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The map label for this gene is dinX

Identifier: 41407346

GI number: 41407346

Start: 1328594

End: 1329985

Strand: Direct

Name: dinX

Synonym: MAP1248

Alternate gene names: 41407346

Gene position: 1328594-1329985 (Clockwise)

Preceding gene: 41407345

Following gene: 41407348

Centisome position: 27.51

GC content: 73.35

Gene sequence:

>1392_bases
GTGGAGTCCCGATGGGTGCTGCACCTGGACATGGACGCGTTCTTCGCGTCCGTCGAGCAGCTCACCCGCCCGACGCTGCG
CGGGCGTCCGGTGCTGGTGGGTGGTTTGGGTGGCCGCGGCGTGGTGGCCGGCGCCAGCTACGAGGCGCGCGTGTTCGGCG
CCCGCTCGGCCATGCCCATGCATCAGGCCAAGAGGCTGGTCGGCGTCTCCGCGGTGGTGTTGCCGCCGCGCGGCGTGGTC
TATGGCGTGGCCAGCAGGAGGGTCTTCGACACCATCCGCGCCGTGGTGCCCGTCGTCGAGCAACTGTCCTTCGACGAGGG
GTTCGGCGAGCCGGCCCAACTCGCCGGCGCGCCGGCTCAGGACGTCGAGGCGTTCTGCGAACAGTTGCGCCGACGGGTTC
GTGAGCAGACCGGGCTGATCGCCTCGGTGGGCGCGGGCTCGGGCAAGCAGATCGCCAAGATCGCCTCCGGCCTGGCCAAA
CCGGACGGGGTCCGGGTGGTGCGCCGCGCCGAGGAACGCGAGCTGCTCGGCGGGTTGCCGGTGCGCCGGCTGTGGGGGAT
CGGGCCGGTCGCCGAGGAGAAGCTGCATCGGCTGGGCATCGAGACCATCGGCGAGCTGGCCGCGCTGACCGACGCCGAGG
CCGCCAACATCCTGGGCGCCACCATCGGCCCCGCGCTGCACCGGCTGGCCCGCGGCATCGACGACCGGCCCGTCGCCGAA
CGCGCCGAAGCCAAACAGATCAGCTCCGAGTCGACCTTCGCCGCCGACCTGACCACCCTCGAGCAGCTGCGCGAGGCGAT
CGAACCGATCGCCGAGCACGCCCATCACCGCCTGCTGCGCGACGGCCGGGGCGCGCGCACCGTCACGGTCAAGCTGAAGA
AGTCCGACATGAGCACGCTGACCCGCTCCGCGACCCTGCCCTACGCGACCACCGAGGCCGCCGCGCTAGTCGGCGTGGCC
CGGCGGCTGCTGCTCGACCCGCGCGAGATCGGGCCGATCCGCCTGCTCGGGGTGGGGTTTTCCGGGCTGAGCGAGGTGCG
TCAGGAGTCGCTGTTCCCGGACCTGGAAATGCCTGCGCCGCAATCGGATTCGCAGTCGGTCGAGACCGCGGCCGAGGCGA
TGTTCGGGCCCGGACACGACGCGGGCTGGCGGGTGGGCGACGACGTCGCCCACCCCGACCTGGGGCACGGCTGGGTGCAG
GGCGCCGGGCACGGCGTGGTCACCGCCCGGTTCGAGACCCGCACCTCCGGCCCGGGCCCCGCCCGCACCTTCCCCGCCGA
CAGCGCCGAGCTGGTGCGCGCCAACCCGGTCGATTCGCTGGACTGGCCGGACTACGTCGAGGGCCTGCAGGAGTCGTCAG
CCCCACCGGCCGAGGACGTCGGCGGCCGGTAG

Upstream 100 bases:

>100_bases
AAAGTGCAACCAGCGACGTGTTTCCCGAGAGGCAGCGTCGGTAGATGCACTCTCGCGGTCAGCCCGGGCCGCAGCAGGCC
CGGGCAATAGCATCGATCGG

Downstream 100 bases:

>100_bases
CCCGGCCGCCAGCGCGGCGATCAGCAGCACCCGGGCCTGCGGCGGCCGCAGCGTGGGCACCGGCACCGCCCCCGCGGCGG
CCATCTCGTGCCCGGGCCCG

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV 1 [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARVFGARSAMPMHQAKRLVGVSAVVLPPRGVV
YGVASRRVFDTIRAVVPVVEQLSFDEGFGEPAQLAGAPAQDVEAFCEQLRRRVREQTGLIASVGAGSGKQIAKIASGLAK
PDGVRVVRRAEERELLGGLPVRRLWGIGPVAEEKLHRLGIETIGELAALTDAEAANILGATIGPALHRLARGIDDRPVAE
RAEAKQISSESTFAADLTTLEQLREAIEPIAEHAHHRLLRDGRGARTVTVKLKKSDMSTLTRSATLPYATTEAAALVGVA
RRLLLDPREIGPIRLLGVGFSGLSEVRQESLFPDLEMPAPQSDSQSVETAAEAMFGPGHDAGWRVGDDVAHPDLGHGWVQ
GAGHGVVTARFETRTSGPGPARTFPADSAELVRANPVDSLDWPDYVEGLQESSAPPAEDVGGR

Sequences:

>Translated_463_residues
MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARVFGARSAMPMHQAKRLVGVSAVVLPPRGVV
YGVASRRVFDTIRAVVPVVEQLSFDEGFGEPAQLAGAPAQDVEAFCEQLRRRVREQTGLIASVGAGSGKQIAKIASGLAK
PDGVRVVRRAEERELLGGLPVRRLWGIGPVAEEKLHRLGIETIGELAALTDAEAANILGATIGPALHRLARGIDDRPVAE
RAEAKQISSESTFAADLTTLEQLREAIEPIAEHAHHRLLRDGRGARTVTVKLKKSDMSTLTRSATLPYATTEAAALVGVA
RRLLLDPREIGPIRLLGVGFSGLSEVRQESLFPDLEMPAPQSDSQSVETAAEAMFGPGHDAGWRVGDDVAHPDLGHGWVQ
GAGHGVVTARFETRTSGPGPARTFPADSAELVRANPVDSLDWPDYVEGLQESSAPPAEDVGGR
>Mature_463_residues
MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARVFGARSAMPMHQAKRLVGVSAVVLPPRGVV
YGVASRRVFDTIRAVVPVVEQLSFDEGFGEPAQLAGAPAQDVEAFCEQLRRRVREQTGLIASVGAGSGKQIAKIASGLAK
PDGVRVVRRAEERELLGGLPVRRLWGIGPVAEEKLHRLGIETIGELAALTDAEAANILGATIGPALHRLARGIDDRPVAE
RAEAKQISSESTFAADLTTLEQLREAIEPIAEHAHHRLLRDGRGARTVTVKLKKSDMSTLTRSATLPYATTEAAALVGVA
RRLLLDPREIGPIRLLGVGFSGLSEVRQESLFPDLEMPAPQSDSQSVETAAEAMFGPGHDAGWRVGDDVAHPDLGHGWVQ
GAGHGVVTARFETRTSGPGPARTFPADSAELVRANPVDSLDWPDYVEGLQESSAPPAEDVGGR

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=340, Percent_Identity=27.3529411764706, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI7706681, Length=341, Percent_Identity=27.2727272727273, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI7705344, Length=254, Percent_Identity=28.3464566929134, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI5729982, Length=169, Percent_Identity=28.9940828402367, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786425, Length=344, Percent_Identity=31.1046511627907, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787432, Length=299, Percent_Identity=29.7658862876254, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17537959, Length=320, Percent_Identity=26.5625, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193205702, Length=223, Percent_Identity=32.7354260089686, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI193205700, Length=223, Percent_Identity=32.7354260089686, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19923006, Length=416, Percent_Identity=26.6826923076923, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21355641, Length=332, Percent_Identity=24.0963855421687, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644984, Length=332, Percent_Identity=24.0963855421687, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 49293; Mature: 49293

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARVFGARSAMPM
CCCCEEEEECHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCEEEECCCCCCCH
HQAKRLVGVSAVVLPPRGVVYGVASRRVFDTIRAVVPVVEQLSFDEGFGEPAQLAGAPAQ
HHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHH
DVEAFCEQLRRRVREQTGLIASVGAGSGKQIAKIASGLAKPDGVRVVRRAEERELLGGLP
HHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VRRLWGIGPVAEEKLHRLGIETIGELAALTDAEAANILGATIGPALHRLARGIDDRPVAE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RAEAKQISSESTFAADLTTLEQLREAIEPIAEHAHHRLLRDGRGARTVTVKLKKSDMSTL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHH
TRSATLPYATTEAAALVGVARRLLLDPREIGPIRLLGVGFSGLSEVRQESLFPDLEMPAP
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCC
QSDSQSVETAAEAMFGPGHDAGWRVGDDVAHPDLGHGWVQGAGHGVVTARFETRTSGPGP
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCCCCCC
ARTFPADSAELVRANPVDSLDWPDYVEGLQESSAPPAEDVGGR
CCCCCCCCHHHEECCCCCCCCCHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MESRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGRGVVAGASYEARVFGARSAMPM
CCCCEEEEECHHHHHHHHHHHHCCCCCCCCEEEECCCCCCEEECCCCCEEEECCCCCCCH
HQAKRLVGVSAVVLPPRGVVYGVASRRVFDTIRAVVPVVEQLSFDEGFGEPAQLAGAPAQ
HHHHHHHCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHH
DVEAFCEQLRRRVREQTGLIASVGAGSGKQIAKIASGLAKPDGVRVVRRAEERELLGGLP
HHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
VRRLWGIGPVAEEKLHRLGIETIGELAALTDAEAANILGATIGPALHRLARGIDDRPVAE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
RAEAKQISSESTFAADLTTLEQLREAIEPIAEHAHHRLLRDGRGARTVTVKLKKSDMSTL
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHH
TRSATLPYATTEAAALVGVARRLLLDPREIGPIRLLGVGFSGLSEVRQESLFPDLEMPAP
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCC
QSDSQSVETAAEAMFGPGHDAGWRVGDDVAHPDLGHGWVQGAGHGVVTARFETRTSGPGP
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEECCCCCCCC
ARTFPADSAELVRANPVDSLDWPDYVEGLQESSAPPAEDVGGR
CCCCCCCCHHHEECCCCCCCCCHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]