKVTAAQIPVDQGSTQY
>Mature_272_residues
AGKLEGRVAFITGAARGQGRAHAVRMAAEGADIIAVDIAGKLPSCVPYDPASPDDLSETVRLVEAANRRIVAAVVDTRDF
DRLRKVVDDGVAALGRLDIIVANAGVAAPQAWDDITPEDFRDVMDINVTGTWNTVMAGAPRIIEGGRGGSIILISSAAGM
KMQPFMIHYTASKHAVTGLARAFAAELGKHSIRVNSVHPGPVNTPMGSGDMVTAVGQAMETNPQLSHVLTPFLPDWVAEP
EDIADTVCWLASDESRKVTAAQIPVDQGSTQY

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=283, Percent_Identity=32.8621908127208, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI31542939, Length=272, Percent_Identity=30.8823529411765, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI4504505, Length=197, Percent_Identity=30.4568527918782, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI7705925, Length=266, Percent_Identity=28.1954887218045, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI10190704, Length=268, Percent_Identity=27.9850746268657, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI32483357, Length=267, Percent_Identity=25.8426966292135, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI19923817, Length=274, Percent_Identity=25.1824817518248, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI66933014, Length=273, Percent_Identity=30.03663003663, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI59889578, Length=137, Percent_Identity=30.6569343065693, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4758504, Length=225, Percent_Identity=28.8888888888889, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI224922801, Length=185, Percent_Identity=34.0540540540541, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI7706318, Length=229, Percent_Identity=25.764192139738, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40254986, Length=200, Percent_Identity=28.5, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082100, Length=275, Percent_Identity=32.7272727272727, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1789208, Length=270, Percent_Identity=31.8518518518519, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789378, Length=263, Percent_Identity=32.319391634981, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1788459, Length=262, Percent_Identity=28.2442748091603, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787335, Length=266, Percent_Identity=26.6917293233083, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787905, Length=269, Percent_Identity=28.996282527881, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082160, Length=267, Percent_Identity=26.5917602996255, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367365, Length=267, Percent_Identity=28.8389513108614, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786812, Length=269, Percent_Identity=27.8810408921933, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI2367175, Length=272, Percent_Identity=27.5735294117647, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790717, Length=267, Percent_Identity=24.7191011235955, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787526, Length=262, Percent_Identity=25.5725190839695, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=277, Percent_Identity=29.6028880866426, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17561402, Length=276, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=272, Percent_Identity=29.0441176470588, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=283, Percent_Identity=27.9151943462898, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17567345, Length=206, Percent_Identity=26.6990291262136, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=279, Percent_Identity=27.5985663082437, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=285, Percent_Identity=29.1228070175439, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193204405, Length=285, Percent_Identity=29.8245614035088, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=278, Percent_Identity=26.978417266187, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=281, Percent_Identity=27.7580071174377, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=267, Percent_Identity=25.8426966292135, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562904, Length=265, Percent_Identity=26.0377358490566, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=282, Percent_Identity=28.0141843971631, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=290, Percent_Identity=27.2413793103448, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17568967, Length=200, Percent_Identity=27, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=273, Percent_Identity=28.9377289377289, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=279, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=284, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=284, Percent_Identity=28.5211267605634, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=209, Percent_Identity=26.7942583732057, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=200, Percent_Identity=27, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=209, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=278, Percent_Identity=23.7410071942446, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=263, Percent_Identity=27.7566539923954, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=25.0950570342205, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=206, Percent_Identity=26.2135922330097, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=202, Percent_Identity=25.2475247524752, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=207, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=285, Percent_Identity=26.3157894736842, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=27.5471698113208, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=276, Percent_Identity=24.6376811594203, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71997099, Length=245, Percent_Identity=25.7142857142857, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=276, Percent_Identity=26.8115942028986, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=213, Percent_Identity=28.6384976525822, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538480, Length=280, Percent_Identity=24.6428571428571, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=270, Percent_Identity=26.2962962962963, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=202, Percent_Identity=28.2178217821782, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324126, Length=266, Percent_Identity=24.4360902255639, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=273, Percent_Identity=27.8388278388278, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24643142, Length=269, Percent_Identity=29.368029739777, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644339, Length=268, Percent_Identity=26.1194029850746, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=266, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24639444, Length=269, Percent_Identity=29.7397769516729, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28571526, Length=264, Percent_Identity=26.8939393939394, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI23397609, Length=267, Percent_Identity=29.2134831460674, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357673, Length=267, Percent_Identity=28.8389513108614, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859837, Length=200, Percent_Identity=30.5, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737361, Length=258, Percent_Identity=29.8449612403101, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644337, Length=176, Percent_Identity=29.5454545454545, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281364892, Length=207, Percent_Identity=28.5024154589372, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=278, Percent_Identity=25.1798561151079, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356301, Length=201, Percent_Identity=25.3731343283582, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24649181, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24580925, Length=203, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28805; Mature: 28674

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MAGKLEGRVAFITGAARGQGRAHAVRMAAEGADIIAVDIAGKLPSCVPYDPASPDDLSET
CCCCCCCEEEEEEECCCCCCCHHEEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHH
VRLVEAANRRIVAAVVDTRDFDRLRKVVDDGVAALGRLDIIVANAGVAAPQAWDDITPED
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHH
FRDVMDINVTGTWNTVMAGAPRIIEGGRGGSIILISSAAGMKMQPFMIHYTASKHAVTGL
HHHHEEEEECCCCHHHHCCCCCEEECCCCCEEEEEECCCCCEECCEEEEEECCHHHHHHH
ARAFAAELGKHSIRVNSVHPGPVNTPMGSGDMVTAVGQAMETNPQLSHVLTPFLPDWVAE
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHCCC
PEDIADTVCWLASDESRKVTAAQIPVDQGSTQY
HHHHHHHHHEEECCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
AGKLEGRVAFITGAARGQGRAHAVRMAAEGADIIAVDIAGKLPSCVPYDPASPDDLSET
CCCCCCEEEEEEECCCCCCCHHEEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHH
VRLVEAANRRIVAAVVDTRDFDRLRKVVDDGVAALGRLDIIVANAGVAAPQAWDDITPED
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHH
FRDVMDINVTGTWNTVMAGAPRIIEGGRGGSIILISSAAGMKMQPFMIHYTASKHAVTGL
HHHHEEEEECCCCHHHHCCCCCEEECCCCCEEEEEECCCCCEECCEEEEEECCHHHHHHH
ARAFAAELGKHSIRVNSVHPGPVNTPMGSGDMVTAVGQAMETNPQLSHVLTPFLPDWVAE
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHCCC
PEDIADTVCWLASDESRKVTAAQIPVDQGSTQY
HHHHHHHHHEEECCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA