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The map label for this gene is tyrS

Identifier: 41407494

GI number: 41407494

Start: 1509305

End: 1510570

Strand: Direct

Name: tyrS

Synonym: MAP1396

Alternate gene names: 41407494

Gene position: 1509305-1510570 (Clockwise)

Preceding gene: 41407493

Following gene: 41407495

Centisome position: 31.25

GC content: 71.48

Gene sequence:

>1266_bases
ATGTCTTCCGGGATCCTCGACGAGCTGGGCTGGCGCGGCCTGATCGCGCAGTCCACCGACCTCGACGCGCTGGCCGCCGA
AGCCCGGCCGATGACCGTGTACGCCGGCTTCGACCCCACCGCGCCGAGCCTGCACGCCGGACACCTGGTGCCGCTGCTGG
CGCTGCGCCGGTTCCAGCGCGCCGGCCACCGCCCGATCGTGCTGGCAGGCGGCGCCACCGGCATGATCGGCGACCCGCGC
GACGTCGGCGAGCGCACCCTCAACGAGGCCGACACCGTCGCCGAGTGGACCGAGCGGATCCGCGGCCAGCTGGAGCGGTT
CGTCGACTTCGACGAATCGGACACCGGCGCCGTCGTCGTCAACAACCTGGACTGGACCCGCCAACTGTCGGCGATCGAGT
TCCTGCGCGACCTCGGCAAGCATTTCTCGGTCAACGTCATGCTGGACCGCGACACCGTCCGGCGGCGGCTGGAGGGCGAC
GGCATCTCCTACACCGAGTTCAGCTACATGCTGTTGCAGGCCAACGACTACGTCGAGTTGCACCGGCGCTACGGGTGCGT
GCTGCAGATCGGCGGGTCCGACCAGTGGGGCAACATCATCGCCGGGGTGCGGCTGGTCCGTCAGAAGCTGGGCGCGACGG
TGCACGCGCTGACGGTGCCGCTGGTGACCGCCGCCGACGGCACCAAGTTCGGCAAGTCCACCGGCGGCGGCAGCCTGTGG
CTTGACCCCGCGCTGACCACGCCGTACGCGTGGTACCAGTACTTCTTCAACACCGCCGACGCCGACGTGATCCGCTACCT
GCGCTGGTTCACCTTCCTGAGCGCCGACGAGCTGGGCGAGCTGGAGCGGGCCACCGCCGAGCGCCCCCAGCAGCGCGCCG
CGCAGCGGCGGCTGGCCCGCGAGCTGACCGTGCTGGTGCACGGCGAGGCGGCCACCGAAGCGGTCAAGCACGCCAGCCGG
GCGCTGTTCGGGCAGGGAGAGCTGGAGCGCCTCGACGCAGCCACGCTGGCGGCGGCGCTGCGCGAGACGTCGGTCGCCGA
GCTCAAACCCGGTGCGCCCGACGGGATCGTCGACCTGTTGGTGGCCAGCGGCCTGTCCGAGAGCCGCAAGGCCGCCCGGC
GCACCCTCGGCGAGGGCGGCGTCTCGGTCAACAACGTGCGCATCGACCGCGAGGACTGGGCGCCGCAACCGTCCGACTTC
CTGCACGGCAAATGGCTGGTGCTGCGCCGCGGCAAGCGCACCATCGCCGGGGTGGAAAAGCTGTAG

Upstream 100 bases:

>100_bases
GGCCGTGGCGGCTGTGGCTGCCCGGGCGCCCGGAGGTGTCGGCCTACCGGCGAAGTCCGCGGGCGCCCGCCCCCGGGACC
AGCGACTAAAGTCGGCGGCG

Downstream 100 bases:

>100_bases
ACCACCGCCGGCCCGACGGCCGCGCAAAACGCGTACGTGTGCACAATCTTTACCTCACCGTGTCGTCGACGTGACCGTGG
CCGAGCACTGTGGTCACGGT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSSGILDELGWRGLIAQSTDLDALAAEARPMTVYAGFDPTAPSLHAGHLVPLLALRRFQRAGHRPIVLAGGATGMIGDPR
DVGERTLNEADTVAEWTERIRGQLERFVDFDESDTGAVVVNNLDWTRQLSAIEFLRDLGKHFSVNVMLDRDTVRRRLEGD
GISYTEFSYMLLQANDYVELHRRYGCVLQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKSTGGGSLW
LDPALTTPYAWYQYFFNTADADVIRYLRWFTFLSADELGELERATAERPQQRAAQRRLARELTVLVHGEAATEAVKHASR
ALFGQGELERLDAATLAAALRETSVAELKPGAPDGIVDLLVASGLSESRKAARRTLGEGGVSVNNVRIDREDWAPQPSDF
LHGKWLVLRRGKRTIAGVEKL

Sequences:

>Translated_421_residues
MSSGILDELGWRGLIAQSTDLDALAAEARPMTVYAGFDPTAPSLHAGHLVPLLALRRFQRAGHRPIVLAGGATGMIGDPR
DVGERTLNEADTVAEWTERIRGQLERFVDFDESDTGAVVVNNLDWTRQLSAIEFLRDLGKHFSVNVMLDRDTVRRRLEGD
GISYTEFSYMLLQANDYVELHRRYGCVLQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKSTGGGSLW
LDPALTTPYAWYQYFFNTADADVIRYLRWFTFLSADELGELERATAERPQQRAAQRRLARELTVLVHGEAATEAVKHASR
ALFGQGELERLDAATLAAALRETSVAELKPGAPDGIVDLLVASGLSESRKAARRTLGEGGVSVNNVRIDREDWAPQPSDF
LHGKWLVLRRGKRTIAGVEKL
>Mature_420_residues
SSGILDELGWRGLIAQSTDLDALAAEARPMTVYAGFDPTAPSLHAGHLVPLLALRRFQRAGHRPIVLAGGATGMIGDPRD
VGERTLNEADTVAEWTERIRGQLERFVDFDESDTGAVVVNNLDWTRQLSAIEFLRDLGKHFSVNVMLDRDTVRRRLEGDG
ISYTEFSYMLLQANDYVELHRRYGCVLQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKSTGGGSLWL
DPALTTPYAWYQYFFNTADADVIRYLRWFTFLSADELGELERATAERPQQRAAQRRLARELTVLVHGEAATEAVKHASRA
LFGQGELERLDAATLAAALRETSVAELKPGAPDGIVDLLVASGLSESRKAARRTLGEGGVSVNNVRIDREDWAPQPSDFL
HGKWLVLRRGKRTIAGVEKL

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=373, Percent_Identity=37.5335120643432, Blast_Score=218, Evalue=7e-57,
Organism=Escherichia coli, GI1787925, Length=421, Percent_Identity=47.0308788598575, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI25145802, Length=312, Percent_Identity=37.8205128205128, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI25145805, Length=213, Percent_Identity=36.6197183098592, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6325160, Length=449, Percent_Identity=33.184855233853, Blast_Score=241, Evalue=1e-64,
Organism=Drosophila melanogaster, GI20130383, Length=375, Percent_Identity=37.8666666666667, Blast_Score=252, Evalue=4e-67,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_MYCPA (Q740F5)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960330.1
- ProteinModelPortal:   Q740F5
- SMR:   Q740F5
- EnsemblBacteria:   EBMYCT00000037960
- GeneID:   2719591
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1396
- NMPDR:   fig|262316.1.peg.1396
- GeneTree:   EBGT00050000017241
- HOGENOM:   HBG288125
- OMA:   TFYIGFD
- ProtClustDB:   PRK05912
- BRENDA:   6.1.1.1
- GO:   GO:0005737
- HAMAP:   MF_02006
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 46300; Mature: 46169

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 34-34 BINDING 169-169 BINDING 173-173 BINDING 232-232

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSGILDELGWRGLIAQSTDLDALAAEARPMTVYAGFDPTAPSLHAGHLVPLLALRRFQR
CCCCCCHHHCCCCEEECCCCHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
AGHRPIVLAGGATGMIGDPRDVGERTLNEADTVAEWTERIRGQLERFVDFDESDTGAVVV
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
NNLDWTRQLSAIEFLRDLGKHFSVNVMLDRDTVRRRLEGDGISYTEFSYMLLQANDYVEL
ECCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHCCCCCCCHHEEEEEEECCCHHHH
HRRYGCVLQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKSTGGGSLW
HHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEHHEEEEEECCCCCCCCCCCCCCEE
LDPALTTPYAWYQYFFNTADADVIRYLRWFTFLSADELGELERATAERPQQRAAQRRLAR
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHH
ELTVLVHGEAATEAVKHASRALFGQGELERLDAATLAAALRETSVAELKPGAPDGIVDLL
HHEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VASGLSESRKAARRTLGEGGVSVNNVRIDREDWAPQPSDFLHGKWLVLRRGKRTIAGVEK
HHCCCCHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCHHCCCCEEEEECCCHHHHHHCC
L
C
>Mature Secondary Structure 
SSGILDELGWRGLIAQSTDLDALAAEARPMTVYAGFDPTAPSLHAGHLVPLLALRRFQR
CCCCCHHHCCCCEEECCCCHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
AGHRPIVLAGGATGMIGDPRDVGERTLNEADTVAEWTERIRGQLERFVDFDESDTGAVVV
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
NNLDWTRQLSAIEFLRDLGKHFSVNVMLDRDTVRRRLEGDGISYTEFSYMLLQANDYVEL
ECCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHCCCCCCCHHEEEEEEECCCHHHH
HRRYGCVLQIGGSDQWGNIIAGVRLVRQKLGATVHALTVPLVTAADGTKFGKSTGGGSLW
HHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEHHEEEEEECCCCCCCCCCCCCCEE
LDPALTTPYAWYQYFFNTADADVIRYLRWFTFLSADELGELERATAERPQQRAAQRRLAR
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHHHH
ELTVLVHGEAATEAVKHASRALFGQGELERLDAATLAAALRETSVAELKPGAPDGIVDLL
HHEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
VASGLSESRKAARRTLGEGGVSVNNVRIDREDWAPQPSDFLHGKWLVLRRGKRTIAGVEK
HHCCCCHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCHHCCCCEEEEECCCHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA