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The map label for this gene is modD [H]

Identifier: 39998054

GI number: 39998054

Start: 3259168

End: 3260019

Strand: Reverse

Name: modD [H]

Synonym: GSU2963

Alternate gene names: 39998054

Gene position: 3260019-3259168 (Counterclockwise)

Preceding gene: 39998055

Following gene: 39998053

Centisome position: 85.47

GC content: 63.97

Gene sequence:

>852_bases
ATGTTGGACCGTCTGCCGGACAGCGAGCTCGATCGCTTTTTTGAAGAGGATTGTCCCTACGGCGACCTCACCACACATCT
TCTCGGCATTGGCCGTCAGAAGGGGCGAATCACCTTTTCCACCCGGGAAGAAACCGTTCTCTGCGGTACCGAGGAGGCCG
GCCGCCTCCTGGATCGGTGCGGTGCCCGTGTGGGGCGGATGGAGGAAAGCGGAACCCGCCTTTCTGCCGGGGTGGAGTTT
CTGGTTGCCGACGGAGAGGCCGGATCCCTCCATGCGGGCTGGAAGGTGGCCCTCAACCTTCTGGAGTATGCCTCGGGGAT
TGCCACCCGCACTGCCCGGATCATTGCGGTGGCCCGGGCCGTCAACCCGGCCGTTGTGGTGACTACCACCCGCAAGTCGT
TCCCCGGCACGAGGAAGATTTCCATCAAGGCAATTACCGCGGCCGGTGCAGTCCCTCACCGGCTCGGTTTGTCGGAGACG
ATTCTTGTTTTCCGGCAGCACACTGCGTTCCTGGGCGGACTGGAGCCGTTCCTCGGCATGATCGGCGACCTTAGGAAAAG
GGCGCCGGAGACCGCCATCATGGTCGAGGCGGAGAGTGTCGCCGATGCTGTGGCCGTGGCCGCCGCCGGTCCCGATGTCC
TTCAGATCGACAAGGTTGCTCCCGCCGATCTTTCGGCGCTTGTACCGCAACTGAGAAAGCTGGCGCCGATGACCAGGATT
TCGGCCGCAGGCGGCATCAACGAGTCGAACGCGGCGGTTTACGCCGCCACCGGCGTTGACATCCTGGTCCTCTCGTCGGC
CTATTTCGGCCGGCCGGCTGACATCGGCGTGCGGTTGGAGCCGGTGGTGTGA

Upstream 100 bases:

>100_bases
GACAATCAAACAAATGGGTTAGGCCCGGGCGGGCTTTTCGGCATCTAGCTTGCGTAAAGGAAATTGAAGGGCACCGCCAG
GGGGGCCCCGGGAGAACAAC

Downstream 100 bases:

>100_bases
AGCCAGGGGGTACTCTTATACAAAAGGAGATTCATCGATGCGAACCGTTATGAAAAACCTGGTCTTCGCCTTCTGTTGCA
TCCTGTTTCTGTCGAACGCC

Product: modD protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLDRLPDSELDRFFEEDCPYGDLTTHLLGIGRQKGRITFSTREETVLCGTEEAGRLLDRCGARVGRMEESGTRLSAGVEF
LVADGEAGSLHAGWKVALNLLEYASGIATRTARIIAVARAVNPAVVVTTTRKSFPGTRKISIKAITAAGAVPHRLGLSET
ILVFRQHTAFLGGLEPFLGMIGDLRKRAPETAIMVEAESVADAVAVAAAGPDVLQIDKVAPADLSALVPQLRKLAPMTRI
SAAGGINESNAAVYAATGVDILVLSSAYFGRPADIGVRLEPVV

Sequences:

>Translated_283_residues
MLDRLPDSELDRFFEEDCPYGDLTTHLLGIGRQKGRITFSTREETVLCGTEEAGRLLDRCGARVGRMEESGTRLSAGVEF
LVADGEAGSLHAGWKVALNLLEYASGIATRTARIIAVARAVNPAVVVTTTRKSFPGTRKISIKAITAAGAVPHRLGLSET
ILVFRQHTAFLGGLEPFLGMIGDLRKRAPETAIMVEAESVADAVAVAAAGPDVLQIDKVAPADLSALVPQLRKLAPMTRI
SAAGGINESNAAVYAATGVDILVLSSAYFGRPADIGVRLEPVV
>Mature_283_residues
MLDRLPDSELDRFFEEDCPYGDLTTHLLGIGRQKGRITFSTREETVLCGTEEAGRLLDRCGARVGRMEESGTRLSAGVEF
LVADGEAGSLHAGWKVALNLLEYASGIATRTARIIAVARAVNPAVVVTTTRKSFPGTRKISIKAITAAGAVPHRLGLSET
ILVFRQHTAFLGGLEPFLGMIGDLRKRAPETAIMVEAESVADAVAVAAAGPDVLQIDKVAPADLSALVPQLRKLAPMTRI
SAAGGINESNAAVYAATGVDILVLSSAYFGRPADIGVRLEPVV

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=273, Percent_Identity=26.7399267399267, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786299, Length=245, Percent_Identity=24.4897959183673, Blast_Score=62, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321162, Length=286, Percent_Identity=24.4755244755245, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.-

Molecular weight: Translated: 29904; Mature: 29904

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRLPDSELDRFFEEDCPYGDLTTHLLGIGRQKGRITFSTREETVLCGTEEAGRLLDRC
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHH
GARVGRMEESGTRLSAGVEFLVADGEAGSLHAGWKVALNLLEYASGIATRTARIIAVARA
HHHHCCCCCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNPAVVVTTTRKSFPGTRKISIKAITAAGAVPHRLGLSETILVFRQHTAFLGGLEPFLGM
CCCEEEEEECCCCCCCCEEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHH
IGDLRKRAPETAIMVEAESVADAVAVAAAGPDVLQIDKVAPADLSALVPQLRKLAPMTRI
HHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHH
SAAGGINESNAAVYAATGVDILVLSSAYFGRPADIGVRLEPVV
HHCCCCCCCCCEEEEECCCEEEEEEHHHCCCCCCCCEEEECCC
>Mature Secondary Structure
MLDRLPDSELDRFFEEDCPYGDLTTHLLGIGRQKGRITFSTREETVLCGTEEAGRLLDRC
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEEECCCCEEEECCHHHHHHHHHH
GARVGRMEESGTRLSAGVEFLVADGEAGSLHAGWKVALNLLEYASGIATRTARIIAVARA
HHHHCCCCCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNPAVVVTTTRKSFPGTRKISIKAITAAGAVPHRLGLSETILVFRQHTAFLGGLEPFLGM
CCCEEEEEECCCCCCCCEEEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHCCHHHHHHH
IGDLRKRAPETAIMVEAESVADAVAVAAAGPDVLQIDKVAPADLSALVPQLRKLAPMTRI
HHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHH
SAAGGINESNAAVYAATGVDILVLSSAYFGRPADIGVRLEPVV
HHCCCCCCCCCEEEEECCCEEEEEEHHHCCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]