BacMap

Definition	Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession	NC_002944
Length	4,829,781

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The map label for this gene is ephD [H]

Identifier: 41408479

GI number: 41408479

Start: 2675969

End: 2676811

Strand: Direct

Name: ephD [H]

Synonym: MAP2381

Alternate gene names: 41408479

Gene position: 2675969-2676811 (Clockwise)

Preceding gene: 41408478

Following gene: 41408480

Centisome position: 55.41

GC content: 70.46

Gene sequence:

>843_bases
ATGAAGTACCAAGGGCGGGTCGTGGTGGTCACAGGCGCCGGCTCGGGCATCGGCCGGGCGCTGACGCAGGCGCTCACCGC
GGGCGGCGCGCATGTCGCGGCGTCCGACATCTACGACAACGGCCTGGCCGAAACCCAGGCGTCGTGCGGGCCCGGACAGG
TCACGCCGTATCGCATCGACGTGGCGGACCGGGATGCGGTGCTGGGCTTCGCCGATGAGGTGCGCCGCAAGCACGGACCC
GCCTCGATGGTGTTCAACAACGCCGGCGTCGACCTGTTCGCCAGCGTGGCCGACATGTCCTGGGAGGACTTCGACTGGCT
GATGGGCATCAACGTCGGCGGTGTGGTCAACGGGACCAAAGCCTTTCTGCCGCAACTCATCGAAGCCGGCTCCGACCGGC
GGCCGTCGCGGTTGGTCAACCTGTCCAGCGCCTTCGGTCTCATCGCGGTCCCCTACCAAGGGGCCTACAGCACGTCGAAG
TTCGCGGTGCGCGGTTTCACGGAGGCCCTGCGCCAGGAGATGATCATCGAACGCCATCCGGTGACGGTGCACTGCGTGCA
CCCCGGAGTCGTGCGTACCAACTTCGGCGCCAACATGCGCACCTCGGACACCGAGGATCCCGACCTGGCCGCCCAGCTCT
TCGACCGGGCGGCGCTCACCACCCCCGCCAGGGCCGCCCGGCTCATCCTGCGCGGCGCCGAGAAGAACCGGGCCCGGATC
CTGATCGGGGCCGACGGACGGGCGATGGCGGCGCTGCCCCGGCTGCTCGGTGTGGCCTATGCGGGCCTGCTGGCGCGTGC
CGCGCGGTTGACCGACTCCCGCGCGGCCCACTCCGGCCGCTGA

Upstream 100 bases:

>100_bases
GCAGCCCGTCGGGCAAGGCCGATTACCGGTGGGCGCGCGAGCAGGCGGTGAACGGATGAAACCCGCTGGGGCCGAGTGCT
TTTAGGCTAGGAGCACACCG

Downstream 100 bases:

>100_bases
CCACACCTGCGGCGCCGCAGCCGGCGGCGATCGGGGCATCGCCCCGCCATATTGTCTACTGTAATAATTACAGTATGATC
TTACGAAGAAGTGCTCGATC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKYQGRVVVVTGAGSGIGRALTQALTAGGAHVAASDIYDNGLAETQASCGPGQVTPYRIDVADRDAVLGFADEVRRKHGP
ASMVFNNAGVDLFASVADMSWEDFDWLMGINVGGVVNGTKAFLPQLIEAGSDRRPSRLVNLSSAFGLIAVPYQGAYSTSK
FAVRGFTEALRQEMIIERHPVTVHCVHPGVVRTNFGANMRTSDTEDPDLAAQLFDRAALTTPARAARLILRGAEKNRARI
LIGADGRAMAALPRLLGVAYAGLLARAARLTDSRAAHSGR

Sequences:

>Translated_280_residues
MKYQGRVVVVTGAGSGIGRALTQALTAGGAHVAASDIYDNGLAETQASCGPGQVTPYRIDVADRDAVLGFADEVRRKHGP
ASMVFNNAGVDLFASVADMSWEDFDWLMGINVGGVVNGTKAFLPQLIEAGSDRRPSRLVNLSSAFGLIAVPYQGAYSTSK
FAVRGFTEALRQEMIIERHPVTVHCVHPGVVRTNFGANMRTSDTEDPDLAAQLFDRAALTTPARAARLILRGAEKNRARI
LIGADGRAMAALPRLLGVAYAGLLARAARLTDSRAAHSGR
>Mature_280_residues
MKYQGRVVVVTGAGSGIGRALTQALTAGGAHVAASDIYDNGLAETQASCGPGQVTPYRIDVADRDAVLGFADEVRRKHGP
ASMVFNNAGVDLFASVADMSWEDFDWLMGINVGGVVNGTKAFLPQLIEAGSDRRPSRLVNLSSAFGLIAVPYQGAYSTSK
FAVRGFTEALRQEMIIERHPVTVHCVHPGVVRTNFGANMRTSDTEDPDLAAQLFDRAALTTPARAARLILRGAEKNRARI
LIGADGRAMAALPRLLGVAYAGLLARAARLTDSRAAHSGR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI142976729, Length=269, Percent_Identity=30.1115241635688, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI109715829, Length=238, Percent_Identity=27.7310924369748, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI20149619, Length=205, Percent_Identity=31.219512195122, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI210032110, Length=200, Percent_Identity=31, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4503817, Length=253, Percent_Identity=28.4584980237154, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI40807363, Length=193, Percent_Identity=31.0880829015544, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7706318, Length=251, Percent_Identity=26.6932270916335, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7705925, Length=215, Percent_Identity=31.6279069767442, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI157739938, Length=200, Percent_Identity=29, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310128830, Length=203, Percent_Identity=31.5270935960591, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310115468, Length=203, Percent_Identity=31.5270935960591, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI66933014, Length=193, Percent_Identity=32.1243523316062, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI40548397, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI214010158, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI214010156, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI22758144, Length=217, Percent_Identity=27.1889400921659, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI25282469, Length=234, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI22507405, Length=196, Percent_Identity=30.6122448979592, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI150247226, Length=199, Percent_Identity=29.1457286432161, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI19743808, Length=204, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI44680136, Length=195, Percent_Identity=31.7948717948718, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI44680133, Length=195, Percent_Identity=31.7948717948718, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI17738292, Length=195, Percent_Identity=31.7948717948718, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI15277342, Length=195, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI31542939, Length=197, Percent_Identity=29.4416243654822, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI223718074, Length=209, Percent_Identity=28.2296650717703, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI166795268, Length=209, Percent_Identity=31.1004784688995, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI32483357, Length=239, Percent_Identity=27.1966527196653, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI186928839, Length=210, Percent_Identity=28.0952380952381, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082100, Length=210, Percent_Identity=33.8095238095238, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787335, Length=201, Percent_Identity=26.3681592039801, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786701, Length=262, Percent_Identity=29.7709923664122, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789208, Length=213, Percent_Identity=24.4131455399061, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082160, Length=204, Percent_Identity=24.0196078431373, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=190, Percent_Identity=30.5263157894737, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567345, Length=173, Percent_Identity=31.7919075144509, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=189, Percent_Identity=30.1587301587302, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=232, Percent_Identity=28.448275862069, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=216, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=280, Percent_Identity=23.9285714285714, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17570069, Length=236, Percent_Identity=27.1186440677966, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534660, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557780, Length=209, Percent_Identity=27.7511961722488, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994600, Length=197, Percent_Identity=28.9340101522843, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=282, Percent_Identity=24.113475177305, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=25.3886010362694, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=214, Percent_Identity=25.2336448598131, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=209, Percent_Identity=29.1866028708134, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=199, Percent_Identity=29.6482412060301, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322067, Length=184, Percent_Identity=25.5434782608696, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21355631, Length=174, Percent_Identity=31.6091954022989, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358495, Length=205, Percent_Identity=30.2439024390244, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24649181, Length=194, Percent_Identity=29.3814432989691, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI23397609, Length=208, Percent_Identity=34.6153846153846, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=32.3699421965318, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221331218, Length=243, Percent_Identity=27.9835390946502, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24665243, Length=243, Percent_Identity=27.9835390946502, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221331216, Length=244, Percent_Identity=28.2786885245902, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640492, Length=206, Percent_Identity=30.5825242718447, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24665247, Length=244, Percent_Identity=28.2786885245902, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644339, Length=200, Percent_Identity=30, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=31.9587628865979, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24639444, Length=190, Percent_Identity=30.5263157894737, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24656154, Length=246, Percent_Identity=29.2682926829268, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922628, Length=246, Percent_Identity=29.2682926829268, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357041, Length=197, Percent_Identity=32.48730964467, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571526, Length=196, Percent_Identity=31.6326530612245, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356301, Length=255, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI28571387, Length=206, Percent_Identity=27.6699029126214, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281364494, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI221510726, Length=189, Percent_Identity=31.2169312169312, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 29674; Mature: 29674

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQGRVVVVTGAGSGIGRALTQALTAGGAHVAASDIYDNGLAETQASCGPGQVTPYRID
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEHHHHHCCCCHHCCCCCCCCCCCEEEEE
VADRDAVLGFADEVRRKHGPASMVFNNAGVDLFASVADMSWEDFDWLMGINVGGVVNGTK
ECCCCHHCCCHHHHHHHCCCHHEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCHH
AFLPQLIEAGSDRRPSRLVNLSSAFGLIAVPYQGAYSTSKFAVRGFTEALRQEMIIERHP
HHHHHHHHCCCCCCCHHHEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VTVHCVHPGVVRTNFGANMRTSDTEDPDLAAQLFDRAALTTPARAARLILRGAEKNRARI
CEEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEE
LIGADGRAMAALPRLLGVAYAGLLARAARLTDSRAAHSGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKYQGRVVVVTGAGSGIGRALTQALTAGGAHVAASDIYDNGLAETQASCGPGQVTPYRID
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEHHHHHCCCCHHCCCCCCCCCCCEEEEE
VADRDAVLGFADEVRRKHGPASMVFNNAGVDLFASVADMSWEDFDWLMGINVGGVVNGTK
ECCCCHHCCCHHHHHHHCCCHHEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCHH
AFLPQLIEAGSDRRPSRLVNLSSAFGLIAVPYQGAYSTSKFAVRGFTEALRQEMIIERHP
HHHHHHHHCCCCCCCHHHEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
VTVHCVHPGVVRTNFGANMRTSDTEDPDLAAQLFDRAALTTPARAARLILRGAEKNRARI
CEEEEECCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEE
LIGADGRAMAALPRLLGVAYAGLLARAARLTDSRAAHSGR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]