Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 39998006

GI number: 39998006

Start: 3213944

End: 3215317

Strand: Reverse

Name: atoC [H]

Synonym: GSU2915

Alternate gene names: 39998006

Gene position: 3215317-3213944 (Counterclockwise)

Preceding gene: 39998007

Following gene: 39998005

Centisome position: 84.3

GC content: 57.42

Gene sequence:

>1374_bases
GTGAGAAAGACAAAGATACTGGTGGTGGATGACGAACATCTCATCCGTTGGTCCCTCGAGCAGAACCTGAAGAAGCAGGG
GTATGACGTGGTTTCCGCCGGTAACGGCGAGGATGCCCTGCGGATCGTCCGCGAGGAGCAGCCCGACTTGGTGCTGCTCG
ATATCCAGCTGCCGGGAATAAGCGGCCTGGAGGCTCTGGAAAAGATCAAAGAATACGATGAGGAAATCCTCGTCATCATG
GTGACCGCTCACGGCGCCCTGGAAACAGCGGTTCATGCCATGAGGCTCGGCGCCTACGATTACATCAACAAGCCGTTCAA
TCTGGACGAAATGTCCATCGTCATCCGCAAGGCCCTGGAAACCTCCGATCTGCGTCGGGAGGTCCAGCGGCTCCGCAGCG
AACAGTCGCGCAAGTTCGGCCCCCCAGACATCATCGGTGCCAGCCGGCACATGAAAAACGTCCTGGAAATGATGGAAAAG
GTTGCCAAGAGTGATGCCTCCACGGTCCTGATCCAGGGGGAATCCGGCACCGGCAAGGAACTGGTGGCCAAGTGGATCCA
TTACCAGTCTGCCCGCGCGGAAAAGCCGTTTGTGGCCATCAACTGCGCGGCAGTACCTGCCACGCTTCTGGAAAGCGAGC
TTTTCGGCCATGAGAAAGGCGCCTTTACTGACGCCAAGGTGATGAAAAAAGGGCTCTTCGAGTTGGCCGACGGGGGTACC
GTTTTCCTCGACGAAATCGGCGACATGGAGATGGGAATGCAGGCGAAGCTCCTGCGCTTCCTGGAGGAAAGGACCTTCCG
CCGGATCGGCGGCACCAAAGCCTTTGCCGTTGATGTCCGGATCATCTCCGCCACCAACCGCGACCTGCTGAAGGCCATTG
AGGAGAAGAATTTCCGCAACGATCTCTACTACCGGCTCCAGGTGATTCCCATTTACCTGCCCCCGCTCCGGGAGCGCAAG
GAAGACATCCTGCAACTGGTCAACCACTTCATCGAGGTGTTCAACCGCGAATTCAACAAGCACGTGACCGGCATCTCGAA
GATGGCCGAGAAGCTGCTCCTGGAATACCACTGGCCCGGCAATATCCGTGAGCTCAAGAACGTGATCGAGCGGGCCATCA
TCCTCGGCAACGAAGATACGCTGCTGCTGGAGCACCTGCCCCTGGAGATCGTTGCCAAGGCATCGAACCAGACCACGGGC
TTGGCGACCTTCAAGCTGCCGCCTGACGGGGTCGATATTGAAGAGGTTGAAAAGGAGCTGATCCGCCAGTCCCTGGAGAT
GAGTGAGTGGAACCAGTCCAAGGCTGCCAAGAAGCTGAACCTGGGAATCGATGCGTTCCGTTACCGGATGAAGAAGTTCG
GCTTCCTTAAATAA

Upstream 100 bases:

>100_bases
GCGCGGGAAGAGCGCTGTGTGCATCAAAGGATTTCCCTATCTGCTGCCGGTAATGCTATAGTGGGTTCATTATACGATTC
AATGCGTTAAAGGAGCTGCC

Downstream 100 bases:

>100_bases
CCCGCCTCACCACTCGGTGGTTCTACGTCAAATAACGGCCCCCTGTCCCCTTTCGGGAATGCGCAGGGGGCCGTTTCCAT
TGGCCTGTCTGCCGCTTCTT

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MRKTKILVVDDEHLIRWSLEQNLKKQGYDVVSAGNGEDALRIVREEQPDLVLLDIQLPGISGLEALEKIKEYDEEILVIM
VTAHGALETAVHAMRLGAYDYINKPFNLDEMSIVIRKALETSDLRREVQRLRSEQSRKFGPPDIIGASRHMKNVLEMMEK
VAKSDASTVLIQGESGTGKELVAKWIHYQSARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKVMKKGLFELADGGT
VFLDEIGDMEMGMQAKLLRFLEERTFRRIGGTKAFAVDVRIISATNRDLLKAIEEKNFRNDLYYRLQVIPIYLPPLRERK
EDILQLVNHFIEVFNREFNKHVTGISKMAEKLLLEYHWPGNIRELKNVIERAIILGNEDTLLLEHLPLEIVAKASNQTTG
LATFKLPPDGVDIEEVEKELIRQSLEMSEWNQSKAAKKLNLGIDAFRYRMKKFGFLK

Sequences:

>Translated_457_residues
MRKTKILVVDDEHLIRWSLEQNLKKQGYDVVSAGNGEDALRIVREEQPDLVLLDIQLPGISGLEALEKIKEYDEEILVIM
VTAHGALETAVHAMRLGAYDYINKPFNLDEMSIVIRKALETSDLRREVQRLRSEQSRKFGPPDIIGASRHMKNVLEMMEK
VAKSDASTVLIQGESGTGKELVAKWIHYQSARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKVMKKGLFELADGGT
VFLDEIGDMEMGMQAKLLRFLEERTFRRIGGTKAFAVDVRIISATNRDLLKAIEEKNFRNDLYYRLQVIPIYLPPLRERK
EDILQLVNHFIEVFNREFNKHVTGISKMAEKLLLEYHWPGNIRELKNVIERAIILGNEDTLLLEHLPLEIVAKASNQTTG
LATFKLPPDGVDIEEVEKELIRQSLEMSEWNQSKAAKKLNLGIDAFRYRMKKFGFLK
>Mature_457_residues
MRKTKILVVDDEHLIRWSLEQNLKKQGYDVVSAGNGEDALRIVREEQPDLVLLDIQLPGISGLEALEKIKEYDEEILVIM
VTAHGALETAVHAMRLGAYDYINKPFNLDEMSIVIRKALETSDLRREVQRLRSEQSRKFGPPDIIGASRHMKNVLEMMEK
VAKSDASTVLIQGESGTGKELVAKWIHYQSARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKVMKKGLFELADGGT
VFLDEIGDMEMGMQAKLLRFLEERTFRRIGGTKAFAVDVRIISATNRDLLKAIEEKNFRNDLYYRLQVIPIYLPPLRERK
EDILQLVNHFIEVFNREFNKHVTGISKMAEKLLLEYHWPGNIRELKNVIERAIILGNEDTLLLEHLPLEIVAKASNQTTG
LATFKLPPDGVDIEEVEKELIRQSLEMSEWNQSKAAKKLNLGIDAFRYRMKKFGFLK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=44.6389496717724, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=44.4444444444444, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1790299, Length=478, Percent_Identity=38.9121338912134, Blast_Score=336, Evalue=1e-93,
Organism=Escherichia coli, GI1788905, Length=441, Percent_Identity=39.6825396825397, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=45.1612903225806, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1789087, Length=363, Percent_Identity=43.2506887052342, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=43.6532507739938, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=42.3197492163009, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87082152, Length=318, Percent_Identity=40.8805031446541, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=252, Percent_Identity=45.6349206349206, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1787583, Length=248, Percent_Identity=44.3548387096774, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789828, Length=270, Percent_Identity=32.962962962963, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI87081858, Length=287, Percent_Identity=29.616724738676, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789809, Length=115, Percent_Identity=40, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=37.6068376068376, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790863, Length=140, Percent_Identity=33.5714285714286, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788394, Length=130, Percent_Identity=32.3076923076923, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788222, Length=114, Percent_Identity=35.9649122807018, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786784, Length=115, Percent_Identity=31.304347826087, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=30.4347826086957, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787229, Length=145, Percent_Identity=28.2758620689655, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789402, Length=108, Percent_Identity=34.2592592592593, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=28.9719626168224, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1786911, Length=116, Percent_Identity=31.8965517241379, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52070; Mature: 52070

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTKILVVDDEHLIRWSLEQNLKKQGYDVVSAGNGEDALRIVREEQPDLVLLDIQLPGI
CCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECCCC
SGLEALEKIKEYDEEILVIMVTAHGALETAVHAMRLGAYDYINKPFNLDEMSIVIRKALE
CHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHH
TSDLRREVQRLRSEQSRKFGPPDIIGASRHMKNVLEMMEKVAKSDASTVLIQGESGTGKE
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
LVAKWIHYQSARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKVMKKGLFELADGGT
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCE
VFLDEIGDMEMGMQAKLLRFLEERTFRRIGGTKAFAVDVRIISATNRDLLKAIEEKNFRN
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCHHHHHHHHHCCCCC
DLYYRLQVIPIYLPPLRERKEDILQLVNHFIEVFNREFNKHVTGISKMAEKLLLEYHWPG
CEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
NIRELKNVIERAIILGNEDTLLLEHLPLEIVAKASNQTTGLATFKLPPDGVDIEEVEKEL
CHHHHHHHHHHHHEECCCCEEEEECCCHHHEEECCCCCCCEEEEECCCCCCCHHHHHHHH
IRQSLEMSEWNQSKAAKKLNLGIDAFRYRMKKFGFLK
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRKTKILVVDDEHLIRWSLEQNLKKQGYDVVSAGNGEDALRIVREEQPDLVLLDIQLPGI
CCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCEEEEEEECCCC
SGLEALEKIKEYDEEILVIMVTAHGALETAVHAMRLGAYDYINKPFNLDEMSIVIRKALE
CHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHHHHH
TSDLRREVQRLRSEQSRKFGPPDIIGASRHMKNVLEMMEKVAKSDASTVLIQGESGTGKE
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
LVAKWIHYQSARAEKPFVAINCAAVPATLLESELFGHEKGAFTDAKVMKKGLFELADGGT
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCE
VFLDEIGDMEMGMQAKLLRFLEERTFRRIGGTKAFAVDVRIISATNRDLLKAIEEKNFRN
EEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCHHHHHHHHHCCCCC
DLYYRLQVIPIYLPPLRERKEDILQLVNHFIEVFNREFNKHVTGISKMAEKLLLEYHWPG
CEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
NIRELKNVIERAIILGNEDTLLLEHLPLEIVAKASNQTTGLATFKLPPDGVDIEEVEKEL
CHHHHHHHHHHHHEECCCCEEEEECCCHHHEEECCCCCCCEEEEECCCCCCCHHHHHHHH
IRQSLEMSEWNQSKAAKKLNLGIDAFRYRMKKFGFLK
HHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]