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The map label for this gene is Dml [H]

Identifier: 41408352

GI number: 41408352

Start: 2518589

End: 2519476

Strand: Direct

Name: Dml [H]

Synonym: MAP2254

Alternate gene names: 41408352

Gene position: 2518589-2519476 (Clockwise)

Preceding gene: 41408351

Following gene: 41408353

Centisome position: 52.15

GC content: 71.28

Gene sequence:

>888_bases
ATGGCCACCACACCCGCCCGCAGGCGGCTCAGGCAATTGCTGGACAACGGCGAACTCATCGTCGCCCCAGGCGTTTTCGA
CGGGCTATCGGCGCACCTGGCCCGCCGGACCGGCCACGTTGCGGCGTACCTGACCGGCGCCGGCGTGGCGGCATCGGGGT
TCGGGCTGCCCGACATCGGCCTGGTCACCGCGACCGAGATGGCGGATCGGGCGGCGATGATCGCGGCCGCATTGGGGGAT
GTCCCGCTGATCGCCGACGCCGACACCGGTTACGGCGGCCCCATGAACGTGGTGCGCACGGTTCGCGCCTACGACGCGGC
CGGGGTGGCCGCCATCCAACTGGAGGACCAGGTGTTTCCCAAACGCTGCGGTCACCTGCCCGACAAGCAGGTCGTCGACG
CCGCGGTGTTCGAACAGACGCTGGCCGCCGCGCTGGACGTCCGATCCGACGACGACCTGCTGGTGGTGGCCCGCACCGAC
GCGCGCGGCCCGCTCGGGCTGGACGCGGCGATCGAGCGCGCCAACCGGTACGCGCGCGCGGGGGCCGACATCGTCTTCGT
GGAGGCGCCGCACGACGCCGGCGAAATCGAGCGCATCGCAACCGAAGTCGACGCACCCCTGCTGATCAACCTGGTGCTCG
GCGGCCTGACGCCGCTGCAGTCGGCGGCGCGGCTGCACGAGCTGGGTTACGCCATCGCCATCCACCCCGGCGACCTGCTG
ATGCACACGACGTTCGCGATGCTGCACAGCCTGTGCGGCCTCAACGGCACCGACCCGGCCGCCCATCTGCCGGCGTCTCC
GGGCGATTTCTTCGACCTGGTGGGCATGGCGCACTGGCGGGCCCTCGACGAGAAGTACGCACACACCGGGGGCCGCACAT
GGGCATGA

Upstream 100 bases:

>100_bases
ACGCGCAGTGATCCGACTCGACGACCTGACCGACGTCGAGAACCTGATGGACCTGCTGGCCGACCCCGTCGCTGGGGCAC
TGGACTGACAAGGAACGAAG

Downstream 100 bases:

>100_bases
CCGTCATCGAGAAGATCTTGGCCCGCAAGGCCGGGCTGGACTCCGTGTCATCGGGCGACACCGTCGTCGTAGACGTCGAC
ATGACCGTCCTGATCGACCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MATTPARRRLRQLLDNGELIVAPGVFDGLSAHLARRTGHVAAYLTGAGVAASGFGLPDIGLVTATEMADRAAMIAAALGD
VPLIADADTGYGGPMNVVRTVRAYDAAGVAAIQLEDQVFPKRCGHLPDKQVVDAAVFEQTLAAALDVRSDDDLLVVARTD
ARGPLGLDAAIERANRYARAGADIVFVEAPHDAGEIERIATEVDAPLLINLVLGGLTPLQSAARLHELGYAIAIHPGDLL
MHTTFAMLHSLCGLNGTDPAAHLPASPGDFFDLVGMAHWRALDEKYAHTGGRTWA

Sequences:

>Translated_295_residues
MATTPARRRLRQLLDNGELIVAPGVFDGLSAHLARRTGHVAAYLTGAGVAASGFGLPDIGLVTATEMADRAAMIAAALGD
VPLIADADTGYGGPMNVVRTVRAYDAAGVAAIQLEDQVFPKRCGHLPDKQVVDAAVFEQTLAAALDVRSDDDLLVVARTD
ARGPLGLDAAIERANRYARAGADIVFVEAPHDAGEIERIATEVDAPLLINLVLGGLTPLQSAARLHELGYAIAIHPGDLL
MHTTFAMLHSLCGLNGTDPAAHLPASPGDFFDLVGMAHWRALDEKYAHTGGRTWA
>Mature_294_residues
ATTPARRRLRQLLDNGELIVAPGVFDGLSAHLARRTGHVAAYLTGAGVAASGFGLPDIGLVTATEMADRAAMIAAALGDV
PLIADADTGYGGPMNVVRTVRAYDAAGVAAIQLEDQVFPKRCGHLPDKQVVDAAVFEQTLAAALDVRSDDDLLVVARTDA
RGPLGLDAAIERANRYARAGADIVFVEAPHDAGEIERIATEVDAPLLINLVLGGLTPLQSAARLHELGYAIAIHPGDLLM
HTTFAMLHSLCGLNGTDPAAHLPASPGDFFDLVGMAHWRALDEKYAHTGGRTWA

Specific function: Catalyzes the formation of proponate and pyruvate from (2R,3S)-2,3-dimethylmalate. Has no activity toward dimethylmaleate, malate, citramalate, isocitrate and citrate [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=214, Percent_Identity=40.6542056074766, Blast_Score=147, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6325263, Length=207, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.32 [H]

Molecular weight: Translated: 30945; Mature: 30813

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTPARRRLRQLLDNGELIVAPGVFDGLSAHLARRTGHVAAYLTGAGVAASGFGLPDIG
CCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCH
LVTATEMADRAAMIAAALGDVPLIADADTGYGGPMNVVRTVRAYDAAGVAAIQLEDQVFP
HEEHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHH
KRCGHLPDKQVVDAAVFEQTLAAALDVRSDDDLLVVARTDARGPLGLDAAIERANRYARA
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
GADIVFVEAPHDAGEIERIATEVDAPLLINLVLGGLTPLQSAARLHELGYAIAIHPGDLL
CCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCHHH
MHTTFAMLHSLCGLNGTDPAAHLPASPGDFFDLVGMAHWRALDEKYAHTGGRTWA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ATTPARRRLRQLLDNGELIVAPGVFDGLSAHLARRTGHVAAYLTGAGVAASGFGLPDIG
CCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCH
LVTATEMADRAAMIAAALGDVPLIADADTGYGGPMNVVRTVRAYDAAGVAAIQLEDQVFP
HEEHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHH
KRCGHLPDKQVVDAAVFEQTLAAALDVRSDDDLLVVARTDARGPLGLDAAIERANRYARA
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
GADIVFVEAPHDAGEIERIATEVDAPLLINLVLGGLTPLQSAARLHELGYAIAIHPGDLL
CCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCEEEEECCCHHH
MHTTFAMLHSLCGLNGTDPAAHLPASPGDFFDLVGMAHWRALDEKYAHTGGRTWA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA