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The map label for this gene is pheS

Identifier: 41407457

GI number: 41407457

Start: 1459912

End: 1460955

Strand: Direct

Name: pheS

Synonym: MAP1359

Alternate gene names: 41407457

Gene position: 1459912-1460955 (Clockwise)

Preceding gene: 41407456

Following gene: 41407458

Centisome position: 30.23

GC content: 70.59

Gene sequence:

>1044_bases
GTGGGTGATCAACCCGTGGACCTGTCGGAAACAGCGTTGGCCGAGGCGGTCGGCGCCGCGCGGCAGGCCTTCGCCCGGGC
CGGCGACCTCGACGCGTTGGCGCGCCTGAAGACCGAGCACCTCGGTGACCGGGCGCCGCTGGCCCTGGCACGCCAGGCGC
TCGGCGGCGTCCCCAAGGACCAGCGCGCCGACGCGGGCAGGCGGGTCAACGCCGCACGCGCGCAGGCCCAGCAGGCCTAC
GACGAACGCCTGGACGTGTTGCGCGCCGAACGCGACGCCGCGGTGCTGGTCGCCGAACGCATCGACGTCACCCTGCCGTC
GACCCGGCAGCCGGTCGGCGCCCGGCATCCCATCACGATCCTGGCCGAACACATCGCCGACACCTTCATCGCGATGGGCT
GGGAACTGGCCGAGGGGCCCGAGGTGGAAGCCGAGCAGTTCAACTTCGACGCGCTCAACTTCCCCGCCGACCACCCGGCG
CGCAGCGAACAGGACACCTTTTACATCGCGCCGGAGGGTTCCCGGCAGCTGTTGCGCACCCACACCTCGCCGGTGCAGGT
GCGCACGCTGCTCGCCCGCGAGCTGCCGGTCTACGTCATCTCGATCGGGCGCACCTTCCGCACCGACGAACTCGATGCCA
CCCACACCCCGGTCTTCCACCAGGTCGAGGGCCTGGCCGTGGACCGCGGCCTGTCCATGGCGCACCTGCGCGGAACGCTG
GATGCGTTCGCGCGAGCAGAATTCGGCCCGCAGGCGCGGACCCGGATCCGGCCGCACTTCTTCCCGTTCACCGAACCGTC
CGCCGAGGTCGACGTGTGGTTCGTCGGCAAGAAGGGCGGCGCCGGCTGGGTGGAGTGGGGCGGCTGCGGAATGGTGCATC
CAAATGTGTTGCGGGCCGCCGGAATCGACCCGGACGTCTACTCCGGGTTCGCATTCGGAATGGGCCTGGAGCGAACCCTG
CAGTTCCGCAACGGGATTCCGGACATGCGTGACATGGTCGAGGGCGACGTGCGGTTCTTGCTGCCGTTCGGGGTGGGCGC
CTGA

Upstream 100 bases:

>100_bases
GGTTCGCGTAGCGACCGAGGAGGAGCCGGGCGAATCGAACCCAGCGCGGCGCCGATGCGGGCAGCCCGTAGAGCCTCGTC
AGCAAGGAGAGTGTCGCCGC

Downstream 100 bases:

>100_bases
TGCGCGTTCCGTACAGCTGGTTGCGCGAGGTCGTGGCCGCCGGGGCGCCGGACTGGGACGTCGCCCCCGCCGAACTGGAA
CAGACCCTGATCCGCATCGG

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MGDQPVDLSETALAEAVGAARQAFARAGDLDALARLKTEHLGDRAPLALARQALGGVPKDQRADAGRRVNAARAQAQQAY
DERLDVLRAERDAAVLVAERIDVTLPSTRQPVGARHPITILAEHIADTFIAMGWELAEGPEVEAEQFNFDALNFPADHPA
RSEQDTFYIAPEGSRQLLRTHTSPVQVRTLLARELPVYVISIGRTFRTDELDATHTPVFHQVEGLAVDRGLSMAHLRGTL
DAFARAEFGPQARTRIRPHFFPFTEPSAEVDVWFVGKKGGAGWVEWGGCGMVHPNVLRAAGIDPDVYSGFAFGMGLERTL
QFRNGIPDMRDMVEGDVRFLLPFGVGA

Sequences:

>Translated_347_residues
MGDQPVDLSETALAEAVGAARQAFARAGDLDALARLKTEHLGDRAPLALARQALGGVPKDQRADAGRRVNAARAQAQQAY
DERLDVLRAERDAAVLVAERIDVTLPSTRQPVGARHPITILAEHIADTFIAMGWELAEGPEVEAEQFNFDALNFPADHPA
RSEQDTFYIAPEGSRQLLRTHTSPVQVRTLLARELPVYVISIGRTFRTDELDATHTPVFHQVEGLAVDRGLSMAHLRGTL
DAFARAEFGPQARTRIRPHFFPFTEPSAEVDVWFVGKKGGAGWVEWGGCGMVHPNVLRAAGIDPDVYSGFAFGMGLERTL
QFRNGIPDMRDMVEGDVRFLLPFGVGA
>Mature_346_residues
GDQPVDLSETALAEAVGAARQAFARAGDLDALARLKTEHLGDRAPLALARQALGGVPKDQRADAGRRVNAARAQAQQAYD
ERLDVLRAERDAAVLVAERIDVTLPSTRQPVGARHPITILAEHIADTFIAMGWELAEGPEVEAEQFNFDALNFPADHPAR
SEQDTFYIAPEGSRQLLRTHTSPVQVRTLLARELPVYVISIGRTFRTDELDATHTPVFHQVEGLAVDRGLSMAHLRGTLD
AFARAEFGPQARTRIRPHFFPFTEPSAEVDVWFVGKKGGAGWVEWGGCGMVHPNVLRAAGIDPDVYSGFAFGMGLERTLQ
FRNGIPDMRDMVEGDVRFLLPFGVGA

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4758340, Length=273, Percent_Identity=32.6007326007326, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI5729820, Length=276, Percent_Identity=31.1594202898551, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1788007, Length=331, Percent_Identity=48.036253776435, Blast_Score=299, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI32563657, Length=261, Percent_Identity=34.0996168582375, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17508957, Length=261, Percent_Identity=34.0996168582375, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI32566635, Length=301, Percent_Identity=31.2292358803987, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6321087, Length=264, Percent_Identity=32.1969696969697, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6325304, Length=279, Percent_Identity=28.3154121863799, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18858079, Length=271, Percent_Identity=33.210332103321, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI17137424, Length=287, Percent_Identity=28.9198606271777, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_MYCPA (Q740J1)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960293.1
- ProteinModelPortal:   Q740J1
- SMR:   Q740J1
- EnsemblBacteria:   EBMYCT00000036907
- GeneID:   2719916
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1359
- NMPDR:   fig|262316.1.peg.1359
- GeneTree:   EBGT00050000016426
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- ProtClustDB:   PRK00488
- BRENDA:   6.1.1.20
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 37935; Mature: 37804

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDQPVDLSETALAEAVGAARQAFARAGDLDALARLKTEHLGDRAPLALARQALGGVPKD
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCH
QRADAGRRVNAARAQAQQAYDERLDVLRAERDAAVLVAERIDVTLPSTRQPVGARHPITI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCEECCCCCCCCCCCCCHHH
LAEHIADTFIAMGWELAEGPEVEAEQFNFDALNFPADHPARSEQDTFYIAPEGSRQLLRT
HHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEECCCCCCCCCCCCCEEEECCCCCHHHHHH
HTSPVQVRTLLARELPVYVISIGRTFRTDELDATHTPVFHQVEGLAVDRGLSMAHLRGTL
CCCHHHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCHHHHHCCEEHHCCCCHHHHHHHH
DAFARAEFGPQARTRIRPHFFPFTEPSAEVDVWFVGKKGGAGWVEWGGCGMVHPNVLRAA
HHHHHHCCCCHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCHHHHHC
GIDPDVYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFLLPFGVGA
CCCCHHHCCHHHHCCHHHHHHHHCCCCHHHHHHCCCEEEEEECCCCC
>Mature Secondary Structure 
GDQPVDLSETALAEAVGAARQAFARAGDLDALARLKTEHLGDRAPLALARQALGGVPKD
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCH
QRADAGRRVNAARAQAQQAYDERLDVLRAERDAAVLVAERIDVTLPSTRQPVGARHPITI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCEECCCCCCCCCCCCCHHH
LAEHIADTFIAMGWELAEGPEVEAEQFNFDALNFPADHPARSEQDTFYIAPEGSRQLLRT
HHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEECCCCCCCCCCCCCEEEECCCCCHHHHHH
HTSPVQVRTLLARELPVYVISIGRTFRTDELDATHTPVFHQVEGLAVDRGLSMAHLRGTL
CCCHHHHHHHHHHHCCEEEEEECCEECCCCCCCCCCCHHHHHCCEEHHCCCCHHHHHHHH
DAFARAEFGPQARTRIRPHFFPFTEPSAEVDVWFVGKKGGAGWVEWGGCGMVHPNVLRAA
HHHHHHCCCCHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEECCCCCCCCHHHHHC
GIDPDVYSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFLLPFGVGA
CCCCHHHCCHHHHCCHHHHHHHHCCCCHHHHHHCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA