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The map label for this gene is echA6

Identifier: 41406938

GI number: 41406938

Start: 859339

End: 860070

Strand: Direct

Name: echA6

Synonym: MAP0840

Alternate gene names: 41406938

Gene position: 859339-860070 (Clockwise)

Preceding gene: 41406935

Following gene: 41406939

Centisome position: 17.79

GC content: 70.36

Gene sequence:

>732_bases
ATGATCGGTGTTACCCGGGCCGAAGCCGTTTTGACCATCGAGCTGCAGCGCCCCGAGCGCCGCAACGCCCTGAACTCCCA
GCTCGTCGAGGAGCTGCGGGAGGCCGTGCTGAAGGCGGGCGACGGCTCCACCCGCGCGATCGTGCTGACCGGCCAGGGCA
CGGTGTTCTGCGCCGGCGCCGACCTGAGCGGCGACGCGTTCGCCGCGGACTACCCCGACCGGCTGATCGAGCTGCACAAG
GTGCTGGACGCCACGCCGATCCCGGTGATCGGCGCCATCAACGGCCCGGCCATCGGCGCCGGACTGCAACTGGCCATGCA
ATGCGACCTGCGGGTCGTGTCGCCGGACGCGTTCTTCCAGTTCCCGACGTCGAAATACGGCCTGGCCCTTGACAACTGGA
GCATCCGGCGGCTGTCGACGCTGGTCGGCCACGGGCGGGCGCGGGCCATGCTGCTGGCCGCGGAGAAGCTGACCGCCGAC
GTGGCGCTGCAGACCGGGATGGCCAACCGCATCGGGACGCTGGCCGACGCGCAGGCCTGGGCCGCCGAGATCGCGGGCCT
CGCGCCGCTGGCCATCGCGCACGCCAAGCGGGTGCTCAACGACGACGGCGCCATCGAAGAGGCCTGGCCATTGCACAAGG
AACTGTTCGACAAGGCCTGGGGCAGCCAGGACGTCATCGAAGCCCAGGTCGCCCGAATAGAGAAGCGGCCGCCGAAGTTC
CAGGGGGCCTGA

Upstream 100 bases:

>100_bases
CGCTGTCCCAGCGGAGGAAGGAATTTTCGTCCAGCACCGCATCGCGTAGTTGACCAGCCGTGATACGACTCACGAGACGA
GGCTATATAGGGTGGCTGCC

Downstream 100 bases:

>100_bases
CGATCATGCGGGGGACGCTTCGGCTGGTCGCCGGGACGGCGTCGCTGGCCGCCGGCGGTTGGCTGGTGCGCGCCCTGCAC
GGCGCCCCGGACGCCCTGGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIGVTRAEAVLTIELQRPERRNALNSQLVEELREAVLKAGDGSTRAIVLTGQGTVFCAGADLSGDAFAADYPDRLIELHK
VLDATPIPVIGAINGPAIGAGLQLAMQCDLRVVSPDAFFQFPTSKYGLALDNWSIRRLSTLVGHGRARAMLLAAEKLTAD
VALQTGMANRIGTLADAQAWAAEIAGLAPLAIAHAKRVLNDDGAIEEAWPLHKELFDKAWGSQDVIEAQVARIEKRPPKF
QGA

Sequences:

>Translated_243_residues
MIGVTRAEAVLTIELQRPERRNALNSQLVEELREAVLKAGDGSTRAIVLTGQGTVFCAGADLSGDAFAADYPDRLIELHK
VLDATPIPVIGAINGPAIGAGLQLAMQCDLRVVSPDAFFQFPTSKYGLALDNWSIRRLSTLVGHGRARAMLLAAEKLTAD
VALQTGMANRIGTLADAQAWAAEIAGLAPLAIAHAKRVLNDDGAIEEAWPLHKELFDKAWGSQDVIEAQVARIEKRPPKF
QGA
>Mature_243_residues
MIGVTRAEAVLTIELQRPERRNALNSQLVEELREAVLKAGDGSTRAIVLTGQGTVFCAGADLSGDAFAADYPDRLIELHK
VLDATPIPVIGAINGPAIGAGLQLAMQCDLRVVSPDAFFQFPTSKYGLALDNWSIRRLSTLVGHGRARAMLLAAEKLTAD
VALQTGMANRIGTLADAQAWAAEIAGLAPLAIAHAKRVLNDDGAIEEAWPLHKELFDKAWGSQDVIEAQVARIEKRPPKF
QGA

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=262, Percent_Identity=32.0610687022901, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI194097323, Length=239, Percent_Identity=32.6359832635983, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI25453481, Length=239, Percent_Identity=25.5230125523013, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI51538573, Length=239, Percent_Identity=25.5230125523013, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4757968, Length=246, Percent_Identity=26.0162601626016, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI49355787, Length=246, Percent_Identity=26.0162601626016, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4757966, Length=227, Percent_Identity=25.9911894273128, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI51538581, Length=227, Percent_Identity=25.9911894273128, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI221136756, Length=241, Percent_Identity=25.7261410788382, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI221136753, Length=241, Percent_Identity=25.7261410788382, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI221307494, Length=241, Percent_Identity=25.7261410788382, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=26.3157894736842, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI31542718, Length=185, Percent_Identity=27.5675675675676, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI116235487, Length=160, Percent_Identity=29.375, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787659, Length=252, Percent_Identity=35.7142857142857, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI221142681, Length=256, Percent_Identity=30.859375, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788597, Length=250, Percent_Identity=27.2, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082183, Length=258, Percent_Identity=25.968992248062, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787660, Length=251, Percent_Identity=31.4741035856574, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788682, Length=173, Percent_Identity=28.9017341040462, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25145438, Length=260, Percent_Identity=31.5384615384615, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17536985, Length=263, Percent_Identity=27.3764258555133, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=29.4354838709677, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17560910, Length=226, Percent_Identity=29.646017699115, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=262, Percent_Identity=29.0076335877863, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=206, Percent_Identity=29.6116504854369, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=237, Percent_Identity=27.4261603375527, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=247, Percent_Identity=25.9109311740891, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20129971, Length=241, Percent_Identity=29.4605809128631, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24653477, Length=241, Percent_Identity=29.4605809128631, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI19920382, Length=214, Percent_Identity=32.7102803738318, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24653139, Length=252, Percent_Identity=23.015873015873, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357171, Length=239, Percent_Identity=28.0334728033473, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24654903, Length=204, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650670, Length=189, Percent_Identity=27.5132275132275, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19922422, Length=252, Percent_Identity=24.2063492063492, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 25965; Mature: 25965

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVTRAEAVLTIELQRPERRNALNSQLVEELREAVLKAGDGSTRAIVLTGQGTVFCAGA
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEECC
DLSGDAFAADYPDRLIELHKVLDATPIPVIGAINGPAIGAGLQLAMQCDLRVVSPDAFFQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEECCEEEECCCCEEE
FPTSKYGLALDNWSIRRLSTLVGHGRARAMLLAAEKLTADVALQTGMANRIGTLADAQAW
CCCCCCCEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHH
AAEIAGLAPLAIAHAKRVLNDDGAIEEAWPLHKELFDKAWGSQDVIEAQVARIEKRPPKF
HHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QGA
CCC
>Mature Secondary Structure
MIGVTRAEAVLTIELQRPERRNALNSQLVEELREAVLKAGDGSTRAIVLTGQGTVFCAGA
CCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCEEEEECC
DLSGDAFAADYPDRLIELHKVLDATPIPVIGAINGPAIGAGLQLAMQCDLRVVSPDAFFQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEEEEECCEEEECCCCEEE
FPTSKYGLALDNWSIRRLSTLVGHGRARAMLLAAEKLTADVALQTGMANRIGTLADAQAW
CCCCCCCEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHH
AAEIAGLAPLAIAHAKRVLNDDGAIEEAWPLHKELFDKAWGSQDVIEAQVARIEKRPPKF
HHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
QGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]