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The map label for this gene is kefC [H]

Identifier: 39997852

GI number: 39997852

Start: 3038707

End: 3040590

Strand: Reverse

Name: kefC [H]

Synonym: GSU2759

Alternate gene names: 39997852

Gene position: 3040590-3038707 (Counterclockwise)

Preceding gene: 39997853

Following gene: 39997851

Centisome position: 79.72

GC content: 66.67

Gene sequence:

>1884_bases
ATGACCGACACCATGCTCGGTCAGGCCGTGGTCTACCTTGCCGCGGCTCTGTTCTGCGTGCCCATTGCCCGGCGCCTGGG
CATGGGGTCCGTCCTGGGCTACCTGCTGGCCGGGATACTGATCGGCCCCTTCTGTCTCGGGTTTGTGGGGCGTGAGGGGG
AGGACATCATGCACTTCGCCGAGTTCGGCGTGGTCATGATGCTCTTCCTGATCGGCCTGGAGCTGGAGCCGGCCCATTTC
TGGCGGATGCGCACCACCATCCTGGGGCTGGGGTCGCTGCAGCTGGCCCTGACCACCTGTGCCCTGACCGCGGGCCTCCT
GCTGCTGGGCCTCGACTGGCGGGGAGCCCTTGCCGCGGGCCTGGCCCTTGCCATGTCGTCCACGGCCATCGTGCTCCAAT
CCCTCAAGGAAAAGGGGCTGGGCAACTCTCACGCCGGGCTGAGCTCCTTTGCGGTGCTCCTGTTCCAGGACATCGCCGTG
ATCCCGATCCTGGCCCTGCTCCCGTTCCTGGCCATCCAGGCCGGCGGGGGGGCCGTCCACGGGGATGCGCCCTCCCTGCT
GGACGGGCTGCCGGTCTGGATGAAGGCCGGCTCGGTCCTCTTCGCCGTGGTGGCGGTGGTGGTCATGGGGCGTTCCATCG
TGGTCCCCTTTCTCCGCATCGTCACCAAGGCCAGCGTCCGCGAGCTCTCGGTCGCCGCGGCGCTGCTGATCATCGTTGCC
ATAGCATACCTGATGGAACTGGTGGGGCTGAGTCCGGCCCTGGGCGCCTTCCTCGCCGGCGTGCTCCTGGCCAACAGCGA
ATTTCGCCACGAACTGGAGAGCGACATCGAGCCCTTCAAGGGGCTGCTGTTGGGCCTCTTTTTCATTGCGGTAGGGGCCT
CCATCAACTTCAGGCTGCTGACGGACAAGCCGGCCACCATCATTTCGCTGGTGCTGGCCGTCATCCTGGTCAAGGCAGTG
GTGCTGGTCGTCGCGGGGCGGCTGTTCCGCCTTTCCTTCGACCAGAACAGCATCTTCGCCATCGGCCTGTCCCAGGTGGG
GGAGTTCGCCTTTGTCCTGTTCGCTTTCATCGACCGGCTGGGGATCATCGGGCGCGACTGGACCGATACCCTGATGGCGG
TGACGGCCATCAGCATGACCATGACCCCCCTGCTCCTGCTGGCGAACGAACGGCTGGTGCTGCCCCGGTTCGGCACCCGG
GAGCGGGAGGAGCAGGAGGCCGACCTGATCGATACGGAGCACCCGGTCATCATTGCCGGGTTCAGCTCCTTCGGCAGCAC
CCTGGGGCGCTTCCTCCGCGCCAACGGCGTGGAAGCGACCATTCTCGACAACGATTCCGACCAGGTGGACCTGCTGCGGC
GCATGGGGTTCAAGGTCTTCTACGGGGACGCGACCCGGCTGGATATCCTCCGTTCGGCCGGGGCCGACAGCGCCCGCGTT
CTGTTCATCGCCATCGACAGCCCCGCCACGGTCAACAAGCTGGTTGCCACGGCGCGGAAGCATTTTCCCCACCTGAAGGT
CATGGCCCGGGCCGGCACCAACCTGGACGCCCACGAACTCCTGGACCTGGGAGTGCGGGACATCTACCGCGATTTTCTCG
ACACCTCGGTGCGGGCCGGGGTGGACGTGCTGGCGAGCCTGGGATACCGGCGGTACGGCGCCACCCGCGCCGGCCAGGAC
TTCATCAGGTACGACGAGTCCGCCATGCACCACCTGGCGCCCCACCGCCACGACGAGTCCAGCTATATCTCCACCGCCCG
GGAACAGATCCGGCTGCAGGAGCAGTTGCTGGCCGGCGACCGCACCGCCAACCATACGCATCATGATCACGCCTGGGATA
CGAGCACGCCGGTCACGGCGGCAGAGGGAGAGACGCAGCCCTGA

Upstream 100 bases:

>100_bases
AGATCCTGCTGAAGCTGGCCCAATCCCCGCCCCTGGAGCAGATCCGGGGGTACGAGTTCCTGAATGACTGGATTTCGGCC
CTGAACCGGAAGGAGGCGCC

Downstream 100 bases:

>100_bases
CACCGTCGCGTCGGTACTCGGTGTCCCCATCGTTTCCATCGCGTTGCGCCCGTTTGCCTGTTATACTCTCTCCCCATGGC
CCACGAATCGATCTCCATCC

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTDTMLGQAVVYLAAALFCVPIARRLGMGSVLGYLLAGILIGPFCLGFVGREGEDIMHFAEFGVVMMLFLIGLELEPAHF
WRMRTTILGLGSLQLALTTCALTAGLLLLGLDWRGALAAGLALAMSSTAIVLQSLKEKGLGNSHAGLSSFAVLLFQDIAV
IPILALLPFLAIQAGGGAVHGDAPSLLDGLPVWMKAGSVLFAVVAVVVMGRSIVVPFLRIVTKASVRELSVAAALLIIVA
IAYLMELVGLSPALGAFLAGVLLANSEFRHELESDIEPFKGLLLGLFFIAVGASINFRLLTDKPATIISLVLAVILVKAV
VLVVAGRLFRLSFDQNSIFAIGLSQVGEFAFVLFAFIDRLGIIGRDWTDTLMAVTAISMTMTPLLLLANERLVLPRFGTR
EREEQEADLIDTEHPVIIAGFSSFGSTLGRFLRANGVEATILDNDSDQVDLLRRMGFKVFYGDATRLDILRSAGADSARV
LFIAIDSPATVNKLVATARKHFPHLKVMARAGTNLDAHELLDLGVRDIYRDFLDTSVRAGVDVLASLGYRRYGATRAGQD
FIRYDESAMHHLAPHRHDESSYISTAREQIRLQEQLLAGDRTANHTHHDHAWDTSTPVTAAEGETQP

Sequences:

>Translated_627_residues
MTDTMLGQAVVYLAAALFCVPIARRLGMGSVLGYLLAGILIGPFCLGFVGREGEDIMHFAEFGVVMMLFLIGLELEPAHF
WRMRTTILGLGSLQLALTTCALTAGLLLLGLDWRGALAAGLALAMSSTAIVLQSLKEKGLGNSHAGLSSFAVLLFQDIAV
IPILALLPFLAIQAGGGAVHGDAPSLLDGLPVWMKAGSVLFAVVAVVVMGRSIVVPFLRIVTKASVRELSVAAALLIIVA
IAYLMELVGLSPALGAFLAGVLLANSEFRHELESDIEPFKGLLLGLFFIAVGASINFRLLTDKPATIISLVLAVILVKAV
VLVVAGRLFRLSFDQNSIFAIGLSQVGEFAFVLFAFIDRLGIIGRDWTDTLMAVTAISMTMTPLLLLANERLVLPRFGTR
EREEQEADLIDTEHPVIIAGFSSFGSTLGRFLRANGVEATILDNDSDQVDLLRRMGFKVFYGDATRLDILRSAGADSARV
LFIAIDSPATVNKLVATARKHFPHLKVMARAGTNLDAHELLDLGVRDIYRDFLDTSVRAGVDVLASLGYRRYGATRAGQD
FIRYDESAMHHLAPHRHDESSYISTAREQIRLQEQLLAGDRTANHTHHDHAWDTSTPVTAAEGETQP
>Mature_626_residues
TDTMLGQAVVYLAAALFCVPIARRLGMGSVLGYLLAGILIGPFCLGFVGREGEDIMHFAEFGVVMMLFLIGLELEPAHFW
RMRTTILGLGSLQLALTTCALTAGLLLLGLDWRGALAAGLALAMSSTAIVLQSLKEKGLGNSHAGLSSFAVLLFQDIAVI
PILALLPFLAIQAGGGAVHGDAPSLLDGLPVWMKAGSVLFAVVAVVVMGRSIVVPFLRIVTKASVRELSVAAALLIIVAI
AYLMELVGLSPALGAFLAGVLLANSEFRHELESDIEPFKGLLLGLFFIAVGASINFRLLTDKPATIISLVLAVILVKAVV
LVVAGRLFRLSFDQNSIFAIGLSQVGEFAFVLFAFIDRLGIIGRDWTDTLMAVTAISMTMTPLLLLANERLVLPRFGTRE
REEQEADLIDTEHPVIIAGFSSFGSTLGRFLRANGVEATILDNDSDQVDLLRRMGFKVFYGDATRLDILRSAGADSARVL
FIAIDSPATVNKLVATARKHFPHLKVMARAGTNLDAHELLDLGVRDIYRDFLDTSVRAGVDVLASLGYRRYGATRAGQDF
IRYDESAMHHLAPHRHDESSYISTAREQIRLQEQLLAGDRTANHTHHDHAWDTSTPVTAAEGETQP

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=406, Percent_Identity=27.3399014778325, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1786232, Length=634, Percent_Identity=42.1135646687697, Blast_Score=450, Evalue=1e-127,
Organism=Escherichia coli, GI1789749, Length=604, Percent_Identity=41.887417218543, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1786685, Length=529, Percent_Identity=26.8431001890359, Blast_Score=155, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67592; Mature: 67461

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTMLGQAVVYLAAALFCVPIARRLGMGSVLGYLLAGILIGPFCLGFVGREGEDIMHFA
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EFGVVMMLFLIGLELEPAHFWRMRTTILGLGSLQLALTTCALTAGLLLLGLDWRGALAAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LALAMSSTAIVLQSLKEKGLGNSHAGLSSFAVLLFQDIAVIPILALLPFLAIQAGGGAVH
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GDAPSLLDGLPVWMKAGSVLFAVVAVVVMGRSIVVPFLRIVTKASVRELSVAAALLIIVA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYLMELVGLSPALGAFLAGVLLANSEFRHELESDIEPFKGLLLGLFFIAVGASINFRLL
HHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
TDKPATIISLVLAVILVKAVVLVVAGRLFRLSFDQNSIFAIGLSQVGEFAFVLFAFIDRL
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCEEEEEHHHHHHHHHHHHHHHHHH
GIIGRDWTDTLMAVTAISMTMTPLLLLANERLVLPRFGTREREEQEADLIDTEHPVIIAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHCCCCCCCCEEEEE
FSSFGSTLGRFLRANGVEATILDNDSDQVDLLRRMGFKVFYGDATRLDILRSAGADSARV
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCEE
LFIAIDSPATVNKLVATARKHFPHLKVMARAGTNLDAHELLDLGVRDIYRDFLDTSVRAG
EEEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDVLASLGYRRYGATRAGQDFIRYDESAMHHLAPHRHDESSYISTAREQIRLQEQLLAGD
HHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
RTANHTHHDHAWDTSTPVTAAEGETQP
CCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDTMLGQAVVYLAAALFCVPIARRLGMGSVLGYLLAGILIGPFCLGFVGREGEDIMHFA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EFGVVMMLFLIGLELEPAHFWRMRTTILGLGSLQLALTTCALTAGLLLLGLDWRGALAAG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
LALAMSSTAIVLQSLKEKGLGNSHAGLSSFAVLLFQDIAVIPILALLPFLAIQAGGGAVH
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GDAPSLLDGLPVWMKAGSVLFAVVAVVVMGRSIVVPFLRIVTKASVRELSVAAALLIIVA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAYLMELVGLSPALGAFLAGVLLANSEFRHELESDIEPFKGLLLGLFFIAVGASINFRLL
HHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
TDKPATIISLVLAVILVKAVVLVVAGRLFRLSFDQNSIFAIGLSQVGEFAFVLFAFIDRL
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCCCEEEEEHHHHHHHHHHHHHHHHHH
GIIGRDWTDTLMAVTAISMTMTPLLLLANERLVLPRFGTREREEQEADLIDTEHPVIIAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHCCCCCCCCEEEEE
FSSFGSTLGRFLRANGVEATILDNDSDQVDLLRRMGFKVFYGDATRLDILRSAGADSARV
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCCEE
LFIAIDSPATVNKLVATARKHFPHLKVMARAGTNLDAHELLDLGVRDIYRDFLDTSVRAG
EEEEECCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VDVLASLGYRRYGATRAGQDFIRYDESAMHHLAPHRHDESSYISTAREQIRLQEQLLAGD
HHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
RTANHTHHDHAWDTSTPVTAAEGETQP
CCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA