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The map label for this gene is moeA

Identifier: 41407023

GI number: 41407023

Start: 956225

End: 957502

Strand: Direct

Name: moeA

Synonym: MAP0925

Alternate gene names: 41407023

Gene position: 956225-957502 (Clockwise)

Preceding gene: 41407022

Following gene: 41407024

Centisome position: 19.8

GC content: 73.63

Gene sequence:

>1278_bases
GTGGAAGAGCAGCAGGCCCGGATCACGGCTGCCGCGGTGGCGCCGCGGCCGATACGTGTGGCGATCGCCGAGGCGCAGGG
GCTGATGTGCGCCGAGGAAGTGGTCACCGAACGCCCGATGCCCGGTTTCGATCAGGCCGCGATCGACGGCTACGCGGTGC
GCAGCGTCGACGTGCTCGGCGTCGGCGAGGTGGGCGCCGAGGGCCTGCCCGCGCCGCTCGACGACTCGGTCGACGACGCG
CGCGACGGGCTGGTGCTGCCGGTGATGGGAACCGTCGAGGCAGGGTCGCGCACCCCCAGTCGGTTGCAGCCGCGGCAGGC
CGTCCGGGTGCAAACCGGCGCCCCGCTGCCCACGCTGGCCGACGCGGTGCTGCCGCTGGGGTGGACCGACGGCGGGACTC
AGCGGGTGCGGATCTACCGGGGCGCGCCCTCGGGCGCCTACGTGCGCCGAGCCGGCGACGACGTCCAGCCCGGCGACGTC
GCGGTGCGCGCCGGAGCGGTGATCGGGGCGGCCCAGGTCGGGCTGCTGGCCGCGGTCGGCCGCGAGCGGGTGCTGGTGCA
TCCGCGGCCGCGGGTGACGATCATGGCGCTGGGCGGAGAACTGGTCGACATCTCGCGCACCCCGGGAAACGGGCAGGTCT
ACGACGTCAACTCCTATGCGCTGGCGGCGGCGGCCCGCGACGCCGGGGCGGAGGTCAACCGGATCGGGATCGTCGGCGGC
GGCCCCAGGGAACTGCGCGACATCGTCGAGGGCCAGATCAACCGCGCCGAGGTGATCGTGATCGCCGGCGCGGTCGGTGG
CGCCGCGGCCGAAGCGGTGCGCCAGGTGCTGTCCGAGCTCGGGGAGATCGAGGTGGTCCGGGTCGCCATGCACCCGGGCT
CCATCCAGGGTTTTGGGCAGCTGGGCCGCGAGGGTGTTCCGACCTTCCTGTTGCCCGCCAATCCGGTGAGCGCGCTGGTG
GTGTTCGAGGTGATGGTCCGCCCGCTGATCCGGTTGTCGCTGGGCAAGCGCCAGCCGATGCGCCGCATCGTGCAGGCCCG
CACGCTGTCGCCCATCACGTCGGTGGCCGGGCGCAAGGGCTATCTGCGCGGGCAGCTGATGCGCGATCAGGACAGCGGCG
AGTATCTGGTGCAGGCGCTGGGCGGCGCCCCGGGCGCGTCGTCGCACCTGCTGGCCACTCTCGCCGAAGCCAACTGCCTG
GTGGTGGTGCCCAGCGGGGCCGAGCAGATCCGCACCGGCGAGATCGTCGACGTCGCCTTCTTGGCTCAGCGCGGCTGA

Upstream 100 bases:

>100_bases
AAGCGGTCCCGGGCGGGGATGCCCCGCCCGCGCAGTGGGCGGGTCGTGCGCCACGCGGCGCCCGCCGGATTTGAGGGCAG
AGAGGCGCGCTGTGCGTTCG

Downstream 100 bases:

>100_bases
GCGGAACGACTGCACACATCGTGAACCTGTTGCGCAACAATTCCCGTCATCCCGGTTGGCCGATGAGTGTCGGTCCGCTG
CGGGTGCCGGCCGGGGTGGT

Product: hypothetical protein

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MEEQQARITAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLGVGEVGAEGLPAPLDDSVDDA
RDGLVLPVMGTVEAGSRTPSRLQPRQAVRVQTGAPLPTLADAVLPLGWTDGGTQRVRIYRGAPSGAYVRRAGDDVQPGDV
AVRAGAVIGAAQVGLLAAVGRERVLVHPRPRVTIMALGGELVDISRTPGNGQVYDVNSYALAAAARDAGAEVNRIGIVGG
GPRELRDIVEGQINRAEVIVIAGAVGGAAAEAVRQVLSELGEIEVVRVAMHPGSIQGFGQLGREGVPTFLLPANPVSALV
VFEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCL
VVVPSGAEQIRTGEIVDVAFLAQRG

Sequences:

>Translated_425_residues
MEEQQARITAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLGVGEVGAEGLPAPLDDSVDDA
RDGLVLPVMGTVEAGSRTPSRLQPRQAVRVQTGAPLPTLADAVLPLGWTDGGTQRVRIYRGAPSGAYVRRAGDDVQPGDV
AVRAGAVIGAAQVGLLAAVGRERVLVHPRPRVTIMALGGELVDISRTPGNGQVYDVNSYALAAAARDAGAEVNRIGIVGG
GPRELRDIVEGQINRAEVIVIAGAVGGAAAEAVRQVLSELGEIEVVRVAMHPGSIQGFGQLGREGVPTFLLPANPVSALV
VFEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCL
VVVPSGAEQIRTGEIVDVAFLAQRG
>Mature_425_residues
MEEQQARITAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLGVGEVGAEGLPAPLDDSVDDA
RDGLVLPVMGTVEAGSRTPSRLQPRQAVRVQTGAPLPTLADAVLPLGWTDGGTQRVRIYRGAPSGAYVRRAGDDVQPGDV
AVRAGAVIGAAQVGLLAAVGRERVLVHPRPRVTIMALGGELVDISRTPGNGQVYDVNSYALAAAARDAGAEVNRIGIVGG
GPRELRDIVEGQINRAEVIVIAGAVGGAAAEAVRQVLSELGEIEVVRVAMHPGSIQGFGQLGREGVPTFLLPANPVSALV
VFEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCL
VVVPSGAEQIRTGEIVDVAFLAQRG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=413, Percent_Identity=31.7191283292978, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI66932975, Length=413, Percent_Identity=31.7191283292978, Blast_Score=149, Evalue=6e-36,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=31.331592689295, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=366, Percent_Identity=28.4153005464481, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562606, Length=345, Percent_Identity=21.7391304347826, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17136978, Length=305, Percent_Identity=25.5737704918033, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24638841, Length=305, Percent_Identity=25.5737704918033, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44213; Mature: 44213

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEQQARITAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLG
CCCHHHEEEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEEEEE
VGEVGAEGLPAPLDDSVDDARDGLVLPVMGTVEAGSRTPSRLQPRQAVRVQTGAPLPTLA
CCCCCCCCCCCCCCCCCHHHHCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHH
DAVLPLGWTDGGTQRVRIYRGAPSGAYVRRAGDDVQPGDVAVRAGAVIGAAQVGLLAAVG
HHHEECCCCCCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHCC
RERVLVHPRPRVTIMALGGELVDISRTPGNGQVYDVNSYALAAAARDAGAEVNRIGIVGG
CCEEEECCCCCEEEEEECCEEEEEEECCCCCEEEECCCCEEEHHHHCCCCCEEEEEEECC
GPRELRDIVEGQINRAEVIVIAGAVGGAAAEAVRQVLSELGEIEVVRVAMHPGSIQGFGQ
CHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH
LGREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKG
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCC
YLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPSGAEQIRTGEIVDVAF
CEECEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCHHHCCCCCEEEEEE
LAQRG
EECCC
>Mature Secondary Structure
MEEQQARITAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVLG
CCCHHHEEEEEECCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEEEEE
VGEVGAEGLPAPLDDSVDDARDGLVLPVMGTVEAGSRTPSRLQPRQAVRVQTGAPLPTLA
CCCCCCCCCCCCCCCCCHHHHCCEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCHHHH
DAVLPLGWTDGGTQRVRIYRGAPSGAYVRRAGDDVQPGDVAVRAGAVIGAAQVGLLAAVG
HHHEECCCCCCCCEEEEEEECCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHCC
RERVLVHPRPRVTIMALGGELVDISRTPGNGQVYDVNSYALAAAARDAGAEVNRIGIVGG
CCEEEECCCCCEEEEEECCEEEEEEECCCCCEEEECCCCEEEHHHHCCCCCEEEEEEECC
GPRELRDIVEGQINRAEVIVIAGAVGGAAAEAVRQVLSELGEIEVVRVAMHPGSIQGFGQ
CHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH
LGREGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRQPMRRIVQARTLSPITSVAGRKG
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHCCCC
YLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPSGAEQIRTGEIVDVAF
CEECEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCHHHCCCCCEEEEEE
LAQRG
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]