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The map label for this gene is mutB

Identifier: 41407324

GI number: 41407324

Start: 1285436

End: 1287688

Strand: Direct

Name: mutB

Synonym: MAP1226

Alternate gene names: 41407324

Gene position: 1285436-1287688 (Clockwise)

Preceding gene: 41407323

Following gene: 41407325

Centisome position: 26.61

GC content: 68.35

Gene sequence:

>2253_bases
ATGACGACCACTGCACCTGCTGTCGGCAGCTTCGCCGACGTGCCACTGCGCAGCGAGCGGCCCGTCGCGCCGGCCACCGA
GGCTGCCGTCGAGGAACACGTCGCGGCGATCGCGGCCGCGCACCTGTACACGCCCGACCAACTGCACTGGCACACACCGG
AAGACATCGCCGTCAAACCGGTTTACATCGGCGCCGACCGGGCCGCCGTCGAGGCCGACGGGTACCCGCTGCACACCTTC
CCCGGCGAGCCGCCGTTCGTGCGCGGCCCCTACCCGACGATGTACGTCAACCAGCCGTGGACCATTCGGCAGTACGCCGG
GTTCTCCACCGCCGCGGAGTCCAACGCCTTCTACCGGCGCAACCTGGCGGCCGGGCAGAAGGGCCTGTCGGTGGCCTTCG
ACCTGGCCACCCACCGCGGCTATGACTCTGATCATCCGCGCGTGCAGGGCGATGTCGGAATGGCCGGTGTGGCAATCGAT
TCCATTCTCGACATGCGGCAGCTGTTCGACGGCATCGACCTGTCGACGGTGAGCGTGTCGATGACCATGAACGGCGCGGT
GCTGCCCATCCTGGCGTTGTACGTGGTGGCCGCCGAGGAGCAGGGGGTACCGCCGGAGAAGCTGGCCGGCACCATCCAGA
ACGACATCCTCAAAGAGTTCATGGTGCGCAACACCTACATCTATCCGCCCAAGCCGTCGATGCGGATCATCTCCGACATC
TTCGCCTACACCAGCGCGAAGATGCCCAAGTTCAACTCCATCTCGATTTCCGGCTACCACATCCAAGAAGCCGGGGCCAC
AGCCGATTTGGAGCTGGCTTACACGCTGGCCGACGGGGTGGACTACATCAAGGCCGGCCTGGACGCCGAGCTGGACATCG
ACAAGTTCGCGCCGCGGCTGTCCTTCTTCTGGGGCATCGGGATGAACTTCTTCATGGAGGTCGCCAAGCTGCGGGCGGGC
CGGCTGCTGTGGAGCGAGCTGGTCTCCCAGTTCAACCCGAAGAACCCCAAATCGCTGTCGCTGCGCACACATTCGCAGAC
CTCGGGCTGGTCGCTGACCGCGCAGGACGCGTTCAACAACGTCGCCCGCACCTGCATCGAGGCGATGGCCGCCACCCAGG
GACACACCCAGTCGCTGCACACCAACGCGCTCGACGAGGCGCTGGCGCTGCCCACCGACTTCTCGGCCCGCATCGCCCGC
AACACCCAGCTGGTGTTGCAGCAGGAGTCGGGCACCACCCGGCCCATCGACCCGTGGGGCGGGTCCTACTACGTGGAATG
GCTGACCCACCACCTGGCCCGCAAGGCCCGCGCGCACATCGCCGAGGTGGCCGAGCACGGCGGCATGGCCCAGGCCATCA
GCGACGGCATCCCCAAGCTGCGCATCGAGGAGGCGGCCGCGCGCACCCAGGCCCGCATCGACTCGGGCATCCAGCCGGTG
ATCGGGGTGAACAAGTACCAGGTCGAGGAGGACCAGGAGGTCGAGGTCCTCAAGGTGGAGAACAGCCGGGTGCGCGCCGA
GCAGCTGGCCAAGCTCAAGGAACTGCGGGACAGCCGCGACCAGTCGGCCGTCGACGCCGCGCTGGCCGAGCTGTCCCGCG
CGGCGGCGGCACAGGGCCGCGCCGGTGAGGACGGGCTGGGTAATAATCTGCTGGCGCTGGCGATCAACGCCGCCCGGGCC
AAGGCCACGGTCGGGGAGATCTCCGACGCGCTGGAAAAGGTATACGGGCGCCATCAGGCGGAGATCCGCACCATCGCCGG
CGTCTACCGTGACGAAGCCGGAAAGGCCACCAACATCGCCACCGCTACGGAACTGGTCGAGAAGTTCGCCGAGGCCGACG
GCCGCCGGCCCCGGATCCTGGTGGCCAAGATGGGCCAGGACGGCCACGACCGCGGCCAGAAGGTGATCGCGACGGCCTTC
GCCGACATCGGCTTCGACGTCGACGTCGGCTCGCTGTTCTCCACCCCCGAGGAGGTGGCCCGCCAGGCCGCCGACAACGA
CGTGCACGTGGTCGGAGTGTCCTCGCTGGCCGCCGGCCACCTGACCCTGGTGCCGGCGCTGCGCGACGCGCTCAAAGAGG
TGGGGCGGCCCGACATCATGATCGTGGTCGGCGGGGTCATCCCGCCCGGCGACTTCGACGAGCTGTACGCCGCCGGGGCC
GCCGCCATCTTCCCGCCCGGGACGGTAATCGCCGACGCCGCAATCGGTTTGCTGCACAAGCTGGCCGAGCGGCTCGGGTA
CGACCTCGGCTGA

Upstream 100 bases:

>100_bases
TGGCGGACGCCGAGCACCGGCCGGACCAATTCCTGACCGCGAAAATCAATGCGGTCGAAGCACTGTCGGATCTGCTCACA
AGGCTGGGGGCGTAGTTACC

Downstream 100 bases:

>100_bases
TGGCCGCGATTCCTGCCGCTCTCGTAACGCTACGGCGAAGAATGGCACCGATTTTCGTCATGGCGTTACAGGCGGCGGTC
CCATGAGCGGGCGGACGGTG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 750; Mature: 749

Protein sequence:

>750_residues
MTTTAPAVGSFADVPLRSERPVAPATEAAVEEHVAAIAAAHLYTPDQLHWHTPEDIAVKPVYIGADRAAVEADGYPLHTF
PGEPPFVRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAID
SILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDI
FAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAELDIDKFAPRLSFFWGIGMNFFMEVAKLRAG
RLLWSELVSQFNPKNPKSLSLRTHSQTSGWSLTAQDAFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIAR
NTQLVLQQESGTTRPIDPWGGSYYVEWLTHHLARKARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQARIDSGIQPV
IGVNKYQVEEDQEVEVLKVENSRVRAEQLAKLKELRDSRDQSAVDAALAELSRAAAAQGRAGEDGLGNNLLALAINAARA
KATVGEISDALEKVYGRHQAEIRTIAGVYRDEAGKATNIATATELVEKFAEADGRRPRILVAKMGQDGHDRGQKVIATAF
ADIGFDVDVGSLFSTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRDALKEVGRPDIMIVVGGVIPPGDFDELYAAGA
AAIFPPGTVIADAAIGLLHKLAERLGYDLG

Sequences:

>Translated_750_residues
MTTTAPAVGSFADVPLRSERPVAPATEAAVEEHVAAIAAAHLYTPDQLHWHTPEDIAVKPVYIGADRAAVEADGYPLHTF
PGEPPFVRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAID
SILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDI
FAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAELDIDKFAPRLSFFWGIGMNFFMEVAKLRAG
RLLWSELVSQFNPKNPKSLSLRTHSQTSGWSLTAQDAFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIAR
NTQLVLQQESGTTRPIDPWGGSYYVEWLTHHLARKARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQARIDSGIQPV
IGVNKYQVEEDQEVEVLKVENSRVRAEQLAKLKELRDSRDQSAVDAALAELSRAAAAQGRAGEDGLGNNLLALAINAARA
KATVGEISDALEKVYGRHQAEIRTIAGVYRDEAGKATNIATATELVEKFAEADGRRPRILVAKMGQDGHDRGQKVIATAF
ADIGFDVDVGSLFSTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRDALKEVGRPDIMIVVGGVIPPGDFDELYAAGA
AAIFPPGTVIADAAIGLLHKLAERLGYDLG
>Mature_749_residues
TTTAPAVGSFADVPLRSERPVAPATEAAVEEHVAAIAAAHLYTPDQLHWHTPEDIAVKPVYIGADRAAVEADGYPLHTFP
GEPPFVRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDS
ILDMRQLFDGIDLSTVSVSMTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDIF
AYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAELDIDKFAPRLSFFWGIGMNFFMEVAKLRAGR
LLWSELVSQFNPKNPKSLSLRTHSQTSGWSLTAQDAFNNVARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARN
TQLVLQQESGTTRPIDPWGGSYYVEWLTHHLARKARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQARIDSGIQPVI
GVNKYQVEEDQEVEVLKVENSRVRAEQLAKLKELRDSRDQSAVDAALAELSRAAAAQGRAGEDGLGNNLLALAINAARAK
ATVGEISDALEKVYGRHQAEIRTIAGVYRDEAGKATNIATATELVEKFAEADGRRPRILVAKMGQDGHDRGQKVIATAFA
DIGFDVDVGSLFSTPEEVARQAADNDVHVVGVSSLAAGHLTLVPALRDALKEVGRPDIMIVVGGVIPPGDFDELYAAGAA
AIFPPGTVIADAAIGLLHKLAERLGYDLG

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=714, Percent_Identity=61.9047619047619, Blast_Score=912, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=704, Percent_Identity=60.9375, Blast_Score=837, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=733, Percent_Identity=61.3915416098226, Blast_Score=921, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 80730; Mature: 80599

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTAPAVGSFADVPLRSERPVAPATEAAVEEHVAAIAAAHLYTPDQLHWHTPEDIAVKP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
VYIGADRAAVEADGYPLHTFPGEPPFVRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRR
EEECCCCCEEECCCEEEECCCCCCCCCCCCCCEEEECCCEEEHHHCCCCCHHCCCCHHHH
NLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDGIDLSTVSVS
HHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
MTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDI
EEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHH
FAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAELDIDKFAPRL
HHHHHCCCCCCCEEEEECEEECCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHH
SFFWGIGMNFFMEVAKLRAGRLLWSELVSQFNPKNPKSLSLRTHSQTSGWSLTAQDAFNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEHHHHHHH
VARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQESGTTRPIDPWG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCC
GSYYVEWLTHHLARKARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQARIDSGIQPV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCC
IGVNKYQVEEDQEVEVLKVENSRVRAEQLAKLKELRDSRDQSAVDAALAELSRAAAAQGR
CCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
AGEDGLGNNLLALAINAARAKATVGEISDALEKVYGRHQAEIRTIAGVYRDEAGKATNIA
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHH
TATELVEKFAEADGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGSLFSTPEEVA
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
RQAADNDVHVVGVSSLAAGHLTLVPALRDALKEVGRPDIMIVVGGVIPPGDFDELYAAGA
HHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCC
AAIFPPGTVIADAAIGLLHKLAERLGYDLG
CEECCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTTAPAVGSFADVPLRSERPVAPATEAAVEEHVAAIAAAHLYTPDQLHWHTPEDIAVKP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
VYIGADRAAVEADGYPLHTFPGEPPFVRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRR
EEECCCCCEEECCCEEEECCCCCCCCCCCCCCEEEECCCEEEHHHCCCCCHHCCCCHHHH
NLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDGIDLSTVSVS
HHHCCCCCCEEEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
MTMNGAVLPILALYVVAAEEQGVPPEKLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDI
EEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHH
FAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIKAGLDAELDIDKFAPRL
HHHHHCCCCCCCEEEEECEEECCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHHHH
SFFWGIGMNFFMEVAKLRAGRLLWSELVSQFNPKNPKSLSLRTHSQTSGWSLTAQDAFNN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEHHHHHHH
VARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQESGTTRPIDPWG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCC
GSYYVEWLTHHLARKARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQARIDSGIQPV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCC
IGVNKYQVEEDQEVEVLKVENSRVRAEQLAKLKELRDSRDQSAVDAALAELSRAAAAQGR
CCCCCEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
AGEDGLGNNLLALAINAARAKATVGEISDALEKVYGRHQAEIRTIAGVYRDEAGKATNIA
CCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHH
TATELVEKFAEADGRRPRILVAKMGQDGHDRGQKVIATAFADIGFDVDVGSLFSTPEEVA
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHH
RQAADNDVHVVGVSSLAAGHLTLVPALRDALKEVGRPDIMIVVGGVIPPGDFDELYAAGA
HHHCCCCEEEEEEHHHCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHCCC
AAIFPPGTVIADAAIGLLHKLAERLGYDLG
CEECCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]