Click here to switch to the map view.

The map label for this gene is ruvC

Identifier: 41407134

GI number: 41407134

Start: 1081289

End: 1081855

Strand: Direct

Name: ruvC

Synonym: MAP1036

Alternate gene names: 41407134

Gene position: 1081289-1081855 (Clockwise)

Preceding gene: 41407131

Following gene: 41407135

Centisome position: 22.39

GC content: 71.6

Gene sequence:

>567_bases
ATGCGGGTGATGGGCGTCGACCCCGGCCTGACCCGGTGCGGGCTGTCGGTGGTGGAAAGCGGGCGCGGTCGCACCGTCGT
CGCGCTGGACGTCGACGTGGTGCGCACCCCGTCGGACGCGCCGCTGGCCGAGCGGCTGCTGAGCATCAGCGACGCGGTCG
AGCATTGGCTGGCCACCCATCAGCCGGACGTGGTGGCCATCGAGCGGGTGTTCTCCCAGCTGAATGTGACGACCGTGATG
GGCACCGCCCAGGCCGGCGGCGTAGTGGCGCTGGCGGCGGCCAAACGCGGCATCGGCGTGCACTTCCACACCCCCAGCGA
GGTCAAGGCCGCGGTGACCGGCAACGGCGCCGCCAACAAGGCCCAAGTCACCGCGATGGTCACCAGAATCCTTGCGCTGC
AAGCCAAACCGACACCCGCCGACGCCGCCGACGCGCTGGCGCTGGCCATCTGCCACTGCTGGCGGGCGCCGATGATCGCC
CGGATGGCGCGGGCCGAGGCGCTGGCGGCCCAGCAGCGGCAGAAATACAAGGACAAGGTGGACGCGACGCTGAGGGCCGC
GCGATGA

Upstream 100 bases:

>100_bases
CTCGACCGGGAATCGGCGCCCGCGCCGCGTGTCCTACCCGGGCCGGTCGGCGCCGGCCGCTAGGCTATCGAACAGCTGTT
CTACTAGGTGGGAGCGGGTA

Downstream 100 bases:

>100_bases
TCGCCTCGGTGCGCGGCGAGGTGCTCGAGGTGGCGCTCGACCATGCCGTGATCGAGGCCGCCGGGGTCGGCTACCGGGTC
AACGCGACGCCCTCGACGCT

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MRVMGVDPGLTRCGLSVVESGRGRTVVALDVDVVRTPSDAPLAERLLSISDAVEHWLATHQPDVVAIERVFSQLNVTTVM
GTAQAGGVVALAAAKRGIGVHFHTPSEVKAAVTGNGAANKAQVTAMVTRILALQAKPTPADAADALALAICHCWRAPMIA
RMARAEALAAQQRQKYKDKVDATLRAAR

Sequences:

>Translated_188_residues
MRVMGVDPGLTRCGLSVVESGRGRTVVALDVDVVRTPSDAPLAERLLSISDAVEHWLATHQPDVVAIERVFSQLNVTTVM
GTAQAGGVVALAAAKRGIGVHFHTPSEVKAAVTGNGAANKAQVTAMVTRILALQAKPTPADAADALALAICHCWRAPMIA
RMARAEALAAQQRQKYKDKVDATLRAAR
>Mature_188_residues
MRVMGVDPGLTRCGLSVVESGRGRTVVALDVDVVRTPSDAPLAERLLSISDAVEHWLATHQPDVVAIERVFSQLNVTTVM
GTAQAGGVVALAAAKRGIGVHFHTPSEVKAAVTGNGAANKAQVTAMVTRILALQAKPTPADAADALALAICHCWRAPMIA
RMARAEALAAQQRQKYKDKVDATLRAAR

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=135, Percent_Identity=35.5555555555556, Blast_Score=70, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_MYCA1 (A0QIB9)

Other databases:

- EMBL:   CP000479
- RefSeq:   YP_882657.1
- ProteinModelPortal:   A0QIB9
- SMR:   A0QIB9
- STRING:   A0QIB9
- EnsemblBacteria:   EBMYCT00000011458
- GeneID:   4526468
- GenomeReviews:   CP000479_GR
- KEGG:   mav:MAV_3475
- TIGR:   MAV_3475
- eggNOG:   COG0817
- GeneTree:   EBGT00050000016429
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- ProtClustDB:   PRK00039
- BioCyc:   MAVI243243:MAV_3475-MONOMER
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 19764; Mature: 19764

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVMGVDPGLTRCGLSVVESGRGRTVVALDVDVVRTPSDAPLAERLLSISDAVEHWLATH
CEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
QPDVVAIERVFSQLNVTTVMGTAQAGGVVALAAAKRGIGVHFHTPSEVKAAVTGNGAANK
CCCHHHHHHHHHHHCHHHEEECCCCCCEEEEEECCCCCEEEEECCHHHEEEEECCCCCCH
AQVTAMVTRILALQAKPTPADAADALALAICHCWRAPMIARMARAEALAAQQRQKYKDKV
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DATLRAAR
HHHHHCCC
>Mature Secondary Structure
MRVMGVDPGLTRCGLSVVESGRGRTVVALDVDVVRTPSDAPLAERLLSISDAVEHWLATH
CEEECCCCCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
QPDVVAIERVFSQLNVTTVMGTAQAGGVVALAAAKRGIGVHFHTPSEVKAAVTGNGAANK
CCCHHHHHHHHHHHCHHHEEECCCCCCEEEEEECCCCCEEEEECCHHHEEEEECCCCCCH
AQVTAMVTRILALQAKPTPADAADALALAICHCWRAPMIARMARAEALAAQQRQKYKDKV
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DATLRAAR
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA