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The map label for this gene is coaE

Identifier: 41407424

GI number: 41407424

Start: 1419170

End: 1420393

Strand: Direct

Name: coaE

Synonym: MAP1326

Alternate gene names: 41407424

Gene position: 1419170-1420393 (Clockwise)

Preceding gene: 41407423

Following gene: 41407430

Centisome position: 29.38

GC content: 70.67

Gene sequence:

>1224_bases
ATGCTGCGCATCGGGTTGACCGGCGGCATCGGCGCCGGCAAGTCGGCGCTGTCCTCCGCGTTCGCGCAGTGCGGTGCGGT
CATCGTCGACGGTGACGTCATCGCCCGTGAGGTGGTCCGGCCCGGTACCGAGGGCCTGGCGGCGCTGGTCGAGGCGTTCG
GACGCGACATCCTGCTCGCGGACGGATCGCTGGACCGGCCGGCGTTGGCGGCCAAGGCTTTCGCCGACGACGCCGCCCGT
CAGACGCTCAACGGGATCGTGCATCCGCTGGTGGGTGCGCGCCGCGCCGAGATAATCGCGTCGGTGCCCGCGGATTCCGT
TGTGGTCGAGGACATTCCGCTGCTGGTGGAATCCGGGATGGCGCCGCTGTTCCCGCTCGTCGTCATCGTGTACGCCGATG
TCGAGGTGCGGCTGCGGCGGCTGGTCGAGCAGCGCGGCATGGCCGAAGCCGACGCCCGCGCCCGGATCGCCGCTCAGGCC
AGCGACGAGCAGCGCCGCGCCGTCGCCGACATCTGGCTGGACAACTCGGGCAGCCCGGCGGAGTTGGTGCAACGGGCCCA
GCAGGTGTGGAACGAGCGCATCGTGCCGTTCGCCCACAACCTGAGCACGCGTCAGATCGCCCGGGCGCCGGTGCGGTTGG
TGCCGCCCGATCCCGAGTGGCCGGCCCAGGCGCAGCGAATCGTCAACCGGCTCAAGACCGCATCCGGCCATCGGGCGCTG
CGCGTCGACCACGTCGGCTCCACGGCGTTGCCCGGGGATCCGGATTTCGCGGCCAAGGACGTCATCGACATCCAGATCAC
CGTGGAATCCCTGGCCGCCGCCGACGAACTCGTCGAACCGTTGCTGGCCGCCGGATACCCTCGCCTCGAACACATCACCG
CCGACGTCGCCAAGCCCGACGCCCGCAGCACCGTCGAGCGCTACGATCACACCGGCGATCCGGCCTTGTGGCACAAGCGG
ATTCACGCCTCGGCGGACCCGGGCCGGCCCACCAACGTGCACATCCGGGTGGACGGCTGGCCCGGCCAGCAGTTCGCCCT
GCTGTTCGTGGACTGGTTGACCGCCGACCCCGATGCTCGGGCCGACTATCTGGCCGTCAAGCGCAGCGCCGAACAGCGGG
CCGACGGTGACATCGACGCCTACGTCGCCGTCAAGGAGCCGTGGTTTCGCGACGCCTACCGGCGGGCCTGGGATTGGGCC
GACTCGACGGGCTGGAAACCCTAG

Upstream 100 bases:

>100_bases
CGGCGCACCGGCGGAGAAGGCGGGCGGTTCGCTGGCCAGCGACGCCCAACTGGCCGCGCTGCGGGAAAAGCTCGCCGGCA
ACGCCTGATTCAGCTCGCTG

Downstream 100 bases:

>100_bases
CCGCGGGGCCTCAGGGCAGCGGTGCGCCGCACTGCAGCGCCCCGTTCATGGGGTCGGTGTTGCCCGGCGCCGGCCTGACC
ATCTGATCGGTCTGCACGAA

Product: dephospho-CoA kinase/protein folding accessory domain-containing protein

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLRIGLTGGIGAGKSALSSAFAQCGAVIVDGDVIAREVVRPGTEGLAALVEAFGRDILLADGSLDRPALAAKAFADDAAR
QTLNGIVHPLVGARRAEIIASVPADSVVVEDIPLLVESGMAPLFPLVVIVYADVEVRLRRLVEQRGMAEADARARIAAQA
SDEQRRAVADIWLDNSGSPAELVQRAQQVWNERIVPFAHNLSTRQIARAPVRLVPPDPEWPAQAQRIVNRLKTASGHRAL
RVDHVGSTALPGDPDFAAKDVIDIQITVESLAAADELVEPLLAAGYPRLEHITADVAKPDARSTVERYDHTGDPALWHKR
IHASADPGRPTNVHIRVDGWPGQQFALLFVDWLTADPDARADYLAVKRSAEQRADGDIDAYVAVKEPWFRDAYRRAWDWA
DSTGWKP

Sequences:

>Translated_407_residues
MLRIGLTGGIGAGKSALSSAFAQCGAVIVDGDVIAREVVRPGTEGLAALVEAFGRDILLADGSLDRPALAAKAFADDAAR
QTLNGIVHPLVGARRAEIIASVPADSVVVEDIPLLVESGMAPLFPLVVIVYADVEVRLRRLVEQRGMAEADARARIAAQA
SDEQRRAVADIWLDNSGSPAELVQRAQQVWNERIVPFAHNLSTRQIARAPVRLVPPDPEWPAQAQRIVNRLKTASGHRAL
RVDHVGSTALPGDPDFAAKDVIDIQITVESLAAADELVEPLLAAGYPRLEHITADVAKPDARSTVERYDHTGDPALWHKR
IHASADPGRPTNVHIRVDGWPGQQFALLFVDWLTADPDARADYLAVKRSAEQRADGDIDAYVAVKEPWFRDAYRRAWDWA
DSTGWKP
>Mature_407_residues
MLRIGLTGGIGAGKSALSSAFAQCGAVIVDGDVIAREVVRPGTEGLAALVEAFGRDILLADGSLDRPALAAKAFADDAAR
QTLNGIVHPLVGARRAEIIASVPADSVVVEDIPLLVESGMAPLFPLVVIVYADVEVRLRRLVEQRGMAEADARARIAAQA
SDEQRRAVADIWLDNSGSPAELVQRAQQVWNERIVPFAHNLSTRQIARAPVRLVPPDPEWPAQAQRIVNRLKTASGHRAL
RVDHVGSTALPGDPDFAAKDVIDIQITVESLAAADELVEPLLAAGYPRLEHITADVAKPDARSTVERYDHTGDPALWHKR
IHASADPGRPTNVHIRVDGWPGQQFALLFVDWLTADPDARADYLAVKRSAEQRADGDIDAYVAVKEPWFRDAYRRAWDWA
DSTGWKP

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=221, Percent_Identity=33.9366515837104, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI191252795, Length=221, Percent_Identity=33.9366515837104, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI110227607, Length=202, Percent_Identity=30.1980198019802, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI110227605, Length=202, Percent_Identity=30.1980198019802, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI110227603, Length=202, Percent_Identity=30.1980198019802, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI110227601, Length=202, Percent_Identity=30.1980198019802, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI205277394, Length=202, Percent_Identity=30.1980198019802, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786292, Length=176, Percent_Identity=37.5, Blast_Score=114, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17554944, Length=196, Percent_Identity=35.7142857142857, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320402, Length=196, Percent_Identity=36.2244897959184, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644728, Length=194, Percent_Identity=31.4432989690722, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658602, Length=194, Percent_Identity=31.4432989690722, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_MYCPA (Q740M4)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_960260.1
- ProteinModelPortal:   Q740M4
- EnsemblBacteria:   EBMYCT00000037829
- GeneID:   2721728
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP1326
- NMPDR:   fig|262316.1.peg.1326
- GeneTree:   EBGT00050000016455
- HOGENOM:   HBG650290
- OMA:   RVDGWPG
- ProtClustDB:   PRK03333
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- InterPro:   IPR007344
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE; PF04229 UPF0157

EC number: =2.7.1.24

Molecular weight: Translated: 44150; Mature: 44150

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIGLTGGIGAGKSALSSAFAQCGAVIVDGDVIAREVVRPGTEGLAALVEAFGRDILLA
CEEEEECCCCCCCHHHHHHHHHHCCEEEECCHHHHHHHHCCCHHHHHHHHHHHCCEEEEE
DGSLDRPALAAKAFADDAARQTLNGIVHPLVGARRAEIIASVPADSVVVEDIPLLVESGM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCEEHHHHHHHHHCCC
APLFPLVVIVYADVEVRLRRLVEQRGMAEADARARIAAQASDEQRRAVADIWLDNSGSPA
CHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHEEECCCCCHH
ELVQRAQQVWNERIVPFAHNLSTRQIARAPVRLVPPDPEWPAQAQRIVNRLKTASGHRAL
HHHHHHHHHHHCCCCCHHHCCCHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEE
RVDHVGSTALPGDPDFAAKDVIDIQITVESLAAADELVEPLLAAGYPRLEHITADVAKPD
EEECCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
ARSTVERYDHTGDPALWHKRIHASADPGRPTNVHIRVDGWPGQQFALLFVDWLTADPDAR
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEEEHHCCCCCCC
ADYLAVKRSAEQRADGDIDAYVAVKEPWFRDAYRRAWDWADSTGWKP
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLRIGLTGGIGAGKSALSSAFAQCGAVIVDGDVIAREVVRPGTEGLAALVEAFGRDILLA
CEEEEECCCCCCCHHHHHHHHHHCCEEEECCHHHHHHHHCCCHHHHHHHHHHHCCEEEEE
DGSLDRPALAAKAFADDAARQTLNGIVHPLVGARRAEIIASVPADSVVVEDIPLLVESGM
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEECCCCCEEHHHHHHHHHCCC
APLFPLVVIVYADVEVRLRRLVEQRGMAEADARARIAAQASDEQRRAVADIWLDNSGSPA
CHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHEEECCCCCHH
ELVQRAQQVWNERIVPFAHNLSTRQIARAPVRLVPPDPEWPAQAQRIVNRLKTASGHRAL
HHHHHHHHHHHCCCCCHHHCCCHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEE
RVDHVGSTALPGDPDFAAKDVIDIQITVESLAAADELVEPLLAAGYPRLEHITADVAKPD
EEECCCCCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
ARSTVERYDHTGDPALWHKRIHASADPGRPTNVHIRVDGWPGQQFALLFVDWLTADPDAR
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEEEEEHHCCCCCCC
ADYLAVKRSAEQRADGDIDAYVAVKEPWFRDAYRRAWDWADSTGWKP
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA