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The map label for this gene is uvrB

Identifier: 41407433

GI number: 41407433

Start: 1430271

End: 1432439

Strand: Direct

Name: uvrB

Synonym: MAP1335

Alternate gene names: 41407433

Gene position: 1430271-1432439 (Clockwise)

Preceding gene: 41407432

Following gene: 41407434

Centisome position: 29.61

GC content: 68.19

Gene sequence:

>2169_bases
ATGGCATTTGCCACGGAACATCCAGTAGTCGCGCATTCGGAGTACCGCCCGGCCGAGGAGGCCGTCGAAGGGTTGGTGCG
GGCCGGCGGCCGCTTCGAGGTGGTCAGCCCGCACGCGCCGGCCGGTGACCAGCCGGCCGCCATCGACGAGCTCGAGCGCC
GCATCAGGGCGGGGGAGCGCGACGTGGTGCTGCTCGGGGCCACCGGCACCGGCAAGTCGGCCACCACCGCCTGGCTCATC
GAGCGGCTGCAACGGCCCACGCTGGTGATGGCGCCCAACAAGACGCTGGCCGCCCAGCTGGCCAACGAACTGCGAGAGAT
GTTGCCGCACAACGCGGTTGAATACTTCGTGTCGTACTACGACTACTACCAGCCCGAGGCGTACATCGCGCAGACCGACA
CCTACATCGAAAAGGACAGCTCCATCAACGACGACGTCGAGCGCCTCAGGCACTCGGCGACCTCGAGCCTGCTGTCGCGC
CGCGACGTGGTGGTGGTGGCCTCGGTGTCGTGCATCTACGGCCTGGGCACGCCGCAGTCCTACCTGGACCGCTCGGTGGA
GCTGCGGGTCGGCACCGAGGTGCCCCGCGACGCCCTGCTGCGGCTGCTGGTCGACGTCCAATACACCCGCAACGACCTGT
CCTTCACCCGCGGCTCGTTCCGGGTCCGCGGCGACACCGTCGAGATCATCCCGTCCTACGAAGAGCTGGCGGTGCGCATC
GAGTTCTTCGGCGACGAGATCGAGGCGTTGTACTACCTGCACCCGCTGACCGGCGACGTGATCCGCCAAGTCGACTCGCT
GCGGATCTTCCCGGCCACCCACTACGTGGCCGGCCCGGAAAGAATGGCCCACGCCATCTCCACCATCGAGCAGGAACTGG
CCGAGCGGCTGGCCGAACTGGAGGGCCAGGGCAAGCTGCTGGAGGCCCAACGGCTGCGGATGCGCACCAACTACGACATC
GAGATGATGCGCCAGGTCGGATTCTGCTCGGGCATCGAGAACTACTCGCGCCACATCGACGGCCGCGGCCCGGGCTCGCC
GCCGGCCACCCTGCTCGACTACTTCCCGGAAGACTTCCTGCTGGTCATCGACGAGTCCCACGTCACCGTCCCGCAGATCG
GCGGCATGTACGAAGGCGACATGTCGCGCAAACGCAACCTGGTCGAGTACGGGTTCCGGCTGCCGTCGGCCTGCGACAAC
CGCCCGCTCACCTGGGAGGAGTTCGCCGACCGCATCGGCCAGACGGTCTACCTGTCGGCCACCCCGGGCCCGTACGAACT
CAGCCAGACCGGCGGCGAGTTCGTCGAGCAGGTGATCCGCCCCACCGGGCTGGTCGATCCCAAGGTGGTGGTCAAGCCGA
CCAAGGGGCAGATCGACGATCTGATCGGCGAAATCCGCAAGCGCACCGAGGCCGACGAACGGGTGCTGGTCACGACGCTG
ACCAAGAAGATGGCCGAAGACCTCACCGACTACCTGCTGGAGATGGGCATCCGGGTGCGCTACCTGCACTCCGAGGTCGA
CACGTTGCGCCGGGTGGAGCTGCTGCGCCAGCTGAGGCTGGGCGAGTACGACGTGCTGGTCGGCATCAACCTGCTGCGTG
AGGGCCTCGACCTGCCCGAGGTGTCGCTGGTGGCGATCCTGGACGCCGACAAGGAAGGCTTCCTGCGGTCCGCGCGCAGC
CTGATTCAAACCATCGGCCGCGCCGCCCGCAACGTCTCCGGCGAGGTGCACATGTACGCCGACACCATCACCGAGTCGAT
GAAGGAGGCCATCGACGAGACCGAGCGGCGCCGGGCCAAGCAGATCGCCTACAACGAGGCCCACGGCATCGACCCGCAGC
CGCTGCGCAAGAAGATCGCCGACATCCTCGACCAGGTCTACCGTGAGGCCGACGACACCGACACCGTCGAGATCGGCTCC
GGGCGCAGCATGTCCCGCGGGCGGCGCGCCCAGGGCGAGCCCGGCCGGGCCGTCAGCGCCGGCATCGTCGAGGGCCGCGA
CACCACCAACATGCCCCGCGCCGAGCTGGCCGACCTGATCAAGGACCTCACCGCGCAGATGATGGCCGCGGCCCGCGACC
TGCAGTTCGAGCTGGCCGCGCGGTTCCGCGACGAGATCGCCGACCTGAAGAAGGAGCTGCGCGGGATGGACGCCGCCGGC
CTGAAATGA

Upstream 100 bases:

>100_bases
CGACCCACCGTGATCGATCCGGTCACCGCGCGACCAGCGTGAGCCACCTTCGCGAACCCGCCCCGCCGCACTTGTCGGTG
ATCGCCTCTACCCTGGTGAC

Downstream 100 bases:

>100_bases
GTTTGCTGGCAACCGATCTCCAGCTCGCATCGCCGCGGCACGCCATACGGCGCCATGCAGGGGGTGGCCGGCGGCTTGCT
GGCCGGCCTGGGCTACGCGG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MAFATEHPVVAHSEYRPAEEAVEGLVRAGGRFEVVSPHAPAGDQPAAIDELERRIRAGERDVVLLGATGTGKSATTAWLI
ERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSR
RDVVVVASVSCIYGLGTPQSYLDRSVELRVGTEVPRDALLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRI
EFFGDEIEALYYLHPLTGDVIRQVDSLRIFPATHYVAGPERMAHAISTIEQELAERLAELEGQGKLLEAQRLRMRTNYDI
EMMRQVGFCSGIENYSRHIDGRGPGSPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDN
RPLTWEEFADRIGQTVYLSATPGPYELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRTEADERVLVTTL
TKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARS
LIQTIGRAARNVSGEVHMYADTITESMKEAIDETERRRAKQIAYNEAHGIDPQPLRKKIADILDQVYREADDTDTVEIGS
GRSMSRGRRAQGEPGRAVSAGIVEGRDTTNMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKKELRGMDAAG
LK

Sequences:

>Translated_722_residues
MAFATEHPVVAHSEYRPAEEAVEGLVRAGGRFEVVSPHAPAGDQPAAIDELERRIRAGERDVVLLGATGTGKSATTAWLI
ERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSR
RDVVVVASVSCIYGLGTPQSYLDRSVELRVGTEVPRDALLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRI
EFFGDEIEALYYLHPLTGDVIRQVDSLRIFPATHYVAGPERMAHAISTIEQELAERLAELEGQGKLLEAQRLRMRTNYDI
EMMRQVGFCSGIENYSRHIDGRGPGSPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDN
RPLTWEEFADRIGQTVYLSATPGPYELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRTEADERVLVTTL
TKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARS
LIQTIGRAARNVSGEVHMYADTITESMKEAIDETERRRAKQIAYNEAHGIDPQPLRKKIADILDQVYREADDTDTVEIGS
GRSMSRGRRAQGEPGRAVSAGIVEGRDTTNMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKKELRGMDAAG
LK
>Mature_721_residues
AFATEHPVVAHSEYRPAEEAVEGLVRAGGRFEVVSPHAPAGDQPAAIDELERRIRAGERDVVLLGATGTGKSATTAWLIE
RLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRR
DVVVVASVSCIYGLGTPQSYLDRSVELRVGTEVPRDALLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRIE
FFGDEIEALYYLHPLTGDVIRQVDSLRIFPATHYVAGPERMAHAISTIEQELAERLAELEGQGKLLEAQRLRMRTNYDIE
MMRQVGFCSGIENYSRHIDGRGPGSPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNR
PLTWEEFADRIGQTVYLSATPGPYELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRTEADERVLVTTLT
KKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSARSL
IQTIGRAARNVSGEVHMYADTITESMKEAIDETERRRAKQIAYNEAHGIDPQPLRKKIADILDQVYREADDTDTVEIGSG
RSMSRGRRAQGEPGRAVSAGIVEGRDTTNMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKKELRGMDAAGL
K

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=682, Percent_Identity=56.4516129032258, Blast_Score=743, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=226, Percent_Identity=23.8938053097345, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80922; Mature: 80791

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFATEHPVVAHSEYRPAEEAVEGLVRAGGRFEVVSPHAPAGDQPAAIDELERRIRAGER
CCCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCC
DVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYY
CEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
DYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQS
HHCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHH
YLDRSVELRVGTEVPRDALLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRI
HHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCHHHHEEEH
EFFGDEIEALYYLHPLTGDVIRQVDSLRIFPATHYVAGPERMAHAISTIEQELAERLAEL
EECCCCEEEEEEECCCCHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EGQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGSPPATLLDYFPEDFL
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEE
LVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSA
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEEC
TPGPYELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRTEADERVLVTTL
CCCCCCHHHCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHH
TKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPE
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
VSLVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITESMKEAIDETERRRAK
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
QIAYNEAHGIDPQPLRKKIADILDQVYREADDTDTVEIGSGRSMSRGRRAQGEPGRAVSA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEC
GIVEGRDTTNMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKKELRGMDAAG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LK
CC
>Mature Secondary Structure 
AFATEHPVVAHSEYRPAEEAVEGLVRAGGRFEVVSPHAPAGDQPAAIDELERRIRAGER
CCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCC
DVVLLGATGTGKSATTAWLIERLQRPTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYY
CEEEEECCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHH
DYYQPEAYIAQTDTYIEKDSSINDDVERLRHSATSSLLSRRDVVVVASVSCIYGLGTPQS
HHCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHH
YLDRSVELRVGTEVPRDALLRLLVDVQYTRNDLSFTRGSFRVRGDTVEIIPSYEELAVRI
HHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEECCCHHHHEEEH
EFFGDEIEALYYLHPLTGDVIRQVDSLRIFPATHYVAGPERMAHAISTIEQELAERLAEL
EECCCCEEEEEEECCCCHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EGQGKLLEAQRLRMRTNYDIEMMRQVGFCSGIENYSRHIDGRGPGSPPATLLDYFPEDFL
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCEE
LVIDESHVTVPQIGGMYEGDMSRKRNLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSA
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCEEEEEC
TPGPYELSQTGGEFVEQVIRPTGLVDPKVVVKPTKGQIDDLIGEIRKRTEADERVLVTTL
CCCCCCHHHCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHH
TKKMAEDLTDYLLEMGIRVRYLHSEVDTLRRVELLRQLRLGEYDVLVGINLLREGLDLPE
HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
VSLVAILDADKEGFLRSARSLIQTIGRAARNVSGEVHMYADTITESMKEAIDETERRRAK
EEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHH
QIAYNEAHGIDPQPLRKKIADILDQVYREADDTDTVEIGSGRSMSRGRRAQGEPGRAVSA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEC
GIVEGRDTTNMPRAELADLIKDLTAQMMAAARDLQFELAARFRDEIADLKKELRGMDAAG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA